NO117919B - - Google Patents

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Info

Publication number: NO117919B
Authority: NO; Norway
Prior art keywords: alcohol; tetracycline; filtered; product; piperazine
Prior art date: 1964-02-21

Application number

NO15684565A

Other languages

English (en)

Norwegian (no)

Inventor

J Christensen

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1964-02-21

Filing date

1965-02-19

Publication date

1969-10-13

1965-02-19 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

1969-10-13 Publication of NO117919B publication Critical patent/NO117919B/no

Links

239000004098 Tetracycline Substances 0.000 claims description 5
238000000034 method Methods 0.000 claims description 5
229960002180 tetracycline Drugs 0.000 claims description 5
235000019364 tetracycline Nutrition 0.000 claims description 5
229930101283 tetracycline Natural products 0.000 claims description 5
150000003522 tetracyclines Chemical class 0.000 claims description 5
RMVMLZHPWMTQGK-SOUFLCLCSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical group C1([C@H]2O)=CC=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O RMVMLZHPWMTQGK-SOUFLCLCSA-N 0.000 claims description 4
239000004099 Chlortetracycline Substances 0.000 claims description 4
CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 4
229960004475 chlortetracycline Drugs 0.000 claims description 4
CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 4
235000019365 chlortetracycline Nutrition 0.000 claims description 4
125000003545 alkoxy group Chemical group 0.000 claims description 2
125000003368 amide group Chemical group 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims description 2
JCSGAUKCDAVARS-UHFFFAOYSA-N demethyltetracycline Natural products CN(C1C(=C(C(C2(C(=C3C(C4=C(C=CC=C4C(C3CC12)O)O)=O)O)O)=O)C(=O)N)O)C JCSGAUKCDAVARS-UHFFFAOYSA-N 0.000 claims description 2
150000003839 salts Chemical class 0.000 claims description 2
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
238000012986 modification Methods 0.000 claims 1
230000004048 modification Effects 0.000 claims 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
235000019441 ethanol Nutrition 0.000 description 8
239000000047 product Substances 0.000 description 7
KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 description 4
WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
239000011541 reaction mixture Substances 0.000 description 3
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 description 2
239000008098 formaldehyde solution Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000002844 melting Methods 0.000 description 2
230000008018 melting Effects 0.000 description 2
229960003506 piperazine hexahydrate Drugs 0.000 description 2
AVRVZRUEXIEGMP-UHFFFAOYSA-N piperazine;hexahydrate Chemical compound O.O.O.O.O.O.C1CNCCN1 AVRVZRUEXIEGMP-UHFFFAOYSA-N 0.000 description 2
150000004885 piperazines Chemical class 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000002904 solvent Substances 0.000 description 2
238000003756 stirring Methods 0.000 description 2
229960002317 succinimide Drugs 0.000 description 2
229960004989 tetracycline hydrochloride Drugs 0.000 description 2
FEFMTWYKZOVFMX-UHFFFAOYSA-N 4-methyl-N-[[4-[[(4-methylphenyl)sulfonylamino]methyl]piperazin-1-yl]methyl]benzenesulfonamide Chemical compound CC1=CC=C(C=C1)S(=O)(=O)NCN1CCN(CC1)CNS(=O)(=O)C1=CC=C(C)C=C1 FEFMTWYKZOVFMX-UHFFFAOYSA-N 0.000 description 1
125000003118 aryl group Chemical group 0.000 description 1
235000019445 benzyl alcohol Nutrition 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000000203 mixture Substances 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
-1 p-toluenesulfonamido group Chemical group 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
229960005141 piperazine Drugs 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 description 1
125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
LMYRWZFENFIFIT-UHFFFAOYSA-N toluene-4-sulfonamide Chemical compound CC1=CC=C(S(N)(=O)=O)C=C1 LMYRWZFENFIFIT-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Hydrogenated Pyridines (AREA)

NO15684565A 1964-02-21 1965-02-19 NO117919B (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HUCI000489		1964-02-21

Publications (1)

Publication Number	Publication Date
NO117919B true NO117919B (de)	1969-10-13

Family

ID=10994311

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO15684565A NO117919B (de)	1964-02-21	1965-02-19

Country Status (5)

Country	Link
AT (1)	AT254200B (de)
DK (1)	DK116439B (de)
FI (1)	FI43877C (de)
NL (1)	NL6502145A (de)
NO (1)	NO117919B (de)

1965
- 1965-02-18 AT AT143465A patent/AT254200B/de active
- 1965-02-18 DK DK85365A patent/DK116439B/da unknown
- 1965-02-19 NO NO15684565A patent/NO117919B/no unknown
- 1965-02-19 FI FI40665A patent/FI43877C/fi active
- 1965-02-19 NL NL6502145A patent/NL6502145A/xx unknown

Also Published As

Publication number	Publication date
FI43877C (fi)	1971-07-12
AT254200B (de)	1967-05-10
FI43877B (de)	1971-03-31
NL6502145A (de)	1965-08-23
DK116439B (da)	1970-01-12

Publication	Publication Date	Title
US2892841A (en)	1959-06-30	Process for aminating nitrogen-containing heterocyclic compounds
SU741797A3 (ru)	1980-06-15	Способ получени производных бензопирана или их солей
NO117919B (de)	1969-10-13
Heymann et al.	1945	Derivatives of p, p'-Diaminodiphenyl Sulfone1a
US2540946A (en)	1951-02-06	Pyridoxal-histamine and processes for preparing the same
SU520913A3 (ru)	1976-07-05	Способ получени производных 3-алкил-4-сульфамоиланилина
Haruki et al.	1968	Some reactions of N-haloamidines
US2839529A (en)	1958-06-17	Isothiazole compounds
SU504490A3 (ru)	1976-02-25	Способ получени производных теофиллина
US2543957A (en)	1951-03-06	Organic nitro diol derivatives and metal salts thereof
US2418944A (en)	1947-04-15	Guansdes and theik preparation
US3417098A (en)	1968-12-17	Phosphoryl derivatives of 4-imidazolidones
US2387019A (en)	1945-10-16	Aliphatic dinitro tetrols
US3036081A (en)	1962-05-22	4, 5-benzo tryptamine and process of producing same
US3549657A (en)	1970-12-22	N-aryl-4,6-dibromo-3-hydroxyphthalimide derivatives
US2265217A (en)	1941-12-09	D - lysergic acid -
US4093627A (en)	1978-06-06	3-[(4-Chromanylidene)amino]-2-oxazolidinones
US2785182A (en)	1957-03-12	Substituted pyrrolecarboxamidopyroles
US3128273A (en)	1964-04-07	4-amino-pteridine-7-carboxamides and method of preparation
IL27647A (en)	1971-11-29	4-(2'-(tetrahydrofurfuryloxycarbonyl)-phenylamino)-chloroquinolines
Dutcher et al.	1951	Studies on the C11H8N2OS Degradation Product of Gliotoxin1
US1983414A (en)	1934-12-04	Bile acid amides and their preparation
SU436057A1 (ru)	1974-07-15	СПОСОБ ПОЛУЧЕНИЯ ИЗОПРОПИЛИДЕНОВЫХ ПРОИЗВОДНЫХ ПИРИДОКСИНАВ ПТ5ФОНЯ mmim
US2310170A (en)	1943-02-02	Vitamin b6 intermediate
US3351589A (en)	1967-11-07	Process for the manufacture of diuretically and saluretically active alkoxysulfamyl-anthranilic acids and their salts