NL8502092A - Tabletten die s-carboxymethylcysteine bevatten en werkwijze voor de bereiding daarvan. - Google Patents

Tabletten die s-carboxymethylcysteine bevatten en werkwijze voor de bereiding daarvan. Download PDF

Info

Publication number: NL8502092A
Authority: NL; Netherlands
Prior art keywords: parts; weight; carboxymethylcysteine; mannitol; starch
Prior art date: 1985-07-22

Application number

NL8502092A

Other languages

English (en)

Dutch (nl)

Original Assignee

Cedona Haarlemmer Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-22

Filing date

1985-07-22

Publication date

1987-02-16

1985-07-22 Application filed by Cedona Haarlemmer Pharma filed Critical Cedona Haarlemmer Pharma

1985-07-22 Priority to NL8502092A priority Critical patent/NL8502092A/nl

1986-07-22 Priority to EP86201294A priority patent/EP0209957B1/de

1986-07-22 Priority to DE8686201294T priority patent/DE3663448D1/de

1986-07-22 Priority to AT86201294T priority patent/ATE43241T1/de

1987-02-16 Publication of NL8502092A publication Critical patent/NL8502092A/nl

Links

GBFLZEXEOZUWRN-VKHMYHEASA-N S-carboxymethyl-L-cysteine Chemical compound OC(=O)[C@@H](N)CSCC(O)=O GBFLZEXEOZUWRN-VKHMYHEASA-N 0.000 title claims abstract description 26
238000000034 method Methods 0.000 title claims description 11
238000002360 preparation method Methods 0.000 title claims description 6
229920002472 Starch Polymers 0.000 claims abstract description 18
235000019698 starch Nutrition 0.000 claims abstract description 18
239000008107 starch Substances 0.000 claims abstract description 18
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims abstract description 16
229960000913 crospovidone Drugs 0.000 claims abstract description 16
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims abstract description 16
229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims abstract description 16
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims abstract description 15
229930195725 Mannitol Natural products 0.000 claims abstract description 15
239000000594 mannitol Substances 0.000 claims abstract description 15
235000010355 mannitol Nutrition 0.000 claims abstract description 15
239000000203 mixture Substances 0.000 claims abstract description 15
239000000454 talc Substances 0.000 claims abstract description 14
235000012222 talc Nutrition 0.000 claims abstract description 14
229910052623 talc Inorganic materials 0.000 claims abstract description 14
235000021355 Stearic acid Nutrition 0.000 claims abstract description 12
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims abstract description 12
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims abstract description 12
150000003839 salts Chemical class 0.000 claims abstract description 12
239000008117 stearic acid Substances 0.000 claims abstract description 12
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 8
239000008119 colloidal silica Substances 0.000 claims abstract description 8
239000008298 dragée Substances 0.000 claims description 13
239000000546 pharmaceutical excipient Substances 0.000 claims description 11
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 6
235000012239 silicon dioxide Nutrition 0.000 claims description 6
239000000126 substance Substances 0.000 claims description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
239000000969 carrier Substances 0.000 claims description 2
239000003814 drug Substances 0.000 claims 1
239000002671 adjuvant Substances 0.000 abstract 1
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
239000013543 active substance Substances 0.000 description 4
239000002775 capsule Substances 0.000 description 4
235000019359 magnesium stearate Nutrition 0.000 description 3
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
229930006000 Sucrose Natural products 0.000 description 2
CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 2
229940063655 aluminum stearate Drugs 0.000 description 2
235000013361 beverage Nutrition 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
239000011575 calcium Substances 0.000 description 2
239000003085 diluting agent Substances 0.000 description 2
239000008187 granular material Substances 0.000 description 2
239000008101 lactose Substances 0.000 description 2
229910052749 magnesium Inorganic materials 0.000 description 2
239000011777 magnesium Substances 0.000 description 2
239000005720 sucrose Substances 0.000 description 2
239000000725 suspension Substances 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
206010035664 Pneumonia Diseases 0.000 description 1
150000001413 amino acids Chemical class 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
206010006451 bronchitis Diseases 0.000 description 1
230000007012 clinical effect Effects 0.000 description 1
239000002552 dosage form Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
235000011389 fruit/vegetable juice Nutrition 0.000 description 1
230000002496 gastric effect Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000000463 material Substances 0.000 description 1
229940100688 oral solution Drugs 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
238000003825 pressing Methods 0.000 description 1
210000001732 sebaceous gland Anatomy 0.000 description 1
230000028327 secretion Effects 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000007916 tablet composition Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

NL8502092A 1985-07-22 1985-07-22 Tabletten die s-carboxymethylcysteine bevatten en werkwijze voor de bereiding daarvan. NL8502092A (nl)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
NL8502092A NL8502092A (nl)	1985-07-22	1985-07-22	Tabletten die s-carboxymethylcysteine bevatten en werkwijze voor de bereiding daarvan.
EP86201294A EP0209957B1 (de)	1985-07-22	1986-07-22	S-carboxymethylcysteinenthaltende Tabletten
DE8686201294T DE3663448D1 (en)	1985-07-22	1986-07-22	Tablets containing s-carboxymethylcysteine
AT86201294T ATE43241T1 (de)	1985-07-22	1986-07-22	S-carboxymethylcysteinenthaltende tabletten.

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8502092		1985-07-22
NL8502092A NL8502092A (nl)	1985-07-22	1985-07-22	Tabletten die s-carboxymethylcysteine bevatten en werkwijze voor de bereiding daarvan.

Publications (1)

Publication Number	Publication Date
NL8502092A true NL8502092A (nl)	1987-02-16

Family

ID=19846346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8502092A NL8502092A (nl)	1985-07-22	1985-07-22	Tabletten die s-carboxymethylcysteine bevatten en werkwijze voor de bereiding daarvan.

Country Status (4)

Country	Link
EP (1)	EP0209957B1 (de)
AT (1)	ATE43241T1 (de)
DE (1)	DE3663448D1 (de)
NL (1)	NL8502092A (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE125702T1 (de) *	1990-10-19	1995-08-15	Spirig Ag	Feste, schnell-lösliche arzneimittelzubereitung enthaltend s-(carboxymethyl)-l-cystein und/oder n-acetylcystein.
JP4098850B2 (ja) *	1997-07-16	2008-06-11	久光製薬株式会社	Ｓ−（３−ヒドロキシプロピル）−ｌ−システインを含有する経口用製剤
PH12018000390A1 (en) *	2018-11-20	2020-09-28	Novex Science Pte Ltd	Carbocysteine and zinc tablet

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3145146A (en) *	1961-10-31	1964-08-18	Warner Lambert Pharmaceutical	Modified mannitol for pharmaceutical tablets
FR2544200B1 (fr) *	1983-04-13	1985-09-13	Sopar Sa Nv	Composition pharmaceutique de glafenine
AU574360B2 (en) *	1983-05-13	1988-07-07	Reichert, D.	Antisnoring agent

1985
- 1985-07-22 NL NL8502092A patent/NL8502092A/nl not_active Application Discontinuation
1986
- 1986-07-22 DE DE8686201294T patent/DE3663448D1/de not_active Expired
- 1986-07-22 AT AT86201294T patent/ATE43241T1/de not_active IP Right Cessation
- 1986-07-22 EP EP86201294A patent/EP0209957B1/de not_active Expired

Also Published As

Publication number	Publication date
EP0209957A1 (de)	1987-01-28
DE3663448D1 (en)	1989-06-29
ATE43241T1 (de)	1989-06-15
EP0209957B1 (de)	1989-05-24

Legal Events

Date	Code	Title	Description
1987-02-16	A1B	A search report has been drawn up
1989-03-01	BV	The patent application has lapsed

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