MY200831A - A Biomarker for Detecting Strongyloides, Methods of Detecting Strongyloides and Diagnosing Strongyloidiasis in a Biological Sample, and a Diagnostic Kit Comprising Thereof - Google Patents

A Biomarker for Detecting Strongyloides, Methods of Detecting Strongyloides and Diagnosing Strongyloidiasis in a Biological Sample, and a Diagnostic Kit Comprising Thereof

Info

Publication number
MY200831A
MY200831A MYPI2020000313A MYPI2020000313A MY200831A MY 200831 A MY200831 A MY 200831A MY PI2020000313 A MYPI2020000313 A MY PI2020000313A MY PI2020000313 A MYPI2020000313 A MY PI2020000313A MY 200831 A MY200831 A MY 200831A
Authority
MY
Malaysia
Prior art keywords
strongyloides
detecting
biomarker
strongyloidiasis
diagnosing
Prior art date
Application number
MYPI2020000313A
Inventor
Binti Noordin Rahmah
Binti Arifin Norsyahida
Ahmad Hussain
Original Assignee
Univ Sains Malaysia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Sains Malaysia filed Critical Univ Sains Malaysia
Priority to MYPI2020000313A priority Critical patent/MY200831A/en
Priority to PCT/MY2020/050044 priority patent/WO2021145757A1/en
Publication of MY200831A publication Critical patent/MY200831A/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43536—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms
    • C07K14/4354—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from worms from nematodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/43504—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates
    • G01N2333/43526—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms
    • G01N2333/4353—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from invertebrates from worms from nematodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention relates to a biomarker for detecting Strongyloides, characterized by a Strongyloides stercoralis protein comprising an amino acid sequence set forth in SEQ ID NO: 2, in which the Strongyloides stercoralis protein is encoded by a nucleic acid molecule comprising a nucleic acid sequence set forth in SEQ ID NO: 1. The present invention also relates to a method (100) of diagnosing Strongyloidiasis in a biological sample via an immunoglobulin E, IgE, immunoassay comprising the biomarker as an antigen, and a method (200) of detecting Strongyloides protein as antigen in a subject comprising an antibody to the biomarker as an antigen-capture. More specifically, the method (200) is configured to detect an acute Strongyloidiasis in the subject. Further, the present invention provides a diagnostic kit for Strongyloides comprising the biomarker for detecting Strongyloides.
MYPI2020000313A 2020-01-17 2020-01-17 A Biomarker for Detecting Strongyloides, Methods of Detecting Strongyloides and Diagnosing Strongyloidiasis in a Biological Sample, and a Diagnostic Kit Comprising Thereof MY200831A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
MYPI2020000313A MY200831A (en) 2020-01-17 2020-01-17 A Biomarker for Detecting Strongyloides, Methods of Detecting Strongyloides and Diagnosing Strongyloidiasis in a Biological Sample, and a Diagnostic Kit Comprising Thereof
PCT/MY2020/050044 WO2021145757A1 (en) 2020-01-17 2020-06-19 A biomarker for detecting strongyloides, methods of detecting strongyloides and diagnosing strongyloidiasis in a biological sample, and a diagnostic kit comprising thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MYPI2020000313A MY200831A (en) 2020-01-17 2020-01-17 A Biomarker for Detecting Strongyloides, Methods of Detecting Strongyloides and Diagnosing Strongyloidiasis in a Biological Sample, and a Diagnostic Kit Comprising Thereof

Publications (1)

Publication Number Publication Date
MY200831A true MY200831A (en) 2024-01-17

Family

ID=76863917

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI2020000313A MY200831A (en) 2020-01-17 2020-01-17 A Biomarker for Detecting Strongyloides, Methods of Detecting Strongyloides and Diagnosing Strongyloidiasis in a Biological Sample, and a Diagnostic Kit Comprising Thereof

Country Status (2)

Country Link
MY (1) MY200831A (en)
WO (1) WO2021145757A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011097216A1 (en) * 2010-02-04 2011-08-11 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Vaccine and methods of use against strongyloides stercoralis infection
MY187887A (en) * 2015-11-27 2021-10-26 Univ Sains Malaysia Strongyloides stercoralis protein and/or corresponding dna and rna sequences for application in diagnosis
WO2018144425A1 (en) * 2017-01-31 2018-08-09 Vanderbilt University Generation of human allergen-and helminth-specific ige monoclonal antibodies for diagnostic and therapeutic use

Also Published As

Publication number Publication date
WO2021145757A1 (en) 2021-07-22

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