NL156140B - Bereiding van racemisch of optisch actief (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno(3,4-d)imidazool-2,4-dion en/of van (+)-biotine. - Google Patents

Bereiding van racemisch of optisch actief (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno(3,4-d)imidazool-2,4-dion en/of van (+)-biotine.

Info

Publication number
NL156140B
NL156140B NL7015567.A NL7015567A NL156140B NL 156140 B NL156140 B NL 156140B NL 7015567 A NL7015567 A NL 7015567A NL 156140 B NL156140 B NL 156140B
Authority
NL
Netherlands
Prior art keywords
thieno
dibenzyl
hexahydro
dione
racemic
Prior art date
Application number
NL7015567.A
Other languages
English (en)
Dutch (nl)
Other versions
NL7015567A (fr
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of NL7015567A publication Critical patent/NL7015567A/xx
Publication of NL156140B publication Critical patent/NL156140B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
NL7015567.A 1969-11-29 1970-10-23 Bereiding van racemisch of optisch actief (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno(3,4-d)imidazool-2,4-dion en/of van (+)-biotine. NL156140B (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1777369A CH556867A (de) 1969-11-29 1969-11-29 Verfahren zur herstellung eines racemischen oder optisch aktiven thiolactons.

Publications (2)

Publication Number Publication Date
NL7015567A NL7015567A (fr) 1971-06-02
NL156140B true NL156140B (nl) 1978-03-15

Family

ID=4428001

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7015567.A NL156140B (nl) 1969-11-29 1970-10-23 Bereiding van racemisch of optisch actief (+)-cis-1,3-dibenzyl-hexahydro-1h-thieno(3,4-d)imidazool-2,4-dion en/of van (+)-biotine.

Country Status (10)

Country Link
US (1) US3740416A (fr)
JP (1) JPS5327279B1 (fr)
BE (1) BE759513A (fr)
CA (1) CA982591A (fr)
CH (1) CH556867A (fr)
DK (1) DK154563C (fr)
FR (1) FR2077540B1 (fr)
GB (2) GB1320799A (fr)
NL (1) NL156140B (fr)
SE (1) SE391928B (fr)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054740A (en) * 1974-12-24 1977-10-18 Hoffmann-La Roche Inc. Hydroxybiotin
US4228295A (en) * 1977-02-23 1980-10-14 Hoffmann-La Roche Inc. Novel cycloheptathiophene intermediates for the synthesis of biotin
US4337345A (en) * 1977-08-05 1982-06-29 Hoffmann-La Roche Inc. Preparation of biotin via thieno [3,2c] isoxazoles
US4189586A (en) * 1977-08-05 1980-02-19 Hoffmann-La Roche Inc. Preparation of biotin
US4130713A (en) * 1977-08-05 1978-12-19 Hoffmann-La Roche Inc. Biotin intermediates
US4245104A (en) * 1978-12-01 1981-01-13 Hoffmann-La Roche Inc. Isoxazolines and isoxazolidines
US4284557A (en) * 1979-05-29 1981-08-18 Hoffmann-La Roche Inc. Intermediate racemates for the preparation of biotin and a process for their preparation
US4247704A (en) * 1979-05-29 1981-01-27 Hoffmann-La Roche Inc. Hexahydro thieno imadazole intermediates for the synthesis of biotin
US4537973A (en) * 1980-03-12 1985-08-27 Sumitomo Chemical Company, Limited Process for preparing biotin
EP0036030B1 (fr) * 1980-03-14 1984-06-13 Sumitomo Chemical Company, Limited Procédé de préparation de biotine
US4320056A (en) * 1980-05-15 1982-03-16 Hoffmann-La Roche Inc. Certain thia-diazatricyclo[3,3,3,08,11 ]tridecanes, and their preparation
US4382031A (en) * 1981-03-12 1983-05-03 Hoffmann-La Roche Inc. Intermediates for the preparation of biotin
DK43985A (da) * 1984-03-09 1985-09-10 Hoffmann La Roche Fremgangsmaade til fremstilling af heterocycliske forbindelser
DE4107121C1 (fr) * 1991-03-06 1992-06-11 Merck Patent Gmbh, 6100 Darmstadt, De
CA2193774C (fr) * 1995-12-26 2005-02-01 Norihiko Hirata Procede de production de l'acide 1-hydroxythienoimidazole-carboxylique et de l'acide thienoimidazole-carboxylique
DE10001317A1 (de) * 2000-01-14 2001-07-19 Merck Patent Gmbh Reaktion von Carbonylverbindungen mit metallorganischen Reagenzien
TW200300676A (en) 2001-12-04 2003-06-16 Tanabe Seiyaku Co Biotin intermediate and its production
CN101096372B (zh) * 2007-01-24 2010-09-29 绍兴文理学院 硫内酯的合成工艺
CN102268007B (zh) * 2010-02-09 2015-11-25 浙江新和成股份有限公司 双苄生物素衍生物的制备方法
CN103788112B (zh) * 2012-11-02 2016-03-09 菏泽市方明制药有限公司 一种苄基生物素脱苄制备生物素的方法
CN103554129B (zh) * 2013-10-09 2016-03-23 安徽泰格维生素实业有限公司 一种生物素中间体硫酮的制备方法
CN107973806A (zh) * 2016-10-21 2018-05-01 大丰海嘉诺药业有限公司 一种制备d-生物素溴盐中间体的方法
WO2020110831A1 (fr) * 2018-11-28 2020-06-04 株式会社トクヤマ Procédé de production de dérivé de thiolactone
WO2021224295A1 (fr) 2020-05-07 2021-11-11 Dsm Ip Assets B.V. Procédé de production d'intermédiaires de d-biotine
JP7665309B2 (ja) * 2020-10-21 2025-04-21 株式会社トクヤマ チオラクトン化合物の製造方法
TW202317584A (zh) * 2021-06-11 2023-05-01 日商德山股份有限公司 羥基噻吩咪唑衍生物、乙烯硫化物衍生物、ｎ－亞丁基硫化物衍生物及取代有飽和直鏈烴之噻吩咪唑衍生物之製造方法
EP4352065A4 (fr) 2021-06-11 2025-03-12 DSM IP Assets B.V. Procédé de production d'un intermédiaire de biotine
EP4495123A1 (fr) 2023-07-19 2025-01-22 DSM IP Assets B.V. Procede ameliore de production d'intermediaires de d-biotine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK71723C (da) * 1946-05-31 1950-11-20 Hoffmann La Roche Fremgangsmåde til fremstilling af d,1-biotin.
DK81470C (da) * 1947-07-24 1956-07-30 Hoffmann La Roche Fremgangsmåde til fremstilling af d- og l-biotin.
DK73837C (da) * 1947-07-24 1952-03-03 Hoffmann La Roche Fremgangsmåde til fremstilling af biotin eller homologe biotinforbindelser.

Also Published As

Publication number Publication date
GB1320799A (en) 1973-06-20
DE2058234B2 (de) 1977-02-17
CA982591A (en) 1976-01-27
NL7015567A (fr) 1971-06-02
US3740416A (en) 1973-06-19
FR2077540A1 (fr) 1971-10-29
DE2058234A1 (de) 1971-06-09
DK154563B (da) 1988-11-28
CH556867A (de) 1974-12-13
BE759513A (fr) 1971-05-27
DK154563C (da) 1989-04-17
FR2077540B1 (fr) 1975-12-12
GB1320798A (en) 1973-06-20
JPS5327279B1 (fr) 1978-08-07
SE391928B (sv) 1977-03-07

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Legal Events

Date Code Title Description
SNR Assignments of patents or rights arising from examined patent applications

Owner name: F. HOFFMANN-LA ROCHE AG

NL80 Information provided on patent owner name for an already discontinued patent

Owner name: HOFFMANN LA

V4 Discontinued because of reaching the maximum lifetime of a patent