MY173864A - Site-directed modification of fviii - Google Patents

Site-directed modification of fviii

Info

Publication number
MY173864A
MY173864A MYPI2013000709A MYPI2013000709A MY173864A MY 173864 A MY173864 A MY 173864A MY PI2013000709 A MYPI2013000709 A MY PI2013000709A MY PI2013000709 A MYPI2013000709 A MY PI2013000709A MY 173864 A MY173864 A MY 173864A
Authority
MY
Malaysia
Prior art keywords
site
fviii
directed modification
polyethylene glycol
covalently bound
Prior art date
Application number
MYPI2013000709A
Inventor
Clark Q Pan
John E Murphy
Baisong Mei
Jonathan S Strauss
Jianmin Chen
Thomas Barnett
Hendri Tjandra
Liang Tang
Deqian Wang
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Priority to MYPI2013000709A priority Critical patent/MY173864A/en
Publication of MY173864A publication Critical patent/MY173864A/en

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  • Peptides Or Proteins (AREA)

Abstract

This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain VIII procoagulant activity and have improved pharmacokinetic properties.
MYPI2013000709A 2007-05-18 2007-05-18 Site-directed modification of fviii MY173864A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MYPI2013000709A MY173864A (en) 2007-05-18 2007-05-18 Site-directed modification of fviii

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI2013000709A MY173864A (en) 2007-05-18 2007-05-18 Site-directed modification of fviii

Publications (1)

Publication Number Publication Date
MY173864A true MY173864A (en) 2020-02-25

Family

ID=79170498

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2013000709A MY173864A (en) 2007-05-18 2007-05-18 Site-directed modification of fviii

Country Status (1)

Country Link
MY (1) MY173864A (en)

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