NO143128B - PROCEDURE FOR INSULATING HEMAGGLUTIN AND NEURAMINIDASE INGREDIENTS FROM AN INFLUENCE VIRUS - Google Patents
PROCEDURE FOR INSULATING HEMAGGLUTIN AND NEURAMINIDASE INGREDIENTS FROM AN INFLUENCE VIRUS Download PDFInfo
- Publication number
- NO143128B NO143128B NO750031A NO750031A NO143128B NO 143128 B NO143128 B NO 143128B NO 750031 A NO750031 A NO 750031A NO 750031 A NO750031 A NO 750031A NO 143128 B NO143128 B NO 143128B
- Authority
- NO
- Norway
- Prior art keywords
- sections
- grid
- air
- curved
- neuraminidase
- Prior art date
Links
- 102000005348 Neuraminidase Human genes 0.000 title abstract 2
- 108010006232 Neuraminidase Proteins 0.000 title abstract 2
- 241000700605 Viruses Species 0.000 title 1
- 239000004615 ingredient Substances 0.000 title 1
- 238000004378 air conditioning Methods 0.000 claims description 6
- 101710154606 Hemagglutinin Proteins 0.000 abstract 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 abstract 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 abstract 1
- 101710176177 Protein A56 Proteins 0.000 abstract 1
- 239000000185 hemagglutinin Substances 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
- 238000009792 diffusion process Methods 0.000 description 4
- 230000004323 axial length Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002775 capsule Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Detergent Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
Fremgangsmåte til isolering av hemagglutinin-og neuraminidase-bestanddeler fra et influensa-virus .Method for isolating hemagglutinin and neuraminidase components from an influenza virus.
Description
Gitter for luftfordeler. Grids for air distributors.
Denne oppfinnelse vedrører et gitter eller en rist for en luftfordeler av den type som omfatter et gitter med i hovedsaken buet avgangsside anordnet til å være montert på den ene ende av en lufttilførsels-kanal eller til å danne en del av et luft-kondisjoner ingssystem, og slike luftforde-lere vil i det følgende tole referert til som en luftfordeler av den angitte type. This invention relates to a grid or a grid for an air distributor of the type comprising a grid with a substantially curved exit side arranged to be mounted on one end of an air supply duct or to form part of an air conditioning system, and such air distributors will hereinafter be referred to as an air distributor of the specified type.
Hastigheten av luft som strømmer ut fra en luftfordeler av den nevnte type kan være vesentlig redusert og en høy grad av diffusjon og fordeling av luften erholdt ved å sørge for at gitteret har et forholds-vis stort antall dyser eller munnstykker hvis akser divergerer 1 forhold til "hverandre. For å oppnå denne høye grad av diffusjon og reduksjonen i lufthastighet når gitterets utløpsside er plan vil aksene -for dysene ved motstående sidepartier av gitteret danne en betydelig vinkel med en linje i rett vinkel på gitterets utløpsside. Dette forårsaker betydelige vanskeligheter ved fabrikasjonen av et tilfredsstillende gitter. Hvis f. eks. vinklene mellom tilgrensende dyser ikke er omsorgsfullt beregnet og dysene plassert for å gi en bred og jevnt adskilt spredning av luften som passerer ut av fordeleren vil luften strømme ut av fordeleren i en praktisk talt konsentrert blåst eller stråle og den ønskede diffusjon vil således ikke være oppnådd. The speed of air flowing out from an air distributor of the aforementioned type can be significantly reduced and a high degree of diffusion and distribution of the air obtained by ensuring that the grid has a relatively large number of nozzles or nozzles whose axes diverge 1 in relation to "each other. In order to achieve this high degree of diffusion and the reduction in air velocity when the outlet side of the grille is flat, the axes - of the nozzles at opposite side portions of the grille form a significant angle with a line at right angles to the outlet side of the grille. This causes considerable difficulties in fabrication of a satisfactory grid. If, for example, the angles between adjacent nozzles are not carefully calculated and the nozzles positioned to give a wide and evenly spaced spread of the air passing out of the distributor, the air will flow out of the distributor in a practically concentrated blast or beam and the desired diffusion will thus not be achieved.
For å bortrydde disse vanskeligheter ved foreliggende oppfinnelse er det til en begynnelse foreslått å bue gitterets utgangsside med dysene forløpende radielt gjennom det buede gitter. En fordel med et slikt buet gitter er at det kan fremstilles av en sammenstilling av identisk buede seksjoner som hver har identisk plasserte dyser. Bruken av et passende buet gitter reiser Imidlertid noen andre vanskeligheter fordi det ikke lett kan monteres" i en lufttilførselskanal eller et luftkondlsjo-nerlngssystem på grunn av gitterets frem-skytende midtparti eller <Jen overdrevne nedtrykning av dets sider. In order to eliminate these difficulties with the present invention, it is initially proposed to curve the output side of the grid with the nozzles extending radially through the curved grid. An advantage of such a curved grid is that it can be made from an assembly of identically curved sections, each of which has identically positioned nozzles. However, the use of a suitable curved grille raises some other difficulties because it cannot be easily mounted in an air supply duct or an air conditioning system due to the projecting central portion of the grille or the excessive depression of its sides.
Et formål med foreliggende oppfinnelse er å tilveiebringe for en luftfordeler av den angitte type et gitter som vil tillate en reduksjon i hastigheten av luften som strømmer ut fra samme, en høy grad av diffusjon a-v denne luft og lett montering av fordeleren på en lufttilførselskanal eller i et luftkondisj oneringssystem uten overdreven fremstikning eller nedpresning av partier av gitteret. An object of the present invention is to provide for an air distributor of the indicated type a grid which will allow a reduction in the speed of the air flowing out from the same, a high degree of diffusion a-v this air and easy mounting of the distributor on an air supply duct or in an air conditioning system without excessive pressing or pressing down of parts of the grid.
Ifølge oppfinnelsen er det for en luftfordeler av den nevnte type anordnet et gitter omfattende et antall seksjoner av hvilke hver har en buet utgangsside og et antall dyser hvis akser står praktisk talt i rett vinkel med utgangssiden, idet seksjonene er forbundet innbyrdes i avtrappet forhold med hverandre slik at gitteret som et hele har redusert projeksj onsdybden i retning av luftbevegelsen gj ennom gitteret. According to the invention, an air distributor of the aforementioned type is provided with a grid comprising a number of sections, each of which has a curved exit side and a number of nozzles whose axes are practically at right angles to the exit side, the sections being interconnected in a staggered relationship with each other so that the grid as a whole has reduced the projection depth in the direction of the air movement through the grid.
En utførelsesform for oppfinnelsen er som eksempel gjengitt på tegningene hvor fig. 1 viser et frontriss av et luftfordeler-gitter ifølge oppfinnelsen og fig. 2 er et snitt etter linjen A—A i fig. 1. An embodiment of the invention is shown as an example in the drawings where fig. 1 shows a front view of an air distributor grille according to the invention and fig. 2 is a section along the line A—A in fig. 1.
Tegningene viser en form for et luft-•fordelergitter ifølge oppfinnelsen bestemt for montering på den ene ende av en luft-tilførselskanal eller til å danne en del av et luftkondlsjoneringssystem. Gitteret er montert i en .kapsel 10 og omfatter et antall, i dette tilfelle fire buepartier av sy-lindriske seksjoner 11, 12, 13, 14. Disse seksjoner er alle identiske, hvilket menes at gitrene kan fremstilles enkelt og billig av seksjoner fremstilt i en eller flere identiske stanser. The drawings show a form of an air distribution grid according to the invention intended for mounting on one end of an air supply duct or to form part of an air conditioning system. The grid is mounted in a capsule 10 and comprises a number, in this case four arc sections, of cylindrical sections 11, 12, 13, 14. These sections are all identical, which means that the grids can be produced simply and cheaply from sections produced in one or more identical punches.
Hver seksjon har et antall gjennom samme gående dyser 1 form av med ilk avstand fra hverandre anordnede slisser 15 og en ende av hver seksj on ender i en halv sliss og den annen ende har et knektparti 16 til bruk for å forbinde tilgrensende seksjoner, idet knektpartiene av seksjonene som skal forenes passer inn i hverandre. Each section has a number of passing through the same nozzles 1 in the form of slots 15 arranged at equal distances from each other and one end of each section ends in a half slot and the other end has a jack part 16 for use to connect adjacent sections, the jack parts of the sections to be joined fit into each other.
Slissene 15 strekker seg nadielt gjennom de buede seksjoner, men krumningen av hver seksjon er liten slik at slissenes akser står praktisk talt i rett vinkel på de respektive gitterseksjoners utgangsside. The slits 15 extend evenly through the curved sections, but the curvature of each section is small so that the axes of the slits are practically at right angles to the output side of the respective grid sections.
De fire buede seksjoner er innbyrdes forbundet til å danine et gitter, som vist i fig. 2, som er festet til huset 10 som kan tilpasses iuftkanalen eller luftkondisjone-ringssystemet, etter som tilfellet kan være. Et system av ledeplater eller deflektorer kan anordnes i kanalen for å lede luften mot gitteret. Hver av sideseksjonene 11, 14 har fast pasning med de respektive tilgrensende midtseksjoner ved hjelp av knektpartiene 16 og de to midtseksjoner støter sammen for å danne et kontinuerlig buet gitterparti. Disse to midtseksjoner 12, 13 er trappeformet bakover i forhold til sideseksjonene hvilket sikrer at gitteret som et hele har en redusert produksjonsdybde i retning av luftbevegelsen uten at noen overdreven nedpresning innad av gitterets sider blir nødvendig. The four curved sections are interconnected to form a grid, as shown in fig. 2, which is attached to the housing 10 which can be adapted to the air duct or the air conditioning system, as the case may be. A system of baffles or deflectors can be arranged in the duct to direct the air towards the grid. Each of the side sections 11, 14 has a fixed fit with the respective adjacent middle sections by means of the jack portions 16 and the two middle sections butt together to form a continuous curved lattice portion. These two middle sections 12, 13 are step-shaped backwards in relation to the side sections, which ensures that the grid as a whole has a reduced production depth in the direction of the air movement without any excessive inward pressing of the grid's sides becoming necessary.
Den aksiale lengde av hver dyse eller sliss 15 er foftrinsvis praktisk talt den samme som bredden for derved å sikre strøm-ning av luften i en aksial retning gjennom slissen. The axial length of each nozzle or slot 15 is preferably practically the same as the width in order thereby to ensure flow of the air in an axial direction through the slot.
I modifikasjoner kan gitterseksjonene være en del av en kule. Videre kan dysene ha sirkulært snitt i hvilket tilfelle den aksiale lengde av hver dyse praktisk talt er lik dens diameter for å sikre aksial strøm-ning av luft gjennom dysen. Gitteret er fortrinsvis fremstilt av et syntetisk har-piksmateriale enskjønt metalldeler også kan være inkorporert. In modifications, the lattice sections may be part of a sphere. Furthermore, the nozzles may have a circular section in which case the axial length of each nozzle is practically equal to its diameter to ensure axial flow of air through the nozzle. The grid is preferably made from a synthetic resin material, although metal parts can also be incorporated.
Claims (2)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH44774A CH589453A5 (en) | 1974-01-14 | 1974-01-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO750031L NO750031L (en) | 1975-08-11 |
| NO143128B true NO143128B (en) | 1980-09-15 |
| NO143128C NO143128C (en) | 1980-12-29 |
Family
ID=4187233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO750031A NO143128C (en) | 1974-01-14 | 1975-01-06 | PROCEDURE FOR INSULATING HEMAGGLUTIN AND NEURAMINIDASE INGREDIENTS FROM AN INFLUENCE VIRUS |
Country Status (27)
| Country | Link |
|---|---|
| JP (2) | JPS58407B2 (en) |
| AT (1) | AT345449B (en) |
| AU (1) | AU500250B2 (en) |
| BE (1) | BE824372A (en) |
| CA (1) | CA1049406A (en) |
| CH (1) | CH589453A5 (en) |
| CS (1) | CS191254B2 (en) |
| DD (1) | DD116239A5 (en) |
| DE (1) | DE2500785B2 (en) |
| DK (1) | DK140003B (en) |
| ES (1) | ES433759A1 (en) |
| FI (1) | FI54053C (en) |
| FR (1) | FR2257305B1 (en) |
| GB (1) | GB1498261A (en) |
| HK (1) | HK56380A (en) |
| HU (1) | HU173920B (en) |
| IE (1) | IE40794B1 (en) |
| IL (1) | IL46426A (en) |
| MY (1) | MY8100204A (en) |
| NL (1) | NL166622C (en) |
| NO (1) | NO143128C (en) |
| PH (1) | PH14458A (en) |
| PL (1) | PL93689B1 (en) |
| SE (1) | SE427238B (en) |
| SU (1) | SU616997A3 (en) |
| YU (1) | YU41289B (en) |
| ZA (1) | ZA75259B (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2829089A1 (en) * | 1977-07-13 | 1979-02-01 | Sandoz Ag | SUBUNIT VACCINE |
| JPH0688911B2 (en) * | 1985-06-06 | 1994-11-09 | 国立予防衛生研究所長 | Influenza vaccine and method for producing the same |
| TW570803B (en) * | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
| EP0919243A1 (en) | 1997-11-25 | 1999-06-02 | Duphar International Research B.V | Vaccine containing B subunits of heat-labile enterotoxin (LTB) of Escherichia coli as an adjuvant |
| DE19938767C2 (en) * | 1999-08-16 | 2002-10-24 | Tad Pharma Gmbh | subunit vaccines |
| WO2007052163A2 (en) * | 2005-11-01 | 2007-05-10 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Cell-derived viral vaccines with low levels of residual cell dna by beta-propiolactone treatment |
| SG10201404101RA (en) * | 2007-08-28 | 2014-09-26 | Baxter Int | Method For Producing Viral Vaccines |
| AU2014350370B2 (en) | 2013-11-15 | 2017-04-13 | Novartis Ag | Removal of residual cell culture impurities |
-
1974
- 1974-01-14 CH CH44774A patent/CH589453A5/xx not_active IP Right Cessation
-
1975
- 1975-01-06 DK DK1475AA patent/DK140003B/en not_active IP Right Cessation
- 1975-01-06 NO NO750031A patent/NO143128C/en unknown
- 1975-01-06 FI FI750014A patent/FI54053C/en not_active IP Right Cessation
- 1975-01-07 SE SE7500130A patent/SE427238B/en not_active IP Right Cessation
- 1975-01-10 DE DE2500785A patent/DE2500785B2/en active Granted
- 1975-01-10 NL NL7500301.A patent/NL166622C/en not_active IP Right Cessation
- 1975-01-13 PH PH16702A patent/PH14458A/en unknown
- 1975-01-13 ES ES433759A patent/ES433759A1/en not_active Expired
- 1975-01-13 PL PL1975177303A patent/PL93689B1/pl unknown
- 1975-01-13 AT AT21475A patent/AT345449B/en not_active IP Right Cessation
- 1975-01-13 HU HU75SA2736A patent/HU173920B/en not_active IP Right Cessation
- 1975-01-13 IE IE59/75A patent/IE40794B1/en unknown
- 1975-01-13 GB GB1290/75A patent/GB1498261A/en not_active Expired
- 1975-01-13 CA CA217,790A patent/CA1049406A/en not_active Expired
- 1975-01-13 IL IL46426A patent/IL46426A/en unknown
- 1975-01-13 DD DD183614A patent/DD116239A5/xx unknown
- 1975-01-13 YU YU58/75A patent/YU41289B/en unknown
- 1975-01-14 ZA ZA00750259A patent/ZA75259B/en unknown
- 1975-01-14 CS CS75255A patent/CS191254B2/en unknown
- 1975-01-14 SU SU752101722A patent/SU616997A3/en active
- 1975-01-14 JP JP50006975A patent/JPS58407B2/en not_active Expired
- 1975-01-14 BE BE152368A patent/BE824372A/en not_active IP Right Cessation
- 1975-01-14 FR FR7501007A patent/FR2257305B1/fr not_active Expired
- 1975-01-14 AU AU77305/75A patent/AU500250B2/en not_active Expired
-
1980
- 1980-10-09 HK HK563/80A patent/HK56380A/en unknown
-
1981
- 1981-01-29 JP JP56012831A patent/JPS6035326B2/en not_active Expired
- 1981-12-30 MY MY204/81A patent/MY8100204A/en unknown
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