NO132851B - - Google Patents

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Info

Publication number: NO132851B
Authority: NO; Norway
Prior art keywords: accordance; blood; ratio; electrodes; electrical
Prior art date: 1968-09-27

Application number

NO3832/69A

Other languages

English (en)

Norwegian (no)

Other versions

NO132851C (fr

Inventor

Amiran Ur

Original Assignee

Amiran Ur

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1968-09-27

Filing date

1969-09-26

Publication date

1975-10-06

1969-09-26 Application filed by Amiran Ur filed Critical Amiran Ur

1975-10-06 Publication of NO132851B publication Critical patent/NO132851B/no

1976-01-14 Publication of NO132851C publication Critical patent/NO132851C/no

Links

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BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 12
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Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
- G01N27/07—Construction of measuring vessels; Electrodes therefor
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/4905—Determining clotting time of blood

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Physics & Mathematics (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Physics & Mathematics (AREA)
Biomedical Technology (AREA)
Pathology (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Electrochemistry (AREA)
Ecology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Investigating Or Analysing Biological Materials (AREA)

NO3832/69A 1968-09-27 1969-09-26 NO132851C (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
GB36850/69A GB1299363A (en)	1968-09-27	1968-09-27	Monitoring of chemical, bio-chemical and biological reactions, particularly blood-clotting
GB4614168		1968-09-27
GB4677168		1968-10-02
GB4754068		1968-10-07
GB5155268		1968-10-30

Publications (2)

Publication Number	Publication Date
NO132851B true NO132851B (fr)	1975-10-06
NO132851C NO132851C (fr)	1976-01-14

Family

ID=27516334

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO3832/69A NO132851C (fr)	1968-09-27	1969-09-26

Country Status (12)

Country	Link
US (1)	US3699437A (fr)
AT (1)	AT320864B (fr)
BE (1)	BE739401A (fr)
CH (1)	CH517942A (fr)
FR (1)	FR2019062A1 (fr)
GB (1)	GB1299363A (fr)
IE (1)	IE33584B1 (fr)
IL (1)	IL33080A (fr)
IT (1)	IT942031B (fr)
NL (1)	NL6914627A (fr)
NO (1)	NO132851C (fr)
SE (1)	SE379860B (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3772591A (en) *	1972-04-12	1973-11-13	Fisher Scientific Co	Method and apparatus for analyzing blood properties
JPS5651758B2 (fr) *	1973-04-25	1981-12-08
GB1585067A (en) *	1976-10-19	1981-02-25	Nat Res Dev	Detection of bacterial activity
EP0010374B1 (fr) *	1978-10-02	1984-01-25	The Wellcome Foundation Limited	Procédé et appareil pour mesurer l'agrégation des plaquettes sanguines et cellule de mesure pour ledit procédé et appareil
US4301414A (en) *	1979-10-29	1981-11-17	United States Surgical Corporation	Disposable sample card and method of making same
DE3175570D1 (en) *	1980-03-08	1986-12-11	Japan Tectron Instr Corp	Methods of monitoring micro-organisms and media for culture
DE3337618A1 (de) *	1983-10-15	1985-04-25	Heinz Prof. Dr. 4400 Münster Schröer	Anordnung zur messung der ex-vivo-blutungszeit
GB8621757D0 (en) *	1986-09-10	1986-10-15	Gorog P	Blood testing device
US5174961A (en) *	1991-01-18	1992-12-29	Hemotec, Inc.	High sensitivity coagulation detection apparatus
US5314826A (en) *	1991-08-23	1994-05-24	Medtronic Hemotec, Inc.	Platelet activation and function evaluation technique
US5316730A (en) *	1992-12-07	1994-05-31	Xylum Corporation	Disposable cartridge for investigating physical properties of blood
US5522255A (en)	1993-08-31	1996-06-04	Boehringer Mannheim Corporation	Fluid dose, flow and coagulation sensor for medical instrument
US5526111A (en) *	1993-08-31	1996-06-11	Boehringer Mannheim Corporation	Method and apparatus for calculating a coagulation characteristic of a sample of blood a blood fraction or a control
US5731212A (en) *	1994-12-20	1998-03-24	International Technidyne Corporation	Test apparatus and method for testing cuvette accommodated samples
US5925319A (en)	1996-04-30	1999-07-20	Medtronic, Inc.	Test cartridge for evaluating blood platelet functionality
US6004819A (en) *	1996-11-04	1999-12-21	Xylum Corporation	Blood testing device
WO1998039643A1 (fr) *	1997-03-05	1998-09-11	Diametrics	Procede et appareil de mesure des parametres de coagulation du sang total
US6046051A (en) *	1997-06-27	2000-04-04	Hemosense, Inc.	Method and device for measuring blood coagulation or lysis by viscosity changes
US7021122B1 (en) *	1998-03-19	2006-04-04	Orgenics Biosensors Ltd.	Device for the determination of blood clotting by capacitance or resistance
AU754536B2 (en) *	1998-03-19	2002-11-21	Orgenics Biosensors Ltd.	Device for the determination of blood clotting by capacitance or resistance
US6620310B1 (en) *	2000-12-13	2003-09-16	Lifescan, Inc.	Electrochemical coagulation assay and device
US7144495B2 (en) *	2000-12-13	2006-12-05	Lifescan, Inc.	Electrochemical test strip with an integrated micro-needle and associated methods
GB0030929D0 (en) *	2000-12-19	2001-01-31	Inverness Medical Ltd	Analyte measurement
GB2392724A (en) *	2002-09-06	2004-03-10	Ian Stoakes	Methods of and apparatus for blood analysis
US7291310B2 (en) *	2002-12-17	2007-11-06	The Regents Of The University Of Michigan	Microsystem for determining clotting time of blood and low-cost, single-use device for use therein
WO2005059532A1 (fr) *	2003-12-16	2005-06-30	Dynabyte Informationssysteme Gmbh	Dispositif de cartouche pour analyse de sang
JP2007538257A (ja) *	2004-05-17	2007-12-27	メドトロニック・インコーポレーテッド	ポイント・オブ・ヘパリン測定システム
US7837941B2 (en) *	2006-04-07	2010-11-23	Agamatrix, Inc.	Method and apparatus for monitoring alteration of flow characteristics in a liquid sample
US7674616B2 (en) *	2006-09-14	2010-03-09	Hemosense, Inc.	Device and method for measuring properties of a sample
US20080297169A1 (en) *	2007-05-31	2008-12-04	Greenquist Alfred C	Particle Fraction Determination of A Sample
WO2009046094A1 (fr)	2007-10-01	2009-04-09	Nabsys, Inc.	Séquençage de biopolymère par hybridation de sondes pour former des complexes ternaires et alignement de plage variable
US8882980B2 (en)	2008-09-03	2014-11-11	Nabsys, Inc.	Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en)	2008-09-03	2012-09-11	Nabsys, Inc.	Devices and methods for determining the length of biopolymers and distances between probes bound thereto
US9650668B2 (en)	2008-09-03	2017-05-16	Nabsys 2.0 Llc	Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
DE102008050092A1 (de) *	2008-10-06	2010-04-08	Hach Lange Gmbh	Mobile Wasser-Analyseanordnung
US8455260B2 (en)	2009-03-27	2013-06-04	Massachusetts Institute Of Technology	Tagged-fragment map assembly
ES2694080T3 (es)	2010-06-09	2018-12-17	Apex Biotechnology Corp.	Dispositivo y método para medir el tiempo de protrombina y hematocrito mediante el análisis del cambio de reactancia en una muestra
US8715933B2 (en)	2010-09-27	2014-05-06	Nabsys, Inc.	Assay methods using nicking endonucleases
EP2640849B1 (fr)	2010-11-16	2016-04-06	Nabsys 2.0 LLC	Procédés de séquençage d'une biomolécule par détection de positions relatives de sondes hybridées
WO2012109574A2 (fr)	2011-02-11	2012-08-16	Nabsys, Inc.	Procédés de dosage à l'aide de protéines de liaison à l'adn
US9914966B1 (en)	2012-12-20	2018-03-13	Nabsys 2.0 Llc	Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation
WO2014113557A1 (fr)	2013-01-18	2014-07-24	Nabsys, Inc.	Liaison améliorée d'une sonde
US20150140671A1 (en) *	2013-11-18	2015-05-21	Johnson Electric S.A.	Method and system for assembling a microfluidic sensor
JP2016061731A (ja) *	2014-09-19	2016-04-25	ソニー株式会社	電気的特性測定装置及びプログラム
CN107107057B (zh) *	2014-09-26	2020-12-15	雅培医护站股份有限公司	用于流体样本中的凝结测定的盒设备识别
WO2016049506A1 (fr)	2014-09-26	2016-03-31	Abbott Point Of Care Inc.	Capteurs pour le dosage de la coagulation dans des échantillons de fluides
EP3198270A1 (fr)	2014-09-26	2017-08-02	Abbott Point Of Care, Inc.	Dispositif cartouche avec jonctions fluidiques pour mesures de coagulation dans des échantillons de fluide
EP3198281B1 (fr)	2014-09-26	2023-01-25	Abbott Point Of Care, Inc.	Formulations d'acide ellagique pour une utilisation dans des tests de coagulation
CN106999931B (zh)	2014-09-26	2020-08-18	雅培医护站股份有限公司	具有用于测定流体样本中的凝结的微环境传感器的微制造设备
ES2911898T3 (es)	2014-09-26	2022-05-23	Abbott Point Of Care Inc	Dispositivo de cartucho de canal único para ensayos de coagulación de sangre en muestras de fluidos
FR3043780B1 (fr) *	2015-11-16	2017-12-15	Hospices Civils Lyon	Methode de diagnostic d'anomalies de la coagulation sanguine
CN108318560B (zh) *	2018-01-19	2021-06-04	国力天（深圳）科技有限公司	一种便携式微电极法血液检测仪及其检测方法
US20260007814A1 (en) *	2024-07-08	2026-01-08	Outset Medical, Inc.	Venous access dislodgement detection system and method

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2555937A (en) *	1949-08-25	1951-06-05	Robert L Rosenthal	Method and apparatus for measuring resistance of blood during clotting
GB707914A (en) *	1951-08-28	1954-04-28	Ass Portland Cement	Method and apparatus for measuring the oxygen content in gaseous mixtures
GB781058A (en) *	1952-05-23	1957-08-14	Elliott Brothers London Ltd	Improvements in the continuous measurement and recording of the conductivity of electrolytic solutions
US3524727A (en) *	1965-06-16	1970-08-18	Corning Glass Works	Method and device for determining serological data by an agglomeration test
US3374672A (en) *	1965-07-06	1968-03-26	California Inst Res Found	Flowmeter
US3467862A (en) *	1967-02-20	1969-09-16	Usher Abramovich Vatmakher	Apparatus for recording resistance changes during the entire coagulation process in a biological fluid

1968
- 1968-09-27 GB GB36850/69A patent/GB1299363A/en not_active Expired
1969
- 1969-08-21 US US863411A patent/US3699437A/en not_active Expired - Lifetime
- 1969-09-25 BE BE739401D patent/BE739401A/xx unknown
- 1969-09-25 AT AT908769A patent/AT320864B/de not_active IP Right Cessation
- 1969-09-26 CH CH1459669A patent/CH517942A/de not_active IP Right Cessation
- 1969-09-26 FR FR6932941A patent/FR2019062A1/fr not_active Withdrawn
- 1969-09-26 NL NL6914627A patent/NL6914627A/xx unknown
- 1969-09-26 SE SE6913270A patent/SE379860B/xx unknown
- 1969-09-26 NO NO3832/69A patent/NO132851C/no unknown
- 1969-09-27 IT IT22600/69A patent/IT942031B/it active
- 1969-09-28 IL IL6933080A patent/IL33080A/xx unknown
- 1969-09-29 IE IE1348/69A patent/IE33584B1/xx unknown

Also Published As

Publication number	Publication date
DE1947051B2 (de)	1976-06-24
FR2019062A1 (fr)	1970-06-26
IL33080A0 (en)	1970-02-19
AT320864B (de)	1975-03-10
CH517942A (de)	1972-01-15
US3699437A (en)	1972-10-17
BE739401A (fr)	1970-03-02
SE379860B (fr)	1975-10-20
IE33584B1 (en)	1974-08-21
IL33080A (en)	1973-06-29
IT942031B (it)	1973-03-20
DE1947051A1 (de)	1970-06-11
NO132851C (fr)	1976-01-14
GB1299363A (en)	1972-12-13
IE33584L (en)	1970-03-27
NL6914627A (fr)	1970-04-01

Publication	Publication Date	Title
US3699437A (en)	1972-10-17	Blood coagulation detection method and apparatus
Cardinal et al.	1980	The electronic aggregometer: a novel device for assessing platelet behavior in blood
US3720097A (en)	1973-03-13	Apparatus and method for measuring mammalian blood viscosity
JP6442858B2 (ja)	2018-12-26	血液状態解析装置、血液状態解析システム、血液状態解析方法、および該方法をコンピューターに実現させるための血液状態解析プログラム
US3674012A (en)	1972-07-04	Blood coagulation detection device
CA1140212A (fr)	1983-01-25	Methode et appareil utilises pour surveiller l'agregation plaquettaire et module d'essai
JP7070641B2 (ja)	2022-05-18	血小板凝集能解析装置、血小板凝集能解析システム、血小板凝集能解析用プログラム及び血小板凝集能の解析方法
Von Kaulla et al.	1975	The impedance machine: a new bedside coagulation recording device
JP6579100B2 (ja)	2019-09-25	血液状態解析装置、血液状態解析システム、血液状態解析方法、及び該方法をコンピューターに実現させるための血液状態解析プログラム
US3840806A (en)	1974-10-08	Instrument for measuring blood clotting times
Alexy et al.	2005	An automated tube‐type blood viscometer: Validation studies
AU2954399A (en)	1999-10-11	Device for the determination of blood clotting by capacitance or resistance
KR101745478B1 (ko)	2017-06-09	적혈구 침강 속도 측정 장치 및 측정 방법
Dormandy	1981	Measurement of whole-blood viscosity
JP6747491B2 (ja)	2020-08-26	血液状態解析装置、血液状態解析システム、血液状態解析方法、および該方法をコンピューターに実現させるための血液状態解析プログラム
JP7230429B2 (ja)	2023-03-01	血小板凝集能解析装置、血小板凝集能解析方法及び血小板凝集能解析システム
JP6973585B2 (ja)	2021-12-01	血小板凝集能解析方法、血小板凝集能解析装置、血小板凝集能解析用プログラム及び血小板凝集能解析システム
Fort et al.	2024	A Measurement System for the Dynamic Assessment of Blood Clot Permeability
WO2013164676A1 (fr)	2013-11-07	Procédé pour analyser le processus de formation d'amas dans un fluide biologique et appareil d'analyse correspondant
US10816493B2 (en)	2020-10-27	Electrical measurement method, electrical measurement device, and blood condition analysis system
WO2018066207A1 (fr)	2018-04-12	Procédé d'analyse de la capacité d'agrégation des plaquettes, dispositif, programme, et système d'analyse de la capacité d'agrégation des plaquettes associés
SU667200A1 (ru)	1979-06-15	Способ диагностики инфаркта миокарда
Zahavi et al.	1970	A method for automatic recording of the osmotic fragility of blood platelets
Kiesewetter et al.	1982	Determination of hematocrit by measuring the impedance.