NL8900726A - Peptide, immunogene samenstelling en vaccin- of geneesmiddelpreparaat; werkwijze voor het immuniseren van een zoogdier tegen lhrh, en werkwijze voor het verbeteren van de vleeskwaliteit van varkens. - Google Patents

Peptide, immunogene samenstelling en vaccin- of geneesmiddelpreparaat; werkwijze voor het immuniseren van een zoogdier tegen lhrh, en werkwijze voor het verbeteren van de vleeskwaliteit van varkens. Download PDF

Info

Publication number: NL8900726A
Authority: NL; Netherlands
Prior art keywords: gly; peptide; lhrh; pigs; amino acids
Prior art date: 1989-03-23

Application number

NL8900726A

Other languages

English (en)

Dutch (nl)

Original Assignee

Stichting Centr Diergeneeskund

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-03-23

Filing date

1989-03-23

Publication date

1990-10-16

1989-03-23 Application filed by Stichting Centr Diergeneeskund filed Critical Stichting Centr Diergeneeskund

1989-03-23 Priority to NL8900726A priority Critical patent/NL8900726A/nl

1990-03-22 Priority to ES90905697T priority patent/ES2050435T3/es

1990-03-22 Priority to CA002049325A priority patent/CA2049325C/fr

1990-03-22 Priority to DE69007616T priority patent/DE69007616T2/de

1990-03-22 Priority to JP02505371A priority patent/JP3098771B2/ja

1990-03-22 Priority to AT90905697T priority patent/ATE103297T1/de

1990-03-22 Priority to SU905001726A priority patent/RU2078770C1/ru

1990-03-22 Priority to PCT/NL1990/000037 priority patent/WO1990011298A1/fr

1990-03-22 Priority to HU902930A priority patent/HU214742B/hu

1990-03-22 Priority to DK90905697.0T priority patent/DK0464124T3/da

1990-03-22 Priority to EP90905697A priority patent/EP0464124B1/fr

1990-10-16 Publication of NL8900726A publication Critical patent/NL8900726A/nl

1993-11-08 Priority to US08/149,001 priority patent/US5484592A/en

Links

XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 title claims abstract description 45
108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 40
101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 title claims abstract description 35
102100024028 Progonadoliberin-1 Human genes 0.000 title claims abstract description 35
101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 title claims abstract description 35
241000282887 Suidae Species 0.000 title claims abstract description 29
241000124008 Mammalia Species 0.000 title claims abstract description 9
229960005486 vaccine Drugs 0.000 title claims description 24
239000000203 mixture Substances 0.000 title claims description 15
230000002163 immunogen Effects 0.000 title claims description 14
238000000034 method Methods 0.000 title claims description 13
230000003053 immunization Effects 0.000 title claims description 10
235000013372 meat Nutrition 0.000 title claims description 10
229940126601 medicinal product Drugs 0.000 title 1
150000001413 amino acids Chemical class 0.000 claims description 27
239000003814 drug Substances 0.000 claims description 10
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims description 8
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 8
238000002360 preparation method Methods 0.000 claims description 8
LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 claims description 6
229940079593 drug Drugs 0.000 claims description 6
101150079396 trpC2 gene Proteins 0.000 claims description 6
BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 claims description 5
ODHCTXKNWHHXJC-GSVOUGTGSA-N Pyroglutamic acid Natural products OC(=O)[C@H]1CCC(=O)N1 ODHCTXKNWHHXJC-GSVOUGTGSA-N 0.000 claims description 4
ODHCTXKNWHHXJC-UHFFFAOYSA-N acide pyroglutamique Natural products OC(=O)C1CCC(=O)N1 ODHCTXKNWHHXJC-UHFFFAOYSA-N 0.000 claims description 4
125000006850 spacer group Chemical group 0.000 claims description 4
230000001571 immunoadjuvant effect Effects 0.000 claims description 3
239000000568 immunological adjuvant Substances 0.000 claims description 3
102000004169 proteins and genes Human genes 0.000 claims description 3
108090000623 proteins and genes Proteins 0.000 claims description 3
102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 2
108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 2
125000003275 alpha amino acid group Chemical group 0.000 claims 3
238000002255 vaccination Methods 0.000 abstract description 10
229940088597 hormone Drugs 0.000 abstract description 2
239000005556 hormone Substances 0.000 abstract description 2
241001465754 Metazoa Species 0.000 description 23
235000001014 amino acid Nutrition 0.000 description 20
210000001550 testis Anatomy 0.000 description 13
102000014914 Carrier Proteins Human genes 0.000 description 9
108010078791 Carrier Proteins Proteins 0.000 description 9
102000004196 processed proteins & peptides Human genes 0.000 description 8
238000010168 coupling process Methods 0.000 description 7
238000012360 testing method Methods 0.000 description 7
230000008878 coupling Effects 0.000 description 6
238000005859 coupling reaction Methods 0.000 description 6
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 5
108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 5
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 4
230000018109 developmental process Effects 0.000 description 4
238000002649 immunization Methods 0.000 description 4
238000003307 slaughter Methods 0.000 description 4
150000003431 steroids Chemical class 0.000 description 4
206010062767 Hypophysitis Diseases 0.000 description 3
239000002671 adjuvant Substances 0.000 description 3
239000003098 androgen Substances 0.000 description 3
210000004369 blood Anatomy 0.000 description 3
239000008280 blood Substances 0.000 description 3
235000018417 cysteine Nutrition 0.000 description 3
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 3
210000003635 pituitary gland Anatomy 0.000 description 3
206010006187 Breast cancer Diseases 0.000 description 2
208000026310 Breast neoplasm Diseases 0.000 description 2
241000282472 Canis lupus familiaris Species 0.000 description 2
239000000579 Gonadotropin-Releasing Hormone Substances 0.000 description 2
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 2
208000007913 Pituitary Neoplasms Diseases 0.000 description 2
201000007552 Pituitary carcinoma Diseases 0.000 description 2
206010060862 Prostate cancer Diseases 0.000 description 2
208000000236 Prostatic Neoplasms Diseases 0.000 description 2
101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 description 2
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 2
229940030486 androgens Drugs 0.000 description 2
230000015572 biosynthetic process Effects 0.000 description 2
210000004899 c-terminal region Anatomy 0.000 description 2
238000004132 cross linking Methods 0.000 description 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 2
230000003111 delayed effect Effects 0.000 description 2
201000010063 epididymitis Diseases 0.000 description 2
229940011871 estrogen Drugs 0.000 description 2
239000000262 estrogen Substances 0.000 description 2
208000011866 pituitary adenocarcinoma Diseases 0.000 description 2
239000000583 progesterone congener Substances 0.000 description 2
210000002307 prostate Anatomy 0.000 description 2
235000018102 proteins Nutrition 0.000 description 2
210000002966 serum Anatomy 0.000 description 2
230000002381 testicular Effects 0.000 description 2
229960003604 testosterone Drugs 0.000 description 2
LLXVXPPXELIDGQ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(2,5-dioxopyrrol-1-yl)benzoate Chemical compound C=1C=CC(N2C(C=CC2=O)=O)=CC=1C(=O)ON1C(=O)CCC1=O LLXVXPPXELIDGQ-UHFFFAOYSA-N 0.000 description 1
ONNFVCVQECBCIU-MERQFXBCSA-N (2s)-2-formamido-3-(1h-indol-3-yl)propanoic acid;1h-indole Chemical compound C1=CC=C2NC=CC2=C1.C1=CC=C2C(C[C@@H](C(=O)O)NC=O)=CNC2=C1 ONNFVCVQECBCIU-MERQFXBCSA-N 0.000 description 1
HBRSBSZURRWMML-ZIUUJSQJSA-N 2-[[(2s)-2-[[(2s)-3-hydroxy-2-[[(2s)-2-[[(2s)-3-(1h-imidazol-5-yl)-2-[[(2s)-5-oxopyrrolidine-2-carbonyl]amino]propanoyl]amino]-3-(1h-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]acetic acid Chemical compound C([C@@H](C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(O)=O)NC(=O)[C@H]1NC(=O)CC1)C1=CN=CN1 HBRSBSZURRWMML-ZIUUJSQJSA-N 0.000 description 1
206010001488 Aggression Diseases 0.000 description 1
206010002091 Anaesthesia Diseases 0.000 description 1
208000019901 Anxiety disease Diseases 0.000 description 1
QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 description 1
241000282326 Felis catus Species 0.000 description 1
102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
108700012941 GNRH1 Proteins 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
206010053759 Growth retardation Diseases 0.000 description 1
ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
102000009151 Luteinizing Hormone Human genes 0.000 description 1
108010073521 Luteinizing Hormone Proteins 0.000 description 1
108020004511 Recombinant DNA Proteins 0.000 description 1
210000000577 adipose tissue Anatomy 0.000 description 1
230000037005 anaesthesia Effects 0.000 description 1
230000036506 anxiety Effects 0.000 description 1
244000309464 bull Species 0.000 description 1
238000012412 chemical coupling Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
239000000539 dimer Substances 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
238000009313 farming Methods 0.000 description 1
229940028334 follicle stimulating hormone Drugs 0.000 description 1
230000003325 follicular Effects 0.000 description 1
ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
239000003163 gonadal steroid hormone Substances 0.000 description 1
XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 1
229940035638 gonadotropin-releasing hormone Drugs 0.000 description 1
231100000001 growth retardation Toxicity 0.000 description 1
230000036541 health Effects 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000001183 hydrocarbyl group Chemical group 0.000 description 1
210000003016 hypothalamus Anatomy 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
125000005647 linker group Chemical group 0.000 description 1
229940040129 luteinizing hormone Drugs 0.000 description 1
230000023508 male gonad development Effects 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
230000035800 maturation Effects 0.000 description 1
238000005259 measurement Methods 0.000 description 1
238000009806 oophorectomy Methods 0.000 description 1
210000001672 ovary Anatomy 0.000 description 1
229940095055 progestogen systemic hormonal contraceptives Drugs 0.000 description 1
230000009467 reduction Effects 0.000 description 1
210000001625 seminal vesicle Anatomy 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
201000010653 vesiculitis Diseases 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/64—Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Reproductive Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Virology (AREA)
Immunology (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicinal Preparation (AREA)

NL8900726A 1989-03-23 1989-03-23 Peptide, immunogene samenstelling en vaccin- of geneesmiddelpreparaat; werkwijze voor het immuniseren van een zoogdier tegen lhrh, en werkwijze voor het verbeteren van de vleeskwaliteit van varkens. NL8900726A (nl)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
NL8900726A NL8900726A (nl)	1989-03-23	1989-03-23	Peptide, immunogene samenstelling en vaccin- of geneesmiddelpreparaat; werkwijze voor het immuniseren van een zoogdier tegen lhrh, en werkwijze voor het verbeteren van de vleeskwaliteit van varkens.
AT90905697T ATE103297T1 (de)	1989-03-23	1990-03-22	Peptid, immunogene zusammensetzung und impfstoff oder medizinische zubereitung, eine methode zur immunisierung eines saeugetieres gegen lhrh und methode zur verbesserung von mea.
CA002049325A CA2049325C (fr)	1989-03-23	1990-03-22	Peptide, composition immunogene et vaccin ou preparation medicinale; methode d'immunisation d'un mammifere contre lhrh et methode pour ameliorer la qualite de la viande de porc
DE69007616T DE69007616T2 (de)	1989-03-23	1990-03-22	Peptid, immunogene zusammensetzung und impfstoff oder medizinische zubereitung, eine methode zur immunisierung eines säugetieres gegen lhrh und methode zur verbesserung von mea.
JP02505371A JP3098771B2 (ja)	1989-03-23	1990-03-22	ペプチド、免疫原性のある組成物、それを含むワクチンまたは製剤、哺乳動物にｌｈｒｈに対する免疫性を付与する方法および豚の肉質を向上させる方法
ES90905697T ES2050435T3 (es)	1989-03-23	1990-03-22	Una preparacion medicinal o vacuna y composicion inmunogenica peptida, un metodo de inmunizacion de un mamifero contra lhrh, y un metodo para mejorar la calidad carnica del ganado porcuno.
SU905001726A RU2078770C1 (ru)	1989-03-23	1990-03-22	Производные пептидов и композиция, вызывающая иммунный ответ на lhrh
PCT/NL1990/000037 WO1990011298A1 (fr)	1989-03-23	1990-03-22	Peptide, composition immunogenique et vaccin ou preparation medicinale; procede d'immunisation d'un mammifere contre la lhrh, et procede d'amelioration de la qualite de la viande de porcs
HU902930A HU214742B (hu)	1989-03-23	1990-03-22	Eljárás immunogén peptidek, továbbá az azokat tartalmazó gyógyszerkészítmények előállítására
DK90905697.0T DK0464124T3 (da)	1989-03-23	1990-03-22	Peptid, immunogen sammensætning og vaccine eller medicinsk præparat, fremgangsmåde til immunisering af et pattedyr mod LHRH og fremgangsmåde til forbedring af kødkvaliteten hos grise
EP90905697A EP0464124B1 (fr)	1989-03-23	1990-03-22	Peptide, composition immunogenique et vaccin ou preparation medicinale; procede d'immunisation d'un mammifere contre la lhrh, et procede d'amelioration de la qualite de la viande de porcs
US08/149,001 US5484592A (en)	1989-03-23	1993-11-08	Peptide, immunogenic composition and vaccine or medicinal preparation: a method of immunising a mammal against LHRH, and a method of improving the meat quality of pigs

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL8900726A NL8900726A (nl)	1989-03-23	1989-03-23	Peptide, immunogene samenstelling en vaccin- of geneesmiddelpreparaat; werkwijze voor het immuniseren van een zoogdier tegen lhrh, en werkwijze voor het verbeteren van de vleeskwaliteit van varkens.
NL8900726		1989-03-23

Publications (1)

Publication Number	Publication Date
NL8900726A true NL8900726A (nl)	1990-10-16

Family

ID=19854349

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL8900726A NL8900726A (nl)	1989-03-23	1989-03-23	Peptide, immunogene samenstelling en vaccin- of geneesmiddelpreparaat; werkwijze voor het immuniseren van een zoogdier tegen lhrh, en werkwijze voor het verbeteren van de vleeskwaliteit van varkens.

Country Status (11)

Country	Link
EP (1)	EP0464124B1 (fr)
JP (1)	JP3098771B2 (fr)
AT (1)	ATE103297T1 (fr)
CA (1)	CA2049325C (fr)
DE (1)	DE69007616T2 (fr)
DK (1)	DK0464124T3 (fr)
ES (1)	ES2050435T3 (fr)
HU (1)	HU214742B (fr)
NL (1)	NL8900726A (fr)
RU (1)	RU2078770C1 (fr)
WO (1)	WO1990011298A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8713240D0 (en) *	1987-06-05	1987-07-08	Proteus Biotech Ltd	Hormones
US5171835A (en) *	1988-10-21	1992-12-15	The Administrators Of The Tulane Educational Fund	LHRH antagonists
US5324512A (en) *	1990-12-26	1994-06-28	The Population Council	[Gln']-luteinizing hormone releasing hormone conjugate of tetanus vaccine and its uses
DK0501882T3 (da) *	1991-03-01	2000-12-11	Merial Sas	Fremgangsmåde til anti-LHRH immunoneutralisering af ikke-kastrerede husdyrhanner og peptider dertil
US5723129A (en) *	1991-10-16	1998-03-03	University Of Saskatchewan	GnRH-leukotoxin chimeras
US5837268A (en) *	1991-10-16	1998-11-17	University Of Saskatchewan	GnRH-leukotoxin chimeras
ZA934199B (en) *	1992-06-18	1994-01-10	Akzo Nv	Carrier system against gnrh
US5759551A (en) *	1993-04-27	1998-06-02	United Biomedical, Inc.	Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
EP0698040A4 (fr) *	1993-05-20	1999-01-07	Biotech Australia Pty Ltd	Antagonistes de la lhrh
US6761890B1 (en)	1995-06-07	2004-07-13	Pepscan Systems B.V.	Peptide, immunogenic composition and vaccine or medical preparation, a method to immunize animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
USRE39048E1 (en)	1995-06-07	2006-03-28	Pepscan Systems B.V.	Peptide, immunogenic composition and vaccine or medical preparation, a method to immunise animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
DK0832107T3 (da) *	1995-06-07	2001-11-19	Dlo Inst Voor Dierhouderij En	Forbedret peptid, immunogen sammensætning og vaccine eller medicinsk præparat, fremgangsmåde til immunisering af dyr mod hormonet LHRH samt analoge af LHRH-tandempeptid-gentagelsespeptidet og deres andvendelse som vaccine
BR9709993A (pt) *	1996-06-25	1999-08-10	Stichting Inst Dierhouderij	Vacina preparação de vacina composição processo para produção de uma preparação imugênica e preparação imugênica
AUPO776897A0 (en)	1997-07-09	1997-07-31	Csl Limited	A method of achieving production gains in livestock and agents useful for same
NZ509137A (en) *	1998-06-04	2004-01-30	Metamorphix Internat Inc	Methods for reducing GnRH levels in prepubertal vertebrates as an alternative to surgical sterilisation
US6838553B1 (en) *	1999-10-05	2005-01-04	Academia Sinica	Peptide repeat immunogens
PT1317478E (pt) *	2000-09-12	2007-03-30	Pepscan Systems Bv	Distinção entre a gnrh-i e a gnrh-ii
CA2523197C (fr)	2003-04-22	2016-05-24	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Vectors de peptide
CU23739A1 (es)	2008-09-30	2011-12-28	Ct Ingenieria Genetica Biotech	Composición farmacéutica utilizando combinaciones de variantes de la hormona liberadora de las gonadotropinas (gnrh) como inmunógeno
RU2521652C2 (ru) *	2010-12-27	2014-07-10	Общество с ограниченной ответственностью "Научно-внедренческое предприятие "Астрафарм"	РЕКОМБИНАНТНАЯ ДНК, КОДИРУЮЩАЯ ГИБРИДНЫЙ ВАКЦИННЫЙ БЕЛОК GHbc ДЛЯ РЕГУЛЯЦИИ ПОЛОВОЙ ФУНКЦИИ У ЖИВОТНЫХ, СОСТОЯЩИЙ ИЗ НУКЛЕОКАПСИДНОГО БЕЛКА ВИРУСА ГЕПАТИТА В ЧЕЛОВЕКА СЛИТОГО С ГОНАДОЛИБЕРИНОМ
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WO1988005308A1 (fr) *	1987-01-14	1988-07-28	Commonwealth Scientific And Industrial Research Or	Hormone contraceptive

1989
- 1989-03-23 NL NL8900726A patent/NL8900726A/nl not_active Application Discontinuation
1990
- 1990-03-22 EP EP90905697A patent/EP0464124B1/fr not_active Expired - Lifetime
- 1990-03-22 DE DE69007616T patent/DE69007616T2/de not_active Expired - Lifetime
- 1990-03-22 JP JP02505371A patent/JP3098771B2/ja not_active Expired - Lifetime
- 1990-03-22 WO PCT/NL1990/000037 patent/WO1990011298A1/fr not_active Ceased
- 1990-03-22 DK DK90905697.0T patent/DK0464124T3/da active
- 1990-03-22 ES ES90905697T patent/ES2050435T3/es not_active Expired - Lifetime
- 1990-03-22 HU HU902930A patent/HU214742B/hu unknown
- 1990-03-22 RU SU905001726A patent/RU2078770C1/ru active
- 1990-03-22 CA CA002049325A patent/CA2049325C/fr not_active Expired - Lifetime
- 1990-03-22 AT AT90905697T patent/ATE103297T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3098771B2 (ja)	2000-10-16
DE69007616T2 (de)	1994-06-30
HU214742B (hu)	1998-10-28
EP0464124B1 (fr)	1994-03-23
ATE103297T1 (de)	1994-04-15
DK0464124T3 (da)	1994-05-02
JPH04504256A (ja)	1992-07-30
RU2078770C1 (ru)	1997-05-10
EP0464124A1 (fr)	1992-01-08
ES2050435T3 (es)	1994-05-16
CA2049325C (fr)	2000-07-25
HUT62916A (en)	1993-06-28
HU902930D0 (en)	1991-12-30
DE69007616D1 (de)	1994-04-28
WO1990011298A1 (fr)	1990-10-04
CA2049325A1 (fr)	1990-09-24

Legal Events

Date	Code	Title	Description
1990-10-16	A1B	A search report has been drawn up
1993-11-01	BV	The patent application has lapsed

Publication	Publication Date	Title
EP0464124B1 (fr)	1994-03-23	Peptide, composition immunogenique et vaccin ou preparation medicinale; procede d'immunisation d'un mammifere contre la lhrh, et procede d'amelioration de la qualite de la viande de porcs
JP5231378B2 (ja)	2013-07-10	免疫原性ｌｈｒｈ組成物およびそれに関する方法
RU2147307C1 (ru)	2000-04-10	Улучшенный пептид, иммуногенная композиция и вакцина с его использованием, способ иммунизации животных против гормона лгвг
US5885966A (en)	1999-03-23	Peptide, immunogenic composition and vaccine or medical preparation, a method to immunise animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
Fan-Mei et al.	2022	Recent advances in immunocastration in sheep and goat and its animal welfare benefits: A review
US5484592A (en)	1996-01-16	Peptide, immunogenic composition and vaccine or medicinal preparation: a method of immunising a mammal against LHRH, and a method of improving the meat quality of pigs
ES2280402T3 (es)	2007-09-16	Discriminacion entre gnrh-i y gnrh-ii.
US7361349B2 (en)	2008-04-22	Peptide, immunogenic composition and vaccine or medical preparation, a method to immunize animals against the hormone LHRH, and analogs of the LHRH tandem repeat peptide and their use as vaccine
Ayalew	2019	A review on the effect of immunocastration against gonadal physiology and boar taint.
Turkstra et al.	2006	Active immunisation against gonadotropin-releasing hormone, an active tool to block the fertility axis in mammals