MY208400A - Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (ror) and pharmaceutical uses thereof - Google Patents

Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (ror) and pharmaceutical uses thereof

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Publication number
MY208400A
MY208400A MYPI2020005364A MYPI2020005364A MY208400A MY 208400 A MY208400 A MY 208400A MY PI2020005364 A MYPI2020005364 A MY PI2020005364A MY PI2020005364 A MYPI2020005364 A MY PI2020005364A MY 208400 A MY208400 A MY 208400A
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MY
Malaysia
Prior art keywords
ror
retinoid
benzimidazole derivatives
receptor gamma
orphan receptor
Prior art date
Application number
MYPI2020005364A
Inventor
Weikang Tao
Feng He
Rumin Zhang
Suxing Liu
Fengqi Zhang
Dong Liu
Minsheng Zhang
Yinfa Yan
Original Assignee
Shanghai hengrui pharmaceutical co ltd
Jiangsu Hengrui Medicine Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shanghai hengrui pharmaceutical co ltd, Jiangsu Hengrui Medicine Co filed Critical Shanghai hengrui pharmaceutical co ltd
Publication of MY208400A publication Critical patent/MY208400A/en

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

ABSTRACT BENZIMIDAZOLE DERIVATIVES AS MODULATORS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR) AND PHARMACEUTICAL USES THEREOF The present invention relates to benzimidazole derivatives of formula (I) as inhibtiors of retinoid-related orphan receptor gamma (ROR protein, pharmaceutical compositions containing the compounds, preparation methods thereof, and the use of the compounds as therapeutic agents for the treatment of ROR-mediated diseases or disorders.
MYPI2020005364A 2018-05-03 2019-05-03 Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (ror) and pharmaceutical uses thereof MY208400A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862666312P 2018-05-03 2018-05-03
PCT/US2019/030526 WO2019213470A1 (en) 2018-05-03 2019-05-03 Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (rorϒ) and pharmaceutical uses thereof

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MY208400A true MY208400A (en) 2025-05-07

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US (2) US11512055B2 (en)
EP (1) EP3781161B1 (en)
JP (1) JP7351851B2 (en)
KR (1) KR102709804B1 (en)
CN (2) CN116514722B (en)
AU (1) AU2019262169B2 (en)
BR (1) BR112020021967A2 (en)
CA (1) CA3097519A1 (en)
ES (1) ES2949366T3 (en)
HR (1) HRP20230643T1 (en)
HU (1) HUE062273T2 (en)
MX (1) MX2020011405A (en)
MY (1) MY208400A (en)
PL (1) PL3781161T3 (en)
RS (1) RS64348B1 (en)
SM (1) SMT202300212T1 (en)
TW (1) TWI818985B (en)
UA (1) UA128161C2 (en)
WO (1) WO2019213470A1 (en)

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Publication number Priority date Publication date Assignee Title
SMT202300212T1 (en) * 2018-05-03 2023-09-06 Shanghai hengrui pharmaceutical co ltd Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (rory) and pharmaceutical uses thereof
BR112022008293A2 (en) * 2019-10-31 2022-07-26 Jiangsu Hengrui Medicine Co ROR REGULATOR ACID ADDITION SALT, PHARMACEUTICAL COMPOSITIONS, USE THEREOF AND METHODS TO PREPARE CRYSTALLINE FORM AND PHARMACEUTICAL COMPOSITION
CN112745268B (en) * 2019-10-31 2022-09-16 江苏恒瑞医药股份有限公司 Crystal form of benzimidazole derivative and preparation method thereof
TW202136238A (en) * 2020-01-06 2021-10-01 大陸商廣東東陽光藥業有限公司 ROR[gamma]T inhibitor, preparation method therefor and use thereof
TW202136237A (en) * 2020-01-06 2021-10-01 大陸商廣東東陽光藥業有限公司 ROR[gamma]T inhibitor, preparation method therefor and use thereof
CN111269126B (en) * 2020-03-12 2023-04-07 北京理工大学重庆创新中心 Preparation method of fusion casting carrier 1,2-difluoro-4,5-dinitrobenzene
CN115702024A (en) 2020-04-07 2023-02-14 Ucb生物制药有限责任公司 Difluorocyclohexyl derivatives as IL-17 modulators
TW202146381A (en) * 2020-05-15 2021-12-16 大陸商上海輝启生物醫藥科技有限公司 Biaryl compound capable of serving as ror[gamma] regulator
WO2022245067A1 (en) * 2021-05-17 2022-11-24 서울대학교 산학협력단 PHARMACEUTICAL COMPOSITION FOR PREVENTION, ALLEVIATION OR TREATMENT OF MUSCULAR DYSTROPHY, CONTAINING RORα ACTIVATOR JC1-40
CN121045325A (en) * 2024-05-31 2025-12-02 中国科学院广州生物医药与健康研究院 sulfonamide acetamide compounds, their preparation methods and applications

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