NO155491B - Analogifremgangsmaate ved fremstilling av terapeutisk aktive, substiuerte 4-hydroxytetrahydropyran-2-oner. - Google Patents
Analogifremgangsmaate ved fremstilling av terapeutisk aktive, substiuerte 4-hydroxytetrahydropyran-2-oner. Download PDFInfo
- Publication number
- NO155491B NO155491B NO802431A NO802431A NO155491B NO 155491 B NO155491 B NO 155491B NO 802431 A NO802431 A NO 802431A NO 802431 A NO802431 A NO 802431A NO 155491 B NO155491 B NO 155491B
- Authority
- NO
- Norway
- Prior art keywords
- alkyl
- rivet
- head
- phenyl
- mandrel
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 239000002253 acid Substances 0.000 abstract 3
- 150000007513 acids Chemical class 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- -1 -haloalkyl Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 125000000490 cinnamyl group Chemical group C(C=CC1=CC=CC=C1)* 0.000 abstract 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 125000000686 lactone group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000003990 capacitor Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005538 encapsulation Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Fremstilling av:. hvor. E er en direkte binding, -CH, -C--, -2CH-CH- eller -CH=CH-;. R, Rog Rj er hver valgt fra H, halogen, C-alkyl,-halogenalkyl, fenyl, fenyl substituert med halogen, C_alkoxy, C_g-alkanoyloxy, C_alkyl, C_halogenalkyl, eller 0Rhvor R4 er H, C_g-alkanoyl, benzoyl, fenyl, halogenfenyl, f enyl-C^-j-alkyl, C_g-alkyl, cinnamyl, C_halogenalkyl, allyl, cycloalkyl-C_-alkyl, adamantyl-C-^-j-alkyl eller substituert fenyl-C_.-alkyl i hver av hvilke substituentene er valgt fra halogen, C_-alkoxy, C_alkyl, eller C_halogenalkyl;. og de tilsvarende dihydroxysyrer i hvilke lactonringen er hydrolytisk åpnet, og de farmasøytisk godtagbare salter av de nevnte dihydroxysyrer, og de lavere alkyl- og fenyl-, dimethylamino-eller acetylamino-substituerte lavere alkylestere av de nevnte dihydroxysyrer; idet alle de nevnte forbindelser er 4-R-enantiomeren av trans-racematet hvis struktur er vist ovenfor.Disse forbindelser er sterke inhibitorer av cholesterolsyntesen av enzymet hydroxy-methyl-glutaryl-coenzym A-reduktase.
Description
Hulnaglesats.
Foreliggende oppfinnelse angår en hulnaglesats av den art som omfatter en hulnagle og en tiltrekkingsdor.
Ved tidligere kjente naglesatser av denne art er tiltrekkingsdoren ført gjennom naglen slik at den stikker frem med sin påvirkningsende fra naglens hode, og den ende av naglen som er lengst fra naglehodet, vil det tiltrekkingen ved hjelp av hodet på tiltrekkingsdoren bli utvidet i radial retning samtidig som stamme-enden i en viss grad kan bli «forkrøblet». Den ut-videde ende av naglestammen vil ved tiltrekkingen få et lite tiltalende utseende, hvilket ikke er ønskelig når de deler som skal forbindes ved hjelp av naglen er i form av f. eks. plater eller andre konstruk-sjonselementer som skal kunne betraktes fra begge sider.
Foreliggende oppfinnelse går ut på en hulnaglesats hvormed det fås en forbindelse som har tilnærmet det samme utseende fra begge sider.
Naglesatsen i henhold til oppfinnelsen kan imidlertid også benyttes med fordel i stedet for de tidligere kjente hulnagler for feste av f. eks. elektrotekniske kon-struksjonselementer i form av eksempelvis bakelitt-innstøpte transformatorer, like-rettere, kondensatorer osv. idet naglesatsen med naglens hode-ende støpes inn eller på annen måte innleires i eller om-sluttes av innkapslingsmaterialet.
Det særegne ved hulnaglesatsen i henhold til oppfinnelsen er at tiltrekkingsdoren strekker seg gjennom naglestammen fra naglens hode-ende, at hodet på
tilstrekkingsdoren ligger i en fordypning i hodet på naglen, og at hodet på doren
har en diameter som er større enn den ytre diameter på naglestammen.
I henhold til ytterligere trekk ved oppfinnelsen er boringen i hodet på naglen lukket utenfor hodet på tiltrekkingsdoren.
Oppfinnelsen skal nærmere beskrives
under henvisning til vedføyde tegning. Fig. 1 og 2 viser aksialsnitt gjennom to hulnaglesatser i henhold til oppfinnelsen, før tiltrekking. Fig. 3 viser et aksialsnitt gjennom naglesatsen i fig. 2, ved avslutningen av
tiltrekkingen, men før tiltrekkingsdoren er brudt.
På tegningen er det vist en hulnagle 1 med en aksial boring 2 og hvis diameter i hodet 3 er større enn den ytre diameter på naglestammen. Den skulder 5 som derved dannes, utgjør et anslag for hodet 6 på en tiltrekkingsdor 7 som strekker seg fra hode-enden på naglen gjennom og utenfor naglestammen 4. Tiltrekkingsdoren 7 er på kjent måte utstyrt med et bruddsted 8 slik at doren ved oppnåelse av en forut bestemt påkjenning, vil brytes.
I den utførelsesform som er vist i fig. 2, og 3 er boringen 2 i hodet 3 på naglen 1 lukket ved 9 utenfor hodet 6 på tiltrekkingsdoren 7. Denne utførelsesform er spe-sielt fordelaktig der det kreves en tett forbindelse. I den utførelse som er vist i fig. 1 er boringen 2 ikke lukket i hodet og denne utførelse vil kunne benyttes der det ikke er påkrevet med en tett forbindelse. Hodet
6 på doren 7 vil nemlig etter at denne er brudt ved bruddstedet 8 kunne tas ut av hodeboringen slik at det blir en gjennom-gående boring. Hulnaglen 1 i henhold til oppfinnelsen, kan benyttes for å forbinde f. eks. to plateformede elementer 10 og 11, men det vil være klart at det eleemnt 10 som ligger nærmest naglehodet 3 kan være en del av et f. eks. klossformet element, hvor naglen 1 er anbrakt slik at hodet er innleiret, f. eks. innstøpt i klossen og stam-men 4 rager utenfor klossen. Det annet element 11 kan f. eks. være i form av et rør eller et annet konstruksjonselement. I fig. 3 betegner 12 påvirkningsenden på et trekkverktøy, f. eks. en trekkpistol, som utøver en tilstrekkelig stor trekk-kraft til først å deformere den fri ende av naglestammen 4 og deretter bryte tiltrekkingsdoren 7 ved bruddstedet 8. Den overflate på verktøyenden 12 som kommer til inn-grep med nagleenden, er hensiktsmessig konkavt utformet, slik at nagle-enden etter
tiltrekking vil få form av et hode 13 om-trent tilsvarende det opprinnelige nagle-hode 3.
Claims (2)
1. Hulnaglesats bestående av en hulnagle og en tiltrekkingsdor, karakterisert ved at tiltrekkingsdoren (7) strekker seg fra hode-enden på naglen, at hodet (6) på doren (7) ligger i en fordypning i hodet (3) på naglen, og at hodet (6) på doren (7) har en diameter som er større enn den ytre diameter på naglestammen (4).
2. Hulnaglesats som angitt i påstand 1, karakterisert ved at boringen (2) i hodet (3) på naglen er lukket utenfor hodet (6) på doren (7).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6757479A | 1979-08-17 | 1979-08-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO802431L NO802431L (no) | 1981-02-18 |
| NO155491B true NO155491B (no) | 1986-12-29 |
| NO155491C NO155491C (no) | 1987-04-08 |
Family
ID=22076933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO802431A NO155491C (no) | 1979-08-17 | 1980-08-14 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive, substiuerte 4-hydroxytetrahydropyran-2-oner. |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP0024348B1 (no) |
| JP (1) | JPS5645470A (no) |
| KR (1) | KR840002170B1 (no) |
| AT (1) | ATE16487T1 (no) |
| AU (1) | AU6108580A (no) |
| CA (1) | CA1137989A (no) |
| CS (1) | CS219921B2 (no) |
| DD (1) | DD152558A5 (no) |
| DE (1) | DE3071230D1 (no) |
| DK (1) | DK353680A (no) |
| ES (1) | ES494301A0 (no) |
| FI (1) | FI802582A7 (no) |
| GR (1) | GR69938B (no) |
| HU (1) | HU182190B (no) |
| IE (1) | IE50789B1 (no) |
| IL (1) | IL60751A (no) |
| MA (1) | MA18929A1 (no) |
| NO (1) | NO155491C (no) |
| NZ (1) | NZ194557A (no) |
| PL (2) | PL127979B1 (no) |
| PT (1) | PT71672B (no) |
| YU (1) | YU207180A (no) |
| ZA (1) | ZA805016B (no) |
| ZW (1) | ZW19080A1 (no) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4440927A (en) * | 1981-06-19 | 1984-04-03 | Merck & Co., Inc. | Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase via a chiral synthon |
| EP0068038B1 (en) * | 1981-06-29 | 1985-09-25 | Merck & Co. Inc. | (+)-(4r,6s)-(e)-6-(2-(4'-fluoro-3,3',5-trimethyl-(1,1'-biphenyl)-2-yl)ethenyl)-3,4,5,6-tetrahydro-4-hydroxy-2h-pyran-2-one, a process for preparing and a pharmaceutical composition containing the same |
| US4588820A (en) * | 1984-06-11 | 1986-05-13 | Merck & Co., Inc. | Process for epimerization at C6 of 3,4,5,6-tetrahydro-2H-pyran-2-one |
| US4647576A (en) * | 1984-09-24 | 1987-03-03 | Warner-Lambert Company | Trans-6-[2-(substitutedpyrrol-1-yl)alkyl]-pyran-2-one inhibitors of cholesterol synthesis |
| DE3615620A1 (de) * | 1986-05-09 | 1987-11-12 | Hoechst Ag | 4(r)-substituierte 6(s)-phenoxymethyl-, 6(s)-(beta)-phenylaethyl-und 6(s)-(beta)-styryl-tetrahydropyran-2-one, ein hochstereoselektives verfahren zu ihrer herstellung, pharmazeutische praeparate auf basis dieser verbindungen und ihre verwendung |
| US4897490A (en) * | 1987-02-25 | 1990-01-30 | Bristol-Meyers Company | Antihypercholesterolemic tetrazole compounds |
| US4898949A (en) * | 1987-02-25 | 1990-02-06 | Bristol-Myers Company | Intermediates for the preparation of antihypercholesterolemic tetrazole compounds |
| US5169976A (en) * | 1987-11-25 | 1992-12-08 | Pfizer Inc. | N-(biphenylmethyl)-3-hydroxyglutaramic acid and derivatives as hypocholesterolemic agents |
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| US5093363A (en) * | 1989-08-22 | 1992-03-03 | Shionogi & Co., Ltd. | 2,4,6-substituted phenol derivatives |
| JP3171931B2 (ja) * | 1992-06-02 | 2001-06-04 | 高砂香料工業株式会社 | （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法 |
| IL129871A (en) * | 1994-05-06 | 2003-11-23 | Pharmacia & Upjohn Inc | Process for preparing 4-phenyl-substituted octanoyl-oxazolidin-2-one intermediates that are useful for preparing pyran-2-ones useful for treating retroviral infections |
| RU2563831C1 (ru) * | 2014-10-13 | 2015-09-20 | Федеральное государственное бюджетное учреждение науки Иркутский институт химии им. А.Е. Фаворского Сибирского отделения Российской академии наук | Применение протатран 4-хлор-2-метилфеноксиацетата (хлоркрезацина) для угнетения активности холестеролэстеразы |
| WO2016161085A1 (en) | 2015-04-01 | 2016-10-06 | Cedars-Sinai Medical Center | Anti-methanogenic lovastatin analogs or derivatives and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53147073A (en) * | 1977-05-24 | 1978-12-21 | Sankyo Co Ltd | Mevalonolactone derivatives |
| JPS5559180A (en) * | 1978-10-30 | 1980-05-02 | Sankyo Co Ltd | 4-hydroxy-2-pyrone ring compound, its preparation, and remedy for hyperlipemia comprising it as active constituent |
-
1980
- 1980-08-04 IL IL60751A patent/IL60751A/xx unknown
- 1980-08-04 NZ NZ194557A patent/NZ194557A/en unknown
- 1980-08-05 AU AU61085/80A patent/AU6108580A/en not_active Abandoned
- 1980-08-07 MA MA19129A patent/MA18929A1/fr unknown
- 1980-08-07 PT PT71672A patent/PT71672B/pt unknown
- 1980-08-11 KR KR1019800003182A patent/KR840002170B1/ko not_active Expired
- 1980-08-12 CS CS805551A patent/CS219921B2/cs unknown
- 1980-08-12 GR GR62660A patent/GR69938B/el unknown
- 1980-08-14 DE DE8080104807T patent/DE3071230D1/de not_active Expired
- 1980-08-14 NO NO802431A patent/NO155491C/no unknown
- 1980-08-14 EP EP80104807A patent/EP0024348B1/en not_active Expired
- 1980-08-14 ES ES494301A patent/ES494301A0/es active Granted
- 1980-08-14 AT AT80104807T patent/ATE16487T1/de not_active IP Right Cessation
- 1980-08-14 DD DD80223335A patent/DD152558A5/de unknown
- 1980-08-15 HU HU802042A patent/HU182190B/hu not_active IP Right Cessation
- 1980-08-15 JP JP11186880A patent/JPS5645470A/ja active Granted
- 1980-08-15 ZW ZW190/80A patent/ZW19080A1/xx unknown
- 1980-08-15 ZA ZA00805016A patent/ZA805016B/xx unknown
- 1980-08-15 DK DK353680A patent/DK353680A/da not_active Application Discontinuation
- 1980-08-15 IE IE1732/80A patent/IE50789B1/en unknown
- 1980-08-15 FI FI802582A patent/FI802582A7/fi not_active Application Discontinuation
- 1980-08-15 CA CA000358416A patent/CA1137989A/en not_active Expired
- 1980-08-15 YU YU02071/80A patent/YU207180A/xx unknown
- 1980-08-16 PL PL1980226285A patent/PL127979B1/pl unknown
- 1980-08-16 PL PL1980238108A patent/PL132249B1/pl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6108580A (en) | 1981-02-19 |
| KR830003465A (ko) | 1983-06-20 |
| NO155491C (no) | 1987-04-08 |
| PL226285A1 (no) | 1981-03-27 |
| EP0024348B1 (en) | 1985-11-13 |
| ES8106152A1 (es) | 1981-07-16 |
| JPS5645470A (en) | 1981-04-25 |
| HU182190B (en) | 1983-12-28 |
| CA1137989A (en) | 1982-12-21 |
| ZW19080A1 (en) | 1982-03-17 |
| IL60751A (en) | 1985-04-30 |
| DD152558A5 (de) | 1981-12-02 |
| NZ194557A (en) | 1984-09-28 |
| EP0024348A1 (en) | 1981-03-04 |
| DK353680A (da) | 1981-02-19 |
| ES494301A0 (es) | 1981-07-16 |
| IE801732L (en) | 1981-02-17 |
| FI802582A7 (fi) | 1981-02-18 |
| ZA805016B (en) | 1982-03-31 |
| GR69938B (no) | 1982-07-21 |
| PT71672A (en) | 1980-09-01 |
| JPH0257550B2 (no) | 1990-12-05 |
| IE50789B1 (en) | 1986-07-23 |
| PL132249B1 (en) | 1985-02-28 |
| KR840002170B1 (ko) | 1984-11-26 |
| DE3071230D1 (en) | 1985-12-19 |
| YU207180A (en) | 1983-02-28 |
| NO802431L (no) | 1981-02-18 |
| ATE16487T1 (de) | 1985-11-15 |
| PL127979B1 (en) | 1983-12-31 |
| MA18929A1 (fr) | 1981-04-01 |
| IL60751A0 (en) | 1980-10-26 |
| CS219921B2 (en) | 1983-03-25 |
| PT71672B (en) | 1982-01-22 |
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