NO170754C - Fremgangsmaate for fremstilling av vandig insulinpreparater - Google Patents

Fremgangsmaate for fremstilling av vandig insulinpreparater

Info

Publication number: NO170754C
Authority: NO; Norway
Prior art keywords: procedure; insulin preparations; aqueous insulin; manufacturing aqueous; manufacturing
Prior art date: 1986-10-20

Application number

NO874347A

Other languages

English (en)

Norwegian (no)

Other versions

NO874347L (no

NO170754B (no

NO874347D0 (no

Inventor

Klavs Holger Joeergensen

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-10-20

Filing date

1987-10-19

Publication date

1992-12-02

1986-10-20 Priority claimed from DK503386A external-priority patent/DK503386D0/da

1987-07-10 Priority claimed from DK356987A external-priority patent/DK356987D0/da

1987-10-19 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

1987-10-19 Publication of NO874347D0 publication Critical patent/NO874347D0/no

1988-04-21 Publication of NO874347L publication Critical patent/NO874347L/no

1992-08-24 Publication of NO170754B publication Critical patent/NO170754B/no

1992-12-02 Publication of NO170754C publication Critical patent/NO170754C/no

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
238000002360 preparation method Methods 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

NO874347A 1986-10-20 1987-10-19 Fremgangsmaate for fremstilling av vandig insulinpreparater NO170754C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DK503386A DK503386D0 (da)	1986-10-20	1986-10-20	Peptidpraeparater
DK356987A DK356987D0 (2)	1987-07-10	1987-07-10

Publications (4)

Publication Number	Publication Date
NO874347D0 NO874347D0 (no)	1987-10-19
NO874347L NO874347L (no)	1988-04-21
NO170754B NO170754B (no)	1992-08-24
NO170754C true NO170754C (no)	1992-12-02

Family

ID=26067111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO874347A NO170754C (no)	1986-10-20	1987-10-19	Fremgangsmaate for fremstilling av vandig insulinpreparater

Country Status (18)

Country	Link
US (1)	US5070186A (2)
EP (1)	EP0265213B1 (2)
KR (1)	KR880004819A (2)
CN (1)	CN87107049A (2)
AU (1)	AU616381B2 (2)
CA (1)	CA1316819C (2)
DE (1)	DE3778287D1 (2)
ES (1)	ES2033871T3 (2)
FI (1)	FI86254C (2)
GR (1)	GR3004912T3 (2)
HU (1)	HU201475B (2)
IE (1)	IE60264B1 (2)
IL (1)	IL84203A (2)
NO (1)	NO170754C (2)
NZ (1)	NZ222214A (2)
PH (1)	PH23446A (2)
PT (1)	PT85949B (2)
YU (1)	YU46665B (2)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5534488A (en) *	1993-08-13	1996-07-09	Eli Lilly And Company	Insulin formulation
YU18596A (sh) *	1995-03-31	1998-07-10	Eli Lilly And Company	Analogne formulacije monomernog insulina
EP1044016B1 (en) *	1998-01-09	2005-03-16	Novo Nordisk A/S	Stabilised insulin compositions
US7678364B2 (en)	1999-08-25	2010-03-16	Alkermes, Inc.	Particles for inhalation having sustained release properties
DE10114178A1 (de) *	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
IL160044A0 (en) *	2001-08-27	2004-06-20	Novo Nordisk As	A cartridge and a medical delivery system accommodating such cartridge
EP2460530A3 (en) *	2002-12-31	2012-08-29	Althea Technologies, Inc.	Human growth hormone crystals and methods for preparing them
NZ554885A (en) *	2002-12-31	2009-07-31	Altus Pharmaceuticals Inc	Complexes of hgh crystals and protamine polymers
US20090023629A1 (en) *	2005-12-23	2009-01-22	Altus Pharmaceuticals Inc.	Compositions comprising polycation-complexed protein crystals and methods of treatment using them
ES2542146T3 (es)	2006-07-31	2015-07-31	Novo Nordisk A/S	Insulinas extendidas PEGiladas.
DK2074141T3 (en)	2006-09-22	2016-11-28	Novo Nordisk As	The protease resistant insulin analogues.
US9387176B2 (en)	2007-04-30	2016-07-12	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
WO2008132229A2 (en) *	2007-04-30	2008-11-06	Novo Nordisk A/S	Highly concentrated insulin solutions and compositions
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
CN102037008B (zh)	2008-03-18	2016-08-31	诺沃-诺迪斯克有限公司	蛋白酶稳定化的、酰化胰岛素类似物
CN102256618A (zh)	2008-10-17	2011-11-23	赛诺菲-安万特德国有限公司	胰岛素和glp-1激动剂的组合
PL2451437T3 (pl)	2009-07-06	2017-05-31	Sanofi-Aventis Deutschland Gmbh	Wodne preparaty insuliny zawierające metioninę
NZ599847A (en)	2009-11-13	2013-09-27	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
TR201809460T4 (tr)	2009-11-13	2018-07-23	Sanofi Aventis Deutschland	Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
CN101912600B (zh) *	2010-01-11	2014-01-29	杨国汉	改善胰岛素在溶液中稳定性的方法
US8637458B2 (en) *	2010-05-12	2014-01-28	Biodel Inc.	Insulin with a stable basal release profile
AU2011202239C1 (en)	2010-05-19	2017-03-16	Sanofi	Long-acting formulations of insulins
WO2012028172A1 (en)	2010-08-30	2012-03-08	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US9481721B2 (en)	2012-04-11	2016-11-01	Novo Nordisk A/S	Insulin formulations
US9381247B2 (en) *	2012-04-16	2016-07-05	Biodel Inc.	Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain
US9399065B2 (en)	2012-04-16	2016-07-26	Biodel Inc.	Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin
EP2983697B1 (en)	2013-04-03	2018-10-31	Sanofi	Treatment of diabetes mellitus by long acting formulations of insulins
AU2014333979B2 (en)	2013-10-07	2018-02-15	Novo Nordisk A/S	Novel derivative of an insulin analogue
PE20171622A1 (es)	2014-12-12	2017-11-02	Sanofi Aventis Deutschland	Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
TWI700091B (zh)	2016-12-16	2020-08-01	丹麥商諾佛儂迪克股份有限公司	含胰島素醫藥組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2076082A (en) *	1935-04-08	1937-04-06	Nordisk Insulinlab	Therapeutic product and process
US2179384A (en) *	1937-04-05	1939-11-07	Univ Alberta	Therapeutic composition and process of making it
US2190134A (en) *	1939-06-09	1940-02-13	Norton Co	Grinding machine
US2538018A (en) *	1944-04-04	1951-01-16	Nordisk Insulinlab	Crystalline product of insulin and alkaline protein and process of making it
US2474729A (en) *	1945-01-03	1949-06-28	Rhone Poulenc Sa	Insulin preparations
US2801953A (en) *	1952-02-28	1957-08-06	Hoechst Ag	Process of preparing crystallized insulin preparations
US3102077A (en) *	1953-08-19	1963-08-27	Christensen Henry Marinus	Preparation of insulin containing 2.75 to 8 percent zinc content
DK98342C (da) *	1959-06-16	1964-03-31	Henry Marinus Dr Christensen	Fremgangsmåde til fremstilling af et insulinpræparat til peroral applikation.
US3868358A (en) *	1971-04-30	1975-02-25	Lilly Co Eli	Protamine-insulin product
GB1426061A (en) *	1972-12-28	1976-02-25	Ici Ltd	Polypeptides
US3856771A (en) *	1973-07-16	1974-12-24	Lilly Co Eli	Process for manufacturing alkali metal or ammonium insulin
US4196196A (en) *	1978-06-19	1980-04-01	Tiholiz Ivan C	Divalen/monovalent bipolar cation therapy for enhancement of tissue perfusion and reperfusion in disease states
AU550068B2 (en) *	1981-03-10	1986-02-27	Novo Nordisk A/S	Zinc insulin stabilized with calcium or magnesium salts
US4839341A (en) *	1984-05-29	1989-06-13	Eli Lilly And Company	Stabilized insulin formulations
US4764592A (en) *	1987-04-23	1988-08-16	Eli Lilly And Company	Crystalline human proinsulin and process for its production

1987
- 1987-10-14 PH PH35937A patent/PH23446A/en unknown
- 1987-10-19 DE DE8787309229T patent/DE3778287D1/de not_active Expired - Lifetime
- 1987-10-19 NO NO874347A patent/NO170754C/no unknown
- 1987-10-19 YU YU191887A patent/YU46665B/sh unknown
- 1987-10-19 HU HU874683A patent/HU201475B/hu not_active IP Right Cessation
- 1987-10-19 FI FI874596A patent/FI86254C/fi not_active IP Right Cessation
- 1987-10-19 EP EP87309229A patent/EP0265213B1/en not_active Expired - Lifetime
- 1987-10-19 AU AU79907/87A patent/AU616381B2/en not_active Ceased
- 1987-10-19 IL IL84203A patent/IL84203A/xx not_active IP Right Cessation
- 1987-10-19 ES ES198787309229T patent/ES2033871T3/es not_active Expired - Lifetime
- 1987-10-19 IE IE279987A patent/IE60264B1/en not_active IP Right Cessation
- 1987-10-19 NZ NZ222214A patent/NZ222214A/xx unknown
- 1987-10-19 PT PT85949A patent/PT85949B/pt unknown
- 1987-10-20 KR KR870011644A patent/KR880004819A/ko not_active Ceased
- 1987-10-20 CA CA000549713A patent/CA1316819C/en not_active Expired - Fee Related
- 1987-10-20 CN CN198787107049A patent/CN87107049A/zh not_active Withdrawn
1989
- 1989-04-19 US US07/340,331 patent/US5070186A/en not_active Expired - Fee Related
1992
- 1992-06-11 GR GR920401262T patent/GR3004912T3/el unknown

Also Published As

Publication number	Publication date
CN87107049A (zh)	1988-07-06
US5070186A (en)	1991-12-03
FI86254C (fi)	1992-08-10
KR880004819A (ko)	1988-06-27
IE60264B1 (en)	1994-06-29
FI874596A0 (fi)	1987-10-19
NO874347L (no)	1988-04-21
YU46665B (sh)	1994-01-20
EP0265213B1 (en)	1992-04-15
DE3778287D1 (de)	1992-05-21
PH23446A (en)	1989-08-07
HU201475B (en)	1990-11-28
AU7990787A (en)	1988-04-21
FI86254B (fi)	1992-04-30
NO170754B (no)	1992-08-24
YU191887A (en)	1989-04-30
IL84203A (en)	1993-04-04
CA1316819C (en)	1993-04-27
FI874596L (fi)	1988-04-21
NZ222214A (en)	1989-11-28
AU616381B2 (en)	1991-10-31
ES2033871T3 (es)	1993-04-01
IE872799L (en)	1988-04-20
EP0265213A2 (en)	1988-04-27
EP0265213A3 (en)	1988-11-09
GR3004912T3 (2)	1993-04-28
PT85949A (en)	1987-11-01
HUT46232A (en)	1988-10-28
NO874347D0 (no)	1987-10-19
PT85949B (pt)	1990-07-31

Publication	Publication Date	Title
NO170754C (no)	1992-12-02	Fremgangsmaate for fremstilling av vandig insulinpreparater
NO171006C (no)	1993-01-13	Fremgangsmaate for fremstilling av antioksyderende preparater
NO872966D0 (no)	1987-07-16	Fremgangsmaate for fremstilling av granulocyttstimulerende preparater.
NO872932D0 (no)	1987-07-14	Fremgangsmaate for fremstilling av proteiner med faktor-viii-aktivitet.
FI883783L (fi)	1988-08-15	Menetelmä nasaalivalmisteiden valmistamiseksi
NO870579D0 (no)	1987-02-13	Fremgangsmaate for fremstilling av indolizin-derivater.
NO872252D0 (no)	1987-05-29	Fremgangsmaate til fremstilling av vandige n-metylmorfolin-n-oksid-opploesninger.
DK413987D0 (da)	1987-08-07	Farmaceutiske praeparater
NO872551D0 (no)	1987-06-18	Fremgangsmaate for fremstilling av farmasoeytiske preparater
NO872174L (no)	1987-11-30	Fremgangsmaate for fremstilling av polypeptidpreparater med oekt biologisk tilgjengelighet.
DK652787D0 (da)	1987-12-11	Farmaceutiske praeparater
NO171291C (no)	1993-03-03	Fremgangsmaate for fremstilling av filetlignende produkter
NO893329D0 (no)	1989-08-18	Fremgangsmaate for fremstilling av titanoksyd.
FI874382A7 (fi)	1988-04-08	Farmaseuttiset valmisteet.
FI882921L (fi)	1988-06-17	Protaminzink-insulinpreparat.
DK401387D0 (da)	1987-07-31	Benzopyranderivatholdige praeparater
NO874200D0 (no)	1987-10-07	Fremgangsmaate for fremstilling av farmasoeytiske preparater
NO873213D0 (no)	1987-07-31	Fremgangsmaate for fremstilling av transdermale preparater.
DK447887D0 (da)	1987-08-27	Frysetoerrede farmaceutiske praeparater
NO871759D0 (no)	1987-04-28	Fremgangsmaate for fremstilling av sucralfat-preparater.
NO872233D0 (no)	1987-05-27	Fremgangsmaate for fremstilling av farmasoeytiske preparater
NO873423D0 (no)	1987-08-14	Fremgangsmaate for fremstilling av farmasoeytiske preparater
NO874199D0 (no)	1987-10-07	Fremgangsmaate for fremstilling av imidazo-pyridinonderivater.
DK503386D0 (da)	1986-10-20	Peptidpraeparater
NO870527D0 (no)	1987-02-11	Fremgangsmaate til fremstilling av et keramisk legeme.