NL9201196A - Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat. - Google Patents

Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat. Download PDF

Info

Publication number: NL9201196A
Authority: NL; Netherlands
Prior art keywords: glucan; active substance; preparation; release; pct
Prior art date: 1992-07-03

Application number

NL9201196A

Other languages

English (en)

Dutch (nl)

Original Assignee

Tno

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-07-03

Filing date

1992-07-03

Publication date

1994-02-01

1992-07-03 Application filed by Tno filed Critical Tno

1992-07-03 Priority to NL9201196A priority Critical patent/NL9201196A/nl

1993-07-02 Priority to ES93916290T priority patent/ES2096934T3/es

1993-07-02 Priority to DE69306390T priority patent/DE69306390T2/de

1993-07-02 Priority to JP6503184A priority patent/JPH07508532A/ja

1993-07-02 Priority to DK93916290.5T priority patent/DK0648115T3/da

1993-07-02 Priority to EP93916290A priority patent/EP0648115B1/de

1993-07-02 Priority to US08/362,442 priority patent/US5629018A/en

1993-07-02 Priority to AT93916290T priority patent/ATE145821T1/de

1993-07-02 Priority to AU45892/93A priority patent/AU677591B2/en

1993-07-02 Priority to CA002139493A priority patent/CA2139493A1/en

1993-07-02 Priority to PCT/NL1993/000138 priority patent/WO1994001091A1/en

1994-02-01 Publication of NL9201196A publication Critical patent/NL9201196A/nl

1997-02-26 Priority to GR970400332T priority patent/GR3022646T3/el

Links

239000013543 active substance Substances 0.000 title claims abstract description 32
238000002360 preparation method Methods 0.000 title claims description 27
238000000034 method Methods 0.000 title claims description 8
230000001105 regulatory effect Effects 0.000 title 1
239000011159 matrix material Substances 0.000 claims abstract description 22
229920001503 Glucan Polymers 0.000 claims abstract description 20
239000000203 mixture Substances 0.000 claims abstract description 18
239000003795 chemical substances by application Substances 0.000 claims abstract description 14
102000004169 proteins and genes Human genes 0.000 claims abstract description 7
108090000623 proteins and genes Proteins 0.000 claims abstract description 7
150000004676 glycans Chemical class 0.000 claims abstract description 6
229920001282 polysaccharide Polymers 0.000 claims abstract description 6
239000005017 polysaccharide Substances 0.000 claims abstract description 6
102000004139 alpha-Amylases Human genes 0.000 claims abstract description 5
108090000637 alpha-Amylases Proteins 0.000 claims abstract description 5
229940024171 alpha-amylase Drugs 0.000 claims abstract description 5
229920000310 Alpha glucan Polymers 0.000 claims abstract description 3
244000005700 microbiome Species 0.000 claims abstract description 3
229920000856 Amylose Polymers 0.000 claims description 13
GUBGYTABKSRVRQ-ASMJPISFSA-N alpha-maltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-ASMJPISFSA-N 0.000 claims description 11
239000003405 delayed action preparation Substances 0.000 claims description 5
239000004480 active ingredient Substances 0.000 claims description 4
238000009472 formulation Methods 0.000 claims description 2
238000005469 granulation Methods 0.000 claims 1
230000003179 granulation Effects 0.000 claims 1
239000000126 substance Substances 0.000 abstract description 11
239000000463 material Substances 0.000 abstract description 6
230000003111 delayed effect Effects 0.000 abstract description 5
229960005486 vaccine Drugs 0.000 abstract description 3
239000013566 allergen Substances 0.000 abstract description 2
239000007891 compressed tablet Substances 0.000 abstract 1
239000003826 tablet Substances 0.000 description 22
108010059892 Cellulase Proteins 0.000 description 9
101710121765 Endo-1,4-beta-xylanase Proteins 0.000 description 9
229940106157 cellulase Drugs 0.000 description 9
239000004382 Amylase Substances 0.000 description 8
102000013142 Amylases Human genes 0.000 description 8
108010065511 Amylases Proteins 0.000 description 8
235000019418 amylase Nutrition 0.000 description 8
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
102000004190 Enzymes Human genes 0.000 description 5
108090000790 Enzymes Proteins 0.000 description 5
239000004366 Glucose oxidase Substances 0.000 description 5
108010015776 Glucose oxidase Proteins 0.000 description 5
229940088598 enzyme Drugs 0.000 description 5
229940116332 glucose oxidase Drugs 0.000 description 5
235000019420 glucose oxidase Nutrition 0.000 description 5
229920002472 Starch Polymers 0.000 description 4
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 4
210000001035 gastrointestinal tract Anatomy 0.000 description 4
239000002953 phosphate buffered saline Substances 0.000 description 4
239000008107 starch Substances 0.000 description 4
235000019698 starch Nutrition 0.000 description 4
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 3
-1 amylose V-helix Chemical compound 0.000 description 3
239000008139 complexing agent Substances 0.000 description 3
238000013270 controlled release Methods 0.000 description 3
230000000593 degrading effect Effects 0.000 description 3
230000000694 effects Effects 0.000 description 3
230000003628 erosive effect Effects 0.000 description 3
TWNIBLMWSKIRAT-VFUOTHLCSA-N levoglucosan Chemical group O[C@@H]1[C@@H](O)[C@H](O)[C@H]2CO[C@@H]1O2 TWNIBLMWSKIRAT-VFUOTHLCSA-N 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
229920000945 Amylopectin Polymers 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
241000124008 Mammalia Species 0.000 description 2
241001465754 Metazoa Species 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
229920000881 Modified starch Polymers 0.000 description 2
239000002253 acid Substances 0.000 description 2
238000010306 acid treatment Methods 0.000 description 2
230000002378 acidificating effect Effects 0.000 description 2
239000002775 capsule Substances 0.000 description 2
239000001913 cellulose Substances 0.000 description 2
229920002678 cellulose Polymers 0.000 description 2
235000010980 cellulose Nutrition 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
150000001875 compounds Chemical class 0.000 description 2
239000002552 dosage form Substances 0.000 description 2
239000003814 drug Substances 0.000 description 2
229940079593 drug Drugs 0.000 description 2
239000000945 filler Substances 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
235000019813 microcrystalline cellulose Nutrition 0.000 description 2
239000008108 microcrystalline cellulose Substances 0.000 description 2
229940016286 microcrystalline cellulose Drugs 0.000 description 2
238000002156 mixing Methods 0.000 description 2
235000019426 modified starch Nutrition 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
239000006069 physical mixture Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
238000003825 pressing Methods 0.000 description 2
239000002689 soil Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
210000002784 stomach Anatomy 0.000 description 2
239000000758 substrate Substances 0.000 description 2
239000012730 sustained-release form Substances 0.000 description 2
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
238000009020 BCA Protein Assay Kit Methods 0.000 description 1
241000894006 Bacteria Species 0.000 description 1
229920002498 Beta-glucan Polymers 0.000 description 1
239000002028 Biomass Substances 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
241000123346 Chrysosporium Species 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
241000233866 Fungi Species 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
239000004368 Modified starch Substances 0.000 description 1
240000004808 Saccharomyces cerevisiae Species 0.000 description 1
241000700605 Viruses Species 0.000 description 1
230000006978 adaptation Effects 0.000 description 1
229960004784 allergens Drugs 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
239000005667 attractant Substances 0.000 description 1
108010079292 betaglycan Proteins 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
235000013339 cereals Nutrition 0.000 description 1
230000000536 complexating effect Effects 0.000 description 1
230000003750 conditioning effect Effects 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
239000000975 dye Substances 0.000 description 1
210000003238 esophagus Anatomy 0.000 description 1
239000003337 fertilizer Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
238000005194 fractionation Methods 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000005556 hormone Substances 0.000 description 1
229940088597 hormone Drugs 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229920001542 oligosaccharide Polymers 0.000 description 1
150000002482 oligosaccharides Chemical class 0.000 description 1
229910052760 oxygen Inorganic materials 0.000 description 1
239000001301 oxygen Substances 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
239000000575 pesticide Substances 0.000 description 1
238000006116 polymerization reaction Methods 0.000 description 1
239000003340 retarding agent Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
229920001221 xylan Polymers 0.000 description 1
150000004823 xylans Chemical class 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Zoology (AREA)
Botany (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

NL9201196A 1992-07-03 1992-07-03 Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat. NL9201196A (nl)

Priority Applications (12)

Application Number	Priority Date	Filing Date	Title
NL9201196A NL9201196A (nl)	1992-07-03	1992-07-03	Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat.
EP93916290A EP0648115B1 (de)	1992-07-03	1993-07-02	Zusammenfassung zur kontrollierten abgabe eines wirkstoffes und verfahren zur herstellung derselbe
DE69306390T DE69306390T2 (de)	1992-07-03	1993-07-02	Zusammenfassung zur kontrollierten abgabe eines wirkstoffes und verfahren zur herstellung derselbe
JP6503184A JPH07508532A (ja)	1992-07-03	1993-07-02	活性物質の制御された放出のための組成物ならびにそのような組成物の調製方法
DK93916290.5T DK0648115T3 (da)	1992-07-03	1993-07-02	Præparat til reguleret frigivelse af et aktivt stof og fremgangsmåde til fremstilling af et sådant præparat
ES93916290T ES2096934T3 (es)	1992-07-03	1993-07-02	Composicion para la liberacion controlada de una sustancia activa y metodo para la preparacion de dicha composicion.
US08/362,442 US5629018A (en)	1992-07-03	1993-07-02	Composition for controlled release of an active substance and method for the preparation of such a composition
AT93916290T ATE145821T1 (de)	1992-07-03	1993-07-02	Zusammenfassung zur kontrollierten abgabe eines wirkstoffes und verfahren zur herstellung derselbe
AU45892/93A AU677591B2 (en)	1992-07-03	1993-07-02	Composition for controlled release of an active substance and method for the preparation of such a composition
CA002139493A CA2139493A1 (en)	1992-07-03	1993-07-02	Composition for controlled release of an active substance and method for the preparation of such a composition
PCT/NL1993/000138 WO1994001091A1 (en)	1992-07-03	1993-07-02	Composition for controlled release of an active substance and method for the preparation of such a composition
GR970400332T GR3022646T3 (en)	1992-07-03	1997-02-26	Composition for controlled release of an active substance and method for the preparation of such a composition.

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NL9201196		1992-07-03
NL9201196A NL9201196A (nl)	1992-07-03	1992-07-03	Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat.

Publications (1)

Publication Number	Publication Date
NL9201196A true NL9201196A (nl)	1994-02-01

Family

ID=19861015

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NL9201196A NL9201196A (nl)	1992-07-03	1992-07-03	Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat.

Country Status (12)

Country	Link
US (1)	US5629018A (de)
EP (1)	EP0648115B1 (de)
JP (1)	JPH07508532A (de)
AT (1)	ATE145821T1 (de)
AU (1)	AU677591B2 (de)
CA (1)	CA2139493A1 (de)
DE (1)	DE69306390T2 (de)
DK (1)	DK0648115T3 (de)
ES (1)	ES2096934T3 (de)
GR (1)	GR3022646T3 (de)
NL (1)	NL9201196A (de)
WO (1)	WO1994001091A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2173818A1 (fr) *	1996-04-10	1997-10-11	Francois Chouinard	Comprime pharmaceutique a liberation controlee contenant un support a base d'amylose reticule et d'hydroxypropylmethylcellulose
DE19737481A1 (de)	1997-08-28	1999-03-04	Hoechst Ag	Sphärische lineare Polysaccharide enthaltende Mikropartikel
WO1999030691A2 (en) *	1997-12-18	1999-06-24	Ato B.V.	Composition for the controlled release of active compounds
DE19860373B4 (de) *	1998-12-28	2004-02-19	Celanese Ventures Gmbh	Mundpflegemittel und Verwendung von sphärischen Mikropartikeln
JP3742335B2 (ja) *	2001-12-20	2006-02-01	富士通株式会社	入出力バッファ回路
US7081261B2 (en) *	2002-05-14	2006-07-25	National Starch And Chemical Investment Holding Corporation	Resistant starch prepared by isoamylase debranching of low amylose starch
US6890571B2 (en) *	2002-05-14	2005-05-10	National Starch And Chemical Investment Holding Corporation	Slowly digestible starch product
US6929817B2 (en) *	2002-05-14	2005-08-16	National Starch & Chemical Investment Holding Corporation	Slowly digestible starch product
US9101155B2 (en)	2003-07-11	2015-08-11	Asahi Kasei Chemicals Corporation	Functional starch powder
US20050033157A1 (en) *	2003-07-25	2005-02-10	Klein Dean A.	Multi-modality marking material and method
US20070071810A1 (en) *	2003-08-26	2007-03-29	Kenichi Kudo	Additive for tablets
JPWO2006082968A1 (ja) *	2005-02-07	2008-06-26	江崎グリコ株式会社	α−１，４−グルカンを含有する吸着剤およびその製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3493652A (en) *	1962-09-14	1970-02-03	Charles W Hartman	Controlled release medicament
JPH0747539B2 (ja) *	1986-10-22	1995-05-24	東京田辺製薬株式会社	胆汁酸固形製剤
DE3721574A1 (de) *	1987-06-30	1989-01-12	Kettelhack Riker Pharma Gmbh	Arzneimittel in form von pellets mit enzymatisch kontrollierter arzneistoff-freisetzung
US4859377A (en) *	1987-07-10	1989-08-22	The United States Of America, As Represented By The Secretary Of Agriculture	Starch encapsulation of entomopathogens

1992
- 1992-07-03 NL NL9201196A patent/NL9201196A/nl not_active Application Discontinuation
1993
- 1993-07-02 EP EP93916290A patent/EP0648115B1/de not_active Expired - Lifetime
- 1993-07-02 DK DK93916290.5T patent/DK0648115T3/da active
- 1993-07-02 JP JP6503184A patent/JPH07508532A/ja active Pending
- 1993-07-02 AU AU45892/93A patent/AU677591B2/en not_active Ceased
- 1993-07-02 ES ES93916290T patent/ES2096934T3/es not_active Expired - Lifetime
- 1993-07-02 DE DE69306390T patent/DE69306390T2/de not_active Expired - Fee Related
- 1993-07-02 CA CA002139493A patent/CA2139493A1/en not_active Abandoned
- 1993-07-02 AT AT93916290T patent/ATE145821T1/de not_active IP Right Cessation
- 1993-07-02 US US08/362,442 patent/US5629018A/en not_active Expired - Fee Related
- 1993-07-02 WO PCT/NL1993/000138 patent/WO1994001091A1/en not_active Ceased
1997
- 1997-02-26 GR GR970400332T patent/GR3022646T3/el unknown

Also Published As

Publication number	Publication date
US5629018A (en)	1997-05-13
GR3022646T3 (en)	1997-05-31
DE69306390T2 (de)	1997-06-05
EP0648115B1 (de)	1996-12-04
ATE145821T1 (de)	1996-12-15
AU4589293A (en)	1994-01-31
JPH07508532A (ja)	1995-09-21
DE69306390D1 (de)	1997-01-16
AU677591B2 (en)	1997-05-01
CA2139493A1 (en)	1994-01-20
ES2096934T3 (es)	1997-03-16
EP0648115A1 (de)	1995-04-19
DK0648115T3 (da)	1997-06-02
WO1994001091A1 (en)	1994-01-20

Legal Events

Date	Code	Title	Description
1994-02-01	A1B	A search report has been drawn up
1995-03-01	BV	The patent application has lapsed

Publication	Publication Date	Title
US5411945A (en)	1995-05-02	Pullulan binder and its uses
NL9201196A (nl)	1994-02-01	Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat.
NL9201195A (nl)	1994-02-01	Preparaat voor de gereguleerde afgifte van een werkzame stof en werkwijze ter bereiding van een dergelijk preparaat.
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US5616343A (en)	1997-04-01	Cross-linked amylose as a binder/disintegrant in tablets
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Dumoulin et al.	1999	Cross-linked amylose tablets containing α-amylase: an enzymatically-controlled drug release system
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US6649191B1 (en)	2003-11-18	Orally administrable compositions comprising cation cross-linked polysaccharide and a polymer digestible in the lower gastrointestinal tract
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EP1174127A1 (de)	2002-01-23	Zuammensetzung zur zielgesteuerten Freigabe eines Wirkstoffs und Verfahren zur Herstellung einer solchen Zusammensetzung