NO171063C - Analogifremgangsmaate til fremstilling av terapeutisk akseptable, alkoksy-substituerte dihydrobenzopyran-2-karboksylatderivater - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk akseptable, alkoksy-substituerte dihydrobenzopyran-2-karboksylatderivater

Info

Publication number: NO171063C
Authority: NO; Norway
Prior art keywords: dihydrobenzopyrane; alcoxy; substituted; preparation; therapeutically acceptable
Prior art date: 1987-05-29

Application number

NO882317A

Other languages

English (en)

Norwegian (no)

Other versions

NO171063B (no

NO882317L (no

NO882317D0 (no

Inventor

Stevan Wakefield Djuric

Robert Larry Shone

Stella Siu Tzyy Yu

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-05-29

Filing date

1988-05-26

Publication date

1993-01-20

1988-05-26 Application filed by Searle & Co filed Critical Searle & Co

1988-05-26 Publication of NO882317D0 publication Critical patent/NO882317D0/no

1988-11-30 Publication of NO882317L publication Critical patent/NO882317L/no

1992-10-12 Publication of NO171063B publication Critical patent/NO171063B/no

1993-01-20 Publication of NO171063C publication Critical patent/NO171063C/no

Links

150000007942 carboxylates Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/66—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/24—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)
Medicinal Preparation (AREA)

NO882317A 1987-05-29 1988-05-26 Analogifremgangsmaate til fremstilling av terapeutisk akseptable, alkoksy-substituerte dihydrobenzopyran-2-karboksylatderivater NO171063C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5713687A	1987-05-29	1987-05-29
US07/188,708 US4889871A (en)	1987-05-29	1988-05-12	Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives

Publications (4)

Publication Number	Publication Date
NO882317D0 NO882317D0 (no)	1988-05-26
NO882317L NO882317L (no)	1988-11-30
NO171063B NO171063B (no)	1992-10-12
NO171063C true NO171063C (no)	1993-01-20

Family

ID=26736113

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO882317A NO171063C (no)	1987-05-29	1988-05-26	Analogifremgangsmaate til fremstilling av terapeutisk akseptable, alkoksy-substituerte dihydrobenzopyran-2-karboksylatderivater

Country Status (17)

Country	Link
US (1)	US4889871A (da)
EP (1)	EP0292977B1 (da)
JP (1)	JP2758902B2 (da)
KR (1)	KR880013914A (da)
AU (1)	AU611153B2 (da)
CA (1)	CA1337660C (da)
DE (1)	DE3864582D1 (da)
DK (1)	DK290188A (da)
ES (1)	ES2051796T3 (da)
FI (1)	FI882505A7 (da)
GR (1)	GR3003177T3 (da)
IE (1)	IE60687B1 (da)
IL (1)	IL86502A (da)
NO (1)	NO171063C (da)
NZ (1)	NZ224807A (da)
PH (1)	PH26153A (da)
PT (1)	PT87603B (da)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0300404A3 (en) *	1987-07-20	1990-07-18	G.D. Searle & Co.	Di-and tetrahydronapthyl anti-allergy agents
IL89713A0 (en) *	1988-03-29	1989-09-28	Ciba Geigy Ag	Novel alkanophenones
IL89840A (en) *	1988-04-06	1996-10-31	Lipha	Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them
US5219883A (en) *	1988-05-20	1993-06-15	G. D. Searle & Co.	2,2-di-substituted benzopyran leukotriene-D4 antagonists
US4931574A (en) *	1988-08-23	1990-06-05	Hoffmann-La Roche Inc.	Process for the preparation of benzopyrans
WO1990012010A1 (en) *	1989-04-07	1990-10-18	Pfizer Inc.	Substituted chromans in the treatment of asthma, arthritis and related diseases
US5212198A (en) *	1990-05-10	1993-05-18	G. D. Searle & Co.	Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5192782A (en) *	1990-05-10	1993-03-09	G. D. Searle & Co.	Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5073562A (en) *	1990-05-10	1991-12-17	G. D. Searle & Co.	Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof
US5051438A (en) *	1990-05-16	1991-09-24	G. D. Searle & Co.	Alkoxy-substituted dihydrobenzopyran-2-carboxylic acids and derivatives thereof, compositions and use
US5124350A (en) *	1990-06-28	1992-06-23	G. D. Searle & Co.	Leukotriene b4 antagonists
FR2665159B1 (fr) *	1990-07-24	1992-11-13	Rhone Poulenc Sante	Nouveaux derives de la pyridine et de la quinoleine, leur preparation et les compositions pharmaceutiques qui les contiennent.
WO1992004321A1 (en) *	1990-09-10	1992-03-19	Rhone-Poulenc Rorer International (Holdings) Inc.	Substituted bicyclic aryl compounds exhibiting selective leukotriene b4 antagonist activity
US5451700A (en) *	1991-06-11	1995-09-19	Ciba-Geigy Corporation	Amidino compounds, their manufacture and methods of treatment
US5488160A (en) *	1991-06-11	1996-01-30	Ciba-Geigy Corporation	Amidino compounds, their manufacture and method of treatment
US5273999A (en) *	1991-09-10	1993-12-28	Hoffmann-La Roche Inc.	Carboxylic acid leukotriene B4 antagonists
AU3172993A (en) *	1991-12-27	1993-07-28	Kureha Chemical Industry Co., Ltd.	Oleaginous ointment
JP2813464B2 (ja) *	1992-01-23	1998-10-22	フアイザー・インコーポレイテツド	ベンゾピラン及び関連ｌｔｂ▲下４▼アンタゴニスト
CA2129526A1 (en) *	1992-02-05	1993-08-06	Franz Birke	Novel amidine derivatives, their preparation and their use as medicaments with ltb4 antagonistic effect
US5352690A (en) *	1992-07-01	1994-10-04	Eli Lilly And Company	1,2,4-trioxygenated benzene derivatives useful as leukotriene antagonists
JPH0625764A (ja) *	1992-07-08	1994-02-01	Sumitomo Metal Ind Ltd	フェロスクラップ中の銅の除去・回収方法
US5324743A (en) *	1992-12-10	1994-06-28	Eli Lilly And Company	Leukotriene B4 antagonists
DE4309285A1 (de) *	1993-03-23	1994-09-29	Boehringer Ingelheim Kg	Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
US5380740A (en) *	1993-04-28	1995-01-10	G. D. Searle & Co.	Anti-inflammatory compounds, compositions and method of use thereof
ES2084547B1 (es) *	1993-07-12	1997-01-16	Pfizer	Antagonistas benzopiranicos y relacionados de leucotrieno b4.
US5457124A (en) *	1993-12-07	1995-10-10	Hoffmann-La Roche Inc.	Carboxylic acid Leukotriene B4 antagonists
WO1995032201A1 (en) *	1994-05-25	1995-11-30	G.D. Searle & Co.	Alkoxy-substituted dihydrobenzopyran-2-sulfonimides derivatives, their preparation and their use as leukotriene b4 antagonists
US5516917A (en) *	1994-06-08	1996-05-14	G. D. Searle & Co.	Leukotriene B4 antagonists
JPH10505348A (ja) *	1994-08-31	1998-05-26	イーライ・リリー・アンド・カンパニー	耐性腫瘍の同定および治療方法
US5543428A (en) *	1994-08-31	1996-08-06	Eli Lilly And Company	Method for treating resistant tumors
KR100232340B1 (ko) *	1994-10-13	1999-12-01	디. 제이. 우드, 스피겔 알렌 제이	류코트리엔 b4(ltb4) 길항물질로서의 벤조피란 및 벤조-축합된 화합물
CN1160399A (zh) *	1994-10-13	1997-09-24	美国辉瑞有限公司	苯并吡喃和苯并稠合化合物、其制备方法和它们作为白三烯b4(ltb4)拮抗剂的用途
IL121931A (en) *	1996-10-17	2000-02-17	Pfizer	Pharmaceutical compositions for preventing allograft rejection
IL141307A0 (en) *	1998-08-28	2002-03-10	Biomedicines Inc	Method of mitigating the adverse effects of interleukin-2
US6436987B1 (en)	2000-06-08	2002-08-20	Pfizer Inc.	Crystalline forms of (3S-trans)-2-[3,4-dihydro-4-hydroxy-3-(phenylmethyl)-2H-1-benzopyran-7-yl]-4-(trifluoromethyl)-benzoic acid
AU2001292874B2 (en) *	2000-09-27	2006-06-15	Merck & Co., Inc.	Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
CA2427610A1 (en)	2000-10-31	2002-08-08	Merck & Co., Inc.	Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders
US20040242676A1 (en) *	2003-05-30	2004-12-02	Alessi Thomas R.	Method of mitigating the adverse effects of IL-2
US8093253B2 (en) *	2008-03-06	2012-01-10	Hoffmann-La Roche Inc.	Leukotriene B4 inhibitors

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4006245A (en) *	1971-07-29	1977-02-01	Fisons Limited	Chemical compounds
GB1384530A (en) *	1971-07-29	1975-02-19	Fisons Ltd	Chromone derivatives
ATE14579T1 (de) *	1979-03-20	1985-08-15	Fisons Plc	Pharmazeutische heterocyclische verbindungen, verfahren zu ihrer herstellung und sie enthaltende zusammensetzungen.
US4474788A (en) *	1981-11-12	1984-10-02	Fisons Plc	Anti-SRSA quinoline carboxylic acid derivatives
ZA844519B (en) *	1983-06-24	1985-02-27	Hoffmann La Roche	Dihydrobenzopyran derivatives
US4665203A (en) *	1983-08-08	1987-05-12	G. D. Searle & Co.	Substituted dihydrobenzopyrans useful as leukotriene D4 inhibitors
AU548450B2 (en) *	1983-08-08	1985-12-12	G.D. Searle & Co.	Substituted dihydrobenzopyrans
US4565882A (en) *	1984-01-06	1986-01-21	G. D. Searle & Co.	Substituted dihydrobenzopyran-2-carboxylates
US4546194A (en) *	1984-05-29	1985-10-08	G. D. Searle & Co.	Substituted chromanon-2-yl alkanols and derivatives thereof
DE3569062D1 (en) *	1985-06-28	1989-04-27	Ibm	Shadow mask colour crt with enhanced resolution and/or brightness
ZA873745B (en) *	1986-06-04	1988-10-26	Daiichi Seiyaku Co	Benzopyran derivatives
US4885309A (en) *	1986-08-01	1989-12-05	Hoffmann-La Roche Inc.	Therapeutic treatment of leukotriene-mediated dermal inflammation by topical administration of 3,4-dihydro-2H-1-benzopyran derivatives

1988
- 1988-05-12 US US07/188,708 patent/US4889871A/en not_active Expired - Lifetime
- 1988-05-26 PH PH36982A patent/PH26153A/en unknown
- 1988-05-26 NO NO882317A patent/NO171063C/no unknown
- 1988-05-26 NZ NZ224807A patent/NZ224807A/xx unknown
- 1988-05-26 CA CA000567806A patent/CA1337660C/en not_active Expired - Fee Related
- 1988-05-26 IL IL8650288A patent/IL86502A/en unknown
- 1988-05-26 AU AU16681/88A patent/AU611153B2/en not_active Ceased
- 1988-05-27 DK DK290188A patent/DK290188A/da not_active Application Discontinuation
- 1988-05-27 EP EP88108449A patent/EP0292977B1/en not_active Expired - Lifetime
- 1988-05-27 JP JP63130037A patent/JP2758902B2/ja not_active Expired - Fee Related
- 1988-05-27 IE IE161188A patent/IE60687B1/en not_active IP Right Cessation
- 1988-05-27 FI FI882505A patent/FI882505A7/fi not_active IP Right Cessation
- 1988-05-27 PT PT87603A patent/PT87603B/pt not_active IP Right Cessation
- 1988-05-27 KR KR1019880006263A patent/KR880013914A/ko not_active Ceased
- 1988-05-27 DE DE8888108449T patent/DE3864582D1/de not_active Expired - Fee Related
- 1988-05-27 ES ES88108449T patent/ES2051796T3/es not_active Expired - Lifetime
1991
- 1991-11-22 GR GR91401338T patent/GR3003177T3/el unknown

Also Published As

Publication number	Publication date
NO171063B (no)	1992-10-12
FI882505A0 (fi)	1988-05-27
FI882505A7 (fi)	1988-11-30
NO882317L (no)	1988-11-30
KR880013914A (ko)	1988-12-22
PH26153A (en)	1992-03-18
PT87603B (pt)	1992-12-31
US4889871A (en)	1989-12-26
IL86502A0 (en)	1988-11-15
DE3864582D1 (de)	1991-10-10
IE881611L (en)	1988-11-29
NO882317D0 (no)	1988-05-26
CA1337660C (en)	1995-11-28
EP0292977A1 (en)	1988-11-30
PT87603A (pt)	1988-06-01
IE60687B1 (en)	1994-08-10
IL86502A (en)	1994-07-31
NZ224807A (en)	1991-03-26
ES2051796T3 (es)	1994-07-01
AU611153B2 (en)	1991-06-06
DK290188A (da)	1988-11-30
JP2758902B2 (ja)	1998-05-28
JPS6438045A (en)	1989-02-08
DK290188D0 (da)	1988-05-27
AU1668188A (en)	1988-12-01
GR3003177T3 (en)	1993-02-17
EP0292977B1 (en)	1991-09-04

Publication	Publication Date	Title
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NO164025C (no)	1990-08-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-imidazolylmetyl-tetrahydrokarbazolon-derivater.
NO884467D0 (no)	1988-10-07	Analogifremgangsmaate for fremstilling av aminomethyloxooxazolidinyl-ycloalkylbenzenderivater.
FI96861C (fi)	1996-09-10	Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
NO156785B (no)	1987-08-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive cyklobutan-derivater.
NO169900C (no)	1992-08-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive (ih-azol-1-ylmetyl)substituerte benzotriazolderivater
NO872946D0 (no)	1987-07-15	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzensulfonamidoindanylforbindelser.
NO169439C (no)	1992-06-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive oxadiazoler
NO874153D0 (no)	1987-10-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazo-benzoksazinon-derivater.
NO161497C (no)	1989-08-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive 9a-aza-9a-homoerytromycin-derivater.
NO903941D0 (no)	1990-09-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive diazepinon-derivater.
NO172575C (no)	1993-08-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzocykloalkanderivater
NO895199D0 (no)	1989-12-21	Analogifremgangsmaate for fremstilling av terapeutisk virksomme kinolinsystemforbindelser.
NO871028D0 (no)	1987-03-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive tiazol- og oksazol-derivater.
NO169963C (no)	1992-08-26	Analogifremgangsmaate til fremstilling av terapeutisk aktive, substituerte 3,4-dihydro-2h-benzopyraner
NO164541C (no)	1990-10-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater.
NO167734C (no)	1991-12-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte aminderivater.
NO902710L (no)	1990-12-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive r(-) 3-kinuklidinol-derivater.
NO159090C (no)	1988-11-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridoindol-derivater.
NO167980C (no)	1992-01-02	Analogifremgangsmaate for fremstilling av tienoimidazol-derivater.
NO894949L (no)	1990-06-11	Analogifremgangsmaate for fremstilling av terapeutisk virksomme benzopyranylpyrrolinonderivater.
NO891009L (no)	1989-09-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzocyklokeptenderivater.
NO821882L (no)	1982-12-07	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrazolo-pyrido-diazepin-derivater
NO168530C (no)	1992-03-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzoksazoninforbindelser.
NO874780D0 (no)	1987-11-17	Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolo-benzimidazol-derivater.