NO171500C - Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater

Info

Publication number: NO171500C
Authority: NO; Norway
Prior art keywords: derivatives; substituted; purinylpiperazine; preparation; therapeutic active
Prior art date: 1988-03-03

Application number

NO890893A

Other languages

English (en)

Norwegian (no)

Other versions

NO890893D0 (no

NO171500B (no

NO890893L (no

Inventor

Zoltan G Hajos

Ramesh M Kanojia

Jeffrey B Press

Original Assignee

Ortho Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-03

Filing date

1989-03-02

Publication date

1993-03-24

1989-03-02 Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp

1989-03-02 Publication of NO890893D0 publication Critical patent/NO890893D0/no

1989-09-04 Publication of NO890893L publication Critical patent/NO890893L/no

1992-12-14 Publication of NO171500B publication Critical patent/NO171500B/no

1993-03-24 Publication of NO171500C publication Critical patent/NO171500C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/36—Sulfur atom
- C07D473/38—Sulfur atom attached in position 6

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO890893A 1988-03-03 1989-03-02 Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater NO171500C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/163,487 US4876257A (en)	1988-03-03	1988-03-03	6-Substituted purinyl piperazine derivatives useful as cardiotonic and antiarrhythmic agents

Publications (4)

Publication Number	Publication Date
NO890893D0 NO890893D0 (no)	1989-03-02
NO890893L NO890893L (no)	1989-09-04
NO171500B NO171500B (no)	1992-12-14
NO171500C true NO171500C (no)	1993-03-24

Family

ID=22590215

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO890893A NO171500C (no)	1988-03-03	1989-03-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater

Country Status (20)

Country	Link
US (1)	US4876257A (de)
EP (1)	EP0331511B1 (de)
JP (1)	JPH0826019B2 (de)
KR (1)	KR940002822B1 (de)
CN (1)	CN1031056C (de)
AT (1)	ATE92067T1 (de)
AU (1)	AU614583B2 (de)
DE (1)	DE68907750T2 (de)
DK (1)	DK101589A (de)
ES (1)	ES2059724T3 (de)
FI (1)	FI92587C (de)
HU (1)	HU205760B (de)
IE (1)	IE63457B1 (de)
IL (1)	IL89458A (de)
MY (1)	MY104959A (de)
NO (1)	NO171500C (de)
NZ (1)	NZ228167A (de)
PH (1)	PH26971A (de)
PT (1)	PT89903B (de)
ZA (1)	ZA891623B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5057517A (en) *	1987-07-20	1991-10-15	Merck & Co., Inc.	Piperazinyl derivatives of purines and isosteres thereof as hypoglycemic agents
US5164390A (en) *	1988-03-03	1992-11-17	Ortho Pharmaceutical Corporation	6-substituted purinyl piperazine derivatives
US5021574A (en) *	1988-03-03	1991-06-04	Ortho Pharmaceutical Corporation	6-substituted purinyl piperazine derivatives
US4885300A (en) *	1988-03-03	1989-12-05	Ortho Pharmaceutical Corporation	4-Substituted pyrazolo[3,4-D]pyrimidine derivatives
NZ237766A (en)	1990-04-23	1993-03-26	Ortho Pharma Corp	Process for preparing optically active isomers of 6-substituted purinyl-piperazine or -piperidine derivatives; optically active intermediates
AU648070B2 (en) *	1990-04-23	1994-04-14	Ortho Pharmaceutical Corporation	Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives
US5215987A (en) *	1990-04-23	1993-06-01	Ortho Pharmaceutical Corporation	Substituted benzhydryl 2-hydroxypropyl piperazine derivatives
US5252569A (en) *	1990-05-23	1993-10-12	Ortho Pharmaceutical Corporation	6-substituted purinyl piperazine derivatives
NZ238122A (en) *	1990-05-23	1994-01-26	Ortho Pharma Corp	6-substituted purinyl piperazine derivatives and pharmaceutical
NZ249286A (en) *	1992-02-13	1996-02-27	Merrell Dow Pharma	Piperidine-4-ylmethyl thiophene and thiazole derivatives and pharmaceutical compositions
US5463061A (en) *	1992-05-15	1995-10-31	Mitsui Toatsu Chemicals, Incorporated	Process for production of glycide derivative
ZA9610736B (en) *	1995-12-22	1997-06-27	Warner Lambert Co	2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
AU4219897A (en) *	1996-09-18	1998-04-14	Daiso Co. Ltd.	Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers
EP0930307B1 (de) *	1996-09-18	2002-12-04	Daiso Co., Ltd.	Verfahren zur herstellung von glycidylethern
EP1017394B1 (de) *	1997-07-12	2005-12-07	Cancer Research Technology Limited	Cyclin-abhängige-kinase inhibierende purinderivate
KR20030025153A (ko) *	2001-09-19	2003-03-28	이보섭	지방족 또는 방향족 관능기를 갖는 6-치환 아미노퓨린유도체 및 이를 함유한 화장료 조성물
KR20050092424A (ko) *	2003-01-17	2005-09-21	씨브이 쎄러퓨틱스, 인코포레이티드	심혈관 질환의 치료에 유용한 치환된 헤테로고리 화합물
IL283725B2 (en)	2017-06-20	2024-04-01	Imbria Pharmaceuticals Inc	Compositions and methods for increasing efficiency of cardiac metabolism
EP3866794B1 (de)	2018-10-17	2024-12-04	Imbria Pharmaceuticals, Inc.	Verfahren zur behandlung von rheumatischen erkrankungen unter verwendung von trimetazidinbasierten verbindungen
EP3976101A4 (de)	2019-05-31	2023-06-21	Imbria Pharmaceuticals, Inc.	Verfahren zur behandlung von fibrose unter verwendung von verbindungen zur förderung der glucoseoxidation
US11780811B2 (en)	2020-06-30	2023-10-10	Imbria Pharmaceuticals, Inc.	Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en)	2020-06-30	2022-12-20	Imbria Pharmaceuticals, Inc.	Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en)	2021-05-03	2024-01-30	Imbria Pharmaceuticals, Inc.	Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3238207A (en) *	1960-03-01	1966-03-01	Burroughs Wellcome Co	6-oxyorganopurines and method of preparing them
US3232937A (en) *	1962-08-02	1966-02-01	Burroughs Wellcome Co	6-benzylmercaptopurines
US3135754A (en) *	1962-08-09	1964-06-02	Burroughs Wellcome Co	Purine derivatives
GB1133989A (en) *	1964-12-08	1968-11-20	Chugai Pharmaceutical Co Ltd	Theophylline derivatives, their salts and process for preparing the same
DE1620576A1 (de) *	1966-11-25	1970-02-26	Troponwerke Dinklage & Co	Verfahren zur Herstellung von Theophyllin- und Theobrominverbindungen
GB1289287A (de) *	1969-03-28	1972-09-13
DE2334009A1 (de) *	1973-07-04	1975-01-23	Boehringer Mannheim Gmbh	Purin-derivate sowie verfahren zu ihrer herstellung
US4189579A (en) *	1977-05-20	1980-02-19	The Dow Chemical Company	Aminoalkylthiopurines
US4426383A (en) *	1980-09-04	1984-01-17	Eisai Co., Ltd.	Theophylline and theobromine derivatives
DE3200304A1 (de) *	1981-01-16	1982-08-26	Sandoz-Patent-GmbH, 7850 Lörrach	3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3364234D1 (en) *	1982-03-02	1986-07-31	Eisai Co Ltd	Antiphlogistic/antipyretic/analgesic pharmaceutical compositions containing theophylline derivatives as active ingredient
DK157135C (da) *	1982-04-07	1990-04-02	Pfizer	Analogifremgangsmaade til fremstilling af 1,2,4-triazol-forbindelser eller farmaceutisk acceptable syreadditionssalte deraf
DE3703633A1 (de) *	1986-02-14	1987-08-20	Sandoz Ag	Purin-derivate, ihre herstellung und sie enthaltende arzneimittel
US4710572A (en) *	1986-07-30	1987-12-01	American Home Products Corporation	Histamine H1 antagonists

1988
- 1988-03-03 US US07/163,487 patent/US4876257A/en not_active Expired - Fee Related
1989
- 1989-02-28 NZ NZ228167A patent/NZ228167A/xx unknown
- 1989-03-01 AU AU30882/89A patent/AU614583B2/en not_active Ceased
- 1989-03-02 IE IE68489A patent/IE63457B1/en not_active IP Right Cessation
- 1989-03-02 DK DK101589A patent/DK101589A/da unknown
- 1989-03-02 FI FI891003A patent/FI92587C/fi not_active IP Right Cessation
- 1989-03-02 IL IL89458A patent/IL89458A/xx not_active IP Right Cessation
- 1989-03-02 ZA ZA891623A patent/ZA891623B/xx unknown
- 1989-03-02 MY MYPI89000259A patent/MY104959A/en unknown
- 1989-03-02 NO NO890893A patent/NO171500C/no unknown
- 1989-03-03 CN CN89102516A patent/CN1031056C/zh not_active Expired - Fee Related
- 1989-03-03 AT AT89302141T patent/ATE92067T1/de not_active IP Right Cessation
- 1989-03-03 EP EP89302141A patent/EP0331511B1/de not_active Expired - Lifetime
- 1989-03-03 ES ES89302141T patent/ES2059724T3/es not_active Expired - Lifetime
- 1989-03-03 JP JP1051804A patent/JPH0826019B2/ja not_active Expired - Lifetime
- 1989-03-03 HU HU891033A patent/HU205760B/hu not_active IP Right Cessation
- 1989-03-03 PH PH38279A patent/PH26971A/en unknown
- 1989-03-03 DE DE89302141T patent/DE68907750T2/de not_active Expired - Fee Related
- 1989-03-03 KR KR1019890002603A patent/KR940002822B1/ko not_active Expired - Fee Related
- 1989-03-03 PT PT89903A patent/PT89903B/pt not_active IP Right Cessation

Also Published As

Publication number	Publication date
ATE92067T1 (de)	1993-08-15
HUT49352A (en)	1989-09-28
US4876257A (en)	1989-10-24
DK101589D0 (da)	1989-03-02
KR890014538A (ko)	1989-10-24
DE68907750T2 (de)	1994-01-05
KR940002822B1 (ko)	1994-04-04
PT89903B (pt)	1994-05-31
JPH0826019B2 (ja)	1996-03-13
JPH01279887A (ja)	1989-11-10
FI92587B (fi)	1994-08-31
DK101589A (da)	1989-09-04
IL89458A0 (en)	1989-09-10
AU3088289A (en)	1989-09-07
NZ228167A (en)	1991-08-27
MY104959A (en)	1994-07-30
EP0331511A1 (de)	1989-09-06
ES2059724T3 (es)	1994-11-16
FI92587C (fi)	1994-12-12
PH26971A (en)	1992-12-28
IE63457B1 (en)	1995-04-19
FI891003A7 (fi)	1989-09-04
IE890684L (en)	1989-09-03
NO890893D0 (no)	1989-03-02
IL89458A (en)	1993-07-08
CN1031056C (zh)	1996-02-21
NO171500B (no)	1992-12-14
DE68907750D1 (de)	1993-09-02
AU614583B2 (en)	1991-09-05
FI891003A0 (fi)	1989-03-02
HU205760B (en)	1992-06-29
CN1036765A (zh)	1989-11-01
NO890893L (no)	1989-09-04
ZA891623B (en)	1990-11-28
EP0331511B1 (de)	1993-07-28
PT89903A (pt)	1989-11-10

Publication	Publication Date	Title
NO171500C (no)	1993-03-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive 6-substituerte purinylpiperazinderivater
DE3750929D1 (de)	1995-02-09	Benzo(5,6)cycloheptapyridine, Zusammensetzungen und Verwendung.
ATE114650T1 (de)	1994-12-15	Heterocyclische n-oxid-derivate substituierter benzo(5,6>cycloheptapyridine, zusammensetzungen und methoden der verwendung.
NO172801C (no)	1993-09-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinuklidin-derivater
NO167142C (no)	1991-10-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive heterocykliske derivater.
NO843979L (no)	1985-04-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-benzyl-aminoalkyl-pyrrolidinon-derivater
NO171909C (no)	1993-05-19	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-dihydropyridinderivater
NO165922C (no)	1991-05-02	Analogifremgangsmaate for fremstilling av terapeutisk aktive estere av hexahydro-8-hydroxy-2,6-methano-2h-kinolizin-3-(4h)-on og beslektede forbindelser.
NO901008D0 (no)	1990-03-02	Fremgangsmaate for fremstilling av (3-(c16-c18)alkansulfinyl- og sulfonyl-2-methoxymethyl-propyl)-(2-trimethylaminio-ethyl)-fosfater.
NO171412C (no)	1993-03-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatiolan- eller 1,3-ditiolanderivater
DE3688721D1 (de)	1993-08-26	Verwendung von porphyrinderivaten bei der entdeckung und behandlung von tumoren.
NO172490C (no)	1993-07-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-disubstituerte piperazinderivater
NO164897C (no)	1990-11-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive oxazolidinonderivater.
NO173185C (no)	1993-11-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoxalinforbindelser
NO169069C (no)	1992-05-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-alkoksy-2-aminopropylaminderivater
NO169648C (no)	1992-07-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive arakidonsyre-derivater
NO171211C (no)	1993-02-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksaner
NO162072C (no)	1989-11-01	Analogifremgangsmaate for fremstilling av terapeutisk aktive tienopyridinderivater.
NO168103C (no)	1992-01-15	Analogifremgangsmaate for fremstilling av terapeutisk aktive aralkylimidazolderivater
ES2061481T3 (es)	1994-12-16	Derivados de 3,4-dihidrobenzoazina opticamente activos y procedimiento para la preparacion de los mismos.
NO164650C (no)	1990-10-31	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1-(acetylaminofenyl)-2-aminopropanon-derivater.
NO171499C (no)	1993-03-24	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6-dihydro-4h-cyklo-penta(b)tiofen-6-karboksylsyre-derivater
MY104804A (en)	1994-05-31	Process for preparing optically active isomers of 6-substituted purinyl piperazine derivatives
NO169589C (no)	1992-07-15	Analogifremgangsmaate for fremstilling av terapeutisk aktive tetraazaacenaftylen-derivater
NO168587C (no)	1992-03-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazodiazepin-derivater