NL7908988A - Paracetamolderivaat, de bereiding en toepassing daar- van. - Google Patents

Paracetamolderivaat, de bereiding en toepassing daar- van. Download PDF

Info

Publication number: NL7908988A
Authority: NL; Netherlands
Prior art keywords: salt; compound; glycine; preparation; adenosine
Prior art date: 1978-12-15

Application number

NL7908988A

Other languages

English (en)

Dutch (nl)

Original Assignee

Bottu Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-12-15

Filing date

1979-12-13

Publication date

1980-06-17

1979-12-13 Application filed by Bottu Sa filed Critical Bottu Sa

1980-06-17 Publication of NL7908988A publication Critical patent/NL7908988A/nl

Links

238000002360 preparation method Methods 0.000 title claims description 8
RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical class CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title description 11
150000001875 compounds Chemical class 0.000 claims description 11
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims description 10
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 10
230000000202 analgesic effect Effects 0.000 claims description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
230000001754 anti-pyretic effect Effects 0.000 claims description 7
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
239000004471 Glycine Substances 0.000 claims description 5
239000002253 acid Substances 0.000 claims description 5
238000000034 method Methods 0.000 claims description 5
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 4
150000003838 adenosines Chemical class 0.000 claims description 4
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims description 3
BTJIUGUIPKRLHP-UHFFFAOYSA-N 4-nitrophenol Chemical compound OC1=CC=C([N+]([O-])=O)C=C1 BTJIUGUIPKRLHP-UHFFFAOYSA-N 0.000 claims description 2
239000002126 C01EB10 - Adenosine Substances 0.000 claims description 2
229960005305 adenosine Drugs 0.000 claims description 2
239000003795 chemical substances by application Substances 0.000 claims description 2
150000002148 esters Chemical class 0.000 claims description 2
KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 2
238000001990 intravenous administration Methods 0.000 claims description 2
239000003814 drug Substances 0.000 claims 2
125000003277 amino group Chemical group 0.000 claims 1
150000008064 anhydrides Chemical class 0.000 claims 1
239000002552 dosage form Substances 0.000 claims 1
238000007918 intramuscular administration Methods 0.000 claims 1
230000001225 therapeutic effect Effects 0.000 claims 1
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 18
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 16
241000699670 Mus sp. Species 0.000 description 8
229960005489 paracetamol Drugs 0.000 description 8
150000003839 salts Chemical class 0.000 description 8
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
239000002244 precipitate Substances 0.000 description 6
206010037660 Pyrexia Diseases 0.000 description 4
230000007059 acute toxicity Effects 0.000 description 4
231100000403 acute toxicity Toxicity 0.000 description 4
150000002333 glycines Chemical class 0.000 description 4
239000000047 product Substances 0.000 description 4
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
241000700159 Rattus Species 0.000 description 3
239000013078 crystal Substances 0.000 description 3
PSQWZQGQIUGIRU-UHFFFAOYSA-N (4-acetamidophenyl) dihydrogen phosphate Chemical compound CC(=O)NC1=CC=C(OP(O)(O)=O)C=C1 PSQWZQGQIUGIRU-UHFFFAOYSA-N 0.000 description 2
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
230000036760 body temperature Effects 0.000 description 2
239000000706 filtrate Substances 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
239000000203 mixture Substances 0.000 description 2
150000004682 monohydrates Chemical class 0.000 description 2
241001465754 Metazoa Species 0.000 description 1
241000238814 Orthoptera Species 0.000 description 1
229910019142 PO4 Inorganic materials 0.000 description 1
208000002193 Pain Diseases 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
241000906446 Theraps Species 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
239000002221 antipyretic Substances 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000003054 catalyst Substances 0.000 description 1
239000012043 crude product Substances 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
KAKKHKRHCKCAGH-UHFFFAOYSA-L disodium;(4-nitrophenyl) phosphate;hexahydrate Chemical compound O.O.O.O.O.O.[Na+].[Na+].[O-][N+](=O)C1=CC=C(OP([O-])([O-])=O)C=C1 KAKKHKRHCKCAGH-UHFFFAOYSA-L 0.000 description 1
230000000694 effects Effects 0.000 description 1
-1 glycine Chemical class 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
150000007529 inorganic bases Chemical class 0.000 description 1
238000007912 intraperitoneal administration Methods 0.000 description 1
239000000155 melt Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
230000036407 pain Effects 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000003014 phosphoric acid esters Chemical class 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000012429 reaction media Substances 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
ZYPZVOKVDNSKLP-UHFFFAOYSA-N tris(4-aminophenyl) phosphate Chemical compound C1=CC(N)=CC=C1OP(=O)(OC=1C=CC(N)=CC=1)OC1=CC=C(N)C=C1 ZYPZVOKVDNSKLP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pain & Pain Management (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NL7908988A 1978-12-15 1979-12-13 Paracetamolderivaat, de bereiding en toepassing daar- van. NL7908988A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR7835429A FR2444043A1 (fr)	1978-12-15	1978-12-15	Nouveau derive du paracetamol, son procede de preparation et son utilisation en therapeutique
FR7835429		1978-12-15

Publications (1)

Publication Number	Publication Date
NL7908988A true NL7908988A (nl)	1980-06-17

Family

ID=9216203

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL7908988A NL7908988A (nl)	1978-12-15	1979-12-13	Paracetamolderivaat, de bereiding en toepassing daar- van.

Country Status (11)

Country	Link
US (1)	US4322410A (fr)
JP (1)	JPS5583792A (fr)
BE (1)	BE880615A (fr)
CA (1)	CA1131627A (fr)
CH (1)	CH642378A5 (fr)
DE (1)	DE2949669A1 (fr)
ES (1)	ES8101613A1 (fr)
FR (1)	FR2444043A1 (fr)
GB (1)	GB2037772B (fr)
IT (1)	IT1126572B (fr)
NL (1)	NL7908988A (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4591582A (en) *	1984-04-17	1986-05-27	Research Corporation	Organophosphorus compounds useful as anticonvulsant agents
IT1213182B (it) *	1984-06-25	1989-12-14	Simes	Derivati di composti a struttura catecolamminica.
US4710566A (en) *	1984-12-27	1987-12-01	Yale University	Purification of the messenger RNA cap-binding protein
GB2289535B (en) *	1994-05-13	1998-08-05	Cambridge Life Sciences	Paracetamol phosphate for immunoassays
US5661138A (en) *	1996-10-03	1997-08-26	Clarion Pharmaceutical, Inc.	(o-Acyl-p-N-acylamino-phenyl)-O-phosphoethanolamines
EP2291084A4 (fr)	2008-05-20	2012-04-25	Neurogesx Inc	Promédicaments carbonatés et leurs méthodes d'utilisation
JP5757864B2 (ja)	2008-05-20	2015-08-05	ニューロジェシックス，インコーポレイテッド	水溶性アセトアミノフェン類似体
US9024055B2 (en)	2011-09-22	2015-05-05	Acorda Therapeutics, Inc.	Acetaminophen conjugates, compositions and methods of use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE254421C (fr) *	1911-08-02
US2023551A (en) *	1933-06-28	1935-12-10	Rosenzweig Salo	Guaiacol compounds and the production thereof
US3032555A (en) *	1955-11-03	1962-05-01	Boots Pure Drug Co Ltd	Dichloroacetanilide esters and the manufacture thereof
US3107262A (en) *	1962-01-25	1963-10-15	Leo K Rochen	Alkyl acid phosphate salts

1978
- 1978-12-15 FR FR7835429A patent/FR2444043A1/fr active Granted
1979
- 1979-12-04 CH CH1073879A patent/CH642378A5/fr not_active IP Right Cessation
- 1979-12-04 US US06/100,005 patent/US4322410A/en not_active Expired - Lifetime
- 1979-12-07 CA CA341,429A patent/CA1131627A/fr not_active Expired
- 1979-12-07 IT IT28015/79A patent/IT1126572B/it active
- 1979-12-11 DE DE19792949669 patent/DE2949669A1/de not_active Withdrawn
- 1979-12-11 GB GB7942697A patent/GB2037772B/en not_active Expired
- 1979-12-13 NL NL7908988A patent/NL7908988A/nl not_active Application Discontinuation
- 1979-12-14 JP JP16343479A patent/JPS5583792A/ja active Pending
- 1979-12-14 ES ES486948A patent/ES8101613A1/es not_active Expired
- 1979-12-14 BE BE2/58269A patent/BE880615A/fr not_active IP Right Cessation

Also Published As

Publication number	Publication date
CH642378A5 (fr)	1984-04-13
FR2444043A1 (fr)	1980-07-11
JPS5583792A (en)	1980-06-24
GB2037772A (en)	1980-07-16
CA1131627A (fr)	1982-09-14
US4322410A (en)	1982-03-30
FR2444043B1 (fr)	1981-07-24
IT7928015A0 (it)	1979-12-07
IT1126572B (it)	1986-05-21
DE2949669A1 (de)	1980-07-03
BE880615A (fr)	1980-06-16
GB2037772B (en)	1983-05-11
ES486948A0 (es)	1980-12-16
ES8101613A1 (es)	1980-12-16

Legal Events

Date	Code	Title	Description
1985-01-01	A85	Still pending on 85-01-01
1985-08-01	BV	The patent application has lapsed

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DE2504565A1 (de)	1975-08-14	Neue derivate von 1h-imidazo(4,5-c) pyridin-7-carboxylsaeuren und -saeureestern
HU197295B (en)	1989-03-28	Process for production of new derivatives of n-/2'-aminphenil/-benzamid and medical preparatives containing those as active substance
GB2057437A (en)	1981-04-01	Salts of (+)-catechin their preparation and use and compositions and formulations containing them
NL7908988A (nl)	1980-06-17	Paracetamolderivaat, de bereiding en toepassing daar- van.
HU193409B (en)	1987-10-28	Process for producing 2-square bracket -n-cyclohexyl-4-bracket-oxo-1,2,3,5-tetrahydro-imidazo-square bracket-2,1-b-square bracket closed-quinazolin-7-yl-bracket closed-oxy-alkqne-carboxamidyl-square bracket closed-alkan-acides
EP0096870A1 (fr)	1983-12-28	Esters du métronidazole avec la N,N-diméthylglycine et ses sels d'addition d'acides
DE2263100C2 (de)	1986-01-30	5,5-Dimethyl-8-(3-methyl-2-octyl)-10-[4-(piperidino)-butyryloxy]-2-(2-propinyl)-1,2,3,4-tetrahydro-5H-[1]-benzopyrano[3,4-d]pyridin, Verfahren zu dessen Herstellung und die Verbindung enthaltende Arzneimittel
Blackwood et al.	1958	The Synthesis of 6-Chloropyridoxine. The Hydride Reduction of Pyridinedicarboxylic Acids
CH628014A5 (en)	1982-02-15	Gamma-aryl-gamma-oxoisovaleric acids having antiphlogistic and antalgic properties
JPS6041670B2 (ja)	1985-09-18	２，６−ジメチル−１，４−ジヒドロピリジン−３，５−ジカルボン酸エステルおよびその製造方法
GB2098989A (en)	1982-12-01	Lysine salts
AU2012212707B2 (en)	2014-03-20	Homo- and hetero-polyamino-acid derivatives of fullerene C60, method for producing same, and pharmaceutical compositions based on said derivatives
CA2478867A1 (fr)	2003-09-25	Formulations de derives d'anthraquinone
US4259332A (en)	1981-03-31	Novel taurine derivatives
DE2632200A1 (de)	1977-10-20	Pyrrolidinoaethyl-amide, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE69323998T2 (de)	1999-08-12	Pharmazeutisch aktive flavilium verbindungen
CN103772323A (zh)	2014-05-07	Dpp-4抑制剂化合物
US3461211A (en)	1969-08-12	Lipotropic compositions and their administration
SU1547251A1 (ru)	1991-04-07	2-Окси-3,5-дийод-N-[2-(4-галогеннафтокси-1)-5-хлорфенил]-бензамиды, обладающие противомал рийной активностью
US4018792A (en)	1977-04-19	5-Cyano-thiophen-2-aldehyde-isothiosemicarbazones and process for preparing them
JPS6348877B2 (fr)	1988-09-30
US4795758A (en)	1989-01-03	5-[2-(pyrrolidin-1-yl)ethoxy]-p-cymene derivatives, the process for the preparation of the said derivatives and drugs in which the said derivatives are present
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