NO173059C - Analogifremgangsmaate ved fremstilling av terapeutisk aktive hydantoin-derivater - Google Patents

Analogifremgangsmaate ved fremstilling av terapeutisk aktive hydantoin-derivater

Info

Publication number: NO173059C
Authority: NO; Norway
Prior art keywords: hydantoin derivatives; hydantoin; preparation; present; compounds
Prior art date: 1987-08-28

Application number

NO89891689A

Other languages

English (en)

Norwegian (no)

Other versions

NO173059B (no

NO891689L (no

NO891689D0 (no

Inventor

Mochida Ei

Kato Kazuo

Kato Katsuaki

Miwa Ichitomo

Okuda Jun

Original Assignee

Mochida Pharm Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-08-28

Filing date

1989-04-24

Publication date

1993-10-20

1989-04-24 Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd

1989-04-24 Publication of NO891689L publication Critical patent/NO891689L/no

1989-04-24 Publication of NO891689D0 publication Critical patent/NO891689D0/no

1993-07-12 Publication of NO173059B publication Critical patent/NO173059B/no

1993-10-20 Publication of NO173059C publication Critical patent/NO173059C/no

Links

229940053195 antiepileptics hydantoin derivative Drugs 0.000 title abstract 5
WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical class O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
150000001469 hydantoins Chemical class 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
102000016912 Aldehyde Reductase Human genes 0.000 abstract 1
108010053754 Aldehyde reductase Proteins 0.000 abstract 1
208000002249 Diabetes Complications Diseases 0.000 abstract 1
206010012655 Diabetic complications Diseases 0.000 abstract 1
238000009825 accumulation Methods 0.000 abstract 1
239000003288 aldose reductase inhibitor Substances 0.000 abstract 1
229940090865 aldose reductase inhibitors used in diabetes Drugs 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229940091173 hydantoin Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000002207 metabolite Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
229920005862 polyol Polymers 0.000 abstract 1
150000003077 polyols Chemical class 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/80—Two oxygen atoms, e.g. hydantoin with hetero atoms or acyl radicals directly attached to ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/28—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/04—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/64—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/14—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 6 and unsubstituted in position 7
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO89891689A 1987-08-28 1989-04-24 Analogifremgangsmaate ved fremstilling av terapeutisk aktive hydantoin-derivater NO173059C (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP62214549A JP2764262B2 (ja)	1987-08-28	1987-08-28	ヒダントイン誘導体及びそれを有効成分とする医薬組成物
PCT/JP1988/000843 WO1989001934A1 (en)	1987-08-28	1988-08-25	Hydantoin derivatives

Publications (4)

Publication Number	Publication Date
NO891689L NO891689L (no)	1989-04-24
NO891689D0 NO891689D0 (no)	1989-04-24
NO173059B NO173059B (no)	1993-07-12
NO173059C true NO173059C (no)	1993-10-20

Family

ID=16657578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO89891689A NO173059C (no)	1987-08-28	1989-04-24	Analogifremgangsmaate ved fremstilling av terapeutisk aktive hydantoin-derivater

Country Status (13)

Country	Link
US (1)	US4914099A (de)
EP (1)	EP0305947B1 (de)
JP (1)	JP2764262B2 (de)
AT (1)	ATE78815T1 (de)
AU (1)	AU609180B2 (de)
CA (1)	CA1312083C (de)
DE (1)	DE3873225T2 (de)
DK (1)	DK207389A (de)
ES (1)	ES2042666T3 (de)
FI (1)	FI97134C (de)
GR (1)	GR3005392T3 (de)
NO (1)	NO173059C (de)
WO (1)	WO1989001934A1 (de)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5004751A (en) *	1987-08-28	1991-04-02	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
JP2673381B2 (ja) *	1990-02-23	1997-11-05	持田製薬株式会社	糖尿病前症治療剤および／または脂質低下剤
US5202339A (en) *	1987-08-28	1993-04-13	Mochida Pharmaceutical Co., Ltd.	Hydantoin derivatives
FI902028A7 (fi) *	1988-08-24	1990-04-23	Mochida Pharm Co Ltd	Hydantoiinijohdannaisia
BR9707010B1 (pt)	1996-01-23	2009-05-05		compostos, composição farmacêutica e composições para inibir metaloproteinase e colagenase do tipo iv.
US6919375B1 (en)	1996-01-23	2005-07-19	Shionogi & Co., Ltd.	Sulfonated amino acid derivatives and metalloproteinase inhibitors containing the same
AU709107B2 (en) *	1996-08-22	1999-08-19	Dong Wha Pharmaceutical Industrial Co., Ltd.	Arylsulfonylimidazolone derivatives as an antitumor agent
US5756545A (en) *	1997-04-21	1998-05-26	Warner-Lambert Company	Biphenysulfonamide matrix metal alloproteinase inhibitors
PT877019E (pt) *	1997-05-09	2002-05-31	Hoechst Ag	Acidos diaminocarboxilicos substituidos
DE19719621A1 (de) *	1997-05-09	1998-11-12	Hoechst Ag	Sulfonylaminocarbonsäuren
DE19719817A1 (de) *	1997-05-13	1998-11-19	Hoechst Ag	Substituierte 6- und 7-Aminotetrahydroisochinolincarbonsäuren
AU754050B2 (en)	1998-07-16	2002-10-31	Sanofi-Aventis Deutschland Gmbh	Phosphinous and phosphonic acid derivatives used as medicaments
DE19851184A1 (de)	1998-11-06	2000-05-11	Aventis Pharma Gmbh	N-Arylsulfonyl-aminosäure-omega-amide
DE10012401A1 (de) *	2000-03-15	2001-09-27	Sigurd Lenzen	Arylsulfonylbenzimidazoione und Arylsulfonylhydantoine als Steigerer der Insulinsekretion
KR20070104953A (ko) *	2000-03-17	2007-10-29	아지노모토 가부시키가이샤	신경 장애용 약제

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US3384643A (en) *	1965-02-17	1968-05-21	Upjohn Co	1-hydrocarbylsulfonyl-2, 2-dichloro (ordialkoxy)-4, 5-imidazolidine diones
US3534022A (en) *	1966-02-17	1970-10-13	Dainippon Pharmaceutical Co	1-sulfonyl-5,5-disubstituted hydantoins and processes for preparation thereof
JPS51123824A (en) *	1975-04-22	1976-10-28	Sumitomo Chem Co Ltd	A non-medical antibacterial and its preparation
CA1260947A (en) *	1984-12-29	1989-09-26	Yoshitaka Ohishi	Benzofuran derivative, process for preparing the same and pharmaceutical composition containing the same
US4743611A (en) *	1986-07-02	1988-05-10	American Home Products Corp.	Naphthalenylsulfonylimidazolidinediones and their thioxo analogs useful as aldose reductase inhibitors
JPS6322565A (ja) *	1986-07-02	1988-01-30	アメリカン・ホ−ム・プロダクツ・コ−ポレイシヨン	アルド−スレダクタ−ゼ抑制剤として有用なナフタレニルスルホニルイミダゾリジンジオンおよびそのチオキソ類似体
EP0303863A3 (de) *	1987-08-17	1991-10-23	American Cyanamid Company	Benzolsulfonylcarboxamid-Verbindungen, Zwischenprodukte und Verfahren zu ihrer Herstellung und die Verwendung dieser Verbindungen und Zwischenprodukte als Herbizide

1987
- 1987-08-28 JP JP62214549A patent/JP2764262B2/ja not_active Expired - Lifetime
1988
- 1988-08-24 US US07/235,557 patent/US4914099A/en not_active Expired - Fee Related
- 1988-08-25 WO PCT/JP1988/000843 patent/WO1989001934A1/en not_active Ceased
- 1988-08-26 CA CA000575759A patent/CA1312083C/en not_active Expired - Fee Related
- 1988-08-26 AU AU21577/88A patent/AU609180B2/en not_active Ceased
- 1988-08-29 EP EP88114050A patent/EP0305947B1/de not_active Expired - Lifetime
- 1988-08-29 DE DE8888114050T patent/DE3873225T2/de not_active Expired - Fee Related
- 1988-08-29 ES ES88114050T patent/ES2042666T3/es not_active Expired - Lifetime
- 1988-08-29 AT AT88114050T patent/ATE78815T1/de not_active IP Right Cessation
1989
- 1989-04-24 FI FI891933A patent/FI97134C/fi not_active IP Right Cessation
- 1989-04-24 NO NO89891689A patent/NO173059C/no unknown
- 1989-04-28 DK DK207389A patent/DK207389A/da not_active Application Discontinuation
1992
- 1992-08-10 GR GR920400879T patent/GR3005392T3/el unknown

Also Published As

Publication number	Publication date
FI97134C (fi)	1996-10-25
DE3873225T2 (de)	1993-01-28
DE3873225D1 (de)	1992-09-03
NO173059B (no)	1993-07-12
US4914099A (en)	1990-04-03
AU609180B2 (en)	1991-04-26
JPS6461465A (en)	1989-03-08
NO891689L (no)	1989-04-24
JP2764262B2 (ja)	1998-06-11
ATE78815T1 (de)	1992-08-15
EP0305947B1 (de)	1992-07-29
FI891933A0 (fi)	1989-04-24
EP0305947A1 (de)	1989-03-08
FI97134B (fi)	1996-07-15
GR3005392T3 (de)	1993-05-24
WO1989001934A1 (en)	1989-03-09
FI891933A7 (fi)	1989-04-24
ES2042666T3 (es)	1993-12-16
CA1312083C (en)	1992-12-29
DK207389D0 (da)	1989-04-28
AU2157788A (en)	1989-03-02
DK207389A (da)	1989-04-28
NO891689D0 (no)	1989-04-24

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NO173059C (no)	1993-10-20	Analogifremgangsmaate ved fremstilling av terapeutisk aktive hydantoin-derivater
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AU591860B2 (en)	1989-12-14	Pyrolidineamide derivative having anti-prolyl endopeptidase
DE3485488D1 (de)	1992-03-12	Imidazoliumsalze, zwischenprodukte fuer ihre herstellung sowie ihre verwendung.
MX9203231A (es)	1993-08-01	Derivados de tetrahidropiprrol[1,2-a]pirazina-4-spiro-3'-pirrolidina, proceso para su obtencion y composicion farmaceutica que los contiene
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RU95100773A (ru)	1996-10-27	Новые сложные эфиры серной кислоты сахарных спиртов
RU94038256A (ru)	1996-08-27	Производные пиразолопиримидина, способ их получения, фармацевтические композиции на их основе
HUT58695A (en)	1992-03-30	Process for producing substituted semicarbazone derivatives and artropodicide compositions containing them as active components
AU8112587A (en)	1988-05-19	Imidazolidinone compound and processes for preparation thereof
ES2062094T3 (es)	1994-12-16	Derivados del acido parabanico y composiciones farmaceuticas que los contienen.
AU696532B2 (en)	1998-09-10	Amidinophenylalanine derivatives, a process for their preparation, their use and compositions containing these as anticoagulants
EP0711773A4 (de)	1996-06-19
EP0353941A3 (de)	1991-05-02	3-Aminopyrazol [3,4-d]pyrimidinderivate enthaltendes Arzneimittel gegen Psoriasis
NO952611L (no)	1995-08-30	Derivater av benzoylekgonin, ekgonin og ekgonidin som medisiner
EP0308515A4 (en)	1990-09-05	Thienocinnoline compounds and their medicinal application
WO2000003978A3 (de)	2000-09-14	2,5-substituierte benzolsulfonylharnstoffe und -thioharnstoffe, v,rfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische präparate
ES8104241A1 (es)	1981-04-16	Un procedimiento para la preparacion de compuestos derivadosde 1-((naftil substituido)etil)imidazol
HK47592A (en)	1992-07-10	Piperazine derivatives
NO303825B1 (no)	1998-09-07	Imidazolyl-substituerte cykloheksanderivater, legemidler inneholdende derivatene, anvendelse av derivatene for fremstilling av legemidler samt mellomprodukter for fremstilling av derivatene
EP0414903A4 (en)	1992-06-03	New thioproline derivative
US4316899A (en)	1982-02-23	Chromanone derivatives, a process for their preparation and compositions containing them