NL187854C - Werkwijze ter bereiding van farmaceutische preparaten met diuretische en saluretische werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte op plaats 2 gesubstitueerde 1-oxo-5-indanyloxy-(of -thio-)-alkaanzuren. - Google Patents

Werkwijze ter bereiding van farmaceutische preparaten met diuretische en saluretische werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte op plaats 2 gesubstitueerde 1-oxo-5-indanyloxy-(of -thio-)-alkaanzuren.

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Publication number
NL187854C
NL187854C NLAANVRAGE7412829,A NL7412829A NL187854C NL 187854 C NL187854 C NL 187854C NL 7412829 A NL7412829 A NL 7412829A NL 187854 C NL187854 C NL 187854C
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NL
Netherlands
Prior art keywords
indanyloxyles
acious
diuretic
thio
substitutes
Prior art date
Application number
NLAANVRAGE7412829,A
Other languages
English (en)
Dutch (nl)
Other versions
NL7412829A (nl
NL187854B (nl
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Merck & Co Inc
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Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NL7412829A publication Critical patent/NL7412829A/xx
Publication of NL187854B publication Critical patent/NL187854B/xx
Application granted granted Critical
Publication of NL187854C publication Critical patent/NL187854C/xx

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    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • C07C255/13—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and singly-bound oxygen atoms bound to the same saturated acyclic carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
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    • C07C333/00—Derivatives of thiocarbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
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    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
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    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
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  • Hematology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NLAANVRAGE7412829,A 1973-10-11 1974-09-27 Werkwijze ter bereiding van farmaceutische preparaten met diuretische en saluretische werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte op plaats 2 gesubstitueerde 1-oxo-5-indanyloxy-(of -thio-)-alkaanzuren. NL187854C (nl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40573673A 1973-10-11 1973-10-11
US49265174A 1974-07-30 1974-07-30

Publications (3)

Publication Number Publication Date
NL7412829A NL7412829A (nl) 1975-04-15
NL187854B NL187854B (nl) 1991-09-02
NL187854C true NL187854C (nl) 1992-02-03

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Application Number Title Priority Date Filing Date
NLAANVRAGE7412829,A NL187854C (nl) 1973-10-11 1974-09-27 Werkwijze ter bereiding van farmaceutische preparaten met diuretische en saluretische werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte op plaats 2 gesubstitueerde 1-oxo-5-indanyloxy-(of -thio-)-alkaanzuren.
NL9100396A NL9100396A (nl) 1973-10-11 1991-03-05 Werkwijze ter bereiding van farmaceutische preparaten met diuretische en uricosurische werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte, op plaats 2 van de indaanrest gesubstitueerde 5-(1-oxo-5-indanyloxy- (of -thio-)methyl)tetrazolen.

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NL9100396A NL9100396A (nl) 1973-10-11 1991-03-05 Werkwijze ter bereiding van farmaceutische preparaten met diuretische en uricosurische werking, alsmede werkwijze ter bereiding van voor toepassing daarbij geschikte, op plaats 2 van de indaanrest gesubstitueerde 5-(1-oxo-5-indanyloxy- (of -thio-)methyl)tetrazolen.

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JP (1) JPS5939415B2 (cs)
KR (1) KR870000034B1 (cs)
AR (4) AR213065A1 (cs)
AT (1) AT342036B (cs)
BG (1) BG28255A3 (cs)
CA (1) CA1063125A (cs)
CH (2) CH610290A5 (cs)
CS (1) CS190439B2 (cs)
CY (1) CY1074A (cs)
DD (1) DD118075A5 (cs)
DE (2) DE2463215C2 (cs)
EG (1) EG11741A (cs)
ES (2) ES430900A1 (cs)
FR (1) FR2247218B1 (cs)
GB (2) GB1474460A (cs)
HK (1) HK47680A (cs)
HU (1) HU169587B (cs)
IE (1) IE39927B1 (cs)
IL (1) IL45779A (cs)
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NL (2) NL187854C (cs)
PH (2) PH22225A (cs)
RO (2) RO71480A (cs)
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Publication number Priority date Publication date Assignee Title
IE51535B1 (en) * 1980-09-02 1987-01-07 Merck & Co Inc Pharmaceutical compositions containing 4-((6,7-dihalogen-2,3-dihydro-1-oxo-1h-inden-5-yl)-oxy)butanoic acid compounds
US5489712A (en) * 1994-11-04 1996-02-06 Hoechst Celanese Corporation Process for preparing cyclic ketones
CN109748785A (zh) * 2019-01-14 2019-05-14 山东大学 一种二芳香烃取代丙烯酮类化合物及制备方法与应用

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Publication number Priority date Publication date Assignee Title
US3668241A (en) * 1968-11-25 1972-06-06 Merck & Co Inc Substituted 1-oxoinden-5-yloxy alkanoic acids
US3704314A (en) * 1968-11-25 1972-11-28 Merck & Co Inc (1-oxo-2-alkylideneindanyloxy) and (1-oxo - 2 - alkylideneindanylthio) alkanoic acids

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NL9100396A (nl) 1991-06-03
RO71480B (ro) 1983-07-30
ES430900A1 (es) 1977-01-01
AU7391674A (en) 1976-04-08
ES449917A1 (es) 1977-11-16
IL45779A0 (en) 1974-12-31
CH613933A5 (en) 1979-10-31
IE39927B1 (en) 1979-01-31
AT342036B (de) 1978-03-10
DE2463215C2 (de) 1986-03-13
FR2247218A1 (cs) 1975-05-09
IL45779A (en) 1978-06-15
CY1074A (en) 1980-10-24
KE3068A (en) 1980-08-08
CH610290A5 (en) 1979-04-12
YU272774A (en) 1983-06-30
DD118075A5 (cs) 1976-02-12
GB1474459A (en) 1977-05-25
GB1474460A (en) 1977-05-25
CA1063125A (en) 1979-09-25
BG28255A3 (en) 1980-03-25
FR2247218B1 (cs) 1978-02-03
YU39727B (en) 1985-04-30
HK47680A (en) 1980-09-05
KR870000034B1 (ko) 1987-02-07
SU738509A3 (ru) 1980-05-30
IE39927L (en) 1975-04-11
AR213170A1 (es) 1978-12-29
AR213840A1 (es) 1979-03-30
JPS5939415B2 (ja) 1984-09-22
PH22225A (en) 1988-07-01
EG11741A (en) 1977-12-31
MY8100163A (en) 1981-12-31
DE2448454A1 (de) 1975-04-24
ATA807874A (de) 1977-07-15
RO64568A (fr) 1979-03-15
DE2448454C2 (de) 1985-08-29
AR213620A1 (es) 1979-02-28
HU169587B (cs) 1976-12-28
PH22017A (en) 1988-05-13
KR830000198A (ko) 1983-03-30
NL7412829A (nl) 1975-04-15
LU71078A1 (cs) 1975-06-24
CS190439B2 (en) 1979-05-31
AR213065A1 (es) 1978-12-15
JPS5076058A (cs) 1975-06-21
NL187854B (nl) 1991-09-02
RO71480A (ro) 1983-08-03

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