NO141892C - Fremgangsmaate ved fremstilling av 5-fluor-2-methyl-1-(p-methylsulfinylbenzyliden)-inden-3-eddiksyre - Google Patents

Fremgangsmaate ved fremstilling av 5-fluor-2-methyl-1-(p-methylsulfinylbenzyliden)-inden-3-eddiksyre

Info

Publication number
NO141892C
NO141892C NO790360A NO790360A NO141892C NO 141892 C NO141892 C NO 141892C NO 790360 A NO790360 A NO 790360A NO 790360 A NO790360 A NO 790360A NO 141892 C NO141892 C NO 141892C
Authority
NO
Norway
Prior art keywords
methylsulphinylbenzylide
inden
fluoro
methyl
preparing
Prior art date
Application number
NO790360A
Other languages
English (en)
Other versions
NO141892B (no
NO790360L (no
Inventor
Roger James Tull
Robert Francis Czaja
Richard Ferriss Shuman
Seemon Hayden Pines
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US426864A external-priority patent/US3870753A/en
Priority claimed from US05/486,031 external-priority patent/US3970693A/en
Priority claimed from US05/509,602 external-priority patent/US3944600A/en
Publication of NO790360L publication Critical patent/NO790360L/no
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of NO141892B publication Critical patent/NO141892B/no
Publication of NO141892C publication Critical patent/NO141892C/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/455Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/75Reactions with formaldehyde
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/54Quaternary phosphonium compounds
    • C07F9/5456Arylalkanephosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO790360A 1973-12-20 1979-02-05 Fremgangsmaate ved fremstilling av 5-fluor-2-methyl-1-(p-methylsulfinylbenzyliden)-inden-3-eddiksyre NO141892C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US426864A US3870753A (en) 1973-12-20 1973-12-20 Process for preparing indenyl acetic acids
US05/486,031 US3970693A (en) 1974-07-05 1974-07-05 Process for preparing indene acetic acids
US05/509,602 US3944600A (en) 1973-12-20 1974-09-30 Indenylidene-3-acetic acid process for preparing indene acetic acids

Publications (3)

Publication Number Publication Date
NO790360L NO790360L (no) 1975-06-23
NO141892B NO141892B (no) 1980-02-18
NO141892C true NO141892C (no) 1980-05-28

Family

ID=27411527

Family Applications (2)

Application Number Title Priority Date Filing Date
NO744395A NO140857C (no) 1973-12-20 1974-12-05 Fremgangsmaate ved fremstilling av 5-fluor-2-methyl-1-(p-methylsulfinylbenxyliden)-inden-3-eddiksyre
NO790360A NO141892C (no) 1973-12-20 1979-02-05 Fremgangsmaate ved fremstilling av 5-fluor-2-methyl-1-(p-methylsulfinylbenzyliden)-inden-3-eddiksyre

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO744395A NO140857C (no) 1973-12-20 1974-12-05 Fremgangsmaate ved fremstilling av 5-fluor-2-methyl-1-(p-methylsulfinylbenxyliden)-inden-3-eddiksyre

Country Status (16)

Country Link
JP (1) JPS5331153B2 (no)
AR (2) AR210484A1 (no)
CA (1) CA1044255A (no)
CH (1) CH616152A5 (no)
DD (1) DD116819A5 (no)
DE (1) DE2462380C2 (no)
DK (1) DK140835B (no)
ES (2) ES432921A1 (no)
FI (1) FI62287C (no)
FR (1) FR2255060B1 (no)
GB (1) GB1479519A (no)
IE (1) IE41529B1 (no)
NL (1) NL170534C (no)
NO (2) NO140857C (no)
SE (2) SE426818B (no)
YU (2) YU41017B (no)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3732292A (en) * 1970-05-01 1973-05-08 Merck & Co Inc Indenyl compounds
NL7200058A (no) * 1971-01-21 1972-07-25
US3822310A (en) * 1971-01-21 1974-07-02 Merck & Co Inc Substituted indenyl acetic acids

Also Published As

Publication number Publication date
AR206334A1 (es) 1976-07-15
FI62287B (fi) 1982-08-31
DK140835B (da) 1979-11-26
SE8107702L (sv) 1981-12-22
FI62287C (fi) 1982-12-10
YU331674A (en) 1982-02-28
CA1044255A (en) 1978-12-12
DE2462380C2 (de) 1982-11-11
NO141892B (no) 1980-02-18
DE2460292B2 (de) 1977-06-16
GB1479519A (en) 1977-07-13
FR2255060B1 (no) 1978-07-21
DK629674A (no) 1975-08-25
JPS5331153B2 (no) 1978-08-31
NL7415701A (nl) 1975-06-24
NO140857B (no) 1979-08-20
SE426818B (sv) 1983-02-14
YU55981A (en) 1982-06-30
FI348974A7 (no) 1975-06-21
DK140835C (no) 1980-04-28
IE41529L (en) 1975-06-20
AU7623674A (en) 1976-06-10
DD116819A5 (no) 1975-12-12
CH616152A5 (en) 1980-03-14
NL170534B (nl) 1982-06-16
NO744395L (no) 1975-07-14
YU41017B (en) 1986-10-31
DE2460292A1 (de) 1975-06-26
NO790360L (no) 1975-06-23
ES455333A1 (es) 1978-05-01
AR210484A1 (es) 1977-08-15
FR2255060A1 (no) 1975-07-18
DE2462380A1 (de) 1977-02-10
SE7415063L (sv) 1975-06-23
JPS5095254A (no) 1975-07-29
IE41529B1 (en) 1980-01-30
SE440774B (sv) 1985-08-19
NO140857C (no) 1979-11-28
ES432921A1 (es) 1977-03-16
NL170534C (nl) 1982-11-16

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