MY173829A - Rocuronium preparation with improved stability - Google Patents
Rocuronium preparation with improved stabilityInfo
- Publication number
- MY173829A MY173829A MYPI2016001945A MYPI2016001945A MY173829A MY 173829 A MY173829 A MY 173829A MY PI2016001945 A MYPI2016001945 A MY PI2016001945A MY PI2016001945 A MYPI2016001945 A MY PI2016001945A MY 173829 A MY173829 A MY 173829A
- Authority
- MY
- Malaysia
- Prior art keywords
- buffer solution
- rocuronium
- rocuronium preparation
- improved stability
- preparation
- Prior art date
Links
- YXRDKMPIGHSVRX-OOJCLDBCSA-N rocuronium Chemical compound N1([C@@H]2[C@@H](O)C[C@@H]3CC[C@H]4[C@@H]5C[C@@H]([C@@H]([C@]5(CC[C@@H]4[C@@]3(C)C2)C)OC(=O)C)[N+]2(CC=C)CCCC2)CCOCC1 YXRDKMPIGHSVRX-OOJCLDBCSA-N 0.000 title abstract 6
- 229960000491 rocuronium Drugs 0.000 title abstract 6
- 239000007853 buffer solution Substances 0.000 abstract 6
- IVLXQGJVBGMLRR-UHFFFAOYSA-N 2-aminoacetic acid;hydron;chloride Chemical compound Cl.NCC(O)=O IVLXQGJVBGMLRR-UHFFFAOYSA-N 0.000 abstract 1
- PQRHBEQNPCVBSM-UHFFFAOYSA-M potassium;2-carboxybenzoate;hydrochloride Chemical compound Cl.[K+].OC(=O)C1=CC=CC=C1C([O-])=O PQRHBEQNPCVBSM-UHFFFAOYSA-M 0.000 abstract 1
- LLVQEXSQFBTIRD-UHFFFAOYSA-M sodium;2,3,4-trihydroxy-4-oxobutanoate;hydrate Chemical compound O.[Na+].OC(=O)C(O)C(O)C([O-])=O LLVQEXSQFBTIRD-UHFFFAOYSA-M 0.000 abstract 1
- IGHGOYDCVRUTSU-UHFFFAOYSA-M sodium;2-hydroxypropane-1,2,3-tricarboxylic acid;hydroxide Chemical compound [OH-].[Na+].OC(=O)CC(O)(C(O)=O)CC(O)=O IGHGOYDCVRUTSU-UHFFFAOYSA-M 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention provides a rocuronium preparation with an excellent stability. The rocuronium preparation contains rocuronium and a buffer solution and having an adjusted pH of 3.5 or less (for example, 2.5 to 3.5). The buffer solution may be a citric acid-sodium hydroxide buffer solution, a tartaric acid-sodium hydroxide buffer solution, a potassium hydrogen phthalate-hydrochloric acid buffer solution, a glycine-hydrochloric acid buffer solution, or the like. Such a rocuronium preparation has, for example, after 6-month storage at 40?C, a generation rate of rocuronium-related substance C of 5% or less.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI2016001945A MY173829A (en) | 2014-06-26 | 2014-06-26 | Rocuronium preparation with improved stability |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI2016001945A MY173829A (en) | 2014-06-26 | 2014-06-26 | Rocuronium preparation with improved stability |
| PCT/JP2014/067023 WO2015198456A1 (en) | 2014-06-26 | 2014-06-26 | Rocuronium formulation with improved stability |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY173829A true MY173829A (en) | 2020-02-24 |
Family
ID=79690115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2016001945A MY173829A (en) | 2014-06-26 | 2014-06-26 | Rocuronium preparation with improved stability |
Country Status (1)
| Country | Link |
|---|---|
| MY (1) | MY173829A (en) |
-
2014
- 2014-06-26 MY MYPI2016001945A patent/MY173829A/en unknown
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