NO163184C - Analogifremgangsm te for fremstilling av terapeutisk aktive 4h-3, 1-benzoksazin-4-on-derivater. - Google Patents

Analogifremgangsm te for fremstilling av terapeutisk aktive 4h-3, 1-benzoksazin-4-on-derivater.

Info

Publication number
NO163184C
NO163184C NO845176A NO845176A NO163184C NO 163184 C NO163184 C NO 163184C NO 845176 A NO845176 A NO 845176A NO 845176 A NO845176 A NO 845176A NO 163184 C NO163184 C NO 163184C
Authority
NO
Norway
Prior art keywords
benzoksazin
derivatives
preparation
therapeutic active
analogy procedure
Prior art date
Application number
NO845176A
Other languages
English (en)
Norwegian (no)
Other versions
NO845176L (no
Inventor
Alexander Krantz
Robin W Spencer
Tim F Tam
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/673,996 external-priority patent/US4657893A/en
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of NO845176L publication Critical patent/NO845176L/no
Publication of NO163184C publication Critical patent/NO163184C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C265/00—Derivatives of isocyanic acid
    • C07C265/16—Derivatives of isocyanic acid having isocyanate groups acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C273/18—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas
    • C07C273/1809—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety
    • C07C273/1818—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of substituted ureas with formation of the N-C(O)-N moiety from -N=C=O and XNR'R"
    • C07C273/1827—X being H
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/24—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in positions 2 and 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO845176A 1983-12-27 1984-12-21 Analogifremgangsm te for fremstilling av terapeutisk aktive 4h-3, 1-benzoksazin-4-on-derivater. NO163184C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56612983A 1983-12-27 1983-12-27
US60860984A 1984-05-09 1984-05-09
US06/673,996 US4657893A (en) 1984-05-09 1984-11-26 4H-3,1-benzoxazin-4-ones and related compounds and use as enzyme inhibitors

Publications (2)

Publication Number Publication Date
NO845176L NO845176L (no) 1985-06-28
NO163184C true NO163184C (no) 1990-04-18

Family

ID=27415984

Family Applications (1)

Application Number Title Priority Date Filing Date
NO845176A NO163184C (no) 1983-12-27 1984-12-21 Analogifremgangsm te for fremstilling av terapeutisk aktive 4h-3, 1-benzoksazin-4-on-derivater.

Country Status (11)

Country Link
EP (1) EP0147211B1 (de)
KR (1) KR890000992B1 (de)
CA (1) CA1269800A (de)
DE (1) DE3483204D1 (de)
DK (1) DK625184A (de)
ES (2) ES8607260A1 (de)
FI (1) FI79842C (de)
HU (1) HU195648B (de)
IL (1) IL73943A (de)
NO (1) NO163184C (de)
NZ (1) NZ210669A (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1309556C (en) * 1987-06-09 1992-10-27 Masayuki Kokubo 4h-3,1-benzoxazin-4-one compounds and pharmaceutical composition thereoffor the inhibition of serine proteases
EP0475531B1 (de) * 1990-09-10 1995-01-18 Asahi Kasei Kogyo Kabushiki Kaisha Benzoesäurephenylesterverbindungen und diese enthaltende Elastase inhibitierende Zusammensetzungen
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
US5985872A (en) * 1995-05-24 1999-11-16 G.D. Searle & Co. 2-amino-benzoxazinones for the treatment of viral infections
GB9700597D0 (en) * 1997-01-14 1997-03-05 Sandoz Pharma Uk Organic compounds
AU2826099A (en) * 1998-03-24 1999-10-18 Novo Nordisk A/S Heterocyclic compounds regulating clotting
US6180625B1 (en) 1998-03-24 2001-01-30 Novo Nordisk A/S Heterocyclic compounds regulating clotting
AU1375000A (en) * 1998-11-26 2000-06-13 Novo Nordisk A/S Heterocyclic compounds regulating clotting
GB9900416D0 (en) * 1999-01-08 1999-02-24 Alizyme Therapeutics Ltd Inhibitors
HK1045157A1 (zh) 1999-01-22 2002-11-15 依兰制药公司 抑制vla-4介导的白细胞粘着的化合物
TW593284B (en) * 1999-01-22 2004-06-21 Elan Pharm Inc Fused ring heteroaryl and heterocyclic compounds which inhibit leukocyte adhesion mediated by VLA-4
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
ATE493405T1 (de) 2005-09-29 2011-01-15 Elan Pharm Inc Pyrimidinylamidverbindungen, die die durch vla-4 vermittelte leukozytenadhäsion inhibieren
ZA200803016B (en) 2005-09-29 2009-10-28 Elan Pharmaceuticals Inc Wyeth Carbamate compounds which inhibit leukocyte adhesion mediated by VLA-4
EA017110B1 (ru) 2006-02-27 2012-09-28 Элан Фамэсьютикэлс, Инк. ПИРИМИДИНИЛСУЛЬФОНАМИДНЫЕ СОЕДИНЕНИЯ (ВАРИАНТЫ), СПОСОБ ПОЛУЧЕНИЯ ПИРИМИДИНИЛСУЛЬФОНАМИДНЫХ СОЕДИНЕНИЙ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ЛЕЧЕНИЯ ЗАБОЛЕВАНИЯ, ОПОСРЕДОВАННОГО ИНТЕГРИНОМ α4, СПОСОБ СНИЖЕНИЯ И/ИЛИ ПРЕДУПРЕЖДЕНИЯ ВОСПАЛИТЕЛЬНОГО КОМПОНЕНТА ЗАБОЛЕВАНИЯ ИЛИ АУТОИММУННОГО ОТВЕТА
SG10201401836RA (en) 2009-04-27 2014-10-30 Elan Pharm Inc Pyridinone antagonists of alpha-4 integrins
WO2018129393A1 (en) * 2017-01-06 2018-07-12 The Regents Of The University Of California Mu opioid receptor modulators
EP3774722B1 (de) 2018-04-04 2024-07-24 Epiodyne, Inc. Opioid-rezeptor-modulatoren sowie zugehörige produkte und verfahren
TW202304869A (zh) 2021-04-05 2023-02-01 美商艾碧奧戴股份有限公司 類鴉片受體調節劑

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3450700A (en) * 1966-12-20 1969-06-17 Upjohn Co 2-tertiary amino-4h-3,1-benzoxazin-4-ones
DE2315303A1 (de) * 1973-03-27 1974-10-17 Bayer Ag Verfahren zur herstellung von n-substituierten 2-amino-3,1-benzoxazin-4-onen

Also Published As

Publication number Publication date
DE3483204D1 (de) 1990-10-18
EP0147211A2 (de) 1985-07-03
NO845176L (no) 1985-06-28
KR850004472A (ko) 1985-07-15
FI845116A0 (fi) 1984-12-27
DK625184D0 (da) 1984-12-21
KR890000992B1 (ko) 1989-04-15
FI79842C (fi) 1990-03-12
FI79842B (fi) 1989-11-30
ES550879A0 (es) 1987-03-01
HU195648B (en) 1988-06-28
IL73943A0 (en) 1985-03-31
ES8607260A1 (es) 1986-06-01
ES8703437A1 (es) 1987-03-01
CA1269800A (en) 1990-05-29
DK625184A (da) 1985-06-28
EP0147211B1 (de) 1990-09-12
EP0147211A3 (en) 1985-08-14
NZ210669A (en) 1988-05-30
IL73943A (en) 1989-01-31
FI845116L (fi) 1985-06-28
HUT36808A (en) 1985-10-28
ES539038A0 (es) 1986-06-01

Similar Documents

Publication Publication Date Title
NO163451C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive aminomethyloxooxazolidinylbenzenderivater.
NO166639C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte, basiske 2-aminotetraliner.
NO165838C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte trans-1,2-diamino-cykloheksylamidforbindelser.
NO158099C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive karbostyrilderivater.
NO162764C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive indolinderivater.
NO165239C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-benzyl-aminoalkyl-pyrrolidinon-derivater.
NO162022C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive cefemderivater.
NO159531C (no) Analogifremgangsmaate for fremstilling av farmasoeytisk aktive karbostyrilderivater.
NO156864C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive piperinderivater.
NO162514C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinonderivater.
NO165192C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive glyserolderivater.
NO164097C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-(n-substituert-guanidino)-4-hetero-aryl-tiazol-derivater.
NO152129C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive omega-cyan-1, omega-difenyl-azaalkanderivater
NO845176L (no) Fremgangsmaate for fremstilling av terapeutisk aktive 4h-3,1-benzoksazin-4-on-derivater
NO156787C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive kinolonderivater.
NO159654C (no) Analogifremgangsm te for fremstilling av terapeutisk aktive 2-guanidin-4-heteroaryltiazolderivater.
NO161562C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive ergolinderivater.
NO161676C (no) Analogifremgangsm te til fremstilling av terapeutisk aktive mitosanderivater.
NO164169C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive benzothiazinderivater.
NO159930C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive indeno-pyridazinon-derivater.
NO161559C (no) Analogifremgangsmaate til fremstilling av terapeutisk aktive triazolderivater.
NO158941C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-piperidino-kinazolinderivater.
NO163486C (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-oxy-4h-3,1-benzoxazin-4-on-derivater.
NO164897C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive oxazolidinonderivater.
NO160079C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive cefem-derivater.