MY176922A - Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis - Google Patents

Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis

Info

Publication number
MY176922A
MY176922A MYPI2016001849A MYPI2016001849A MY176922A MY 176922 A MY176922 A MY 176922A MY PI2016001849 A MYPI2016001849 A MY PI2016001849A MY PI2016001849 A MYPI2016001849 A MY PI2016001849A MY 176922 A MY176922 A MY 176922A
Authority
MY
Malaysia
Prior art keywords
zinc finger
finger proteins
fatty acid
acid biosynthesis
genes involved
Prior art date
Application number
MYPI2016001849A
Inventor
Gupta Manju
C Miller Jeffrey
Novak Stephen
F Petolino Joseph
Dekelver Russell
Original Assignee
Sangamo Biosciences Inc
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sangamo Biosciences Inc, Dow Agrosciences Llc filed Critical Sangamo Biosciences Inc
Publication of MY176922A publication Critical patent/MY176922A/en

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    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • C12N15/8218Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/415Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8216Methods for controlling, regulating or enhancing expression of transgenes in plant cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C12N15/8247Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01041Beta-ketoacyl-acyl-carrier-protein synthase I (2.3.1.41)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Botany (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Virology (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The present disclosure relates to engineered zinc finger proteins that target genes in plants involved in fatty acid biosynthesis. Methods of using such zinc finger proteins in modulating gene expression, gene inactivation, and targeted gene modification are also provided. FIG. 4
MYPI2016001849A 2009-10-22 2010-10-22 Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis MY176922A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27952809P 2009-10-22 2009-10-22

Publications (1)

Publication Number Publication Date
MY176922A true MY176922A (en) 2020-08-26

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
MYPI2016001849A MY176922A (en) 2009-10-22 2010-10-22 Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
MYPI2012700197A MY174390A (en) 2009-10-22 2010-10-22 Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis

Family Applications After (1)

Application Number Title Priority Date Filing Date
MYPI2012700197A MY174390A (en) 2009-10-22 2010-10-22 Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis

Country Status (18)

Country Link
US (3) US8592645B2 (en)
EP (2) EP2722392B1 (en)
JP (1) JP5827233B2 (en)
KR (1) KR101813981B1 (en)
CN (2) CN104277100B (en)
AR (1) AR078740A1 (en)
AU (1) AU2010308569B2 (en)
BR (2) BR122019025207B1 (en)
CA (1) CA2777753C (en)
DK (2) DK2722392T3 (en)
ES (2) ES2646138T3 (en)
IL (1) IL219137A (en)
MY (2) MY176922A (en)
NZ (2) NZ619018A (en)
RU (2) RU2568056C2 (en)
UA (2) UA120742C2 (en)
WO (1) WO2011049627A1 (en)
ZA (1) ZA201202814B (en)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
HUE041436T2 (en) 2009-12-10 2019-05-28 Univ Minnesota Tal-effector-mediated DNA modification
JP6208580B2 (en) 2010-05-17 2017-10-04 サンガモ セラピューティクス, インコーポレイテッド Novel DNA binding protein and use thereof
US9057057B2 (en) * 2010-07-27 2015-06-16 The Johns Hopkins University Obligate heterodimer variants of foki cleavage domain
CN107556389B (en) 2012-02-02 2021-10-26 陶氏益农公司 Plant transactivation interaction motifs and uses thereof
CA2872124C (en) 2012-05-02 2022-05-03 Dow Agrosciences Llc Plant with targeted modification of the endogenous malate dehydrogenase gene
EP2861737B1 (en) 2012-06-19 2019-04-17 Regents Of The University Of Minnesota Gene targeting in plants using dna viruses
UA119135C2 (en) * 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Engineered transgene integration platform (etip) for gene targeting and trait stacking
CA2884162C (en) 2012-09-07 2020-12-29 Dow Agrosciences Llc Fad3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
UA118090C2 (en) * 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі METHOD OF THE METHER OF THE METHOD OF THE INTEGRED EMBLED SUBSTITUTION OF NUCLEIC NUCLE OF NUCLEIC ACID AND NON-NUCLIC ACID AND NON-SPECIAL SPECIES
ES2894832T3 (en) 2012-11-01 2022-02-16 Cellectis Plants for the production of therapeutic proteins
EP2934097B1 (en) 2012-12-21 2018-05-02 Cellectis Potatoes with reduced cold-induced sweetening
US10351867B2 (en) 2013-03-01 2019-07-16 The Regents Of The University Of California Methods and compositions for targeting RNA polymerases and non-coding RNA biogenesis to specific loci
US10113162B2 (en) 2013-03-15 2018-10-30 Cellectis Modifying soybean oil composition through targeted knockout of the FAD2-1A/1B genes
CN105246324B (en) * 2013-03-15 2018-08-28 塞尔克蒂斯股份有限公司 Improvement of soybean oil composition by targeted knockout of FAD2-1A/1B gene
EP2981166B1 (en) 2013-04-05 2020-09-09 Dow AgroSciences LLC Methods and compositions for integration of an exogenous sequence within the genome of plants
CN105683376A (en) 2013-05-15 2016-06-15 桑格摩生物科学股份有限公司 Methods and compositions for treating genetic conditions
EP3004370B1 (en) * 2013-06-05 2024-08-21 Duke University Rna-guided gene editing and gene regulation
KR102269769B1 (en) 2013-11-04 2021-06-28 코르테바 애그리사이언스 엘엘씨 Optimal maize loci
KR102269371B1 (en) 2013-11-04 2021-06-28 코르테바 애그리사이언스 엘엘씨 Optimal maize loci
UY35814A (en) 2013-11-04 2015-05-29 Dow Agrosciences Llc ? OPTIMAL PLACES FOR SOYBEAN ?.
MX358066B (en) 2013-11-04 2018-08-03 Dow Agrosciences Llc Optimal soybean loci.
US10774338B2 (en) 2014-01-16 2020-09-15 The Regents Of The University Of California Generation of heritable chimeric plant traits
EP4039807A1 (en) * 2014-06-10 2022-08-10 Erasmus University Rotterdam Medical Center Antisense oligonucleotides useful in treatment of pompe disease
CA2952906A1 (en) 2014-06-20 2015-12-23 Cellectis Potatoes with reduced granule-bound starch synthase
MX382223B (en) * 2015-05-12 2025-03-13 Sangamo Therapeutics Inc NUCLEASE-MEDIATED REGULATION OF GENE EXPRESSION.
US10837024B2 (en) 2015-09-17 2020-11-17 Cellectis Modifying messenger RNA stability in plant transformations
EP3410843B1 (en) 2016-02-02 2025-06-18 Cellectis Modifying soybean oil composition through targeted knockout of the fad3a/b/c genes
CR20220377A (en) 2016-03-11 2022-09-23 Monsanto Technology Llc PLANT REGULATORY ELEMENTS AND THEIR USES
CA3021682A1 (en) * 2016-05-25 2017-11-30 Cargill Incorporated Engineered nucleases to generate deletion mutants in plants
UY37482A (en) 2016-11-16 2018-05-31 Cellectis METHODS TO CHANGE THE CONTENT OF AMINO ACIDS IN PLANTS THROUGH FRAMEWORK DISPLACEMENT MUTATIONS
CR20210122A (en) 2017-01-19 2021-04-14 Monsanto Technology Llc PLANT REGULATORY ELEMENTS AND THEIR USES (DIVISIONAL EXP. 2019-377)
CN106987599B (en) * 2017-03-28 2021-06-11 重庆医科大学 Zinc finger nuclease for inhibiting expression of human bcr-abl fusion gene or causing loss of function of human bcr-abl gene and application thereof
US11479782B2 (en) 2017-04-25 2022-10-25 Cellectis Alfalfa with reduced lignin composition
WO2019104056A1 (en) * 2017-11-21 2019-05-31 Cargill, Incorporated Engineered nucleases in plant generation
WO2020244759A1 (en) 2019-06-05 2020-12-10 Klemm & Sohn Gmbh & Co. Kg New plants having a white foliage phenotype
AU2020322021A1 (en) 2019-07-30 2022-02-10 Pairwise Plants Services, Inc. Morphogenic regulators and methods of using the same
CN111518220A (en) * 2020-05-14 2020-08-11 重庆英茂盛业生物科技有限公司 Fusion protein and design method thereof
CN112662670B (en) * 2020-12-25 2024-04-02 河南省农业科学院 Peanut fatty acyl-acyl carrier protein thioesterase AhFATB2 gene promoter, and preparation method and application thereof
EP4658061A1 (en) 2023-02-01 2025-12-10 United Beet Seeds Beet yellows virus resistance
US12239091B2 (en) 2023-03-27 2025-03-04 Redsea Science And Technology Inc. Tomato plant designated ‘MX20-06’
CN119978083B (en) * 2025-02-12 2026-01-13 江西农业大学 Application of navel orange zinc finger protein transcription factor CsZAT in regulating and controlling fruit green mold resistance

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5102796A (en) 1983-04-15 1992-04-07 Lubrizol Genetics, Inc. Plant structural gene expression
EP0222493A1 (en) 1985-10-04 1987-05-20 Lubrizol Genetics Inc. TR-based sub-TI plasmids
US5422251A (en) 1986-11-26 1995-06-06 Princeton University Triple-stranded nucleic acids
US5176996A (en) 1988-12-20 1993-01-05 Baylor College Of Medicine Method for making synthetic oligonucleotides which bind specifically to target sites on duplex DNA molecules, by forming a colinear triplex, the synthetic oligonucleotides and methods of use
US5861187A (en) 1990-08-30 1999-01-19 Cargill, Incorporated Oil from canola seed with altered fatty acid profiles and a method of producing oil
CA2123495A1 (en) * 1991-11-15 1993-05-27 Anthony J. Kinney B-ketoacyl-acp synthetase ii genes from plants
JPH07501701A (en) 1991-12-04 1995-02-23 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー Plant-derived fatty acid desaturase gene
US5420032A (en) 1991-12-23 1995-05-30 Universitge Laval Homing endonuclease which originates from chlamydomonas eugametos and recognizes and cleaves a 15, 17 or 19 degenerate double stranded nucleotide sequence
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US5792632A (en) 1992-05-05 1998-08-11 Institut Pasteur Nucleotide sequence encoding the enzyme I-SceI and the uses thereof
DE69334225D1 (en) 1992-07-07 2008-07-31 Japan Tobacco Inc METHOD FOR TRANSFORMING A MONOCOTYLEDONE PLANT
CA2176137A1 (en) * 1993-11-10 1995-05-18 Alois Toni Voelker Plant acyl acp thioesterase sequences
US6140466A (en) 1994-01-18 2000-10-31 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
DE69534629D1 (en) 1994-01-18 2005-12-29 Scripps Research Inst DERIVATIVES OF ZINC FINGER PROTEINS AND METHODS
US6242568B1 (en) 1994-01-18 2001-06-05 The Scripps Research Institute Zinc finger protein derivatives and methods therefor
US5585245A (en) 1994-04-22 1996-12-17 California Institute Of Technology Ubiquitin-based split protein sensor
ATE524545T1 (en) 1994-08-20 2011-09-15 Gendaq Ltd IMPROVEMENTS IN OR RELATED TO BINDING PROTEINS FOR DNA DETECTION
GB9824544D0 (en) 1998-11-09 1999-01-06 Medical Res Council Screening system
US5789538A (en) 1995-02-03 1998-08-04 Massachusetts Institute Of Technology Zinc finger proteins with high affinity new DNA binding specificities
US5773695A (en) 1996-01-26 1998-06-30 North Carolina State University Plant nuclear scaffold attachment region and method for increasing gene expression in transgenic cells
US5925523A (en) 1996-08-23 1999-07-20 President & Fellows Of Harvard College Intraction trap assay, reagents and uses thereof
DE19635568C1 (en) * 1996-09-02 1998-03-26 Gsf Forschungszentrum Umwelt Vector systems for conditional gene expression
GB2338237B (en) 1997-02-18 2001-02-28 Actinova Ltd In vitro peptide or protein expression library
GB9703369D0 (en) 1997-02-18 1997-04-09 Lindqvist Bjorn H Process
US6342345B1 (en) 1997-04-02 2002-01-29 The Board Of Trustees Of The Leland Stanford Junior University Detection of molecular interactions by reporter subunit complementation
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6323395B1 (en) 1997-12-24 2001-11-27 Dow Agrosciences Llc Nucleotide sequences of maize and soybean β-Ketoacyl-Acyl Carrier Protein Synthase II and their use in the regulation of fatty acid content of oil
AR014491A1 (en) 1998-01-29 2001-02-28 Dow Agrosciences Llc METHOD FOR OBTAINING FERTILE TRANSGEN PLANTS FROM GOSSYPIUM HIRSUTUM.
US6410248B1 (en) 1998-01-30 2002-06-25 Massachusetts Institute Of Technology General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
DE69942334D1 (en) 1998-03-02 2010-06-17 Massachusetts Inst Technology POLY ZINC FINGER PROTEINS WITH IMPROVED LINKERS
US6365802B2 (en) * 1998-08-14 2002-04-02 Calgene Llc Methods for increasing stearate content in soybean oil
DE19842276A1 (en) * 1998-09-16 2000-03-30 Bosch Gmbh Robert Paste for welding ceramics to metals and method for making a welded joint
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6599692B1 (en) 1999-09-14 2003-07-29 Sangamo Bioscience, Inc. Functional genomics using zinc finger proteins
US6794136B1 (en) 2000-11-20 2004-09-21 Sangamo Biosciences, Inc. Iterative optimization in the design of binding proteins
US7030215B2 (en) 1999-03-24 2006-04-18 Sangamo Biosciences, Inc. Position dependent recognition of GNN nucleotide triplets by zinc fingers
JP3107304B1 (en) * 1999-08-10 2000-11-06 株式会社オハラ Glass ceramics for optical filters and optical filters
US7151201B2 (en) * 2000-01-21 2006-12-19 The Scripps Research Institute Methods and compositions to modulate expression in plants
WO2001053480A1 (en) 2000-01-24 2001-07-26 Sangamo Biosciences, Inc. Nucleic acid binding polypeptides characterized by flexible linkers connected nucleic acid binding modules
US20020061512A1 (en) 2000-02-18 2002-05-23 Kim Jin-Soo Zinc finger domains and methods of identifying same
EP1276859B1 (en) 2000-04-28 2007-02-07 Sangamo Biosciences Inc. Targeted modification of chromatin structure
US20020178467A1 (en) * 2000-05-12 2002-11-28 Katayoon Dehesh Plastid transit peptide sequences for efficient plastid targeting
US20030044787A1 (en) 2000-05-16 2003-03-06 Joung J. Keith Methods and compositions for interaction trap assays
JP2002060786A (en) 2000-08-23 2002-02-26 Kao Corp Bactericidal antifouling agent for hard surfaces
WO2002057294A2 (en) * 2001-01-22 2002-07-25 Sangamo Biosciences, Inc. Zinc finger proteins for dna binding and gene regulation in plants
GB0108491D0 (en) 2001-04-04 2001-05-23 Gendaq Ltd Engineering zinc fingers
US20040224385A1 (en) 2001-08-20 2004-11-11 Barbas Carlos F Zinc finger binding domains for cnn
US7262054B2 (en) 2002-01-22 2007-08-28 Sangamo Biosciences, Inc. Zinc finger proteins for DNA binding and gene regulation in plants
US20030232410A1 (en) 2002-03-21 2003-12-18 Monika Liljedahl Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
DE10220894A1 (en) * 2002-05-10 2003-11-27 Rhein Biotech Proz & Prod Gmbh Promoters with changed transcription efficiency
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
JP4555292B2 (en) 2003-08-08 2010-09-29 サンガモ バイオサイエンシズ インコーポレイテッド Methods and compositions for targeted cleavage and recombination
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
WO2005028630A2 (en) 2003-09-19 2005-03-31 Sangamo Biosciences, Inc. Engineered zinc finger proteins for regulation of gene expression
KR100535326B1 (en) * 2004-01-20 2005-12-09 한국생명공학연구원 Differentiation regulating agent containing gene which regulating differentiation from stem cell to natural killer cell as effective ingradient
AU2006272634B2 (en) 2005-07-26 2013-01-24 Sangamo Therapeutics, Inc. Targeted integration and expression of exogenous nucleic acid sequences
CA2891996A1 (en) 2005-10-18 2007-04-26 Duke University Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity
JP5266210B2 (en) 2006-05-25 2013-08-21 サンガモ バイオサイエンシズ インコーポレイテッド Modified cleavage half-domain
KR101520507B1 (en) 2006-12-14 2015-05-29 다우 아그로사이언시즈 엘엘씨 Optimized non-regular zinc finger protein
AU2008274551B2 (en) 2007-07-09 2014-05-29 BASF Agricultural Solutions Seed US LLC Brassica plant comprising mutant fatty acyl-ACP thioesterase alleles
DK2205749T3 (en) 2007-09-27 2016-08-22 Dow Agrosciences Llc MODIFIED PROTEINS zinc finger, which target the 5-enolpyruvylshikimate-3-phosphate synthase genes
US9394531B2 (en) 2008-05-28 2016-07-19 Sangamo Biosciences, Inc. Compositions for linking DNA-binding domains and cleavage domains
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
CA2993567C (en) 2010-07-21 2022-06-28 Sangamo Biosciences, Inc. Methods and compositions for modification of a t-cell receptor gene
US9401201B1 (en) 2015-05-22 2016-07-26 Qualcomm Incorporated Write driver for memory

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