NO171633C - Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider

Info

Publication number: NO171633C
Authority: NO; Norway
Prior art keywords: cycloal; sulphonamides; indol; preparation; change
Prior art date: 1986-02-21

Application number

NO870437A

Other languages

English (en)

Norwegian (no)

Other versions

NO870437L (no

NO870437D0 (no

NO171633B (no

Inventor

Horst Boeshagen

Ulrich Rosentreter

Folker Lieb

Hermann Oediger

Friedel Seuter

Elisabeth Perzborn

Volker-Bernd Fiedler

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-02-21

Filing date

1987-02-04

Publication date

1993-04-14

1987-02-04 Application filed by Bayer Ag filed Critical Bayer Ag

1987-02-04 Publication of NO870437D0 publication Critical patent/NO870437D0/no

1987-08-24 Publication of NO870437L publication Critical patent/NO870437L/no

1993-01-04 Publication of NO171633B publication Critical patent/NO171633B/no

1993-04-14 Publication of NO171633C publication Critical patent/NO171633C/no

Links

-1 INDOL SULPHONAMIDES Chemical class 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Pulmonology (AREA)
Hematology (AREA)
Diabetes (AREA)
Immunology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

NO870437A 1986-02-21 1987-02-04 Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider NO171633C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE3605566		1986-02-21
DE19863631824 DE3631824A1 (de)	1986-02-21	1986-09-19	Cycloalkano(1.2-b)indol-sulfonamide

Publications (4)

Publication Number	Publication Date
NO870437D0 NO870437D0 (no)	1987-02-04
NO870437L NO870437L (no)	1987-08-24
NO171633B NO171633B (no)	1993-01-04
NO171633C true NO171633C (no)	1993-04-14

Family

ID=25841196

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO870437A NO171633C (no)	1986-02-21	1987-02-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider

Country Status (19)

Country	Link
US (3)	US4827032A (cs)
EP (1)	EP0242518B1 (cs)
JP (1)	JPH075552B2 (cs)
KR (2)	KR940007302B1 (cs)
AU (1)	AU595855B2 (cs)
CA (1)	CA1309414C (cs)
CS (1)	CS275837B6 (cs)
DE (2)	DE3631824A1 (cs)
DK (1)	DK167009B1 (cs)
ES (1)	ES2028801T3 (cs)
FI (1)	FI86544C (cs)
GR (1)	GR3001763T3 (cs)
HU (1)	HU198686B (cs)
IE (1)	IE59470B1 (cs)
IL (1)	IL81611A (cs)
NO (1)	NO171633C (cs)
NZ (1)	NZ219319A (cs)
PH (1)	PH24491A (cs)
PT (1)	PT84316B (cs)

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DE3826371A1 (de) *	1988-08-03	1990-02-08	Bayer Ag	Tetrahydro-1-benz-(c,d)-indolpropionsaeure-sulfonamide
DE3829455A1 (de) *	1988-08-31	1990-03-15	Boehringer Mannheim Gmbh	Sulfonamidoalkyl-cyclohexan-verbindungen, verfahren zu ihrer herstellung sowie arzneimittel
US5006542A (en) *	1988-10-31	1991-04-09	E. R. Squibb & Sons, Inc.	Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use
US5070099A (en) *	1988-10-31	1991-12-03	E. R. Squibb & Sons, Inc.	Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
US4959383A (en) *	1988-10-31	1990-09-25	E. R. Squibb & Sons, Inc.	Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use
GB8924392D0 (en) *	1989-10-30	1989-12-20	Bayer Ag	Substituted cycloalkano/b/dihydroindole-and-indolesulphonamides
GB9008108D0 (en) *	1990-04-10	1990-06-06	Bayer Ag	Cycloalkano(b)dihydroindoles and-indolesulphonamides substituted by heterocycles
DE4027278A1 (de) *	1990-08-29	1992-03-05	Bayer Ag	Heterocyclisch substituierte indolsulfonamide
US5827871A (en) *	1991-06-26	1998-10-27	Smithkline Beecham Plc	Medicaments 1,2,3,4-tetrahydrocarbazoles and 5-HT1 agonist use thereof
DE4131346A1 (de) *	1991-09-20	1993-03-25	Bayer Ag	Indolsulfonamid substituierte dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
ES2122982T3 (es) *	1992-12-18	1999-01-01	Smithkline Beecham Plc	Derivados de tetrahidrocarbazol para la fabricacion de un medicamento para el tratamiento de una enfermedad en la que esta indicado un agonista similar a 5-ht1.
DE19507751A1 (de) *	1995-03-06	1996-09-12	Bayer Ag	Verfahren zur Herstellung von substituierten 1,2,3,4-Tetrahydrocarbazolen
US5708187A (en) *	1996-06-27	1998-01-13	Eli Lilly And Company	6-substituted-1,2,3,4-tetrahydro-9H-carbazoles and 7-substituted-10H-cyclohepta 7,6-B!indoles: New 5-HT1F agonists
DE19757983A1 (de) *	1997-12-24	1999-07-01	Bayer Yakuhin Ltd	Thermodynamisch stabile Form von (r)-3[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazol-0-propansäure (Ramatroban)
US7696222B2 (en) *	2005-08-12	2010-04-13	Merck Frosst Canada Ltd	Indole derivatives as CRTH2 receptor antagonists
US7601856B2 (en) *	2006-07-27	2009-10-13	Wyeth	Benzofurans as potassium ion channel modulators
US7662831B2 (en) *	2006-07-27	2010-02-16	Wyeth Llc	Tetracyclic indoles as potassium channel modulators
KR101411820B1 (ko)	2006-08-07	2014-06-24	액테리온 파마슈티칼 리미티드	(3-아미노-1,2,3,4-테트라하이드로-9ｈ-카르바졸-9-일)-아세트산 유도체
GB0624090D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amine salts
GB0624087D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril combination salt
GB0624084D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril amino acid salts
WO2008075028A1 (en) *	2006-12-20	2008-06-26	Cardoz Ab	New combination for use in the treatment of inflammatory disorders
WO2008087371A1 (en) *	2007-01-16	2008-07-24	Cardoz Ab	New combination for use in the treatment of inflammatory disorders
WO2009007674A2 (en) *	2007-07-11	2009-01-15	Cardoz Ab	Combination for use in the treatment of atherosclerosis comprising a mast cell inhibitor and ramatroban or seratrodast
EP2300425A4 (en) *	2008-06-24	2012-03-21	Panmira Pharmaceuticals Llc	PROSTAGLANDIN D2 RECEPTOR CYCLOALCANEÝBINDLUCK ANTAGONISTS
CA2728311A1 (en)	2008-07-15	2010-01-21	F. Hoffmann-La Roche Ag	Aminotetrahydroindazoloacetic acids
CN102216273A (zh)	2008-11-17	2011-10-12	霍夫曼-拉罗奇有限公司	用作crth2拮抗剂或部分激动剂的萘乙酸
RU2011124149A (ru)	2008-11-17	2012-12-27	Ф.Хоффманн-Ля Рош Аг	Нафтилуксусные кислоты
MX2011005120A (es)	2008-11-17	2011-05-30	Hoffmann La Roche	Acidos naftilaceticos.
WO2011117798A1 (en)	2010-03-22	2011-09-29	Actelion Pharmaceuticals Ltd	3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators
MY165623A (en)	2011-04-14	2018-04-18	Idorsia Pharmaceuticals Ltd	7-(heteroaryl-amino)-6,7,8,9-tetrahydropyrido[1,2-a]indol acetic acid derivatives and their use as prostaglandin d2 receptor modulators
US8470884B2 (en)	2011-11-09	2013-06-25	Hoffmann-La Roche Inc.	Alkenyl naphthylacetic acids
HRP20181555T1 (hr)	2014-03-17	2018-11-30	Idorsia Pharmaceuticals Ltd	Derivati azaindol-octene kiseline i njihova uporaba kao modulatora receptora prostaglandina d2
RU2016140708A (ru)	2014-03-18	2018-04-18	Идорсиа Фармасьютиклз Лтд	Производные азаиндол уксусной кислоты и их применение в качестве модуляторов рецептора простагландина d2
ES2991300T3 (es)	2015-02-13	2024-12-03	Inserm Institut Nat De La Sante Et De Larecherche Medicale	Antagonistas de PTGDR-1 y/o PTGDR-2 para prevenir y/o tratar lupus eritematoso sistémico
PL3350179T3 (pl)	2015-09-15	2021-08-02	Idorsia Pharmaceuticals Ltd	Krystaliczne postacie

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1415322A (fr) *	1963-12-09	1965-10-22	Eastman Kodak Co	Nouveaux composés de 3-sulfamidocyclobutanone et de 3-sulfamidocyclobutanol
US3642816A (en) *	1967-08-10	1972-02-15	Sterling Drug Inc	3-acetamido-1 2 3 4-tetrahydrocarbazole
JPS4713658Y1 (cs) *	1969-12-18	1972-05-18
CH586678A5 (cs) *	1970-05-25	1977-04-15	Hoffmann La Roche
DE2226702A1 (de) *	1972-05-25	1973-12-13	Schering Ag	Neue mittel zur behandlung des diabetes mellitus
JPS5186117A (en) *	1975-01-27	1976-07-28	Tanabe Seiyaku Co	Johoseibiryushiseizainoseiho
US4235901A (en) *	1978-05-08	1980-11-25	American Home Products Corporation	1-Hydroxyalkanamine pyrano(3,4-b)indole compositions and use thereof

1986
- 1986-09-19 DE DE19863631824 patent/DE3631824A1/de not_active Withdrawn
1987
- 1987-02-04 NO NO870437A patent/NO171633C/no unknown
- 1987-02-11 EP EP87101901A patent/EP0242518B1/de not_active Expired - Lifetime
- 1987-02-11 ES ES198787101901T patent/ES2028801T3/es not_active Expired - Lifetime
- 1987-02-11 DE DE8787101901T patent/DE3769191D1/de not_active Expired - Lifetime
- 1987-02-13 AU AU68808/87A patent/AU595855B2/en not_active Expired
- 1987-02-18 IL IL81611A patent/IL81611A/xx not_active IP Right Cessation
- 1987-02-18 NZ NZ219319A patent/NZ219319A/en unknown
- 1987-02-19 CS CS871093A patent/CS275837B6/cs unknown
- 1987-02-19 PT PT84316A patent/PT84316B/pt not_active IP Right Cessation
- 1987-02-19 FI FI870693A patent/FI86544C/fi not_active IP Right Cessation
- 1987-02-19 PH PH34883A patent/PH24491A/en unknown
- 1987-02-19 CA CA000530077A patent/CA1309414C/en not_active Expired - Lifetime
- 1987-02-19 HU HU87650A patent/HU198686B/hu unknown
- 1987-02-20 IE IE43987A patent/IE59470B1/en not_active IP Right Cessation
- 1987-02-20 DK DK087187A patent/DK167009B1/da not_active IP Right Cessation
- 1987-02-20 KR KR1019870001410A patent/KR940007302B1/ko not_active Expired - Lifetime
- 1987-07-31 KR KR87008383A patent/KR960001914B1/ko not_active Expired - Fee Related
1988
- 1988-06-29 US US07/212,840 patent/US4827032A/en not_active Expired - Lifetime
1989
- 1989-02-08 US US07/308,152 patent/US4904797A/en not_active Expired - Lifetime
- 1989-11-28 US US07/442,043 patent/US4965258A/en not_active Expired - Lifetime
1991
- 1991-04-11 GR GR91400361T patent/GR3001763T3/el unknown
1992
- 1992-02-27 JP JP4076232A patent/JPH075552B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE3769191D1 (de)	1991-05-16
IE870439L (en)	1987-08-21
AU6880887A (en)	1987-08-27
IE59470B1 (en)	1994-03-09
HU198686B (en)	1989-11-28
FI870693A7 (fi)	1987-08-22
PT84316B (pt)	1989-09-14
KR870007885A (ko)	1987-09-22
GR3001763T3 (en)	1992-11-23
ES2028801T3 (es)	1992-07-16
US4904797A (en)	1990-02-27
KR940007302B1 (ko)	1994-08-12
DK87187D0 (da)	1987-02-20
US4965258A (en)	1990-10-23
FI86544B (fi)	1992-05-29
NO870437L (no)	1987-08-24
JPH075552B2 (ja)	1995-01-25
PT84316A (en)	1987-03-01
NO870437D0 (no)	1987-02-04
EP0242518A1 (de)	1987-10-28
JPH0592954A (ja)	1993-04-16
DE3631824A1 (de)	1988-03-31
CA1309414C (en)	1992-10-27
DK87187A (da)	1987-08-22
CS275837B6 (en)	1992-03-18
HUT44493A (en)	1988-03-28
AU595855B2 (en)	1990-04-12
KR890001982A (ko)	1989-04-07
US4827032A (en)	1989-05-02
NO171633B (no)	1993-01-04
IL81611A (en)	1991-03-10
KR960001914B1 (en)	1996-02-06
FI870693A0 (fi)	1987-02-19
DK167009B1 (da)	1993-08-16
FI86544C (fi)	1992-09-10
EP0242518B1 (de)	1991-04-10
CS8701093A2 (en)	1990-11-14
PH24491A (en)	1990-07-18
NZ219319A (en)	1990-12-21

Publication	Publication Date	Title
NO171633C (no)	1993-04-14	Analogifremgangsmaate for fremstilling av terapeutisk aktive cykloalkano(1.2-b)indol-sulfonamider
NO165344C (no)	1991-01-30	Analogifremgangsmaate for fremstilling av teraputisk aktive indolizin-derivater.
NO870075L (no)	1987-07-09	Fremgangsmaate for fremstilling av terapeutisk aktive indol-derivater.
NO166639C (no)	1991-08-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte, basiske 2-aminotetraliner.
NO171787C (no)	1993-05-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive 8-azabicyclo(3.2.1)oct-2-en-forbindelser
NO167384C (no)	1991-10-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-aralkylpiperidinmethanolderivater.
NO871267L (no)	1987-09-28	Fremgangsmaate for fremstilling av terapeutisk aktive tiazepinforbindelser.
NO871266D0 (no)	1987-03-26	Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater.
NO902411D0 (no)	1990-05-31	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-hydroksy-n-propylaminer.
NO874869L (no)	1988-05-25	Fremgangsmaate for fremstilling av terapeutisk aktive forbindelser.
NO870526L (no)	1987-08-13	Fremgangsmaate for fremstilling av terapeutisk aktive dikloranilin-derivater.
NO162238C (no)	1989-12-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,4-dihydro-4-oksonaftyridinderivater.
NO880182D0 (no)	1988-01-18	Fremgangsmaate for fremstilling av terapeutisk aktive 1, 2-dihydro-3h-indazol-3h-indazol-3-on-derivater.
NO871588D0 (no)	1987-04-14	Fremgangsmaate for fremstilling av terapeutisk aktive heterocykliske karboksamider.
NO166080C (no)	1991-05-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5,6,8-trifluorkinoliner.
NO863671D0 (no)	1986-09-15	Fremgangsmaate for fremstilling av terapeutisk aktive tetrahydro-2-heterocykloalkylpyrido(4,3)indoler.
NO171412C (no)	1993-03-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatiolan- eller 1,3-ditiolanderivater
NO166130C (no)	1991-06-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive 4-pyridonderivater.
NO873108D0 (no)	1987-07-24	Fremgangsmaate for fremstilling av terapeutisk aktive 1,4-benzodiazepiner.
NO167802C (no)	1991-12-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzotiazepinderivater.
NO871766D0 (no)	1987-04-28	Fremgangsmaate for fremstilling av terapeutisk aktive benzo(de)isokinolin-1,3-dioner.
NO171211C (no)	1993-02-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksaner
NO168247C (no)	1992-01-29	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-metoksy-alkyl-ammonium-tetrahydrofuraner.
NO893768D0 (no)	1989-09-22	Fremgangsmaate for fremstilling av terapeutisk aktive 2,7-diamino-1,2,3,4-tetrahydronaftalenderivater.
NO882281D0 (no)	1988-05-25	Fremgangsmaate for fremstilling av terapeutisk aktive pyrazinamider.