NL8104818A - Geneesmiddel voor het behandelen van suikerziekte en werkwijze voor de toediening van het preparaat. - Google Patents

Geneesmiddel voor het behandelen van suikerziekte en werkwijze voor de toediening van het preparaat. Download PDF

Info

Publication number: NL8104818A
Authority: NL; Netherlands
Prior art keywords: biotin; insulin; patient; serum; glucose
Prior art date: 1980-10-27

Application number

NL8104818A

Other languages

English (en)

Dutch (nl)

Original Assignee

Capital Medical Ass

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-27

Filing date

1981-10-26

Publication date

1982-05-17

1981-10-26 Application filed by Capital Medical Ass filed Critical Capital Medical Ass

1982-05-17 Publication of NL8104818A publication Critical patent/NL8104818A/nl

Links

238000000034 method Methods 0.000 title claims description 28
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title description 9
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YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims description 323
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 170
239000011616 biotin Substances 0.000 claims description 157
229960002685 biotin Drugs 0.000 claims description 157
235000020958 biotin Nutrition 0.000 claims description 151
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229940125396 insulin Drugs 0.000 claims description 85
210000002966 serum Anatomy 0.000 claims description 55
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201000001421 hyperglycemia Diseases 0.000 claims description 12
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239000003814 drug Substances 0.000 claims description 7
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239000000203 mixture Substances 0.000 claims description 2
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239000008103 glucose Substances 0.000 description 72
206010067584 Type 1 diabetes mellitus Diseases 0.000 description 39
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239000002131 composite material Substances 0.000 description 5
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230000029142 excretion Effects 0.000 description 5
239000002933 immunoreactive insulin Substances 0.000 description 5
241000700159 Rattus Species 0.000 description 4
HIMXGTXNXJYFGB-UHFFFAOYSA-N alloxan Chemical compound O=C1NC(=O)C(=O)C(=O)N1 HIMXGTXNXJYFGB-UHFFFAOYSA-N 0.000 description 4
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210000004185 liver Anatomy 0.000 description 4
238000007619 statistical method Methods 0.000 description 4
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WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 3
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QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
235000021411 American diet Nutrition 0.000 description 1
235000007319 Avena orientalis Nutrition 0.000 description 1
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108010075254 C-Peptide Proteins 0.000 description 1
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235000019750 Crude protein Nutrition 0.000 description 1
235000000638 D-biotin Nutrition 0.000 description 1
239000011665 D-biotin Substances 0.000 description 1
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240000005979 Hordeum vulgare Species 0.000 description 1
235000007340 Hordeum vulgare Nutrition 0.000 description 1
208000028389 Nerve injury Diseases 0.000 description 1
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CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 1
240000006394 Sorghum bicolor Species 0.000 description 1
235000011684 Sorghum saccharatum Nutrition 0.000 description 1
235000009430 Thespesia populnea Nutrition 0.000 description 1
235000021307 Triticum Nutrition 0.000 description 1
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239000003472 antidiabetic agent Substances 0.000 description 1
238000013459 approach Methods 0.000 description 1
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102000023732 binding proteins Human genes 0.000 description 1
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235000013399 edible fruits Nutrition 0.000 description 1
235000013345 egg yolk Nutrition 0.000 description 1
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239000000194 fatty acid Substances 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
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208000019622 heart disease Diseases 0.000 description 1
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235000012054 meals Nutrition 0.000 description 1
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235000011912 vitamin B7 Nutrition 0.000 description 1
239000011735 vitamin B7 Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Health & Medical Sciences (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Hematology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

NL8104818A 1980-10-27 1981-10-26 Geneesmiddel voor het behandelen van suikerziekte en werkwijze voor de toediening van het preparaat. NL8104818A (nl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US20078480A	1980-10-27	1980-10-27
US20078480		1980-10-27

Publications (1)

Publication Number	Publication Date
NL8104818A true NL8104818A (nl)	1982-05-17

Family

ID=22743169

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8104818A NL8104818A (nl)	1980-10-27	1981-10-26	Geneesmiddel voor het behandelen van suikerziekte en werkwijze voor de toediening van het preparaat.

Country Status (6)

Country	Link
JP (1)	JPS5799520A (fr)
AU (1)	AU7683381A (fr)
BE (1)	BE890888A (fr)
DE (1)	DE3142590A1 (fr)
FR (1)	FR2492662A1 (fr)
NL (1)	NL8104818A (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3363567D1 (en) *	1982-03-01	1986-06-26	Efamol Ltd	Pharmaceutical and dietary composition
US20050256178A1 (en) *	2002-08-23	2005-11-17	Eggersdorfer Manfred L	Novel nutraceutical compositions comprising boitin
JP2004203863A (ja) *	2002-12-09	2004-07-22	Taisho Pharmaceut Co Ltd	抗糖尿病用組成物
JP2006089392A (ja) *	2004-09-22	2006-04-06	Tohoku Univ	生活習慣病改善食品および生活習慣病治療薬

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE788779A (fr) *	1971-09-13	1973-01-02	Magnor Inc	Produit a base de biotine pour le traitement du diabete

1981
- 1981-10-26 AU AU76833/81A patent/AU7683381A/en not_active Abandoned
- 1981-10-26 NL NL8104818A patent/NL8104818A/nl not_active Application Discontinuation
- 1981-10-27 BE BE0/206366A patent/BE890888A/fr not_active IP Right Cessation
- 1981-10-27 FR FR8120147A patent/FR2492662A1/fr active Granted
- 1981-10-27 DE DE19813142590 patent/DE3142590A1/de not_active Withdrawn
- 1981-10-27 JP JP56171944A patent/JPS5799520A/ja active Pending

Also Published As

Publication number	Publication date
BE890888A (fr)	1982-02-15
AU7683381A (en)	1982-05-06
FR2492662A1 (fr)	1982-04-30
JPS5799520A (en)	1982-06-21
DE3142590A1 (de)	1982-08-12
FR2492662B1 (fr)	1985-04-19

Legal Events

Date	Code	Title	Description
1985-01-01	A85	Still pending on 85-01-01
1985-06-03	BV	The patent application has lapsed

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