MY150599A - [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-fluoro-1-(2-methoxy-ethyl)-4-trifluoromethoxy-1h-indol-3-yl]-methanone as an inhibitor of mast cell tryptase - Google Patents

[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-fluoro-1-(2-methoxy-ethyl)-4-trifluoromethoxy-1h-indol-3-yl]-methanone as an inhibitor of mast cell tryptase

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Publication number
MY150599A
MY150599A MYPI20110395A MY150599A MY 150599 A MY150599 A MY 150599A MY PI20110395 A MYPI20110395 A MY PI20110395A MY 150599 A MY150599 A MY 150599A
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MY
Malaysia
Prior art keywords
fluoro
inhibitor
methanone
indol
piperidin
Prior art date
Application number
Inventor
Choi-Sledeski Yong Mi
Choy Nakyen
Poli Gregory Bernard
Jr John J Shay
Shum Patrick Wai-Kwok
Adam W Sledeski
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MY150599A publication Critical patent/MY150599A/en

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

THE PRESENT INVENTION IS DIRECTED TO AN INDOLE BENZYLAMINE COMPOUND OF FORMULA I: USEFUL AS AN INHIBITOR OF TRYPTASE. IN ADDITION, THE PRESENT INVENTION IS DIRECTED TO THE USE OF THE COMPOUND FOR TREATING A PATIENT SUFFERING FROM, OR SUBJECT TO, A PHYSIOLOGICAL CONDITION IN NEED OF AMELIORATION BY INHIBITION OF TRYPTASE, COMPRISING ADMINISTERING TO THE PATIENT OF A THERAPEUTICALLY EFFECTIVE AMOUNT OF THE COMPOUND, AND TO A PHARMACEUTICAL COMPOSITION COMPRISING A PHARMACEUTICALLY EFFECTIVE AMOUNT OF THE COMPOUND OF FORMULA I, AND A PHARMACEUTICALLY ACCEPTABLE CARRIER.
MYPI20110395 2008-08-22 2009-08-20 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-fluoro-1-(2-methoxy-ethyl)-4-trifluoromethoxy-1h-indol-3-yl]-methanone as an inhibitor of mast cell tryptase MY150599A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9101108P 2008-08-22 2008-08-22
US9101808P 2008-08-22 2008-08-22

Publications (1)

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MY150599A true MY150599A (en) 2014-01-30

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MYPI20110395 MY150599A (en) 2008-08-22 2009-08-20 [4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-[7-fluoro-1-(2-methoxy-ethyl)-4-trifluoromethoxy-1h-indol-3-yl]-methanone as an inhibitor of mast cell tryptase

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US (2) US8217178B2 (en)
EP (1) EP2367812B1 (en)
JP (1) JP5656834B2 (en)
KR (1) KR101630217B1 (en)
CN (2) CN102149705B (en)
AR (1) AR073117A1 (en)
AU (1) AU2009282884B8 (en)
BR (1) BRPI0916920A2 (en)
CA (1) CA2734877C (en)
CL (1) CL2009001759A1 (en)
CO (1) CO6341624A2 (en)
CR (1) CR20110093A (en)
CY (1) CY1117261T1 (en)
DK (1) DK2367812T3 (en)
DO (1) DOP2011000055A (en)
EC (1) ECSP11010841A (en)
ES (1) ES2556764T3 (en)
HR (1) HRP20151338T1 (en)
HU (1) HUE026331T2 (en)
IL (2) IL211265A (en)
MA (1) MA32639B1 (en)
MX (1) MX2011001135A (en)
MY (1) MY150599A (en)
NI (1) NI201100024A (en)
NZ (1) NZ591234A (en)
PE (1) PE20100235A1 (en)
PL (1) PL2367812T3 (en)
PT (1) PT2367812E (en)
RS (1) RS54413B1 (en)
RU (1) RU2509766C2 (en)
SI (1) SI2367812T1 (en)
TW (1) TWI473613B (en)
UA (1) UA104148C2 (en)
UY (1) UY32069A (en)
WO (1) WO2010022196A2 (en)
ZA (1) ZA201100597B (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102149705B (en) 2008-08-22 2013-08-07 赛诺菲-安万特 [4-(5-Aminomethyl-2-fluorophenyl)-piperidin-1-yl]-[7-fluoro-1-(2-methoxyethyl) as a mast cell tryptase inhibitor -4-Trifluoromethoxy-1H-indol-3-yl]-methanone
FR2955324A1 (en) * 2010-01-15 2011-07-22 Sanofi Aventis DISUBSTITUTED 4- (5-AMINOMETHYL-PHENYL) -PIPERIDIN-1-YL] -1H-INDOL-3-YL] -METHANONES
CA2784894A1 (en) * 2009-12-23 2011-06-30 Sanofi Indolyl-piperidinyl benzylamines as beta-tryptase inhibitors
PL2516418T3 (en) 2009-12-23 2014-10-31 Sanofi Sa Prodrugs of [4[4-(5-aminomethyl-2-fluoro-phenyl)-piperidin-1-yl]-(1h-pyrrolo-pyridin-yl)-methanones and synthesis thereof
EP2516428A1 (en) * 2009-12-23 2012-10-31 Sanofi Tropinone benzylamines as beta-tryptase inhibitors
AU2010333892A1 (en) * 2009-12-23 2012-07-19 Sanofi Treatment for inflammatory bowel disease
AU2011220909A1 (en) * 2010-02-24 2012-09-13 Sanofi Treatment of dermatological allergic conditions
EP2397074B1 (en) 2010-06-19 2012-10-24 M Stenqvist AB A system and computer readable medium for determination of transpulmonary pressure in a patient connected to a breathing apparatus
PL2763979T3 (en) 2011-10-07 2019-06-28 Takeda Pharmaceutical Company Limited 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
DE102020120900A1 (en) * 2020-08-07 2022-02-10 Drägerwerk AG & Co. KGaA Device and method for measuring lung compliance
JP2024506384A (en) 2021-02-10 2024-02-13 イオリクス セラピューティクス，インコーポレーテッド Roflumilast ophthalmological delivery method
CA3231766A1 (en) 2021-09-22 2023-03-30 Elizabeth W. JEFFORDS Methods of treating ocular inflammatory diseases

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087240A (en) 1983-08-18 1992-02-11 Drug Delivery Systems Inc. Transdermal drug patch with conductive fibers
US4921475A (en) 1983-08-18 1990-05-01 Drug Delivery Systems Inc. Transdermal drug patch with microtubes
US4879119A (en) 1984-02-21 1989-11-07 Yamanouchi Pharmaceutical Co., Ltd. Patch
EP0545913B1 (en) 1986-08-18 1999-02-24 Emisphere Technologies, Inc. Delivery systems for pharmacological agents
US5163899A (en) 1987-03-20 1992-11-17 Drug Delivery Systems Inc. Transdermal drug delivery system
US5312325A (en) 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
GB8804164D0 (en) 1988-02-23 1988-03-23 Tucker J M Bandage for administering physiologically active compound
US5008110A (en) 1988-11-10 1991-04-16 The Procter & Gamble Company Storage-stable transdermal patch
US5088977A (en) 1988-12-21 1992-02-18 Drug Delivery Systems Inc. Electrical transdermal drug applicator with counteractor and method of drug delivery
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
EP0431519B1 (en) 1989-12-04 1994-06-15 G.D. Searle & Co. System for transdermal albuterol administration
AU643141B2 (en) 1991-03-15 1993-11-04 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5352456A (en) 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
DE69228827T2 (en) 1991-12-18 1999-10-21 Minnesota Mining And Mfg. Co., Saint Paul MULTI-LAYER LOCK STRUCTURES
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
RU2278115C2 (en) * 1999-05-21 2006-06-20 Сайос Инк. DERIVATIVES OF INDOLE ORDER AS p38 KINASE INHIBITORS
GB0012362D0 (en) * 2000-05-22 2000-07-12 Aventis Pharma Ltd Chemical compounds
DZ3347A1 (en) * 2000-05-22 2001-11-29 Aventis Pharma Inc ARYLMETHYLAMINE DERIVATIVES FOR THEIR USE AS TRYPTASE INHIBITORS
EP1571150A1 (en) * 2004-03-02 2005-09-07 Aventis Pharma Deutschland GmbH Process for the preparation of tryptase inhibitors
DOP2005000039A (en) * 2004-03-26 2005-10-31 Aventis Pharma Inc HYDROCHLORIDE OF [4- (5-AMINOMETIL-2-FLUORO-PHENYL) - PIPERIDIN-1-IL] - (4-BOMO-3-METHYL-5-PROPOXI-TIOFEN-2-IL) -METANONE AS AN INHIBITOR OF THE MASTOCYT TRIPTASE
AR065859A1 (en) * 2007-03-29 2009-07-08 Sanofi Aventis ESTER OF 2,5-DIOXO-PIRROLIDIN-1-ILO OF ACID 4-BROMO-3-METIL-5-PROPOXITIOFEN-2- CARBOXILICO, ITS REGIO-SPECIFIC SYNTHESIS AND AN INTERMEDIATE OF THE SAME
AR065858A1 (en) * 2007-03-29 2009-07-08 Sanofi Aventis METHOD FOR PREPARING THE TRIPTASE INHIBITOR [4- (5-AMINOETIL-2-FLUORO-PHENYL) -PIPERIDIN-1-IL] - (4-BROMO-3-METHYL-5-PROPOXI-TIOFEN-2-IL) -METANONE .
CN102149705B (en) 2008-08-22 2013-08-07 赛诺菲-安万特 [4-(5-Aminomethyl-2-fluorophenyl)-piperidin-1-yl]-[7-fluoro-1-(2-methoxyethyl) as a mast cell tryptase inhibitor -4-Trifluoromethoxy-1H-indol-3-yl]-methanone

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