MY159197A - Anticancer derivatives, preparation thereof and therapeutic use thereof - Google Patents

Anticancer derivatives, preparation thereof and therapeutic use thereof

Info

Publication number
MY159197A
MY159197A MYPI2013000240A MYPI2013000240A MY159197A MY 159197 A MY159197 A MY 159197A MY PI2013000240 A MYPI2013000240 A MY PI2013000240A MY PI2013000240 A MYPI2013000240 A MY PI2013000240A MY 159197 A MY159197 A MY 159197A
Authority
MY
Malaysia
Prior art keywords
therapeutic use
preparation
anticancer
anticancer derivatives
derivatives
Prior art date
Application number
MYPI2013000240A
Inventor
Alain Commercon
Laurence Gauzy-Lazo
Philippe Hubert
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43027561&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MY159197(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MY159197A publication Critical patent/MY159197A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

THE PRESENT INVENTION RELATES TO CONJUGATES OF PYRROLO[1,4]BENZODIAZEPINE (PBD) DIMERS, TO COMPOSITIONS CONTAINING THEM AND TO THEIR THERAPEUTIC USE, ESPECIALLY AS ANTICANCER AGENTS. THE INVENTION ALSO RELATES TO THE PROCESS FOR PREPARING THE CONJUGATES AND TO THEIR USE AS ANTICANCER AGENTS, AND ALSO TO THE DIMERS THEMSELVES. FORMULA (I) IN WHICH : REPRESENTS A SINGLE BOND OR A DOUBLE BOND.
MYPI2013000240A 2010-07-26 2011-07-25 Anticancer derivatives, preparation thereof and therapeutic use thereof MY159197A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1056103A FR2963007B1 (en) 2010-07-26 2010-07-26 ANTICANCER DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (1)

Publication Number Publication Date
MY159197A true MY159197A (en) 2016-12-30

Family

ID=43027561

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2013000240A MY159197A (en) 2010-07-26 2011-07-25 Anticancer derivatives, preparation thereof and therapeutic use thereof

Country Status (31)

Country Link
US (1) US9056914B2 (en)
EP (1) EP2598507B1 (en)
JP (1) JP5814366B2 (en)
KR (1) KR20130094806A (en)
CN (1) CN103140491B (en)
AR (1) AR082341A1 (en)
AU (1) AU2011284339B2 (en)
BR (1) BR112013001978B1 (en)
CA (1) CA2806665A1 (en)
CL (1) CL2013000250A1 (en)
CO (1) CO6650375A2 (en)
CR (1) CR20130035A (en)
DO (1) DOP2013000021A (en)
EA (1) EA201390162A1 (en)
EC (1) ECSP13012404A (en)
ES (1) ES2638520T3 (en)
FR (1) FR2963007B1 (en)
GT (1) GT201300025A (en)
MA (1) MA34469B1 (en)
MX (1) MX2013001069A (en)
MY (1) MY159197A (en)
NI (1) NI201300010A (en)
NZ (1) NZ606246A (en)
PE (1) PE20130489A1 (en)
PH (1) PH12013500154A1 (en)
SG (1) SG187191A1 (en)
TW (1) TW201208689A (en)
UA (1) UA111164C2 (en)
UY (1) UY33531A (en)
WO (1) WO2012014147A1 (en)
ZA (1) ZA201300685B (en)

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AU2014244245C1 (en) * 2013-03-13 2018-04-19 Genentech, Inc. Pyrrolobenzodiazepines and conjugates thereof
MY186334A (en) 2014-09-12 2021-07-12 Genentech Inc Anti-her2 antibodies and immunoconjugates
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
CN107124870A (en) * 2014-09-17 2017-09-01 基因泰克公司 Immunoconjugates comprising an anti-HER2 antibody and a pyrrolobenzodiazepine*
KR20170102981A (en) 2015-01-14 2017-09-12 브리스톨-마이어스 스큅 컴퍼니 Heteroarylene-crosslinked benzodiazepine dimer, conjugates thereof, and methods of making and using
MX2017009145A (en) 2015-01-14 2017-11-22 Bristol Myers Squibb Co Benzodiazepine dimers, conjugates thereof, and methods of making and using.
CN108391434A (en) 2015-06-23 2018-08-10 百时美施贵宝公司 Macrocyclic benzodiazepine* dimers, their conjugates, preparation and use
KR102111338B1 (en) 2015-10-02 2020-05-15 제넨테크, 인크. Pyrrolobenzodiazepine antibody drug conjugates and methods of use thereof
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
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GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
US11160872B2 (en) 2017-02-08 2021-11-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
EP3612537B1 (en) 2017-04-18 2022-07-13 Medimmune Limited Pyrrolobenzodiazepine conjugates
RS62928B1 (en) 2017-08-18 2022-03-31 Medimmune Ltd Pyrrolobenzodiazepine conjugates
SG11202001430SA (en) 2017-09-29 2020-04-29 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
ES2967878T3 (en) 2019-03-15 2024-05-06 Medimmune Ltd Azetidobenzodiazepine dimers and conjugates comprising them for use in the treatment of cancer
CN115466231B (en) * 2022-10-23 2024-03-08 浙江大学 Method for preparing 3-[2-(4-morpholino)ethoxy]propionitrile in pipeline

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Also Published As

Publication number Publication date
US20130137659A1 (en) 2013-05-30
UA111164C2 (en) 2016-04-11
NI201300010A (en) 2013-05-13
JP5814366B2 (en) 2015-11-17
AU2011284339B2 (en) 2015-11-05
MX2013001069A (en) 2013-12-02
PH12013500154A1 (en) 2013-02-18
CA2806665A1 (en) 2012-02-02
WO2012014147A1 (en) 2012-02-02
CN103140491A (en) 2013-06-05
JP2013532680A (en) 2013-08-19
US9056914B2 (en) 2015-06-16
KR20130094806A (en) 2013-08-26
EP2598507B1 (en) 2017-05-31
AU2011284339A1 (en) 2013-02-14
CL2013000250A1 (en) 2013-04-12
ECSP13012404A (en) 2013-03-28
EA201390162A1 (en) 2013-11-29
EP2598507A1 (en) 2013-06-05
ES2638520T3 (en) 2017-10-23
UY33531A (en) 2012-02-29
TW201208689A (en) 2012-03-01
CR20130035A (en) 2013-03-04
BR112013001978B1 (en) 2020-03-03
FR2963007B1 (en) 2013-04-05
SG187191A1 (en) 2013-02-28
FR2963007A1 (en) 2012-01-27
AR082341A1 (en) 2012-11-28
MA34469B1 (en) 2013-08-01
GT201300025A (en) 2014-07-11
PE20130489A1 (en) 2013-05-08
CO6650375A2 (en) 2013-04-15
DOP2013000021A (en) 2013-04-15
ZA201300685B (en) 2014-10-29
NZ606246A (en) 2015-04-24
CN103140491B (en) 2016-08-10
BR112013001978A2 (en) 2016-05-24

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