MY197636A - Chemical compounds as inhibitors of interleukin-1 activity - Google Patents

Chemical compounds as inhibitors of interleukin-1 activity

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Publication number
MY197636A
MY197636A MYPI2019004010A MYPI2019004010A MY197636A MY 197636 A MY197636 A MY 197636A MY PI2019004010 A MYPI2019004010 A MY PI2019004010A MY PI2019004010 A MYPI2019004010 A MY PI2019004010A MY 197636 A MY197636 A MY 197636A
Authority
MY
Malaysia
Prior art keywords
interleukin
inhibitors
activity
chemical compounds
nlrp3
Prior art date
Application number
MYPI2019004010A
Inventor
Jeffrey A Stafford
James M Veal
Lynnie Lin Trzoss
Christopher Mcbride
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MY197636A publication Critical patent/MY197636A/en

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    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
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Abstract

The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1? and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process. (NO SUITABLE FIGURE)
MYPI2019004010A 2017-01-23 2018-01-22 Chemical compounds as inhibitors of interleukin-1 activity MY197636A (en)

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