MY197240A - Method for preparing an extract of hevea latex and composition thereof - Google Patents
Method for preparing an extract of hevea latex and composition thereofInfo
- Publication number
- MY197240A MY197240A MYPI2019002474A MYPI2019002474A MY197240A MY 197240 A MY197240 A MY 197240A MY PI2019002474 A MYPI2019002474 A MY PI2019002474A MY PI2019002474 A MYPI2019002474 A MY PI2019002474A MY 197240 A MY197240 A MY 197240A
- Authority
- MY
- Malaysia
- Prior art keywords
- extract
- hevea latex
- composition
- serum
- optionally
- Prior art date
Links
- 241000221020 Hevea Species 0.000 title abstract 5
- 229920003211 cis-1,4-polyisoprene Polymers 0.000 title abstract 5
- 239000004816 latex Substances 0.000 title abstract 5
- 229920000126 latex Polymers 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 210000002966 serum Anatomy 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 238000003490 calendering Methods 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- DSCFFEYYQKSRSV-FIZWYUIZSA-N (-)-Quebrachitol Chemical compound CO[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@H]1O DSCFFEYYQKSRSV-FIZWYUIZSA-N 0.000 abstract 1
- DSCFFEYYQKSRSV-UHFFFAOYSA-N 1L-O1-methyl-muco-inositol Natural products COC1C(O)C(O)C(O)C(O)C1O DSCFFEYYQKSRSV-UHFFFAOYSA-N 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 230000005907 cancer growth Effects 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 235000014633 carbohydrates Nutrition 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 235000013376 functional food Nutrition 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08C—TREATMENT OR CHEMICAL MODIFICATION OF RUBBERS
- C08C1/00—Treatment of rubber latex
- C08C1/02—Chemical or physical treatment of rubber latex before or during concentration
- C08C1/04—Purifying; Deproteinising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Alternative & Traditional Medicine (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The present disclosure provides for the method of preparing, from serum of calendered acidified Hevea latex, an extract that is rich in low-molecular weight carbohydrates and having anti-cancer activity. The method comprises the steps of: obtaining the serum released when acidified Hevea latex is calendered; removing debris and micro-organisms from the serum; removing proteins; removing quebrachitol and small polar molecules; optionally dissolving the remaining solid powder in water; further removing proteins by treatment with acid; optionally neutralizing the excess acid; precipitating with solvent; collecting the precipitate; and optionally freeze drying the precipitate. The disclosure also provides a composition comprising the extract of Hevea latex for use in the treatment of cancer growth and/or metastasis and inhibiting tumor cell proliferation in a patient. Furthermore, there are provided a pharmaceutical composition and a functional food composition comprising the disclosed extract of Hevea latex.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/TH2016/000075 WO2018044242A1 (en) | 2016-09-02 | 2016-09-02 | Method for preparing an extract of hevea latex and composition thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY197240A true MY197240A (en) | 2023-06-07 |
Family
ID=61309153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI2019002474A MY197240A (en) | 2016-09-02 | 2016-09-02 | Method for preparing an extract of hevea latex and composition thereof |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP3510052A4 (en) |
| CN (1) | CN110023342B (en) |
| MY (1) | MY197240A (en) |
| WO (1) | WO2018044242A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023055307A1 (en) * | 2021-09-29 | 2023-04-06 | Master Labs Incorporation Company Limited | Process for extracting hevea latex polysaccharides from effluent of the rubber manufacturing industry, polysaccharide extract, composition and use thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1758616A (en) * | 1925-12-02 | 1930-05-13 | Naugatuck Chem Co | Method for recovering quebrachitol from rubber latex serum |
| JPS61293201A (en) * | 1985-06-22 | 1986-12-24 | Yokohama Rubber Co Ltd:The | Powdered nonrubber component obtained from serum of natural rubber latex and production thereof |
| JPH0291035A (en) * | 1988-07-06 | 1990-03-30 | Yokohama Rubber Co Ltd:The | Collection of l-quebrachitol in natural rubber serum |
| DE69232220D1 (en) | 1992-09-22 | 2002-01-03 | Takeo Takayanagi | Carbohydrate complexes for the destruction of cancer cells |
| US5834442A (en) | 1994-07-07 | 1998-11-10 | Barbara Ann Karmanos Cancer Institute | Method for inhibiting cancer metastasis by oral administration of soluble modified citrus pectin |
| AUPO864097A0 (en) | 1997-08-19 | 1997-09-11 | Peplin Pty Ltd | Anti-cancer compounds |
| MY139558A (en) * | 2003-02-28 | 2009-10-30 | Malaysian Rubber Board | A protein |
| WO2005095463A1 (en) | 2004-03-26 | 2005-10-13 | Glycogenesys, Inc. | Modified pectins, compositions and methods related thereto |
| MY153171A (en) * | 2006-12-21 | 2015-01-29 | Thailand Ct Of Excellence For Life Sciences | Skin whitening composition containing extracts derived from natural rubber latex |
| CN102076631B (en) * | 2008-06-27 | 2014-04-16 | 阿克佐诺贝尔股份有限公司 | Redispersible polymer powder |
| CN102516041A (en) * | 2011-12-16 | 2012-06-27 | 云南省热带作物科学研究所 | Method for extracting quebrachitol from natural rubber whey |
-
2016
- 2016-09-02 MY MYPI2019002474A patent/MY197240A/en unknown
- 2016-09-02 CN CN201680090627.8A patent/CN110023342B/en not_active Expired - Fee Related
- 2016-09-02 EP EP16915342.6A patent/EP3510052A4/en not_active Withdrawn
- 2016-09-02 WO PCT/TH2016/000075 patent/WO2018044242A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| CN110023342B (en) | 2022-01-11 |
| WO2018044242A1 (en) | 2018-03-08 |
| EP3510052A4 (en) | 2020-06-17 |
| CN110023342A (en) | 2019-07-16 |
| EP3510052A1 (en) | 2019-07-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Schenk et al. | BCL-2: Long and winding path from discovery to therapeutic target | |
| Kumar et al. | Molecular mechanisms underlying chemopreventive potential of curcumin: Current challenges and future perspectives | |
| MX2021004558A (en) | PROTON BINDING POLYMERS FOR ORAL ADMINISTRATION. | |
| Hartmann et al. | MicroRNAs and vascular (dys) function | |
| EA201491700A1 (en) | HUMAN ANTIBODIES TO CD27, METHODS AND APPLICATIONS | |
| WO2016182959A8 (en) | Optimized crispr/cas9 systems and methods for gene editing in stem cells | |
| MX387845B (en) | PROTON-LINKED POLYMERS FOR ORAL ADMINISTRATION. | |
| MY197091A (en) | Compositions for treating acid-base disorders | |
| MX2018010508A (en) | Improved preparations of adult liver progenitor cells. | |
| WO2015200828A8 (en) | Conjugates for immunotherapy | |
| FR2969495B1 (en) | EXTRACT OF MACA-RICH AERIAL PARTS OF POLYPHENOLS AND COMPOSITION COMPRISING THE SAME | |
| HK1220145A1 (en) | Treatment for bile leakage | |
| MX2019005693A (en) | Red blood cell targeted factor viii and method of using the same. | |
| WO2019118793A3 (en) | Subject-specific tumor inhibiting cells and the use thereof | |
| Decaluwé et al. | Treatment of erectile dysfunction: new targets and strategies from recent research | |
| MX385961B (en) | A METHOD FOR THE ACTIVATION OF LACTIC ACID BACTERIA. | |
| MY197240A (en) | Method for preparing an extract of hevea latex and composition thereof | |
| WO2011091154A3 (en) | Use of human erythrocytes for prevention and treatment of cancer dissemination and growth | |
| RU2013130449A (en) | METHOD FOR COMBINED TREATMENT OF RECTAL GUT CANCER | |
| Poverty | Change in | |
| 張耀文 et al. | Elderly Oropharynx-Hypopharynx Carcinoma Patients: Induction Chemotherapy Plus Chemoradiotherapy Improve Cancer Controls Than Radiotherapy Alone | |
| 吴健 et al. | Preparation and cell proliferation activity of propylene glycol alginate sodium sulfate oligosaccharides | |
| Baranov | Creation of E-Government in the Russian Federation: Problems and Prospects of Development of Regional Projects | |
| Bölk et al. | Impact of the red-vine leaf extract AS195 on nitric oxide bioavailability in diabetes patients and its potential role in the wound healing process | |
| TH149241A (en) | Pathways and methods for active cellular immunotherapy to treat cancer using tumor cells killed by high hydrostatic pressure and dendritic cells. |