NL930104I2 - Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan. - Google Patents

Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan.

Info

Publication number
NL930104I2
NL930104I2 NL930104C NL930104C NL930104I2 NL 930104 I2 NL930104 I2 NL 930104I2 NL 930104 C NL930104 C NL 930104C NL 930104 C NL930104 C NL 930104C NL 930104 I2 NL930104 I2 NL 930104I2
Authority
NL
Netherlands
Prior art keywords
heparin fragments
preparation
anticoagulant activity
selective
sulphate
Prior art date
Application number
NL930104C
Other languages
English (en)
Other versions
NL930104I1 (nl
Original Assignee
Kabipharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20336970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NL930104(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kabipharmacia Ab filed Critical Kabipharmacia Ab
Publication of NL930104I1 publication Critical patent/NL930104I1/nl
Publication of NL930104I2 publication Critical patent/NL930104I2/nl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Detergent Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
NL930104C 1979-01-08 1993-01-28 Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan. NL930104I2 (nl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7900164 1979-01-08

Publications (2)

Publication Number Publication Date
NL930104I1 NL930104I1 (nl) 1993-10-01
NL930104I2 true NL930104I2 (nl) 1997-02-03

Family

ID=20336970

Family Applications (1)

Application Number Title Priority Date Filing Date
NL930104C NL930104I2 (nl) 1979-01-08 1993-01-28 Heparinefragmenten met selectieve anticoagulatie activiteit en werkwijze ter bereiding daarvan.

Country Status (11)

Country Link
US (1) US4303651A (nl)
EP (1) EP0014184B2 (nl)
JP (1) JPS6344764B2 (nl)
AT (1) ATE8998T1 (nl)
CA (1) CA1136620A (nl)
DE (1) DE3068924D1 (nl)
DK (1) DK160764C (nl)
NL (1) NL930104I2 (nl)
NO (1) NO150801C (nl)
SU (1) SU1209033A3 (nl)
WO (1) WO1980001383A1 (nl)

Families Citing this family (68)

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US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4438261A (en) 1980-05-19 1984-03-20 Riker Laboratories, Inc. Anticoagulant substance
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
WO1982001377A1 (en) * 1980-10-09 1982-04-29 Lill Helmut Method for determining a bm-antithrombin
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2535324A1 (fr) * 1982-10-27 1984-05-04 Choay Sa Station perfectionnee pour l'epuration d'eaux usees
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
EP0066908B1 (en) 1981-05-21 1985-08-28 Akzo N.V. New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
CA1265132A (en) * 1982-01-15 1990-01-30 Mahmoud Nassr Process for the organic synthesis of oligosaccharides and derivatives thereof
US4539398A (en) * 1982-01-22 1985-09-03 Riker Laboratories, Inc. Affinity fractionation of heparin on immobilized Concanavalin A
ATE22899T1 (de) 1982-06-10 1986-11-15 Kabivitrum Ab Antithrombin-heparin komplex.
ZA829463B (en) * 1982-07-19 1983-10-26 Hepar Ind Inc Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
FR2538404B1 (nl) * 1982-12-28 1985-08-23 Anic Spa
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
GB8614189D0 (en) * 1986-06-11 1986-07-16 Leo Pharm Prod Ltd Pharmaceutical composition
US4942156A (en) * 1986-08-20 1990-07-17 Hepar Industries, Inc. Low molecular weight heparin derivatives having improved anti-Xa specificity
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
AU7742591A (en) * 1990-04-06 1991-10-30 Washington University Anticoagulant oligosaccharides
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5665379A (en) * 1990-09-28 1997-09-09 Pharmacia & Upjohn Aktiebolag Lipid particle forming matrix, preparation and use thereof
FI921689L (fi) * 1991-04-16 1992-10-17 Seikagagu Kogyo Kabushiki Kais Oligosackarid med affinitet foer fibroblasttillvaextfaktor och foerfarande foer framstaellning av denna
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
GB9206291D0 (en) * 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
DE4217916C2 (de) * 1992-05-30 1995-05-18 Job Prof Dr Med Harenberg N-Alkylamin- und N-Arylalkylaminderivate von Heparin, Verfahren zu ihrer Herstellung und ihrer Verwendung
GB9306255D0 (en) * 1993-03-25 1993-05-19 Cancer Res Campaign Tech Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity
FR2704861B1 (fr) * 1993-05-07 1995-07-28 Sanofi Elf Fractions d'héparine purifiées, procédé d'obtention et compositions pharmaceutiques les contenant.
SE9302135D0 (sv) * 1993-06-18 1993-06-18 Kabi Pharmacia Ab New pharmaceutical composition
EP0735050B1 (en) * 1995-03-31 2002-09-25 Hamilton Civic Hospitals Research Development, Inc. Compositions for inhibiting thrombogenesis
UA63929C2 (uk) * 1996-11-27 2004-02-16 Aventis Pharm Prod Inc Фармацевтична композиція та продукт, що містить сполуки з анти-ха активністю і антагоніст агрегації тромбоцитів, спосіб і набір для лікування або профілактики захворювань, які супроводжують тромбоутворення
CA2293595A1 (en) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
CA2370539C (en) 1999-04-23 2009-01-06 Massachusetts Institute Of Technology System and method for notating polymers
CA2377734A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
JP2002097143A (ja) * 2000-07-18 2002-04-02 Koyo Chemical Kk 血流改善剤及び血栓予防治療剤または食品
CA2420890A1 (en) * 2000-09-08 2002-03-14 Hamilton Civic Hospitals Research Development, Inc. Antithrombotic compositions
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
US6933372B2 (en) 2003-03-07 2005-08-23 Warner-Lambert Company Method to produce a solid form of heparin
AU2004244756A1 (en) * 2003-06-05 2004-12-16 Centelion Plasmid encoding fibroblast growth factor for the treatment of hypercholesterolemia or diabetes associated angiogenic defects
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US20050096294A1 (en) * 2003-10-31 2005-05-05 Takashi Komai Novel anti-coagulant
EP1582531A1 (en) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
ES2567079T3 (es) * 2007-11-02 2016-04-19 Momenta Pharmaceuticals, Inc. Composiciones de polisacáridos que no son anticoagulantes
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
AU2009250803A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
ES2340902B1 (es) * 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
BR112012026542A2 (pt) 2010-04-16 2016-07-12 Momenta Pharmaceuticals Inc abordagem seletiva de tecido
CA2795868A1 (en) 2010-06-17 2011-12-22 Momenta Pharmaceuticals, Inc. Methods and compositions for modulating hair growth
CN104144950B (zh) 2011-12-19 2017-09-05 迪乐方有限责任公司 含有重复的二糖单元的非抗凝的葡糖胺聚糖及其医药用途
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
JP2016520613A (ja) 2013-05-28 2016-07-14 モメンタ ファーマシューティカルズ インコーポレイテッド 薬学的組成物
RU2612813C1 (ru) * 2015-12-07 2017-03-13 Павел Андреевич Канаев Способ получения гепарина
CN111727204B (zh) 2018-02-14 2023-01-31 生物E有限公司 用于制备达肝素钠的改进方法
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
CA3144968A1 (en) 2019-07-09 2021-01-14 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

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US3135660A (en) * 1956-11-09 1964-06-02 Riker Laboratories Inc Method for purifying sulfated carbohydrates with oxidizing agents
US3066076A (en) * 1958-12-15 1962-11-27 Fo We Forschungs Und Verwertun Soluble heparin product and process for preparing same
US3835112A (en) * 1970-06-08 1974-09-10 Etude Et D Exploit De Marques Heparin esters
DE2148011C3 (de) * 1970-10-05 1978-11-09 Aminkemi Ab Verfahren zum Herstellen nichtthrombogener Kunststoffoberflächen
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
GB1399824A (en) * 1971-08-16 1975-07-02 Mar Pha Etu Expl Marques Heparin esters
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche

Also Published As

Publication number Publication date
DK160764C (da) 1991-09-23
SU1209033A3 (ru) 1986-01-30
JPS56500066A (nl) 1981-01-22
DK380280A (da) 1980-09-05
US4303651A (en) 1981-12-01
DK160764B (da) 1991-04-15
EP0014184B2 (en) 1989-10-18
NO150801B (no) 1984-09-10
ATE8998T1 (de) 1984-09-15
CA1136620A (en) 1982-11-30
WO1980001383A1 (en) 1980-07-10
EP0014184A3 (en) 1980-10-01
NO150801C (no) 1984-12-27
DE3068924D1 (en) 1984-09-20
JPS6344764B2 (nl) 1988-09-06
NL930104I1 (nl) 1993-10-01
EP0014184B1 (en) 1984-08-15
NO802626L (no) 1980-09-05
EP0014184A2 (en) 1980-08-06

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