NL8600250A - Vaginaal anticonceptiemiddel. - Google Patents

Vaginaal anticonceptiemiddel. Download PDF

Info

Publication number: NL8600250A
Authority: NL; Netherlands
Prior art keywords: contraceptive; mixture; spermicides; vol; vaginal
Prior art date: 1986-02-01

Application number

NL8600250A

Other languages

English (en)

Dutch (nl)

Original Assignee

Fundatech Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-01

Filing date

1986-02-01

Publication date

1987-09-01

1986-02-01 Application filed by Fundatech Sa filed Critical Fundatech Sa

1986-02-01 Priority to NL8600250A priority Critical patent/NL8600250A/nl

1986-12-23 Priority to EP86202369A priority patent/EP0247251B1/de

1986-12-23 Priority to ES86202369T priority patent/ES2051689T3/es

1986-12-23 Priority to DE8686202369T priority patent/DE3681793D1/de

1986-12-23 Priority to AT86202369T priority patent/ATE67929T1/de

1987-09-01 Publication of NL8600250A publication Critical patent/NL8600250A/nl

1991-12-24 Priority to GR91402156T priority patent/GR3003435T3/el

Links

230000002254 contraceptive effect Effects 0.000 claims abstract description 23
239000003433 contraceptive agent Substances 0.000 claims abstract description 22
239000000203 mixture Substances 0.000 claims abstract description 16
239000003814 drug Substances 0.000 claims abstract description 9
229940087419 nonoxynol-9 Drugs 0.000 claims abstract description 9
229920004918 nonoxynol-9 Polymers 0.000 claims abstract description 9
239000000934 spermatocidal agent Substances 0.000 claims abstract description 9
FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 claims abstract description 9
229940079593 drug Drugs 0.000 claims abstract description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 8
229940123208 Biguanide Drugs 0.000 claims abstract description 6
239000003599 detergent Substances 0.000 claims abstract description 6
XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims abstract description 4
230000002421 anti-septic effect Effects 0.000 claims abstract description 3
150000004283 biguanides Chemical group 0.000 claims abstract 2
YZIYKJHYYHPJIB-UUPCJSQJSA-N chlorhexidine gluconate Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O.C1=CC(Cl)=CC=C1NC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NC1=CC=C(Cl)C=C1 YZIYKJHYYHPJIB-UUPCJSQJSA-N 0.000 claims description 7
229960003333 chlorhexidine gluconate Drugs 0.000 claims description 7
-1 alkyl phenol Chemical compound 0.000 abstract description 2
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 abstract 2
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 abstract 2
229960003260 chlorhexidine Drugs 0.000 abstract 2
229940050410 gluconate Drugs 0.000 abstract 2
239000007788 liquid Substances 0.000 abstract 1
210000001215 vagina Anatomy 0.000 description 6
239000004033 plastic Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 2
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
239000004480 active ingredient Substances 0.000 description 2
229940088623 biologically active substance Drugs 0.000 description 2
229940124558 contraceptive agent Drugs 0.000 description 2
230000003111 delayed effect Effects 0.000 description 2
JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
238000003780 insertion Methods 0.000 description 2
230000037431 insertion Effects 0.000 description 2
230000019100 sperm motility Effects 0.000 description 2
230000001150 spermicidal effect Effects 0.000 description 2
230000002195 synergetic effect Effects 0.000 description 2
JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
229930003347 Atropine Natural products 0.000 description 1
WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 1
206010017533 Fungal infection Diseases 0.000 description 1
RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 description 1
208000031888 Mycoses Diseases 0.000 description 1
AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical compound IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
230000001548 androgenic effect Effects 0.000 description 1
AEMFNILZOJDQLW-QAGGRKNESA-N androst-4-ene-3,17-dione Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AEMFNILZOJDQLW-QAGGRKNESA-N 0.000 description 1
229960005471 androstenedione Drugs 0.000 description 1
AEMFNILZOJDQLW-UHFFFAOYSA-N androstenedione Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 AEMFNILZOJDQLW-UHFFFAOYSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000003110 anti-inflammatory effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229960000396 atropine Drugs 0.000 description 1
RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 description 1
210000003756 cervix mucus Anatomy 0.000 description 1
VUHJZBBCZGVNDZ-TTYLFXKOSA-N chlormadinone Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 VUHJZBBCZGVNDZ-TTYLFXKOSA-N 0.000 description 1
229960003996 chlormadinone Drugs 0.000 description 1
239000006071 cream Substances 0.000 description 1
229960000648 digitoxin Drugs 0.000 description 1
WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 1
229960005309 estradiol Drugs 0.000 description 1
229930182833 estradiol Natural products 0.000 description 1
229940106582 estrogenic substances Drugs 0.000 description 1
JKKFKPJIXZFSSB-CBZIJGRNSA-N estrone 3-sulfate Chemical compound OS(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 JKKFKPJIXZFSSB-CBZIJGRNSA-N 0.000 description 1
235000013312 flour Nutrition 0.000 description 1
239000011888 foil Substances 0.000 description 1
229960001340 histamine Drugs 0.000 description 1
230000003054 hormonal effect Effects 0.000 description 1
229960000890 hydrocortisone Drugs 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
229940039009 isoproterenol Drugs 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
229960004961 mechlorethamine Drugs 0.000 description 1
HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical class ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 1
PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
229960002985 medroxyprogesterone acetate Drugs 0.000 description 1
230000004899 motility Effects 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000002984 plastic foam Substances 0.000 description 1
230000001072 progestational effect Effects 0.000 description 1
229960003387 progesterone Drugs 0.000 description 1
239000000186 progesterone Substances 0.000 description 1
229960003604 testosterone Drugs 0.000 description 1
229940035722 triiodothyronine Drugs 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
- A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Gynecology & Obstetrics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Orthopedics, Nursing, And Contraception (AREA)
Mechanical Operated Clutches (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

NL8600250A 1986-02-01 1986-02-01 Vaginaal anticonceptiemiddel. NL8600250A (nl)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
NL8600250A NL8600250A (nl)	1986-02-01	1986-02-01	Vaginaal anticonceptiemiddel.
EP86202369A EP0247251B1 (de)	1986-02-01	1986-12-23	Vaginales Antikonzeptionsmittel
ES86202369T ES2051689T3 (es)	1986-02-01	1986-12-23	Anticonceptivo vaginal.
DE8686202369T DE3681793D1 (de)	1986-02-01	1986-12-23	Vaginales antikonzeptionsmittel.
AT86202369T ATE67929T1 (de)	1986-02-01	1986-12-23	Vaginales antikonzeptionsmittel.
GR91402156T GR3003435T3 (en)	1986-02-01	1991-12-24	Vaginal contraceptive

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8600250		1986-02-01
NL8600250A NL8600250A (nl)	1986-02-01	1986-02-01	Vaginaal anticonceptiemiddel.

Publications (1)

Publication Number	Publication Date
NL8600250A true NL8600250A (nl)	1987-09-01

Family

ID=19847512

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8600250A NL8600250A (nl)	1986-02-01	1986-02-01	Vaginaal anticonceptiemiddel.

Country Status (6)

Country	Link
EP (1)	EP0247251B1 (de)
AT (1)	ATE67929T1 (de)
DE (1)	DE3681793D1 (de)
ES (1)	ES2051689T3 (de)
GR (1)	GR3003435T3 (de)
NL (1)	NL8600250A (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8812928D0 (en) *	1988-06-01	1988-07-06	Univ Manchester	Contraceptive methods & compositions
FR2691325B1 (fr) *	1992-05-21	1997-06-06	Hutchinson	Compositions a base d'antiseptiques et leurs applications.
FR2686221B1 (fr) *	1992-01-22	2000-02-25	Hutchinson	Compositions a base d'antiseptiques et leurs applications.
ES2132202T3 (es) *	1992-01-22	1999-08-16	Hutchinson	Composiciones a base de antisepticos y sus aplicaciones.
ATE169451T1 (de) *	1992-03-18	1998-08-15	Univ Columbia	Antivirale kondome
ZA942302B (en) *	1993-12-03	1995-09-29	Lafor Lab Ltd	Viracidal bactericidal and spermicidal vaginal suppository

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3545439A (en) *	1968-01-04	1970-12-08	Upjohn Co	Medicated devices and methods
US4031202A (en) *	1975-12-08	1977-06-21	The Procter & Gamble Company	Controlled release contraceptive article
GB1601777A (en) *	1977-04-29	1981-11-04	Ortho Pharma Corp	Vaginal diaphragm and a method for the production thereof
AU538963B2 (en) *	1979-07-09	1984-09-06	Seth Thomas Shaw Jr.	Drug for use with an iud
US4589880A (en) *	1983-07-14	1986-05-20	Southern Research Institute	Disposable spermicide-releasing diaphragm

1986
- 1986-02-01 NL NL8600250A patent/NL8600250A/nl not_active Application Discontinuation
- 1986-12-23 ES ES86202369T patent/ES2051689T3/es not_active Expired - Lifetime
- 1986-12-23 EP EP86202369A patent/EP0247251B1/de not_active Expired
- 1986-12-23 DE DE8686202369T patent/DE3681793D1/de not_active Expired - Lifetime
- 1986-12-23 AT AT86202369T patent/ATE67929T1/de not_active IP Right Cessation
1991
- 1991-12-24 GR GR91402156T patent/GR3003435T3/el unknown

Also Published As

Publication number	Publication date
GR3003435T3 (en)	1993-02-17
ES2051689T3 (es)	1994-07-01
DE3681793D1 (de)	1991-11-07
ATE67929T1 (de)	1991-10-15
EP0247251B1 (de)	1991-10-02
EP0247251A1 (de)	1987-12-02

Legal Events

Date	Code	Title	Description
1987-09-01	A1B	A search report has been drawn up
1990-10-01	BV	The patent application has lapsed

Publication	Publication Date	Title
US4252787A (en)	1981-02-24	Anti-fertility composition and method
US4310510A (en)	1982-01-12	Self administrable anti-fertility composition
Garg et al.	2001	Properties of a new acid-buffering bioadhesive vaginal formulation (ACIDFORM)
US5527534A (en)	1996-06-18	Vaginal sponge delivery system
US4368186A (en)	1983-01-11	Methods and compositions for intravaginal contraception
US4309997A (en)	1982-01-12	Contraceptive and/or antivenereal disease tampon
US6328991B1 (en)	2001-12-11	Composition and method for prevention of sexually transmitted diseases, including aids
BR0014159A (pt)	2002-05-07	Combinação farmacêutica de etinilestradiol e drospirenona para uso como um anticoncepcional
WO1994008536A9 (en)	1994-08-04	Vaginal sponge delivery system
HU206634B (en)	1992-12-28	Process for producing pharmaceutical compositions for inhibiting infections with sexual illnesses
DE68928897D1 (de)	1999-02-18	Verfahren und system zur empfängnisverhütung
ES2033850T5 (es)	2001-07-01	Forma farmaceutica consistente en una combinacion dosificada, destinada al tratamiento de las mujeres pre-menopausicas.
CA1338877C (en)	1997-01-28	Long lasting contraceptive suppository composition and methods of use
CZ186096A3 (en)	1997-06-11	Preparation for hormonal contraception and/or for treating acne
EP0576425B1 (de)	1999-02-03	Verfahren zur inaktivierung von spermien
US3755575A (en)	1973-08-28	Pharmaceutical compositions
KR920011514A (ko)	1992-07-24	프로게스토겐만을 함유하는 피임제
Canobbio et al.	2005	Gynecological health of females with congenital heart disease
Paufler et al.	1969	Spermatogenesis in the rabbit following ligation of the epididymidis at different levels
Wang et al.	2002	Characterization of a female controlled drug delivery system for microbicides
US4228797A (en)	1980-10-21	Intravaginal contraception method
Witjaksono et al.	1996	Oestrogen treatment for increased bleeding in Norplant users: preliminary results
Morris et al.	1966	Post-coital oral contraception
El-Mahgoub et al.	1972	The long-term use of injectable norethisterone enanthate as a contraceptive
EP0247251B1 (de)	1991-10-02	Vaginales Antikonzeptionsmittel