NO127694B - - Google Patents

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Info

Publication number: NO127694B
Authority: NO; Norway
Prior art keywords: protodyne; protoplasm; extraction; bacterial; cells
Prior art date: 1967-10-24

Application number

NO03396/68A

Other languages

English (en)

Norwegian (no)

Inventor

F Berger

J Rosselet

B Ludwig

Original Assignee

Carter Wallace

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1967-10-24

Filing date

1968-08-31

Publication date

1973-08-06

1968-08-31 Application filed by Carter Wallace filed Critical Carter Wallace

1973-08-06 Publication of NO127694B publication Critical patent/NO127694B/no

Links

210000004027 cell Anatomy 0.000 claims description 18
108010015658 protodyne Proteins 0.000 claims description 17
238000000605 extraction Methods 0.000 claims description 10
239000000463 material Substances 0.000 claims description 10
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 9
230000001580 bacterial effect Effects 0.000 claims description 9
241000894006 Bacteria Species 0.000 claims description 8
210000000805 cytoplasm Anatomy 0.000 claims description 8
241001465754 Metazoa Species 0.000 claims description 7
210000002421 cell wall Anatomy 0.000 claims description 5
230000000694 effects Effects 0.000 claims description 5
208000015181 infectious disease Diseases 0.000 claims description 5
238000000034 method Methods 0.000 claims description 5
206010037660 Pyrexia Diseases 0.000 claims description 4
231100000419 toxicity Toxicity 0.000 claims description 4
230000001988 toxicity Effects 0.000 claims description 4
239000007787 solid Substances 0.000 description 10
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
238000005119 centrifugation Methods 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
241000588724 Escherichia coli Species 0.000 description 5
239000002158 endotoxin Substances 0.000 description 5
239000000243 solution Substances 0.000 description 5
241000699670 Mus sp. Species 0.000 description 4
238000004090 dissolution Methods 0.000 description 4
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
229910021536 Zeolite Inorganic materials 0.000 description 3
235000021588 free fatty acids Nutrition 0.000 description 3
150000002632 lipids Chemical class 0.000 description 3
239000000203 mixture Substances 0.000 description 3
239000000725 suspension Substances 0.000 description 3
239000010457 zeolite Substances 0.000 description 3
241000589517 Pseudomonas aeruginosa Species 0.000 description 2
241000607142 Salmonella Species 0.000 description 2
150000001720 carbohydrates Chemical class 0.000 description 2
239000012153 distilled water Substances 0.000 description 2
150000004676 glycans Chemical class 0.000 description 2
239000007924 injection Substances 0.000 description 2
238000002347 injection Methods 0.000 description 2
239000007788 liquid Substances 0.000 description 2
239000002504 physiological saline solution Substances 0.000 description 2
229920001282 polysaccharide Polymers 0.000 description 2
239000005017 polysaccharide Substances 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
241000607715 Serratia marcescens Species 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
241000194017 Streptococcus Species 0.000 description 1
241000193998 Streptococcus pneumoniae Species 0.000 description 1
XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
206010048222 Xerosis Diseases 0.000 description 1
DNEHKUCSURWDGO-UHFFFAOYSA-N aluminum sodium Chemical compound [Na].[Al] DNEHKUCSURWDGO-UHFFFAOYSA-N 0.000 description 1
239000000908 ammonium hydroxide Substances 0.000 description 1
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 1
230000008033 biological extinction Effects 0.000 description 1
OHJMTUPIZMNBFR-UHFFFAOYSA-N biuret Chemical compound NC(=O)NC(N)=O OHJMTUPIZMNBFR-UHFFFAOYSA-N 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
235000011089 carbon dioxide Nutrition 0.000 description 1
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
229960002442 glucosamine Drugs 0.000 description 1
150000002337 glycosamines Chemical class 0.000 description 1
239000012678 infectious agent Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
244000005700 microbiome Species 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
YRTWNFXASSUQEW-UHFFFAOYSA-M sodium;methanol;acetate Chemical class [Na+].OC.CC([O-])=O YRTWNFXASSUQEW-UHFFFAOYSA-M 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000010257 thawing Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000004448 titration Methods 0.000 description 1
239000002023 wood Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Microbiology (AREA)
Mycology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Molecular Biology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Compounds Of Unknown Constitution (AREA)

NO03396/68A 1967-10-24 1968-08-31 NO127694B (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US67774267A	1967-10-24	1967-10-24

Publications (1)

Publication Number	Publication Date
NO127694B true NO127694B (da)	1973-08-06

Family

ID=24719946

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO03396/68A NO127694B (da)	1967-10-24	1968-08-31

Country Status (18)

Country	Link
US (1)	US3483290A (da)
JP (1)	JPS507130B1 (da)
AT (1)	AT287194B (da)
BE (1)	BE722736A (da)
CH (1)	CH560542A5 (da)
DE (1)	DE1767793A1 (da)
DK (1)	DK122008B (da)
ES (1)	ES357845A1 (da)
FI (1)	FI44270C (da)
FR (1)	FR1604222A (da)
GB (1)	GB1217753A (da)
IE (1)	IE32427B1 (da)
IL (1)	IL30664A (da)
IN (1)	IN117571B (da)
LU (1)	LU56854A1 (da)
NL (1)	NL6813299A (da)
NO (1)	NO127694B (da)
SE (1)	SE359446B (da)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1281844A (en) *	1970-04-11	1972-07-19	Beecham Group Ltd	Method of separating allergenic material
FR2374042A1 (fr) *	1976-06-04	1978-07-13	Merieux Inst	Nouveau medicament immunostimulant et son procede de preparation
US4220584A (en) *	1978-01-30	1980-09-02	Merck & Co., Inc.	E. coli enterotoxin vaccine for veterinary and human use
US4285931A (en) *	1978-01-30	1981-08-25	Merck & Co., Inc.	E. coli enterotoxin vaccine for veterinary and human use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2340318A (en) *	1941-07-19	1944-02-01	Squibb & Sons Inc	Process of fractionating mixtures of bacterial origin
US3148120A (en) *	1952-01-24	1964-09-08	Wander Ag Dr A	Hot aqueous phenol extraction of gramnegative bacterial lipopolysaccharides
US3089821A (en) *	1959-10-28	1963-05-14	Merck & Co Inc	Process for the preparation of lipids
US3119741A (en) *	1962-04-10	1964-01-28	Princeton Lab Inc	Non-specific immunizing agent
US3132995A (en) *	1961-10-20	1964-05-12	Carter Prod Inc	Endotoxin fractions and method for producing same
GB1056839A (en) *	1963-09-19	1967-02-01	Johnson & Johnson	Brucella antigen

1967
- 1967-10-24 US US677742A patent/US3483290A/en not_active Expired - Lifetime
1968
- 1968-06-19 DE DE19681767793 patent/DE1767793A1/de active Pending
- 1968-08-27 ES ES357845A patent/ES357845A1/es not_active Expired
- 1968-08-30 CH CH1305668A patent/CH560542A5/xx not_active IP Right Cessation
- 1968-08-30 AT AT847268A patent/AT287194B/de not_active IP Right Cessation
- 1968-08-31 NO NO03396/68A patent/NO127694B/no unknown
- 1968-09-04 IL IL30664A patent/IL30664A/en unknown
- 1968-09-05 IN IN117571A patent/IN117571B/en unknown
- 1968-09-10 LU LU56854D patent/LU56854A1/xx unknown
- 1968-09-11 JP JP43064972A patent/JPS507130B1/ja active Pending
- 1968-09-12 FI FI682559A patent/FI44270C/fi active
- 1968-09-18 NL NL6813299A patent/NL6813299A/xx unknown
- 1968-09-25 DK DK462068AA patent/DK122008B/da unknown
- 1968-09-26 SE SE12967/68A patent/SE359446B/xx unknown
- 1968-10-21 IE IE1264/68A patent/IE32427B1/xx unknown
- 1968-10-21 GB GB49812/68A patent/GB1217753A/en not_active Expired
- 1968-10-22 FR FR1604222D patent/FR1604222A/fr not_active Expired
- 1968-10-23 BE BE722736D patent/BE722736A/xx unknown

Also Published As

Publication number	Publication date
LU56854A1 (da)	1968-12-17
CH560542A5 (da)	1975-04-15
FI44270B (da)	1971-06-30
IL30664A (en)	1972-06-28
IE32427L (en)	1969-04-24
US3483290A (en)	1969-12-09
IN117571B (da)	1975-09-20
GB1217753A (en)	1970-12-31
FI44270C (fi)	1971-10-11
IL30664A0 (en)	1968-11-27
NL6813299A (da)	1969-04-28
ES357845A1 (es)	1970-03-16
FR1604222A (da)	1971-10-04
AT287194B (de)	1971-01-11
BE722736A (da)	1969-04-01
DE1767793A1 (de)	1971-09-30
DK122008B (da)	1972-01-03
SE359446B (da)	1973-09-03
IE32427B1 (en)	1973-07-25
JPS507130B1 (da)	1975-03-22

Publication	Publication Date	Title
Kass et al.	1944	The role of the mucoid polysaccharide (hyaluronic acid) in the virulence of group A hemolytic streptococci
Burnet et al.	1947	The receptor-destroying enzyme of V. cholerae.
Pirie	1950	The isolation from normal tobacco leaves of nucleoprotein with some similarity to plant viruses
RM	1963	Symposium on relationship of structure of microorganisms to their immunological properties. IV. Antigenic and biochemical composition of hemolytic streptococcal cell walls.
CA1139302A (en)	1983-01-11	Process for the preparation of purified bacterial membranal proteoglycans
Rimler et al.	1984	Lipopolysaccharides of the Heddleston serotypes of Pasteurella multocida
Springer et al.	1965	Cross reactive human blood-group H (O) specific polysaccharide from Sassafras albidum and characterization of its hapten
EP0041897B1 (en)	1986-12-03	Polysaccharide antigen from streptococcus and vaccines
Kiss et al.	1978	Structural studies on the immunogenic form of the enterobacterial common antigen
Batshon et al.	1963	Immunologic paralysis produced in mice by Klebsiella pneumoniae type 2 polysaccharide
Knox et al.	1960	Pasteurella multocida Type I: The Antigens of: I. Capsular Polysaccharides
US4242270A (en)	1980-12-30	Process for separating lipids from endotoxins
US3483290A (en)	1969-12-09	Bacterial fractions
Smith et al.	1956	The chemical basis of the virulence of Bacillus anthracis. VI: an extracellular immunising aggressin isolated from exudates of infected guinea-pigs
Rüde et al.	1962	COLICINE K: V. The Somatic Antigen of a Non-Colicinogenic Variant of E. coli K235
Männel et al.	1978	Serological and immunological properties of isolated enterobacterial common antigen
WO2025175807A1 (zh)	2025-08-28	一种肺炎链球菌荚膜多糖的制备方法
Krause	1963	IV. ANTIGENIC AND BIOCHEMICAL COMPOSITION OF HEMOLYTIC STREPTOCOCCAL CELL WALLS
US2166963A (en)	1939-07-25	Antigenic polysaccharide complex
CN118853720A (zh)	2024-10-29	一种外膜囊泡疫苗的制备方法及其应用
M. æland et al.	1971	IMMUNOCHEMICAL INVESTIGATIONS ON NEISSERIA GONORRHOEAE ENDOTOXIN: 1. Characterization of Phenol‐Water Extracted Endotoxin and Comparison with Aqueous Ether Preparations
Fitting et al.	1952	OBSERVATIONS ON A STRAIN OF NEISSERIA MENINGITIDIS IN THE PRESENCE OF GLUCOSE AND MALTOSE III: Cell-free Extracts and the Phosphorolysis of Maltose
Razin et al.	1974	[42] isolation, solubilization, and reconstitution of mycoplasma membranes
Heidelberger et al.	1959	Cross-Reactions of Streptococcal A and V Carbohydrates in Type II Antipneumococcal Horse Sera
KR930001382B1 (ko)	1993-02-27	경구용 장티프스 생균백신 및 그의 제조방법