NL8100719A - Microbiologisch bereid polypeptide met de aminozuur-orde van menselijk interferon, dna en plasmiden, die voor deze volgorde coderen, microoerganismen, die deze genetische informatie bevatten en werkwijze voor het maken daarvan. - Google Patents

Microbiologisch bereid polypeptide met de aminozuur-orde van menselijk interferon, dna en plasmiden, die voor deze volgorde coderen, microoerganismen, die deze genetische informatie bevatten en werkwijze voor het maken daarvan. Download PDF

Info

Publication number: NL8100719A
Authority: NL; Netherlands
Prior art keywords: plasmid; interferon; polypeptide; amino acid; dna
Prior art date: 1980-02-16

Application number

NL8100719A

Other languages

English (en)

Dutch (nl)

Original Assignee

Hoechst Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-02-16

Filing date

1981-02-13

Publication date

1981-09-16

1981-02-13 Application filed by Hoechst Ag filed Critical Hoechst Ag

1981-09-16 Publication of NL8100719A publication Critical patent/NL8100719A/nl

Links

102000014150 Interferons Human genes 0.000 title claims abstract description 33
108010050904 Interferons Proteins 0.000 title claims abstract description 33
229940079322 interferon Drugs 0.000 title claims abstract description 30
239000013612 plasmid Substances 0.000 title claims abstract description 28
244000005700 microbiome Species 0.000 title claims abstract description 12
229920001184 polypeptide Polymers 0.000 title claims abstract description 11
102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 11
108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 11
230000002068 genetic effect Effects 0.000 title claims abstract description 6
238000000034 method Methods 0.000 title claims description 10
150000001413 amino acids Chemical class 0.000 title 1
210000002950 fibroblast Anatomy 0.000 claims abstract description 9
241000588724 Escherichia coli Species 0.000 claims abstract description 8
238000004519 manufacturing process Methods 0.000 claims abstract description 7
125000003275 alpha amino acid group Chemical group 0.000 claims abstract description 6
108090000623 proteins and genes Proteins 0.000 claims description 11
230000015572 biosynthetic process Effects 0.000 claims description 8
AIYUHDOJVYHVIT-UHFFFAOYSA-M caesium chloride Chemical compound [Cl-].[Cs+] AIYUHDOJVYHVIT-UHFFFAOYSA-M 0.000 claims description 6
102000003996 Interferon-beta Human genes 0.000 claims description 3
108090000467 Interferon-beta Proteins 0.000 claims description 3
239000006166 lysate Substances 0.000 claims description 2
238000011084 recovery Methods 0.000 claims description 2
229910052792 caesium Inorganic materials 0.000 claims 1
TVFDJXOCXUVLDH-UHFFFAOYSA-N caesium atom Chemical compound [Cs] TVFDJXOCXUVLDH-UHFFFAOYSA-N 0.000 claims 1
229940098124 cesium chloride Drugs 0.000 claims 1
239000002299 complementary DNA Substances 0.000 abstract description 8
108020004999 messenger RNA Proteins 0.000 abstract description 5
241001646716 Escherichia coli K-12 Species 0.000 abstract description 2
108020004511 Recombinant DNA Proteins 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 25
108020004414 DNA Proteins 0.000 description 18
239000007983 Tris buffer Substances 0.000 description 17
238000006243 chemical reaction Methods 0.000 description 16
239000000243 solution Substances 0.000 description 16
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 10
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 10
229960001484 edetic acid Drugs 0.000 description 10
DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 9
102100034343 Integrase Human genes 0.000 description 8
108010092799 RNA-directed DNA polymerase Proteins 0.000 description 8
239000000203 mixture Substances 0.000 description 8
239000002244 precipitate Substances 0.000 description 8
241000894006 Bacteria Species 0.000 description 7
102000053602 DNA Human genes 0.000 description 7
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 7
238000000605 extraction Methods 0.000 description 7
102000004169 proteins and genes Human genes 0.000 description 7
239000001632 sodium acetate Substances 0.000 description 7
235000017281 sodium acetate Nutrition 0.000 description 7
239000001226 triphosphate Substances 0.000 description 7
235000011178 triphosphate Nutrition 0.000 description 7
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
102000004190 Enzymes Human genes 0.000 description 6
108090000790 Enzymes Proteins 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
229940088598 enzyme Drugs 0.000 description 6
238000011534 incubation Methods 0.000 description 6
108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
101710163270 Nuclease Proteins 0.000 description 5
239000001963 growth medium Substances 0.000 description 5
239000002609 medium Substances 0.000 description 5
125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
239000002253 acid Substances 0.000 description 4
210000004027 cell Anatomy 0.000 description 4
125000000086 dCMP group Chemical group 0.000 description 4
RGWHQCVHVJXOKC-SHYZEUOFSA-J dCTP(4-) Chemical compound O=C1N=C(N)C=CN1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)C1 RGWHQCVHVJXOKC-SHYZEUOFSA-J 0.000 description 4
239000005549 deoxyribonucleoside Substances 0.000 description 4
239000006228 supernatant Substances 0.000 description 4
238000012360 testing method Methods 0.000 description 4
229920001817 Agar Polymers 0.000 description 3
229920005654 Sephadex Polymers 0.000 description 3
239000012507 Sephadex™ Substances 0.000 description 3
239000008272 agar Substances 0.000 description 3
230000003115 biocidal effect Effects 0.000 description 3
239000000872 buffer Substances 0.000 description 3
238000005119 centrifugation Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
230000014509 gene expression Effects 0.000 description 3
230000001900 immune effect Effects 0.000 description 3
239000000725 suspension Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
108010010803 Gelatin Proteins 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
229940123573 Protein synthesis inhibitor Drugs 0.000 description 2
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
241000700605 Viruses Species 0.000 description 2
KZENBFUSKMWCJF-UHFFFAOYSA-N [5-[5-[5-(hydroxymethyl)-2-thiophenyl]-2-furanyl]-2-thiophenyl]methanol Chemical compound S1C(CO)=CC=C1C1=CC=C(C=2SC(CO)=CC=2)O1 KZENBFUSKMWCJF-UHFFFAOYSA-N 0.000 description 2
230000001580 bacterial effect Effects 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
238000004113 cell culture Methods 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
238000003776 cleavage reaction Methods 0.000 description 2
YPHMISFOHDHNIV-FSZOTQKASA-N cycloheximide Chemical compound C1[C@@H](C)C[C@H](C)C(=O)[C@@H]1[C@H](O)CC1CC(=O)NC(=O)C1 YPHMISFOHDHNIV-FSZOTQKASA-N 0.000 description 2
OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
125000003791 dGMP group Chemical group 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
239000005547 deoxyribonucleotide Substances 0.000 description 2
125000002637 deoxyribonucleotide group Chemical group 0.000 description 2
239000008273 gelatin Substances 0.000 description 2
229920000159 gelatin Polymers 0.000 description 2
235000019322 gelatine Nutrition 0.000 description 2
235000011852 gelatine desserts Nutrition 0.000 description 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
238000003780 insertion Methods 0.000 description 2
230000037431 insertion Effects 0.000 description 2
238000002955 isolation Methods 0.000 description 2
238000005259 measurement Methods 0.000 description 2
229910052757 nitrogen Inorganic materials 0.000 description 2
239000002773 nucleotide Substances 0.000 description 2
125000003729 nucleotide group Chemical group 0.000 description 2
239000000007 protein synthesis inhibitor Substances 0.000 description 2
230000010076 replication Effects 0.000 description 2
108091008146 restriction endonucleases Proteins 0.000 description 2
230000007017 scission Effects 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
238000012546 transfer Methods 0.000 description 2
230000009466 transformation Effects 0.000 description 2
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 2
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
229930024421 Adenine Natural products 0.000 description 1
GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
108091003079 Bovine Serum Albumin Proteins 0.000 description 1
PCDQPRRSZKQHHS-XVFCMESISA-N CTP Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 PCDQPRRSZKQHHS-XVFCMESISA-N 0.000 description 1
241000218236 Cannabis Species 0.000 description 1
108020004635 Complementary DNA Proteins 0.000 description 1
108010008286 DNA nucleotidylexotransferase Proteins 0.000 description 1
102100033215 DNA nucleotidylexotransferase Human genes 0.000 description 1
102000016943 Muramidase Human genes 0.000 description 1
108010014251 Muramidase Proteins 0.000 description 1
108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
108091028043 Nucleic acid sequence Proteins 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
239000004098 Tetracycline Substances 0.000 description 1
ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
229960000643 adenine Drugs 0.000 description 1
229960000723 ampicillin Drugs 0.000 description 1
AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000008033 biological extinction Effects 0.000 description 1
238000010804 cDNA synthesis Methods 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
230000032823 cell division Effects 0.000 description 1
238000010367 cloning Methods 0.000 description 1
238000004440 column chromatography Methods 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000012258 culturing Methods 0.000 description 1
229940104302 cytosine Drugs 0.000 description 1
HAAZLUGHYHWQIW-KVQBGUIXSA-N dGTP Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 HAAZLUGHYHWQIW-KVQBGUIXSA-N 0.000 description 1
230000029087 digestion Effects 0.000 description 1
VHJLVAABSRFDPM-ZXZARUISSA-N dithioerythritol Chemical compound SC[C@H](O)[C@H](O)CS VHJLVAABSRFDPM-ZXZARUISSA-N 0.000 description 1
238000001035 drying Methods 0.000 description 1
238000010828 elution Methods 0.000 description 1
DNJIEGIFACGWOD-UHFFFAOYSA-N ethyl mercaptane Natural products CCS DNJIEGIFACGWOD-UHFFFAOYSA-N 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000012894 fetal calf serum Substances 0.000 description 1
210000003953 foreskin Anatomy 0.000 description 1
238000005227 gel permeation chromatography Methods 0.000 description 1
ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
230000000899 immune system response Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000006698 induction Effects 0.000 description 1
230000001939 inductive effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000002799 interferon inducing agent Substances 0.000 description 1
229910052740 iodine Inorganic materials 0.000 description 1
239000011630 iodine Substances 0.000 description 1
239000007788 liquid Substances 0.000 description 1
210000004698 lymphocyte Anatomy 0.000 description 1
229960000274 lysozyme Drugs 0.000 description 1
239000004325 lysozyme Substances 0.000 description 1
235000010335 lysozyme Nutrition 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
150000004712 monophosphates Chemical group 0.000 description 1
229920001220 nitrocellulos Polymers 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
HJRIWDYVYNNCFY-UHFFFAOYSA-M potassium;dimethylarsinate Chemical compound [K+].C[As](C)([O-])=O HJRIWDYVYNNCFY-UHFFFAOYSA-M 0.000 description 1
230000000644 propagated effect Effects 0.000 description 1
238000000751 protein extraction Methods 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
238000001226 reprecipitation Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
229960002180 tetracycline Drugs 0.000 description 1
229930101283 tetracycline Natural products 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Biomedical Technology (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Analytical Chemistry (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Crystallography & Structural Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

NL8100719A 1980-02-16 1981-02-13 Microbiologisch bereid polypeptide met de aminozuur-orde van menselijk interferon, dna en plasmiden, die voor deze volgorde coderen, microoerganismen, die deze genetische informatie bevatten en werkwijze voor het maken daarvan. NL8100719A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19803005843 DE3005843A1 (de)	1980-02-16	1980-02-16	Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
DE3005843		1980-02-16

Publications (1)

Publication Number	Publication Date
NL8100719A true NL8100719A (nl)	1981-09-16

Family

ID=6094790

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8100719A NL8100719A (nl)	1980-02-16	1981-02-13	Microbiologisch bereid polypeptide met de aminozuur-orde van menselijk interferon, dna en plasmiden, die voor deze volgorde coderen, microoerganismen, die deze genetische informatie bevatten en werkwijze voor het maken daarvan.

Country Status (13)

Country	Link
EP (1)	EP0034306B1 (fr)
JP (1)	JPS56131522A (fr)
AT (1)	ATE26999T1 (fr)
AU (1)	AU6728781A (fr)
BE (1)	BE887530A (fr)
DE (2)	DE3005843A1 (fr)
ES (3)	ES8205430A1 (fr)
FR (1)	FR2482132A1 (fr)
GB (1)	GB2069504A (fr)
IT (1)	IT1141976B (fr)
NL (1)	NL8100719A (fr)
SE (1)	SE8101004L (fr)
ZA (1)	ZA81973B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK33181A (da) *	1980-02-06	1981-08-07	Searle & Co	Fremgangsmaade til fremstilling af et interferonlignende protein
DE3177213D1 (de)	1980-04-03	1990-10-18	Biogen Inc	Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.
EP0042246B1 (fr) *	1980-06-12	1987-03-18	The Cancer Institute Of Japanese Foundation For Cancer Research	Plasmid
FR2490675B1 (fr) *	1980-09-25	1985-11-15	Genentech Inc	Production microbienne d'interferon de fibroplaste humain
IT1167610B (it) *	1982-01-19	1987-05-13	Cetus Corp	Interfreron ibrido multiclasse, composizione farmaceutica che lo contiene e procedimento di produzione
IE54592B1 (en) *	1982-03-08	1989-12-06	Genentech Inc	Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US5827694A (en) *	1982-03-08	1998-10-27	Genentech, Inc.	DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en)	1982-03-08	2002-08-13	Genentech, Inc.	Non-human animal interferons
DE3220116A1 (de) *	1982-05-28	1983-12-01	Dr. Karl Thomae Gmbh, 7950 Biberach	Mikrobiologisch hergestellte (alpha)- und ss-interferone, dna-sequenzen, die fuer diese interferone codieren, mikroorganismen, die diese genetische information enthalten, und verfahren zu ihrer herstellung
US5831023A (en) *	1982-11-01	1998-11-03	Genentech, Inc.	Recombinant animal interferon polypeptides

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI77877C (fi) *	1979-04-20	1989-05-10	Technobiotic Ltd	Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
AU538665B2 (en) *	1979-10-30	1984-08-23	Juridical Foundation, Japanese Foundation For Cancer Research	Human interferon dna
IL58765A (en) *	1979-11-21	1986-09-30	Yeda Res & Dev	Process for the production of essentially pure messenger rna of human fibroblast interferon and process for the production of interferon beta
CY1346A (en) *	1980-01-08	1987-01-16	Biogen Nv	Dna sequences,recombinant dna molecules and processes for producing human interferon-like polypeptides
DK33181A (da) *	1980-02-06	1981-08-07	Searle & Co	Fremgangsmaade til fremstilling af et interferonlignende protein
AU545912B2 (en) *	1980-03-10	1985-08-08	Cetus Corporation	Cloned heterologous jive products in bacillies
DE3177213D1 (de) *	1980-04-03	1990-10-18	Biogen Inc	Dns-sequenzen, rekombinante dns-molekuele und verfahren zur herstellung von dem menschlichen fibroblast-interferon.

1980
- 1980-02-16 DE DE19803005843 patent/DE3005843A1/de not_active Withdrawn
1981
- 1981-02-05 EP EP81100802A patent/EP0034306B1/fr not_active Expired
- 1981-02-05 DE DE8181100802T patent/DE3176161D1/de not_active Expired
- 1981-02-05 AT AT81100802T patent/ATE26999T1/de not_active IP Right Cessation
- 1981-02-10 ES ES499290A patent/ES8205430A1/es not_active Expired
- 1981-02-10 ES ES499289A patent/ES8205429A1/es not_active Expired
- 1981-02-10 ES ES499285A patent/ES8302089A1/es not_active Expired
- 1981-02-13 IT IT19759/81A patent/IT1141976B/it active
- 1981-02-13 ZA ZA00810973A patent/ZA81973B/xx unknown
- 1981-02-13 AU AU67287/81A patent/AU6728781A/en not_active Abandoned
- 1981-02-13 SE SE8101004A patent/SE8101004L/ not_active Application Discontinuation
- 1981-02-13 NL NL8100719A patent/NL8100719A/nl not_active Application Discontinuation
- 1981-02-16 JP JP2130781A patent/JPS56131522A/ja active Pending
- 1981-02-16 FR FR8102963A patent/FR2482132A1/fr active Pending
- 1981-02-16 BE BE0/203804A patent/BE887530A/fr not_active IP Right Cessation
- 1981-02-16 GB GB8104763A patent/GB2069504A/en not_active Withdrawn

Also Published As

Publication number	Publication date
EP0034306A2 (fr)	1981-08-26
EP0034306A3 (en)	1981-11-04
DE3005843A1 (de)	1981-09-10
IT1141976B (it)	1986-10-08
IT8119759A0 (it)	1981-02-13
ES499289A0 (es)	1982-06-01
ES499285A0 (es)	1983-01-01
ZA81973B (en)	1982-03-31
EP0034306B1 (fr)	1987-05-06
ATE26999T1 (de)	1987-05-15
ES499290A0 (es)	1982-06-01
SE8101004L (sv)	1981-08-17
BE887530A (fr)	1981-08-17
AU6728781A (en)	1981-08-27
GB2069504A (en)	1981-08-26
ES8302089A1 (es)	1983-01-01
ES8205429A1 (es)	1982-06-01
JPS56131522A (en)	1981-10-15
FR2482132A1 (fr)	1981-11-13
DE3176161D1 (en)	1987-06-11
ES8205430A1 (es)	1982-06-01

Legal Events

Date	Code	Title	Description
1983-10-03	BV	The patent application has lapsed

Publication	Publication Date	Title
NL8100718A (nl)	1981-09-16	Microbiologisch gevormd polypeptide met de aminozuur-volgorde van menselijk interferon, dna en plasmiden, die deze volgorde coderen, microoerganismen, die deze genetische informaties bevatten en werkwijze voor het maken daarvan.
US4440859A (en)	1984-04-03	Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
KR920006349B1 (ko)	1992-08-03	미생물을 이용한 α- 및 β-인터페론의 제조방법
JP2612149B2 (ja)	1997-05-21	α−インターフェロン及びその製造方法
JPH0284186A (ja)	1990-03-26	プラスミノーゲンアクチベーター蛋白質をコードするポリデオキシリボヌクレオチド、それを含むベクター及びそれを含む形質転換体
US4652525A (en)	1987-03-24	Recombinant bacterial plasmids containing the coding sequences of insulin genes
JPH07106156B2 (ja)	1995-11-15	ファクタ−▲ｖｉｉｉ▼および関連生産物の製造
JPH0659218B2 (ja)	1994-08-10	Ｄｎａ導入ベクタ−
JPS63269979A (ja)	1988-11-08	巨大菌からのグルコース・デヒドロゲナーゼの調製方法
JPS59501694A (ja)	1984-10-11	シグナルｄｎａ配列を含むｄｎａ断片、その製造方法およびそれにより形質転換された微生物
GB2069504A (en)	1981-08-26	Microbiologically Prepared Polypeptide Comprising the Amino Acid Sequence of Human Interferon, DNA and Plasmids which Code for this Sequence, Microorganisms which Contain this Genetic Information, and Processes for their Preparation
EP0133321A1 (fr)	1985-02-20	Gène d'ADN, procédé pour sa production et plasmide contenant ce gène
CA1192153A (fr)	1985-08-20	Polypeptide prepare par les microorganismes a l'aide de la sequence d'acides amines de la proinsuline de primates, l'adn et des plasmides qui agissent comme codes pour cette sequence, microorganismes contenant cette information et leur procede de preparation
CN114230644A (zh)	2022-03-25	一种gp32蛋白突变体、重组载体及其构建方法和应用
JPH012584A (ja)	1989-01-06	Ｄｎａおよびプラスミド並びにそれらを含有する微生物
CN110551722A (zh)	2019-12-10	一种核酸复合物及其制备方法和应用
JPS62126972A (ja)	1987-06-09	新規制限酵素及びその製造法
CN115873811B (zh)	2023-08-08	一种pbcv-1连接酶突变体、表达纯化方法及应用
Stenn et al.	1988	Beyond Hybridomas Cell Identification by in Situ Nucleic Acid Hybridization
JP2833793B2 (ja)	1998-12-09	ヘパリナーゼをコードするプラスミド、このプラスミドを保持するヘパリナーゼ生産株及びヘパリナーゼの製造法
Bahl et al.	1980	[78] Lactose operator-Repressor interaction: Use of synthetic oligonucleotides in determining the minimal recognition sequence of the lactose operator
SU1436887A3 (ru)	1988-11-07	Способ получени рекомбинантной плазмидной ДНК,кодирующей гормон роста крысы или человека
CA1156166A (fr)	1983-11-01	Plasmides bacteriens recombinants contenant les codes de genes pour la production d'insuline
SU994554A1 (ru)	1983-02-07	Способ получени метиониназы
JPH03112484A (ja)	1991-05-14	新規制限酵素及びその製造方法