NO133774B - - Google Patents

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Info

Publication number: NO133774B
Authority: NO; Norway
Prior art keywords: testosterone; chloral; plate; hemiacetal; damper
Prior art date: 1971-01-29

Application number

NO214/72A

Other languages

English (en)

Norwegian (no)

Other versions

NO133774C (fr

Inventor

G A De Lepeleire

Original Assignee

Danfoss As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1971-01-29

Filing date

1972-01-28

Publication date

1976-03-15

1972-01-28 Application filed by Danfoss As filed Critical Danfoss As

1976-03-15 Publication of NO133774B publication Critical patent/NO133774B/no

1976-06-23 Publication of NO133774C publication Critical patent/NO133774C/no

Links

239000012530 fluid Substances 0.000 claims 4
230000001105 regulatory effect Effects 0.000 claims 1
MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 19
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
238000002844 melting Methods 0.000 description 13
230000008018 melting Effects 0.000 description 13
239000000243 solution Substances 0.000 description 13
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
241001465754 Metazoa Species 0.000 description 10
229960003604 testosterone Drugs 0.000 description 10
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 9
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 9
239000000203 mixture Substances 0.000 description 9
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 8
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 8
239000007900 aqueous suspension Substances 0.000 description 8
230000000694 effects Effects 0.000 description 7
WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
150000002148 esters Chemical class 0.000 description 6
238000000034 method Methods 0.000 description 6
239000002245 particle Substances 0.000 description 5
238000001953 recrystallisation Methods 0.000 description 5
HFFLGKNGCAIQMO-UHFFFAOYSA-N trichloroacetaldehyde Chemical compound ClC(Cl)(Cl)C=O HFFLGKNGCAIQMO-UHFFFAOYSA-N 0.000 description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 4
XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 4
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
PYHZLMFTKOTWGQ-WAUHAFJUSA-N [(8r,9s,10r,13s,14s,17s)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl] 2-methylpropanoate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)C(C)C)[C@@]1(C)CC2 PYHZLMFTKOTWGQ-WAUHAFJUSA-N 0.000 description 4
150000001875 compounds Chemical class 0.000 description 4
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 4
239000007787 solid Substances 0.000 description 4
239000000725 suspension Substances 0.000 description 4
241000700159 Rattus Species 0.000 description 3
PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 description 3
238000002347 injection Methods 0.000 description 3
239000007924 injection Substances 0.000 description 3
KQNPFQTWMSNSAP-UHFFFAOYSA-N isobutyric acid Chemical compound CC(C)C(O)=O KQNPFQTWMSNSAP-UHFFFAOYSA-N 0.000 description 3
210000002307 prostate Anatomy 0.000 description 3
239000011343 solid material Substances 0.000 description 3
229960001712 testosterone propionate Drugs 0.000 description 3
238000002211 ultraviolet spectrum Methods 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
239000004342 Benzoyl peroxide Substances 0.000 description 2
OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 2
125000002252 acyl group Chemical group 0.000 description 2
239000003098 androgen Substances 0.000 description 2
230000001548 androgenic effect Effects 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
235000019400 benzoyl peroxide Nutrition 0.000 description 2
RNFNDJAIBTYOQL-UHFFFAOYSA-N chloral hydrate Chemical compound OC(O)C(Cl)(Cl)Cl RNFNDJAIBTYOQL-UHFFFAOYSA-N 0.000 description 2
229960002327 chloral hydrate Drugs 0.000 description 2
239000013078 crystal Substances 0.000 description 2
210000004907 gland Anatomy 0.000 description 2
150000002373 hemiacetals Chemical class 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
239000012074 organic phase Substances 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
-1 testosterone chloral hemiacetal Chemical class 0.000 description 2
150000003515 testosterones Chemical class 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
239000007832 Na2SO4 Substances 0.000 description 1
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 1
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 1
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
150000001241 acetals Chemical class 0.000 description 1
239000002253 acid Substances 0.000 description 1
230000001195 anabolic effect Effects 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000008346 aqueous phase Substances 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000012065 filter cake Substances 0.000 description 1
235000019253 formic acid Nutrition 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
230000000977 initiatory effect Effects 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
LSACYLWPPQLVSM-UHFFFAOYSA-N isobutyric acid anhydride Chemical compound CC(C)C(=O)OC(=O)C(C)C LSACYLWPPQLVSM-UHFFFAOYSA-N 0.000 description 1
239000003589 local anesthetic agent Substances 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
239000000047 product Substances 0.000 description 1
WYVAMUWZEOHJOQ-UHFFFAOYSA-N propionic anhydride Chemical compound CCC(=O)OC(=O)CC WYVAMUWZEOHJOQ-UHFFFAOYSA-N 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1

Classifications

- G—PHYSICS
- G05—CONTROLLING; REGULATING
- G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
- G05D7/00—Control of flow
- G05D7/01—Control of flow without auxiliary power
- G05D7/0173—Control of flow without auxiliary power using pivoting sensing element acting as a valve mounted within the flow-path
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F24—HEATING; RANGES; VENTILATING
- F24F—AIR-CONDITIONING; AIR-HUMIDIFICATION; VENTILATION; USE OF AIR CURRENTS FOR SCREENING
- F24F11/00—Control or safety arrangements
- F24F11/70—Control systems characterised by their outputs; Constructional details thereof
- F24F11/72—Control systems characterised by their outputs; Constructional details thereof for controlling the supply of treated air, e.g. its pressure
- F24F11/74—Control systems characterised by their outputs; Constructional details thereof for controlling the supply of treated air, e.g. its pressure for controlling air flow rate or air velocity
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K1/00—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces
- F16K1/16—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members
- F16K1/18—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps
- F16K1/20—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps with axis of rotation arranged externally of valve member
- F16K1/2007—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps with axis of rotation arranged externally of valve member specially adapted operating means therefor
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K1/00—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces
- F16K1/16—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members
- F16K1/18—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps
- F16K1/20—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps with axis of rotation arranged externally of valve member
- F16K1/2021—Lift valves or globe valves, i.e. cut-off apparatus with closure members having at least a component of their opening and closing motion perpendicular to the closing faces with pivoted closure-members with pivoted discs or flaps with axis of rotation arranged externally of valve member with a plurality of valve members

Landscapes

Engineering & Computer Science (AREA)
General Engineering & Computer Science (AREA)
Mechanical Engineering (AREA)
Physics & Mathematics (AREA)
Fluid Mechanics (AREA)
Chemical & Material Sciences (AREA)
Combustion & Propulsion (AREA)
Automation & Control Theory (AREA)
General Physics & Mathematics (AREA)
Measuring Fluid Pressure (AREA)
Examining Or Testing Airtightness (AREA)
Lift Valve (AREA)
Diaphragms And Bellows (AREA)
Air-Flow Control Members (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Basic Packing Technique (AREA)

NO214/72A 1971-01-29 1972-01-28 NO133774C (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
LU62512		1971-01-29

Publications (2)

Publication Number	Publication Date
NO133774B true NO133774B (fr)	1976-03-15
NO133774C NO133774C (fr)	1976-06-23

Family

ID=19726608

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO214/72A NO133774C (fr)	1971-01-29	1972-01-28

Country Status (9)

Country	Link
JP (1)	JPS5614910B1 (fr)
AU (1)	AU471691B2 (fr)
BR (1)	BR7200475D0 (fr)
CA (1)	CA961690A (fr)
ES (2)	ES399272A1 (fr)
FI (1)	FI55712C (fr)
LU (1)	LU62512A1 (fr)
NO (1)	NO133774C (fr)
SE (1)	SE377837B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4643353A (en) *	1985-02-19	1987-02-17	Anemostat Products Division, Dynamics Corp.	Air conditioning control system with enhanced operating range
SE458802B (sv) *	1987-04-03	1989-05-08	Stifab Ab	Regleranordning foer instaellning av ett spjaell i en ventilationskanal
BR9007823A (pt) *	1989-11-10	1992-09-01	Commw Of Australia	Acionador a gas para girar um elemento e um alvo de tiro com porta incorporada ao mesmo

1971
- 1971-01-29 LU LU62512D patent/LU62512A1/xx unknown
- 1971-08-27 CA CA121,631A patent/CA961690A/en not_active Expired
1972
- 1972-01-28 BR BR475/72A patent/BR7200475D0/pt unknown
- 1972-01-28 SE SE7200998A patent/SE377837B/xx unknown
- 1972-01-28 NO NO214/72A patent/NO133774C/no unknown
- 1972-01-28 FI FI229/72A patent/FI55712C/fi active
- 1972-01-28 AU AU38448/72A patent/AU471691B2/en not_active Expired
- 1972-01-28 ES ES399272A patent/ES399272A1/es not_active Expired
- 1972-01-29 JP JP1093172A patent/JPS5614910B1/ja active Pending
1974
- 1974-06-17 ES ES1974204104U patent/ES204104Y/es not_active Expired

Also Published As

Publication number	Publication date
FI55712B (fi)	1979-05-31
ES399272A1 (es)	1975-05-01
LU62512A1 (fr)	1972-08-23
JPS5614910B1 (fr)	1981-04-07
BR7200475D0 (pt)	1973-06-12
SE377837B (fr)	1975-07-28
FI55712C (fi)	1979-09-10
AU471691B2 (en)	1973-08-02
ES204104Y (es)	1976-05-01
CA961690A (en)	1975-01-28
ES204104U (es)	1976-01-16
AU3844872A (en)	1973-08-02
NO133774C (fr)	1976-06-23

Publication	Publication Date	Title
DE2323215C3 (de)	1978-03-30	Pregna-l,4-dien-ll-ol-3,20-dione, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel
US3266991A (en)	1966-08-16	Pharmaceutical preparations of 1-dehydro-testosterone undecyclenate
US3318926A (en)	1967-05-09	7alpha-methyl-16alpha-hydroxy-estrones
DE2007417A1 (de)	1970-09-03	Ein neues Oestratriol und ein Verfahren zu dessen Herstellung
DE2932607A1 (de)	1980-02-21	Chlorambucilderivate, verfahren zur herstellung derselben und antitumormittel mit einem gehalt derselben
NO132558B (fr)	1975-08-18
DD146296A5 (de)	1981-02-04	Verfahren zur herstellung von kortikoid-21-sulfopropionaten
NO133774B (fr)	1976-03-15
US3485852A (en)	1969-12-23	6-halo-6-dehydro-progesterones
US2933514A (en)	1960-04-19	New derivatives of testosterone
US3856829A (en)	1974-12-24	16{62 -hydrocarbon substituted estrane compounds
US3373157A (en)	1968-03-12	6, 6-ethylene-19 nortestosterones
US3483235A (en)	1969-12-09	New oestratrienes and process for their manufacture
US3904599A (en)	1975-09-09	Cardenolide-3-(2'-desoxy-glycosides)+0 and process for their manufacture
DE1947221A1 (de)	1970-04-16	3-Aza-19-hydroxy-3,19-cyclo-A-homosteroide und ein Verfahren zu deren Herstellung
US3738984A (en)	1973-06-12	14,15-beta-epoxycardenolides
US3128291A (en)	1964-04-07	New hemiacetals and hemicaetal esters of the androstane series and a method for their production
US3708503A (en)	1973-01-02	A-homo-delta'(10),2,4a(5)-3-substituted-estratrien-4-ones
AT275054B (de)	1969-10-10	Verfahren zur Herstellung von neuen 9β,10α-Steroiden
US2992244A (en)	1961-07-11	2 alpha-methyl-9 alpha-fluoro-11 beta-17 alpha-dihydroxy-4-pregnene-3, 20-dione 17-acylates
DE1468988B1 (de)	1971-11-25	17alpha-Chloraethinyl-13beta-aethyl-4- oder -5(10)-gonen-3-ketone
US3043855A (en)	1962-07-10	16-ethers of 16, 17-dihydroxy steroids of the pregnane series
US3161663A (en)	1964-12-15	Novel 17-desoxy-delta1, 4-pregnadienes and preparation thereof
US3624077A (en)	1971-11-30	1,4-PREGNADIENE-11B-HYDROXY-(17a,16a-d)-2{40 -ALKYLOXA-ZOLINES
US2847428A (en)	1958-08-12	Pregnan-2-oil-3, 20-dione, allopregnan-2-ol-3, 20-dione, esters thereof, and preparation thereof