NL8004297A - Antigeenpreparaten. - Google Patents

Antigeenpreparaten. Download PDF

Info

Publication number: NL8004297A
Authority: NL; Netherlands
Prior art keywords: emulsion; mixture according; organisms; oil; aluminum
Prior art date: 1979-07-27

Application number

NL8004297A

Other languages

English (en)

Dutch (nl)

Original Assignee

Wellcome Found

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-07-27

Filing date

1980-07-25

Publication date

1981-01-29

1980-07-25 Application filed by Wellcome Found filed Critical Wellcome Found

1981-01-29 Publication of NL8004297A publication Critical patent/NL8004297A/nl

Links

239000000427 antigen Substances 0.000 title claims description 23
102000036639 antigens Human genes 0.000 title claims description 23
108091007433 antigens Proteins 0.000 title claims description 23
238000002360 preparation method Methods 0.000 title claims description 19
229960005486 vaccine Drugs 0.000 claims description 61
239000000203 mixture Substances 0.000 claims description 55
239000000839 emulsion Substances 0.000 claims description 31
241001494479 Pecora Species 0.000 claims description 28
239000003995 emulsifying agent Substances 0.000 claims description 25
239000000463 material Substances 0.000 claims description 24
241000605721 Dichelobacter nodosus Species 0.000 claims description 23
230000000890 antigenic effect Effects 0.000 claims description 23
239000003921 oil Substances 0.000 claims description 21
239000012071 phase Substances 0.000 claims description 20
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 18
229910052782 aluminium Inorganic materials 0.000 claims description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
239000000546 pharmaceutical excipient Substances 0.000 claims description 17
-1 sorbitan fatty acid ester Chemical class 0.000 claims description 16
208000010801 foot rot Diseases 0.000 claims description 13
238000000034 method Methods 0.000 claims description 12
235000014113 dietary fatty acids Nutrition 0.000 claims description 10
239000000194 fatty acid Substances 0.000 claims description 10
229930195729 fatty acid Natural products 0.000 claims description 10
208000015181 infectious disease Diseases 0.000 claims description 10
239000008346 aqueous phase Substances 0.000 claims description 9
235000011126 aluminium potassium sulphate Nutrition 0.000 claims description 5
229940050271 potassium alum Drugs 0.000 claims description 5
GRLPQNLYRHEGIJ-UHFFFAOYSA-J potassium aluminium sulfate Chemical group [Al+3].[K+].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRLPQNLYRHEGIJ-UHFFFAOYSA-J 0.000 claims description 5
239000012736 aqueous medium Substances 0.000 claims description 4
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 4
229920000053 polysorbate 80 Polymers 0.000 claims description 4
238000011282 treatment Methods 0.000 claims description 4
239000000654 additive Substances 0.000 claims description 3
230000000996 additive effect Effects 0.000 claims description 3
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 3
239000007762 w/o emulsion Substances 0.000 claims description 3
JNYAEWCLZODPBN-KVTDHHQDSA-N (2r,3r,4r)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical group OC[C@@H](O)[C@H]1OC[C@@H](O)[C@H]1O JNYAEWCLZODPBN-KVTDHHQDSA-N 0.000 claims description 2
239000005662 Paraffin oil Substances 0.000 claims description 2
LUXUAZKGQZPOBZ-SAXJAHGMSA-N [(3S,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (Z)-octadec-9-enoate Chemical group CCCCCCCC\C=C/CCCCCCCC(=O)OC1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O LUXUAZKGQZPOBZ-SAXJAHGMSA-N 0.000 claims description 2
ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
229940057995 liquid paraffin Drugs 0.000 claims description 2
239000002480 mineral oil Substances 0.000 claims description 2
235000010446 mineral oil Nutrition 0.000 claims description 2
239000012875 nonionic emulsifier Substances 0.000 claims description 2
238000011321 prophylaxis Methods 0.000 claims description 2
150000005846 sugar alcohols Polymers 0.000 claims description 2
230000009974 thixotropic effect Effects 0.000 claims description 2
101150000874 11 gene Proteins 0.000 claims 1
241000606125 Bacteroides Species 0.000 claims 1
229940024545 aluminum hydroxide Drugs 0.000 claims 1
229940024546 aluminum hydroxide gel Drugs 0.000 claims 1
229940009859 aluminum phosphate Drugs 0.000 claims 1
SMYKVLBUSSNXMV-UHFFFAOYSA-K aluminum;trihydroxide;hydrate Chemical compound O.[OH-].[OH-].[OH-].[Al+3] SMYKVLBUSSNXMV-UHFFFAOYSA-K 0.000 claims 1
229940037003 alum Drugs 0.000 description 9
210000002683 foot Anatomy 0.000 description 9
238000011109 contamination Methods 0.000 description 8
201000010099 disease Diseases 0.000 description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
238000001556 precipitation Methods 0.000 description 7
241001465754 Metazoa Species 0.000 description 6
210000004027 cell Anatomy 0.000 description 6
239000006228 supernatant Substances 0.000 description 6
229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
239000000243 solution Substances 0.000 description 5
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 4
239000007924 injection Substances 0.000 description 4
238000002347 injection Methods 0.000 description 4
239000002244 precipitate Substances 0.000 description 4
238000002255 vaccination Methods 0.000 description 4
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
206010052428 Wound Diseases 0.000 description 3
208000027418 Wounds and injury Diseases 0.000 description 3
239000002253 acid Substances 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
150000002148 esters Chemical class 0.000 description 3
231100000252 nontoxic Toxicity 0.000 description 3
230000003000 nontoxic effect Effects 0.000 description 3
CUNWUEBNSZSNRX-RKGWDQTMSA-N (2r,3r,4r,5s)-hexane-1,2,3,4,5,6-hexol;(z)-octadec-9-enoic acid Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O CUNWUEBNSZSNRX-RKGWDQTMSA-N 0.000 description 2
JDRAOGVAQOVDEB-KTKRTIGZSA-N (3-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl) (z)-octadec-9-enoate Chemical compound OC1COC2C(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC21 JDRAOGVAQOVDEB-KTKRTIGZSA-N 0.000 description 2
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
241000894006 Bacteria Species 0.000 description 2
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
239000005639 Lauric acid Substances 0.000 description 2
239000005642 Oleic acid Substances 0.000 description 2
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
150000007513 acids Chemical class 0.000 description 2
230000004520 agglutination Effects 0.000 description 2
230000002051 biphasic effect Effects 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
230000006378 damage Effects 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
239000000499 gel Substances 0.000 description 2
238000003306 harvesting Methods 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
230000002163 immunogen Effects 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
239000011707 mineral Substances 0.000 description 2
238000002156 mixing Methods 0.000 description 2
239000002736 nonionic surfactant Substances 0.000 description 2
239000007764 o/w emulsion Substances 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
235000021313 oleic acid Nutrition 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
229920000136 polysorbate Polymers 0.000 description 2
238000012545 processing Methods 0.000 description 2
102000004169 proteins and genes Human genes 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
230000005855 radiation Effects 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
238000007920 subcutaneous administration Methods 0.000 description 2
238000012360 testing method Methods 0.000 description 2
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
IJJWOSAXNHWBPR-HUBLWGQQSA-N 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-n-(6-hydrazinyl-6-oxohexyl)pentanamide Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)NCCCCCC(=O)NN)SC[C@@H]21 IJJWOSAXNHWBPR-HUBLWGQQSA-N 0.000 description 1
240000002791 Brassica napus Species 0.000 description 1
241001112696 Clostridia Species 0.000 description 1
241001112695 Clostridiales Species 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
201000004624 Dermatitis Diseases 0.000 description 1
102000002322 Egg Proteins Human genes 0.000 description 1
108010000912 Egg Proteins Proteins 0.000 description 1
240000002989 Euphorbia neriifolia Species 0.000 description 1
241000605909 Fusobacterium Species 0.000 description 1
241000605952 Fusobacterium necrophorum Species 0.000 description 1
239000004166 Lanolin Substances 0.000 description 1
206010024769 Local reaction Diseases 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
229920001213 Polysorbate 20 Polymers 0.000 description 1
229920001219 Polysorbate 40 Polymers 0.000 description 1
229920001214 Polysorbate 60 Polymers 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 description 1
239000004147 Sorbitan trioleate Substances 0.000 description 1
PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
241000481723 Thinopyrum caespitosum Species 0.000 description 1
NWGKJDSIEKMTRX-BFWOXRRGSA-N [(2r)-2-[(3r,4s)-3,4-dihydroxyoxolan-2-yl]-2-hydroxyethyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)C1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-BFWOXRRGSA-N 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
239000003513 alkali Substances 0.000 description 1
229910000147 aluminium phosphate Inorganic materials 0.000 description 1
239000012874 anionic emulsifier Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
230000005875 antibody response Effects 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
229960001212 bacterial vaccine Drugs 0.000 description 1
238000010009 beating Methods 0.000 description 1
235000013871 bee wax Nutrition 0.000 description 1
239000012166 beeswax Substances 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
239000012620 biological material Substances 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000001569 carbon dioxide Substances 0.000 description 1
229910002092 carbon dioxide Inorganic materials 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
150000001805 chlorine compounds Chemical class 0.000 description 1
238000000975 co-precipitation Methods 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000012141 concentrate Substances 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000000645 desinfectant Substances 0.000 description 1
150000005690 diesters Chemical class 0.000 description 1
231100000676 disease causative agent Toxicity 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
239000003792 electrolyte Substances 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
230000001804 emulsifying effect Effects 0.000 description 1
239000010685 fatty oil Substances 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
238000001914 filtration Methods 0.000 description 1
239000008394 flocculating agent Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
239000001963 growth medium Substances 0.000 description 1
244000144980 herd Species 0.000 description 1
150000004679 hydroxides Chemical class 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
238000002649 immunization Methods 0.000 description 1
230000003053 immunization Effects 0.000 description 1
230000000415 inactivating effect Effects 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
238000011835 investigation Methods 0.000 description 1
230000007794 irritation Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
229940070765 laurate Drugs 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000009630 liquid culture Methods 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
239000002609 medium Substances 0.000 description 1
238000003801 milling Methods 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
229960005030 other vaccine in atc Drugs 0.000 description 1
210000004681 ovum Anatomy 0.000 description 1
AQEZCDJYCYMVIB-UHFFFAOYSA-N oxoalumane Chemical compound [AlH]=O AQEZCDJYCYMVIB-UHFFFAOYSA-N 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000002245 particle Substances 0.000 description 1
229920000447 polyanionic polymer Polymers 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000002787 reinforcement Effects 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
238000011218 seed culture Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
VMOXILJFUFEZJL-UHFFFAOYSA-M sodium;ethylmercury;2-sulfanylbenzoate Chemical compound [Na+].CC[Hg].[O-]C(=O)C1=CC=CC=C1S VMOXILJFUFEZJL-UHFFFAOYSA-M 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
239000001587 sorbitan monostearate Substances 0.000 description 1
235000011076 sorbitan monostearate Nutrition 0.000 description 1
229940035048 sorbitan monostearate Drugs 0.000 description 1
229960005078 sorbitan sesquioleate Drugs 0.000 description 1
235000019337 sorbitan trioleate Nutrition 0.000 description 1
229960000391 sorbitan trioleate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
230000001629 suppression Effects 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229960004906 thiomersal Drugs 0.000 description 1
210000003371 toe Anatomy 0.000 description 1
150000005691 triesters Chemical class 0.000 description 1
125000001874 trioxidanyl group Chemical group [*]OOO[H] 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
241001148471 unidentified anaerobic bacterium Species 0.000 description 1
235000013311 vegetables Nutrition 0.000 description 1
230000001018 virulence Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0216—Bacteriodetes, e.g. Bacteroides, Ornithobacter, Porphyromonas
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Immunology (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

NL8004297A 1979-07-27 1980-07-25 Antigeenpreparaten. NL8004297A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB7926323		1979-07-27
GB7926323		1979-07-27

Publications (1)

Publication Number	Publication Date
NL8004297A true NL8004297A (nl)	1981-01-29

Family

ID=10506837

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8004297A NL8004297A (nl)	1979-07-27	1980-07-25	Antigeenpreparaten.

Country Status (9)

Country	Link
AU (1)	AU529322B2 (fr)
BE (1)	BE884487A (fr)
CA (1)	CA1153310A (fr)
DE (1)	DE3028248A1 (fr)
FR (1)	FR2462166B1 (fr)
IT (1)	IT1128549B (fr)
NL (1)	NL8004297A (fr)
NZ (1)	NZ194448A (fr)
ZA (1)	ZA804525B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE940698L (en) *	1984-04-05	1985-10-05	Univ Missouri	Vaccine and serum for endotoxin associated disease and method of preparing same as well as to methods of immunization and treatment of such disease and to a detoxified endotoxin and bacterial mutant
AU580825B2 (en) *	1984-12-24	1989-02-02	Commonwealth Scientific And Industrial Research Organisation	Bacteroides nodosus vaccine
ZA883975B (en) *	1987-06-05	1989-04-26	Commw Scient Ind Res Org	Treatment and diagnosis of footrot using the basic protease of b.nodosus
ES2105980B1 (es) *	1995-11-13	1998-06-01	Univ Extremadura	Una vacuna para el pedero, procedimiento para su preparacion y aplicaciones.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA714355B (en) *	1970-07-06	1972-03-29	New Zealand Inventions Dev	Improvements in or relating to methods of preparation and use of a vaccine from bacteroides nodosus
US3843451A (en) *	1970-08-20	1974-10-22	Burroughs Wellcome Co	Microorganism production

1980
- 1980-07-24 AU AU60749/80A patent/AU529322B2/en not_active Expired
- 1980-07-25 DE DE19803028248 patent/DE3028248A1/de not_active Withdrawn
- 1980-07-25 CA CA000357009A patent/CA1153310A/fr not_active Expired
- 1980-07-25 NL NL8004297A patent/NL8004297A/nl not_active Application Discontinuation
- 1980-07-25 ZA ZA00804525A patent/ZA804525B/xx unknown
- 1980-07-25 IT IT49346/80A patent/IT1128549B/it active
- 1980-07-25 FR FR8016442A patent/FR2462166B1/fr not_active Expired
- 1980-07-25 BE BE0/201537A patent/BE884487A/fr not_active IP Right Cessation
- 1980-07-25 NZ NZ194448A patent/NZ194448A/xx unknown

Also Published As

Publication number	Publication date
FR2462166A1 (fr)	1981-02-13
AU6074980A (en)	1981-01-29
DE3028248A1 (de)	1981-02-19
NZ194448A (en)	1982-12-07
IT8049346A0 (it)	1980-07-25
ZA804525B (en)	1982-03-31
FR2462166B1 (fr)	1985-06-21
CA1153310A (fr)	1983-09-06
AU529322B2 (en)	1983-06-02
BE884487A (fr)	1981-01-26
IT1128549B (it)	1986-05-28

Legal Events

Date	Code	Title
1981-10-01	BT	A notification was added to the application dossier and made available to the public
1985-01-01	A85	Still pending on 85-01-01
1987-09-01	BV	The patent application has lapsed

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