NL9100150A - Werkwijze voor het bepalen van het slagvolume en het hartminuutvolume van het menselijk hart. - Google Patents
Werkwijze voor het bepalen van het slagvolume en het hartminuutvolume van het menselijk hart. Download PDFInfo
- Publication number
- NL9100150A NL9100150A NL9100150A NL9100150A NL9100150A NL 9100150 A NL9100150 A NL 9100150A NL 9100150 A NL9100150 A NL 9100150A NL 9100150 A NL9100150 A NL 9100150A NL 9100150 A NL9100150 A NL 9100150A
- Authority
- NL
- Netherlands
- Prior art keywords
- pressure
- aorta
- volume
- compliance
- stroke
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 31
- 210000000709 aorta Anatomy 0.000 claims abstract description 49
- 230000005540 biological transmission Effects 0.000 claims abstract description 19
- 238000004364 calculation method Methods 0.000 claims abstract description 12
- 230000036581 peripheral resistance Effects 0.000 claims abstract description 12
- 230000003205 diastolic effect Effects 0.000 claims abstract description 8
- 230000035487 diastolic blood pressure Effects 0.000 claims abstract description 7
- 230000000747 cardiac effect Effects 0.000 claims description 14
- 239000008280 blood Substances 0.000 claims description 13
- 210000004369 blood Anatomy 0.000 claims description 13
- 210000001367 artery Anatomy 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000001595 flow curve Methods 0.000 description 10
- 230000002093 peripheral effect Effects 0.000 description 9
- 230000002792 vascular Effects 0.000 description 5
- 238000013459 approach Methods 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 239000012530 fluid Substances 0.000 description 3
- 238000001356 surgical procedure Methods 0.000 description 3
- 238000003556 assay Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 238000012935 Averaging Methods 0.000 description 1
- NRCDWSXDXQHMGN-SNVBAGLBSA-N CC(C)CCCCC[C@@H](C)N Chemical compound CC(C)CCCCC[C@@H](C)N NRCDWSXDXQHMGN-SNVBAGLBSA-N 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 210000001765 aortic valve Anatomy 0.000 description 1
- 230000004872 arterial blood pressure Effects 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000005399 mechanical ventilation Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000009022 nonlinear effect Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000003909 pattern recognition Methods 0.000 description 1
- 230000001902 propagating effect Effects 0.000 description 1
- 230000000541 pulsatile effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording for evaluating the cardiovascular system, e.g. pulse, heart rate, blood pressure or blood flow
- A61B5/026—Measuring blood flow
- A61B5/029—Measuring blood output from the heart, e.g. minute volume
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Physiology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9100150A NL9100150A (nl) | 1991-01-29 | 1991-01-29 | Werkwijze voor het bepalen van het slagvolume en het hartminuutvolume van het menselijk hart. |
| DE69205417T DE69205417T2 (de) | 1991-01-29 | 1992-01-28 | Verfahren zur bestimmung des schlagvolumens und des herzzeitvolumens des menschlichen herzes. |
| AT92905499T ATE128837T1 (de) | 1991-01-29 | 1992-01-28 | Verfahren zur bestimmung des schlagvolumens und des herzzeitvolumens des menschlichen herzes. |
| CA002101531A CA2101531C (en) | 1991-01-29 | 1992-01-28 | Method of determining the stroke volume and the cardiac output of the human heart |
| DK92905499.7T DK0569506T3 (da) | 1991-01-29 | 1992-01-28 | Fremgangsmåde til bestemmelse af slagvolumen og minutvolumen af det menneskelige hjerte |
| JP50509092A JP3293621B2 (ja) | 1991-01-29 | 1992-01-28 | 血液拍出量を決定するための装置 |
| EP92905499A EP0569506B1 (de) | 1991-01-29 | 1992-01-28 | Verfahren zur bestimmung des schlagvolumens und des herzzeitvolumens des menschlichen herzes |
| ES92905499T ES2080489T3 (es) | 1991-01-29 | 1992-01-28 | Procedimiento para determinar el caudal sistolico y el caudal cardiaco del corazon humano. |
| PCT/NL1992/000022 WO1992012669A1 (en) | 1991-01-29 | 1992-01-28 | Method of determining the stroke volume and the cardiac output of the human heart |
| US08/094,052 US5400793A (en) | 1991-01-29 | 1992-01-28 | Method of determining the stroke volume and the cardiac output of the human heart |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL9100150 | 1991-01-29 | ||
| NL9100150A NL9100150A (nl) | 1991-01-29 | 1991-01-29 | Werkwijze voor het bepalen van het slagvolume en het hartminuutvolume van het menselijk hart. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NL9100150A true NL9100150A (nl) | 1992-08-17 |
Family
ID=19858791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NL9100150A NL9100150A (nl) | 1991-01-29 | 1991-01-29 | Werkwijze voor het bepalen van het slagvolume en het hartminuutvolume van het menselijk hart. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5400793A (de) |
| EP (1) | EP0569506B1 (de) |
| JP (1) | JP3293621B2 (de) |
| AT (1) | ATE128837T1 (de) |
| CA (1) | CA2101531C (de) |
| DE (1) | DE69205417T2 (de) |
| DK (1) | DK0569506T3 (de) |
| ES (1) | ES2080489T3 (de) |
| NL (1) | NL9100150A (de) |
| WO (1) | WO1992012669A1 (de) |
Families Citing this family (72)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5584298A (en) * | 1993-10-25 | 1996-12-17 | Kabal; John | Noninvasive hemodynamic analyzer alterable to a continuous invasive hemodynamic monitor |
| US5836884A (en) | 1993-12-17 | 1998-11-17 | Pulse Metric, Inc. | Method for diagnosing, monitoring and treating hypertension and other cardiac problems |
| US5535753A (en) * | 1994-10-04 | 1996-07-16 | Rutgers University | Apparatus and methods for the noninvasive measurement of cardiovascular system parameters |
| WO1997016114A1 (en) * | 1995-11-01 | 1997-05-09 | Seiko Epson Corporation | Living body condition measuring apparatus |
| US6569103B2 (en) | 1995-12-22 | 2003-05-27 | Arrow International Investment Corp. | Device for determining a characteristic point in the cardiac cycle |
| US6010457A (en) * | 1996-03-15 | 2000-01-04 | Pmv Medical Pty Ltd | Non-invasive determination of aortic flow velocity waveforms |
| US5971934A (en) * | 1996-10-04 | 1999-10-26 | Trustees Of The University Of Pennsylvania | Noninvasive method and apparatus for determining cardiac output |
| GB9714550D0 (en) | 1997-07-10 | 1997-09-17 | Lidco Ltd | Improved method and apparatus for the measurement of cardiac output |
| DE19814371A1 (de) * | 1998-03-31 | 1999-10-14 | Pulsion Verwaltungs Gmbh & Co | Verfahren zur in-vivo Bestimmung der Compliance-Funktion und des systemischen Blutflusses eines Lebewesens und Vorrichtung zur Durchführung der Verfahren |
| US6117087A (en) * | 1998-04-01 | 2000-09-12 | Massachusetts Institute Of Technology | Method and apparatus for noninvasive assessment of a subject's cardiovascular system |
| US6986744B1 (en) * | 1999-02-02 | 2006-01-17 | Transonic Systems, Inc. | Method and apparatus for determining blood flow during a vascular corrective procedure |
| US6315735B1 (en) | 1999-03-31 | 2001-11-13 | Pulsion Medical Systems Ag | Devices for in-vivo determination of the compliance function and the systemic blood flow of a living being |
| IT1315206B1 (it) * | 1999-04-27 | 2003-02-03 | Salvatore Romano | Metodo e apparato per la misura della portata cardiaca. |
| US6939303B2 (en) * | 1999-07-23 | 2005-09-06 | Provecto Tecnico R-2000, Ca | Method and system of determining cardiac contractility |
| US6440078B1 (en) | 1999-07-23 | 2002-08-27 | Roberto Curiel | Method and system of determining cardiac contractility |
| AU776098B2 (en) * | 1999-11-24 | 2004-08-26 | Edwards Lifesciences Corporation | Method and apparatus for determining cardiac output or total peripheral resistance |
| AUPQ420599A0 (en) * | 1999-11-24 | 1999-12-16 | Duncan Campbell Patents Pty Ltd | Method and apparatus for determining cardiac output or total peripheral resistance |
| US6510337B1 (en) * | 1999-11-26 | 2003-01-21 | Koninklijke Philips Electronics, N.V. | Multi-phase cardiac imager |
| NL1016320C2 (nl) | 2000-10-03 | 2002-04-04 | Jozef Reinier Cornelis Jansen | Inrichting voor het aansturen van hartondersteunende apparaten. |
| US7011631B2 (en) * | 2003-01-21 | 2006-03-14 | Hemonix, Inc. | Noninvasive method of measuring blood density and hematocrit |
| AU2003275033A1 (en) * | 2003-02-10 | 2004-09-06 | Massachusetts Institute Of Technology | Methods and apparatus for determining cardiac output |
| FR2860980B1 (fr) * | 2003-10-16 | 2005-12-30 | Ela Medical Sa | Dispositif medical implantable actif comprenant des moyens d'ajustement de la frequence maximale de stimulation ventriculaire en fonction de l'etat hemodynamique du patient |
| US7452333B2 (en) | 2003-12-05 | 2008-11-18 | Edwards Lifesciences Corporation | Arterial pressure-based, automatic determination of a cardiovascular parameter |
| US7422562B2 (en) | 2003-12-05 | 2008-09-09 | Edwards Lifesciences | Real-time measurement of ventricular stroke volume variations by continuous arterial pulse contour analysis |
| US7220230B2 (en) | 2003-12-05 | 2007-05-22 | Edwards Lifesciences Corporation | Pressure-based system and method for determining cardiac stroke volume |
| US7813808B1 (en) | 2004-11-24 | 2010-10-12 | Remon Medical Technologies Ltd | Implanted sensor system with optimized operational and sensing parameters |
| US20060167361A1 (en) * | 2005-01-27 | 2006-07-27 | Bennett Tommy D | Method and apparatus for continuous pulse contour cardiac output |
| US7935062B2 (en) * | 2005-01-27 | 2011-05-03 | Medtronic, Inc. | Derivation of flow contour from pressure waveform |
| US7651466B2 (en) * | 2005-04-13 | 2010-01-26 | Edwards Lifesciences Corporation | Pulse contour method and apparatus for continuous assessment of a cardiovascular parameter |
| EP1887929B1 (de) * | 2005-05-19 | 2009-07-22 | Jozef Reinier Cornelis Jansen | Vorrichtung zur bestimmung von mindestens einem mit dem patienten in beziehung stehenden parameter zur patientenüberwachung |
| US7742815B2 (en) * | 2005-09-09 | 2010-06-22 | Cardiac Pacemakers, Inc. | Using implanted sensors for feedback control of implanted medical devices |
| AT502922B1 (de) * | 2005-11-08 | 2011-07-15 | Arc Seibersdorf Res Gmbh | Verfahren und vorrichtung zur bestimmung des herzzeitvolumens |
| US20070142727A1 (en) * | 2005-12-15 | 2007-06-21 | Cardiac Pacemakers, Inc. | System and method for analyzing cardiovascular pressure measurements made within a human body |
| WO2007109065A1 (en) | 2006-03-15 | 2007-09-27 | Board Of Trustees Of Michigan State University | Method and apparatus for determining a central aortic pressure waveform |
| US8905939B2 (en) | 2006-07-13 | 2014-12-09 | Edwards Lifesciences Corporation | Method and apparatus for continuous assessment of a cardiovascular parameter using the arterial pulse pressure propagation time and waveform |
| US7955268B2 (en) * | 2006-07-21 | 2011-06-07 | Cardiac Pacemakers, Inc. | Multiple sensor deployment |
| WO2008144525A1 (en) | 2007-05-16 | 2008-11-27 | Massachusetts Institute Of Technology | System and method for prediction and detection of circulatory shock |
| WO2008144404A1 (en) | 2007-05-16 | 2008-11-27 | Massachusetts Instutute Of Technology | Systems and methods for model-based estimation of cardiac output and total peripheral resistance |
| WO2008144490A1 (en) * | 2007-05-16 | 2008-11-27 | Massachusetts Instutute Of Technology | Systems and methods for model-based estimation of cardiac ejection fraction, cardiac contractility, and ventricular end-diastolic volume |
| EP2178433A1 (de) * | 2007-07-20 | 2010-04-28 | Bmeye B.V. | Verfahren, system und computerprogrammprodukt zur bestimmung eines schlag-auf-schlag-schlagvolumens und/oder des herzzeitminutenvolumens |
| DE102007057235A1 (de) * | 2007-11-28 | 2009-06-04 | Iprm Intellectual Property Rights Management Ag | Verfahren und Vorrichtung zur Bestimmung des Endes des systolischen Teils eines Druckverlaufs |
| US20090270739A1 (en) * | 2008-01-30 | 2009-10-29 | Edwards Lifesciences Corporation | Real-time detection of vascular conditions of a subject using arterial pressure waveform analysis |
| JP5211177B2 (ja) * | 2008-02-11 | 2013-06-12 | カーディアック ペースメイカーズ， インコーポレイテッド | 心臓内の調律識別のための血行動態の監視方法 |
| WO2009102640A1 (en) | 2008-02-12 | 2009-08-20 | Cardiac Pacemakers, Inc. | Systems and methods for controlling wireless signal transfers between ultrasound-enabled medical devices |
| DE102008008840A1 (de) * | 2008-02-13 | 2009-09-24 | Up Management Gmbh | Verfahren und Vorrichtung zur nicht-invasiven Messung von dynamischen Herz-Lungen Interaktionsparametern |
| WO2009101140A1 (en) * | 2008-02-15 | 2009-08-20 | Universite Paris Sud | Device and process for calculating new indices of arterial stiffness, and/or for stroke volume monitoring |
| KR101006198B1 (ko) * | 2008-04-16 | 2011-01-12 | ㈜비엔컴 | 블루투스를 이용한 핸즈프리 시스템 |
| US10251566B2 (en) | 2008-05-27 | 2019-04-09 | Board Of Trustees Of Michigan State University | Methods and apparatus for determining a central aortic pressure waveform from a peripheral artery pressure waveform |
| US20100152547A1 (en) | 2008-07-02 | 2010-06-17 | Sterling Bernhard B | Method and system for determining cardiac performance |
| WO2010027652A1 (en) * | 2008-08-26 | 2010-03-11 | Cardiac Pacemakers, Inc. | Cardiac output estimation using pulmonary artery pressure |
| EP2334230A1 (de) * | 2008-10-10 | 2011-06-22 | Cardiac Pacemakers, Inc. | Systeme und verfahren zur bestimmung des herzminutenvolumens anhand von messungen des lungenarteriendrucks |
| GB0821084D0 (en) * | 2008-11-18 | 2008-12-24 | King S College London | Apparatus and method |
| US8632470B2 (en) | 2008-11-19 | 2014-01-21 | Cardiac Pacemakers, Inc. | Assessment of pulmonary vascular resistance via pulmonary artery pressure |
| US20100324378A1 (en) * | 2009-06-17 | 2010-12-23 | Tran Binh C | Physiologic signal monitoring using ultrasound signals from implanted devices |
| US20110040194A1 (en) * | 2009-08-12 | 2011-02-17 | Rajendra Prasad Jadiyappa | Method and system for determining cardiac parameters |
| CN102791192B (zh) * | 2009-10-29 | 2015-02-25 | Cn体系药物技术有限公司 | 增强和分析来自连续无创血压设备的信号的装置 |
| WO2011094487A2 (en) | 2010-01-29 | 2011-08-04 | Edwards Lifesciences Corporation | Elimination of the effects of irregular cardiac cycles in the determination of cardiovascular parameters |
| US9782089B2 (en) | 2010-09-08 | 2017-10-10 | Siemens Healthcare Gmbh | Worksheet system for determining measured patient values for use in clinical assessment and calculations |
| US9968304B2 (en) | 2011-10-07 | 2018-05-15 | Edwards Lifesciences Corporation | Detecting a vasoactive agent in the bloodstream |
| CN102499658B (zh) * | 2011-11-08 | 2013-12-11 | 中国科学院深圳先进技术研究院 | 中心血压波形重建模型及重建方法 |
| WO2015006295A1 (en) | 2013-07-08 | 2015-01-15 | Edwards Lifesciences Corporation | Determination of a hemodynamic parameter |
| AU2015223182B2 (en) | 2014-02-25 | 2017-09-14 | Icu Medical, Inc. | Patient monitoring system with gatekeeper signal |
| AU2016341195B2 (en) | 2015-10-19 | 2019-03-14 | Icu Medical, Inc. | Hemodynamic monitoring system with detachable display unit |
| CN105496360B (zh) * | 2015-12-03 | 2018-06-19 | 北京大学人民医院 | 一种辅助判断全人群系统血管顺应性的试剂盒 |
| CN105361886B (zh) * | 2015-12-03 | 2018-06-19 | 北京大学人民医院 | 一种辅助判断亚健康人群系统血管顺应性的试剂盒 |
| DE102015015784A1 (de) * | 2015-12-08 | 2017-06-08 | WSH Engineering Services GbR (vertretungsberechtigter Gesellschafter: Hieronymi, Andreas, 61440 Oberursel) | Verfahren zur Erfassung von arteriellen Parametern eines Menschen und Vorrichtung zur Durchführung des Verfahrens |
| DE102016001710B4 (de) | 2016-02-15 | 2022-08-25 | Fresenius Medical Care Deutschland Gmbh | Gerät zur extrakorporalen Blutbehandlung mit einer Auswerte- und Steuereinheit |
| CN108882869B (zh) * | 2016-04-15 | 2021-03-23 | 欧姆龙株式会社 | 生物体信息分析装置、系统以及程序 |
| US12102415B2 (en) | 2019-11-07 | 2024-10-01 | The Curators Of The University Of Missouri | Systems and methods to improve management and monitoring of cardiovascular disease |
| CN111493855B (zh) * | 2020-04-21 | 2023-01-06 | 重庆理工大学 | 个体化心输出量的无创测量系统与方法 |
| CN115462831A (zh) * | 2022-09-02 | 2022-12-13 | 南京师范大学 | 一种基于超声和心电联用测量血压及动脉血管弹性模量的系统及其测量方法 |
| GB2622396B (en) * | 2022-09-14 | 2025-06-04 | Carelight Ltd | Real time opto-physiological monitoring method and system |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4632125A (en) * | 1984-01-13 | 1986-12-30 | American Hospital Supply Corp. | Right heart ejection fraction and cardiac output catheter |
| JPS62207435A (ja) * | 1986-03-07 | 1987-09-11 | テルモ株式会社 | 心拍出量測定用カテ−テル |
| US5211177A (en) * | 1990-12-28 | 1993-05-18 | Regents Of The University Of Minnesota | Vascular impedance measurement instrument |
| US5183051A (en) * | 1991-01-14 | 1993-02-02 | Jonathan Kraidin | Means and apparatus for continuously determining cardiac output in a subject |
-
1991
- 1991-01-29 NL NL9100150A patent/NL9100150A/nl not_active Application Discontinuation
-
1992
- 1992-01-28 DK DK92905499.7T patent/DK0569506T3/da active
- 1992-01-28 EP EP92905499A patent/EP0569506B1/de not_active Expired - Lifetime
- 1992-01-28 AT AT92905499T patent/ATE128837T1/de not_active IP Right Cessation
- 1992-01-28 DE DE69205417T patent/DE69205417T2/de not_active Expired - Lifetime
- 1992-01-28 US US08/094,052 patent/US5400793A/en not_active Expired - Lifetime
- 1992-01-28 JP JP50509092A patent/JP3293621B2/ja not_active Expired - Lifetime
- 1992-01-28 ES ES92905499T patent/ES2080489T3/es not_active Expired - Lifetime
- 1992-01-28 WO PCT/NL1992/000022 patent/WO1992012669A1/en not_active Ceased
- 1992-01-28 CA CA002101531A patent/CA2101531C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH06505651A (ja) | 1994-06-30 |
| WO1992012669A1 (en) | 1992-08-06 |
| DK0569506T3 (da) | 1995-12-04 |
| US5400793A (en) | 1995-03-28 |
| DE69205417D1 (de) | 1995-11-16 |
| CA2101531A1 (en) | 1992-07-30 |
| ATE128837T1 (de) | 1995-10-15 |
| DE69205417T2 (de) | 1996-05-30 |
| CA2101531C (en) | 2003-01-14 |
| EP0569506A1 (de) | 1993-11-18 |
| EP0569506B1 (de) | 1995-10-11 |
| ES2080489T3 (es) | 1996-02-01 |
| JP3293621B2 (ja) | 2002-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1B | A search report has been drawn up | ||
| BV | The patent application has lapsed |