NO170633C - Analogifremgangsmaate for fremstilling av det terapeutisk aktive 8-(1,2-dihydroksyetyl)-7-fenyl-1,2,4-triazolo(2,3-c)pyrimidin-5-amin - Google Patents

Analogifremgangsmaate for fremstilling av det terapeutisk aktive 8-(1,2-dihydroksyetyl)-7-fenyl-1,2,4-triazolo(2,3-c)pyrimidin-5-amin

Info

Publication number: NO170633C
Authority: NO; Norway
Prior art keywords: dihydroxythyl; triazolo; pyrimidin; amine; phenyl
Prior art date: 1988-12-22

Application number

NO895179A

Other languages

English (en)

Norwegian (no)

Other versions

NO895179L (no

NO895179D0 (no

NO170633B (no

Inventor

Earl George Burton

Christopher Peter Chengelis

Gerald Michael Walsh

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-12-22

Filing date

1989-12-21

Publication date

1992-11-11

1989-12-21 Application filed by Searle & Co filed Critical Searle & Co

1989-12-21 Publication of NO895179D0 publication Critical patent/NO895179D0/no

1990-06-25 Publication of NO895179L publication Critical patent/NO895179L/no

1992-08-03 Publication of NO170633B publication Critical patent/NO170633B/no

1992-11-11 Publication of NO170633C publication Critical patent/NO170633C/no

Links

FVLAYJRLBLHIPV-UHFFFAOYSA-N pyrimidin-5-amine Chemical compound NC1=CN=CN=C1 FVLAYJRLBLHIPV-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 2
230000001882 diuretic effect Effects 0.000 abstract 2
239000002207 metabolite Substances 0.000 abstract 2
231100000457 cardiotoxic Toxicity 0.000 abstract 1
230000001451 cardiotoxic effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002934 diuretic Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical compound BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO895179A 1988-12-22 1989-12-21 Analogifremgangsmaate for fremstilling av det terapeutisk aktive 8-(1,2-dihydroksyetyl)-7-fenyl-1,2,4-triazolo(2,3-c)pyrimidin-5-amin NO170633C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/289,068 US4866063A (en)	1988-12-22	1988-12-22	Diol metabolites of 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines

Publications (4)

Publication Number	Publication Date
NO895179D0 NO895179D0 (no)	1989-12-21
NO895179L NO895179L (no)	1990-06-25
NO170633B NO170633B (no)	1992-08-03
NO170633C true NO170633C (no)	1992-11-11

Family

ID=23109911

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO895179A NO170633C (no)	1988-12-22	1989-12-21	Analogifremgangsmaate for fremstilling av det terapeutisk aktive 8-(1,2-dihydroksyetyl)-7-fenyl-1,2,4-triazolo(2,3-c)pyrimidin-5-amin

Country Status (16)

Country	Link
US (1)	US4866063A (da)
EP (1)	EP0374914B1 (da)
JP (1)	JPH02221276A (da)
AT (1)	ATE104670T1 (da)
AU (1)	AU622963B2 (da)
CA (1)	CA2006354A1 (da)
DE (1)	DE68914808T2 (da)
DK (1)	DK656389A (da)
ES (1)	ES2051980T3 (da)
FI (1)	FI91408C (da)
IE (1)	IE894187L (da)
IL (1)	IL92828A0 (da)
NO (1)	NO170633C (da)
NZ (1)	NZ231937A (da)
PT (1)	PT92663B (da)
ZA (1)	ZA899837B (da)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5338743A (en) *	1988-06-06	1994-08-16	Fujisawa Pharmaceutical Co., Ltd.	New use of the adenosine antagonist

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4405780A (en) *	1979-08-08	1983-09-20	G. D. Searle & Co.	8-Substituted 7-phenyl-1,2,4,-triazolo[4,3-c]/[2,3-c]pyrimidines-5-amines and amides
DE3029871C2 (de) *	1979-08-08	1987-01-15	G.D. Searle & Co., Skokie, Ill.	8-(2-Ethoxyethyl)-7-phenyl-1,2,4-triazolo[1,5-c]pyrimidin-5-amin, Verfahren zu dessen Herstellung und pharmazeutische Zubereitung, die diese Verbindung enthält
US4483987A (en) *	1983-06-20	1984-11-20	G. D. Searle & Co.	8-Substituted 7-phenyl-1,2,4-triazolo[2,3-c]pyrimidines-5-amines and amides
FR2567596B1 (fr) *	1984-07-16	1986-12-26	Peugeot	Agrafe pour l'assemblage de pieces, telles que des panneaux

1988
- 1988-12-22 US US07/289,068 patent/US4866063A/en not_active Expired - Lifetime
1989
- 1989-12-21 PT PT92663A patent/PT92663B/pt not_active IP Right Cessation
- 1989-12-21 NZ NZ231937A patent/NZ231937A/xx unknown
- 1989-12-21 CA CA002006354A patent/CA2006354A1/en not_active Abandoned
- 1989-12-21 ZA ZA899837A patent/ZA899837B/xx unknown
- 1989-12-21 AT AT8989123654T patent/ATE104670T1/de not_active IP Right Cessation
- 1989-12-21 ES ES89123654T patent/ES2051980T3/es not_active Expired - Lifetime
- 1989-12-21 AU AU47124/89A patent/AU622963B2/en not_active Ceased
- 1989-12-21 NO NO895179A patent/NO170633C/no unknown
- 1989-12-21 IE IE894187A patent/IE894187L/xx unknown
- 1989-12-21 FI FI896173A patent/FI91408C/fi not_active IP Right Cessation
- 1989-12-21 DK DK656389A patent/DK656389A/da not_active Application Discontinuation
- 1989-12-21 DE DE68914808T patent/DE68914808T2/de not_active Expired - Fee Related
- 1989-12-21 IL IL92828A patent/IL92828A0/xx not_active IP Right Cessation
- 1989-12-21 EP EP89123654A patent/EP0374914B1/en not_active Expired - Lifetime
- 1989-12-22 JP JP1334618A patent/JPH02221276A/ja active Pending

Also Published As

Publication number	Publication date
AU4712489A (en)	1990-06-14
IL92828A0 (en)	1990-09-17
US4866063A (en)	1989-09-12
NO895179L (no)	1990-06-25
CA2006354A1 (en)	1990-06-22
JPH02221276A (ja)	1990-09-04
ZA899837B (en)	1991-02-27
DE68914808T2 (de)	1994-08-25
DE68914808D1 (de)	1994-05-26
ES2051980T3 (es)	1994-07-01
ATE104670T1 (de)	1994-05-15
EP0374914A1 (en)	1990-06-27
AU622963B2 (en)	1992-04-30
FI91408B (fi)	1994-03-15
PT92663A (pt)	1990-06-29
FI91408C (fi)	1994-06-27
NZ231937A (en)	1991-09-25
DK656389D0 (da)	1989-12-21
DK656389A (da)	1990-06-23
EP0374914B1 (en)	1994-04-20
PT92663B (pt)	1995-09-12
FI896173A0 (fi)	1989-12-21
NO895179D0 (no)	1989-12-21
NO170633B (no)	1992-08-03
IE894187L (en)	1990-06-22

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