MY156538A - Methods of treating diabetes with dll4 antagonists - Google Patents
Methods of treating diabetes with dll4 antagonistsInfo
- Publication number
- MY156538A MY156538A MYPI2012003169A MYPI2012003169A MY156538A MY 156538 A MY156538 A MY 156538A MY PI2012003169 A MYPI2012003169 A MY PI2012003169A MY PI2012003169 A MYPI2012003169 A MY PI2012003169A MY 156538 A MY156538 A MY 156538A
- Authority
- MY
- Malaysia
- Prior art keywords
- dii4
- antagonists
- block
- antibodies
- auto
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Zoology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
THE PRESENT INVENTION PROVIDES METHODS OF PREVENTING, TREATING OR AMELIORATING DIABETES BY ADMINISTERING TO A SUBJECT IN NEED THEREOF A THERAPEUTICALLY EFFECTIVE AMOUNT OF DII4 ANTAGONISTS THAT BLOCK DII4-NOTCH SIGNAL PATHWAYS. AS OBSERVED IN A MOUSE MODEL OF DIABETES, DII4 ANTAGONISTS EXHIBIT PROTECTIVE EFFECTS ON PANCREATIC ISLETS, LOWER BLOOD GLUCOSE LEVELS, AND BLOCK THE PRODUCTION OF AUTO-ANTIBODIES, INCLUDING THOSE AGAINST INSULIN AND GLUTAMIC ACID DECARBOXYLASE 65 (GAD65), VIA THE EXPANSION OF REGULATORY T CELLS (TREGS). THUS, THE PRESENT INVENTION FURTHER PROVIDES METHODS OF LOWERING THE LEVELS OF BLOOD GLUCOSE, AND/OR REDUCING OR BLOCKING THE PRODUCTION OF AUTO-ANTIBODIES, BY ADMINISTERING TO A SUBJECT IN NEED THEREOF A THERAPEUTICALLY EFFECTIVE AMOUNT OF DII4 ANTAGONISTS.; SUITABLE DII4 ANTAGONISTS FOR THE INVENTION INCLUDE ANTIBODIES OR ANTIBODY FRAGMENTS THAT SPECIFICALLY BIND DII4 AND BLOCK DII4-NOTCH INTERACTIONS, THE EXTRACELLULAR DOMAIN OF DII4, AND THE LIKE.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29980110P | 2010-01-29 | 2010-01-29 | |
| US36168710P | 2010-07-06 | 2010-07-06 | |
| US38869710P | 2010-10-01 | 2010-10-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY156538A true MY156538A (en) | 2016-02-26 |
Family
ID=43925413
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2012003169A MY156538A (en) | 2010-01-29 | 2011-01-28 | Methods of treating diabetes with dll4 antagonists |
| MYPI2012003168A MY156353A (en) | 2010-01-29 | 2011-01-28 | Methods of treating autoimmune diseases with dll4 antagonists |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2012003168A MY156353A (en) | 2010-01-29 | 2011-01-28 | Methods of treating autoimmune diseases with dll4 antagonists |
Country Status (29)
| Country | Link |
|---|---|
| US (3) | US8889133B2 (en) |
| EP (2) | EP2528945B1 (en) |
| JP (2) | JP5997613B2 (en) |
| KR (2) | KR101797918B1 (en) |
| CN (2) | CN102947336B (en) |
| AR (1) | AR080026A1 (en) |
| AU (2) | AU2011210771B2 (en) |
| BR (2) | BR112012018766A2 (en) |
| CA (2) | CA2787394C (en) |
| CY (2) | CY1118223T1 (en) |
| DK (2) | DK2528946T3 (en) |
| ES (2) | ES2609663T3 (en) |
| HR (2) | HRP20170130T1 (en) |
| HU (2) | HUE032985T2 (en) |
| IL (2) | IL220889A (en) |
| JO (2) | JO3183B1 (en) |
| LT (2) | LT2528945T (en) |
| MX (2) | MX343553B (en) |
| MY (2) | MY156538A (en) |
| PL (2) | PL2528946T3 (en) |
| PT (2) | PT2528946T (en) |
| RS (2) | RS55595B1 (en) |
| RU (2) | RU2587624C2 (en) |
| SG (4) | SG10201500404QA (en) |
| SI (2) | SI2528945T1 (en) |
| SM (3) | SMT201700021T1 (en) |
| TW (2) | TWI564019B (en) |
| UY (1) | UY33206A (en) |
| WO (2) | WO2011094467A2 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2448979C2 (en) * | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Human antibodies to delta-like human ligand-4 |
| CA2771575A1 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| EP3485908B1 (en) | 2009-10-16 | 2021-08-18 | Mereo BioPharma 5, Inc. | Therapeutic combination and use of dll4 antagonist antibodies and anti-hypertensive agents |
| JO3183B1 (en) | 2010-01-29 | 2018-03-08 | Regeneron Pharma | Methods for treating autoimmune diseases anti-DLL4 |
| WO2011109298A2 (en) | 2010-03-02 | 2011-09-09 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| TWI583699B (en) | 2011-09-23 | 2017-05-21 | 安可美德藥物股份有限公司 | VEGF/DLL4 binding agents and their use |
| KR101535341B1 (en) | 2012-07-02 | 2015-07-13 | 한화케미칼 주식회사 | Novel monoclonal antibody that specifically binds to DLL4 and use thereof |
| PE20151179A1 (en) | 2012-11-01 | 2015-09-12 | Abbvie Inc | DUAL ANTI-VEGF / DLL4 VARIABLE DOMAIN IMMUNOGLOBULINS AND USES OF THEM |
| TW201438736A (en) * | 2012-11-14 | 2014-10-16 | Regeneron Pharma | Methods of treating ovarian cancer with Dll4 antagonists |
| CA2917402C (en) | 2013-07-09 | 2019-10-22 | Hanwha Chemical Corporation | Novel dual-targeting protein binding specifically to dll4 and vegf and use thereof |
| WO2015057968A2 (en) * | 2013-10-17 | 2015-04-23 | The General Hospital Corporation | Methods of identifying subjects responsive to treatment for an autoimmune disease and compositions for treating the same |
| CA2944811C (en) * | 2014-04-08 | 2022-06-21 | Urs Christen | Combination therapy for the treatment of autoimmune diseases |
| EP3212233B1 (en) | 2014-10-31 | 2020-06-24 | Oncomed Pharmaceuticals, Inc. | Combination therapy for treatment of disease |
| US11339213B2 (en) | 2015-09-23 | 2022-05-24 | Mereo Biopharma 5, Inc. | Methods and compositions for treatment of cancer |
| US11446262B2 (en) | 2018-11-29 | 2022-09-20 | Debora Zucco Sassi Yonezawa Siviglia | Neuroquiescence—a treatment for neurodevelopmental and neurodegenerative bioelectrical dysregulation and demyelination |
| EP3886856A4 (en) | 2018-11-29 | 2022-01-19 | Zucco Sassi Yonezawa Siviglia, Debora | Method for treating or preventing seizures associated with an epileptic disorder |
| US20240287173A1 (en) * | 2021-03-30 | 2024-08-29 | National University Corporation Kumamoto University | Therapeutic agent for muscular atrophy |
| WO2023159166A1 (en) * | 2022-02-18 | 2023-08-24 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Single-domain antibodies (nanobodies) targeting the notch ligand dll4 and methods of their use |
| US20240148789A1 (en) * | 2022-07-15 | 2024-05-09 | The University Of Toledo | Synergistic Inhibition of eIF5A and Notch Signaling |
| WO2025212726A2 (en) | 2024-04-04 | 2025-10-09 | Compass Therapeutics, Inc. | Combination of antibodies targeting dll4/vegf and cd137 agonists or anti-pd1/anti-pd-l1 antibodies for the treatment of cancer |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| AU2003248558B8 (en) * | 2002-05-21 | 2009-07-09 | Gilead Sciences, Inc. | Method of treating diabetes |
| EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
| US20060134121A1 (en) | 2004-10-29 | 2006-06-22 | Gavin Thurston | DII4 antagonists, assays, and therapeutic methods thereof |
| PL1962895T3 (en) | 2005-12-16 | 2013-06-28 | Regeneron Pharma | THERAPEUTIC USE OF A Dll4 ANTAGONIST AND A VEGF INHIBITOR FOR INHIBITING TUMOR GROWTH |
| ATE537190T1 (en) | 2006-06-02 | 2011-12-15 | Regeneron Pharma | HIGH AFFINE ANTIBODIES AGAINST THE HUMAN IL-6 RECEPTOR |
| JP2009539870A (en) | 2006-06-06 | 2009-11-19 | ジェネンテック・インコーポレーテッド | Compositions and methods for modulating angiogenesis |
| AU2007319672B2 (en) * | 2006-06-06 | 2011-06-30 | Genentech, Inc. | Anti-DLL4 antibodies and methods using same |
| NZ574794A (en) | 2006-08-07 | 2011-06-30 | Regeneron Pharma | Use of delta-like ligand 4 (DLL4) antagonists for treating eye vascular and ischemic injury |
| HRP20160082T1 (en) | 2006-09-29 | 2016-02-26 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for diagnosing and treating cancer |
| RU2448979C2 (en) * | 2006-12-14 | 2012-04-27 | Ридженерон Фармасьютикалз, Инк. | Human antibodies to delta-like human ligand-4 |
| CA2771575A1 (en) | 2009-08-29 | 2011-03-03 | Abbott Laboratories | Therapeutic dll4 binding proteins |
| JO3183B1 (en) | 2010-01-29 | 2018-03-08 | Regeneron Pharma | Methods for treating autoimmune diseases anti-DLL4 |
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2011
- 2011-01-23 JO JOP/2011/0021A patent/JO3183B1/en active
- 2011-01-26 AR ARP110100250A patent/AR080026A1/en unknown
- 2011-01-28 JP JP2012551293A patent/JP5997613B2/en active Active
- 2011-01-28 SI SI201131011A patent/SI2528945T1/en unknown
- 2011-01-28 WO PCT/US2011/022817 patent/WO2011094467A2/en not_active Ceased
- 2011-01-28 LT LTEP11701735.0T patent/LT2528945T/en unknown
- 2011-01-28 CN CN201180016820.4A patent/CN102947336B/en not_active Expired - Fee Related
- 2011-01-28 BR BR112012018766A patent/BR112012018766A2/en active Search and Examination
- 2011-01-28 CA CA2787394A patent/CA2787394C/en active Active
- 2011-01-28 SM SM20170021T patent/SMT201700021T1/en unknown
- 2011-01-28 HU HUE11701735A patent/HUE032985T2/en unknown
- 2011-01-28 SG SG10201500404QA patent/SG10201500404QA/en unknown
- 2011-01-28 ES ES11701933.1T patent/ES2609663T3/en active Active
- 2011-01-28 SG SG10201500416RA patent/SG10201500416RA/en unknown
- 2011-01-28 DK DK11701933.1T patent/DK2528946T3/en active
- 2011-01-28 RS RS20170036A patent/RS55595B1/en unknown
- 2011-01-28 SM SM201600412T patent/SMT201600412B/en unknown
- 2011-01-28 MX MX2012008740A patent/MX343553B/en active IP Right Grant
- 2011-01-28 EP EP11701735.0A patent/EP2528945B1/en active Active
- 2011-01-28 HU HUE11701933A patent/HUE031432T2/en unknown
- 2011-01-28 UY UY0001033206A patent/UY33206A/en not_active Application Discontinuation
- 2011-01-28 EP EP11701933.1A patent/EP2528946B1/en active Active
- 2011-01-28 KR KR1020127022496A patent/KR101797918B1/en not_active Expired - Fee Related
- 2011-01-28 SG SG2012052056A patent/SG182528A1/en unknown
- 2011-01-28 PL PL11701933T patent/PL2528946T3/en unknown
- 2011-01-28 SI SI201131020A patent/SI2528946T1/en unknown
- 2011-01-28 US US13/015,652 patent/US8889133B2/en active Active
- 2011-01-28 MX MX2012008638A patent/MX343555B/en active IP Right Grant
- 2011-01-28 WO PCT/US2011/022810 patent/WO2011094465A1/en not_active Ceased
- 2011-01-28 AU AU2011210771A patent/AU2011210771B2/en active Active
- 2011-01-28 CA CA2787615A patent/CA2787615C/en active Active
- 2011-01-28 JP JP2012551294A patent/JP5883801B2/en active Active
- 2011-01-28 PT PT117019331T patent/PT2528946T/en unknown
- 2011-01-28 KR KR1020127022506A patent/KR101832118B1/en not_active Expired - Fee Related
- 2011-01-28 PL PL11701735T patent/PL2528945T3/en unknown
- 2011-01-28 TW TW100103219A patent/TWI564019B/en not_active IP Right Cessation
- 2011-01-28 TW TW105101963A patent/TWI600433B/en not_active IP Right Cessation
- 2011-01-28 HR HRP20170130TT patent/HRP20170130T1/en unknown
- 2011-01-28 RU RU2012136817/10A patent/RU2587624C2/en not_active IP Right Cessation
- 2011-01-28 SG SG2012052049A patent/SG182527A1/en unknown
- 2011-01-28 LT LTEP11701933.1T patent/LT2528946T/en unknown
- 2011-01-28 AU AU2011210773A patent/AU2011210773B2/en active Active
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