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Application filed by Bayer Pharma AGfiledCriticalBayer Pharma AG
Priority claimed from PCT/EP2017/060367external-prioritypatent/WO2017191104A1/en
Publication of MY198496ApublicationCriticalpatent/MY198496A/en
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Abstract
The present application relates to a novel and improved process for preparing 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives of the formula (I) in which R and R are independently selected from the group consisting of hydrogen, fluorine, chlorine, methyl, monofluoromethyl, difluoromethyl, trifluoromethyl, ethyl, methoxy, difluoromethoxy and trifluoromethoxy, to novel precursors for preparation thereof, and to the preparation and use of the crystalline polymorph I of ( 5-( 4-chloropheny 1)-2-( { 1-(3-chlorophenyl)-5-[(lS)-1-hydroxyethyl]-lH-l ,2,4-triazol-3-yl }methyl)-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one of the formula (I-A-1).
MYPI2018704052A2016-05-032017-05-02Method for producing 5-hydroxyalkyl-substituted 1-phenyl-1,2,4- triazole derivatives
MY198496A
(en)
Process for the preparation of methyl 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3 fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylate
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