NL156140B - Bereiding van racemisch of optisch actief (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno(3,4-d)imidazool-2,4-dion en/of van (+)-biotine. - Google Patents

Bereiding van racemisch of optisch actief (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno(3,4-d)imidazool-2,4-dion en/of van (+)-biotine.

Info

Publication number: NL156140B
Authority: NL; Netherlands
Prior art keywords: thieno; dibenzyl; hexahydro; dione; racemic
Prior art date: 1969-11-29

Application number

NL7015567.A

Other languages

English (en)

Dutch (nl)

Other versions

NL7015567A (de

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1969-11-29

Filing date

1970-10-23

Publication date

1978-03-15

1970-10-23 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

1971-06-02 Publication of NL7015567A publication Critical patent/NL7015567A/xx

1978-03-15 Publication of NL156140B publication Critical patent/NL156140B/xx

Links

YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 title 2
XJZIDYQGGLZUIO-IRXDYDNUSA-N (3as,6ar)-1,3-dibenzyl-6,6a-dihydro-3ah-thieno[3,4-d]imidazole-2,4-dione Chemical compound N1([C@H]2[C@@H](N(C1=O)CC=1C=CC=CC=1)CSC2=O)CC1=CC=CC=C1 XJZIDYQGGLZUIO-IRXDYDNUSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NL7015567.A 1969-11-29 1970-10-23 Bereiding van racemisch of optisch actief (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno(3,4-d)imidazool-2,4-dion en/of van (+)-biotine. NL156140B (nl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1777369A CH556867A (de)	1969-11-29	1969-11-29	Verfahren zur herstellung eines racemischen oder optisch aktiven thiolactons.

Publications (2)

Publication Number	Publication Date
NL7015567A NL7015567A (de)	1971-06-02
NL156140B true NL156140B (nl)	1978-03-15

Family

ID=4428001

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL7015567.A NL156140B (nl)	1969-11-29	1970-10-23	Bereiding van racemisch of optisch actief (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno(3,4-d)imidazool-2,4-dion en/of van (+)-biotine.

Country Status (10)

Country	Link
US (1)	US3740416A (de)
JP (1)	JPS5327279B1 (de)
BE (1)	BE759513A (de)
CA (1)	CA982591A (de)
CH (1)	CH556867A (de)
DK (1)	DK154563C (de)
FR (1)	FR2077540B1 (de)
GB (2)	GB1320798A (de)
NL (1)	NL156140B (de)
SE (1)	SE391928B (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4054740A (en) *	1974-12-24	1977-10-18	Hoffmann-La Roche Inc.	Hydroxybiotin
US4228295A (en) *	1977-02-23	1980-10-14	Hoffmann-La Roche Inc.	Novel cycloheptathiophene intermediates for the synthesis of biotin
US4337345A (en) *	1977-08-05	1982-06-29	Hoffmann-La Roche Inc.	Preparation of biotin via thieno [3,2c] isoxazoles
US4130713A (en) *	1977-08-05	1978-12-19	Hoffmann-La Roche Inc.	Biotin intermediates
US4189586A (en) *	1977-08-05	1980-02-19	Hoffmann-La Roche Inc.	Preparation of biotin
US4245104A (en) *	1978-12-01	1981-01-13	Hoffmann-La Roche Inc.	Isoxazolines and isoxazolidines
US4247704A (en) *	1979-05-29	1981-01-27	Hoffmann-La Roche Inc.	Hexahydro thieno imadazole intermediates for the synthesis of biotin
US4284557A (en) *	1979-05-29	1981-08-18	Hoffmann-La Roche Inc.	Intermediate racemates for the preparation of biotin and a process for their preparation
US4537973A (en) *	1980-03-12	1985-08-27	Sumitomo Chemical Company, Limited	Process for preparing biotin
DE3068160D1 (en) *	1980-03-14	1984-07-19	Sumitomo Chemical Co	Process for preparing biotin
US4320056A (en) *	1980-05-15	1982-03-16	Hoffmann-La Roche Inc.	Certain thia-diazatricyclo[3,3,3,08,11 ]tridecanes, and their preparation
US4382031A (en) *	1981-03-12	1983-05-03	Hoffmann-La Roche Inc.	Intermediates for the preparation of biotin
DK43985A (da) *	1984-03-09	1985-09-10	Hoffmann La Roche	Fremgangsmaade til fremstilling af heterocycliske forbindelser
DE4107121C1 (de) *	1991-03-06	1992-06-11	Merck Patent Gmbh, 6100 Darmstadt, De
CA2193774C (en) *	1995-12-26	2005-02-01	Norihiko Hirata	Process for producing 1-hydroxythienoimidazole carboxylic acid and thienoimidazole carboxylic acid
DE10001317A1 (de) *	2000-01-14	2001-07-19	Merck Patent Gmbh	Reaktion von Carbonylverbindungen mit metallorganischen Reagenzien
TW200300676A (en)	2001-12-04	2003-06-16	Tanabe Seiyaku Co	Biotin intermediate and its production
CN101096372B (zh) *	2007-01-24	2010-09-29	绍兴文理学院	硫内酯的合成工艺
CN102268007B (zh) *	2010-02-09	2015-11-25	浙江新和成股份有限公司	双苄生物素衍生物的制备方法
CN103788112B (zh) *	2012-11-02	2016-03-09	菏泽市方明制药有限公司	一种苄基生物素脱苄制备生物素的方法
CN103554129B (zh) *	2013-10-09	2016-03-23	安徽泰格维生素实业有限公司	一种生物素中间体硫酮的制备方法
CN107973806A (zh) *	2016-10-21	2018-05-01	大丰海嘉诺药业有限公司	一种制备d-生物素溴盐中间体的方法
JPWO2020110831A1 (ja) *	2018-11-28	2021-10-21	株式会社トクヤマ	チオラクトン誘導体の製造方法
WO2021224295A1 (en)	2020-05-07	2021-11-11	Dsm Ip Assets B.V.	A process for producing d-biotin intermediates
JP7665309B2 (ja) *	2020-10-21	2025-04-21	株式会社トクヤマ	チオラクトン化合物の製造方法
EP4353728A4 (de) *	2021-06-11	2025-07-16	Tokuyama Corp	Hydroxythienoimidazolderivat, vinylsulfidderivat, n-butylidensulfidderivat und herstellungsverfahren für gesättigtes, geradkettiges kohlenwasserstoffsubstituiertes thienoimidazolderivat
CN117440956B (zh)	2021-06-11	2026-03-17	帝斯曼知识产权资产管理有限公司	用于生产生物素中间体的工艺
EP4495123A1 (de)	2023-07-19	2025-01-22	DSM IP Assets B.V.	Verbessertes verfahren zur herstellung von d-biotin-zwischenprodukten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK71723C (da) *	1946-05-31	1950-11-20	Hoffmann La Roche	Fremgangsmåde til fremstilling af d,1-biotin.
DK73837C (da) *	1947-07-24	1952-03-03	Hoffmann La Roche	Fremgangsmåde til fremstilling af biotin eller homologe biotinforbindelser.
DK81470C (da) *	1947-07-24	1956-07-30	Hoffmann La Roche	Fremgangsmåde til fremstilling af d- og l-biotin.

0
- BE BE759513D patent/BE759513A/xx not_active IP Right Cessation
1969
- 1969-11-29 CH CH1777369A patent/CH556867A/de not_active IP Right Cessation
1970
- 1970-10-23 NL NL7015567.A patent/NL156140B/xx not_active IP Right Cessation
- 1970-11-17 US US00090477A patent/US3740416A/en not_active Expired - Lifetime
- 1970-11-18 CA CA098,432A patent/CA982591A/en not_active Expired
- 1970-11-26 FR FR7042501A patent/FR2077540B1/fr not_active Expired
- 1970-11-27 GB GB5640670A patent/GB1320798A/en not_active Expired
- 1970-11-27 SE SE7016133A patent/SE391928B/xx unknown
- 1970-11-27 DK DK607270A patent/DK154563C/da not_active IP Right Cessation
- 1970-11-27 GB GB4870372A patent/GB1320799A/en not_active Expired
- 1970-11-28 JP JP10451070A patent/JPS5327279B1/ja active Pending

Also Published As

Publication number	Publication date
NL7015567A (de)	1971-06-02
DE2058234A1 (de)	1971-06-09
BE759513A (fr)	1971-05-27
US3740416A (en)	1973-06-19
GB1320799A (en)	1973-06-20
FR2077540A1 (de)	1971-10-29
GB1320798A (en)	1973-06-20
DE2058234B2 (de)	1977-02-17
CH556867A (de)	1974-12-13
JPS5327279B1 (de)	1978-08-07
DK154563C (da)	1989-04-17
DK154563B (da)	1988-11-28
CA982591A (en)	1976-01-27
FR2077540B1 (de)	1975-12-12
SE391928B (sv)	1977-03-07

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Legal Events

Date	Code	Title	Description
1989-12-18	SNR	Assignments of patents or rights arising from examined patent applications	Owner name: F. HOFFMANN-LA ROCHE AG
1990-10-31	NL80	Information provided on patent owner name for an already discontinued patent	Owner name: HOFFMANN LA
1990-12-17	V4	Discontinued because of reaching the maximum lifetime of a patent