NO177008C - Analogifremgangsmåte for fremstilling av terapeutisk aktive tiazolidinon-derivater - Google Patents

Analogifremgangsmåte for fremstilling av terapeutisk aktive tiazolidinon-derivater

Info

Publication number: NO177008C
Authority: NO; Norway
Prior art keywords: alkyl; hydrogen; therapeutically active; analogous process; bond
Prior art date: 1988-03-08

Application number

NO894425A

Other languages

English (en)

Norwegian (no)

Other versions

NO177008B (no

NO894425D0 (no

NO894425L (no

Inventor

David Alan Clark

Steven Wayne Goldstein

Bernard Hulin

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-08

Filing date

1989-11-07

Publication date

1995-07-05

1989-11-07 Application filed by Pfizer filed Critical Pfizer

1989-11-07 Publication of NO894425D0 publication Critical patent/NO894425D0/no

1989-11-07 Publication of NO894425L publication Critical patent/NO894425L/no

1995-03-27 Publication of NO177008B publication Critical patent/NO177008B/no

1995-07-05 Publication of NO177008C publication Critical patent/NO177008C/no

Links

238000004519 manufacturing process Methods 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
125000006701 (C1-C7) alkyl group Chemical group 0.000 abstract 1
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
150000001473 2,4-thiazolidinediones Chemical class 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000002091 cationic group Chemical group 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001153 fluoro group Chemical group F* 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000002218 hypoglycaemic effect Effects 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Medicines Containing Plant Substances (AREA)
Separation Using Semi-Permeable Membranes (AREA)
Paints Or Removers (AREA)
Photoreceptors In Electrophotography (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)

NO894425A 1988-03-08 1989-11-07 Analogifremgangsmåte for fremstilling av terapeutisk aktive tiazolidinon-derivater NO177008C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US1988/000733 WO1989008651A1 (en)	1988-03-08	1988-03-08	Hypoglycemic thiazolidinedione derivatives

Publications (4)

Publication Number	Publication Date
NO894425D0 NO894425D0 (no)	1989-11-07
NO894425L NO894425L (no)	1989-11-07
NO177008B NO177008B (no)	1995-03-27
NO177008C true NO177008C (no)	1995-07-05

Family

ID=22208589

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO894425A NO177008C (no)	1988-03-08	1989-11-07	Analogifremgangsmåte for fremstilling av terapeutisk aktive tiazolidinon-derivater

Country Status (25)

Country	Link
EP (1)	EP0332332B1 (de)
JP (1)	JP2610990B2 (de)
KR (1)	KR910000723B1 (de)
AT (1)	ATE87624T1 (de)
AU (1)	AU593754B2 (de)
CA (1)	CA1328873C (de)
CZ (1)	CZ285957B6 (de)
DD (1)	DD279245A5 (de)
DE (1)	DE68905639T2 (de)
DK (1)	DK108089A (de)
EG (1)	EG19168A (de)
ES (1)	ES2053977T3 (de)
FI (1)	FI93115C (de)
IE (1)	IE62776B1 (de)
IL (1)	IL89482A (de)
MX (1)	MX15171A (de)
MY (1)	MY103979A (de)
NO (1)	NO177008C (de)
NZ (1)	NZ228249A (de)
PH (1)	PH26572A (de)
PL (1)	PL159728B1 (de)
PT (1)	PT89912B (de)
WO (1)	WO1989008651A1 (de)
YU (1)	YU47066B (de)
ZA (1)	ZA891680B (de)

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TW222626B (de) *	1991-07-22	1994-04-21	Pfizer
US5175179A (en) *	1991-09-25	1992-12-29	Pfizer Inc.	Method for treating hypertension
FR2696743B1 (fr) *	1992-10-12	1994-12-23	Adir	Nouveaux composés de thiazolidine dione, leur procédé de préparation et les compositions pharmaceutiques les contenant.
TW245716B (de) *	1992-12-28	1995-04-21	Takeda Pharm Industry Co
US5614544A (en) *	1993-09-14	1997-03-25	Takeda Chemical Industries, Ltd.	Oxazolidinedione derivatives and their use
NZ274346A (en) *	1993-09-15	1997-06-24	Sankyo Co	Use of various thiazolidine-2,4-dione and oxazolidine-2,4-dione derivatives to prevent or delay onset of non-insulin dependent diabetes mellitus
US5874454A (en) *	1993-09-15	1999-02-23	Warner-Lambert Company	Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
US5478852C1 (en) *	1993-09-15	2001-03-13	Sankyo Co	Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus
US6046222A (en) *	1993-09-15	2000-04-04	Warner-Lambert Company	Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus
TW420669B (en) *	1994-03-28	2001-02-01	Nissan Chemical Ind Ltd	Pyridine type thiazolidines
CA2195559A1 (en) *	1994-08-10	1996-02-22	Takashi Sohda	Thiazolidinedione derivatives, their production and use
US5925656A (en) *	1995-04-10	1999-07-20	Dr. Reddy's Research Foundation	Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5708012A (en) *	1995-04-28	1998-01-13	Sankyo Company, Limited	Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus
IL118778A (en) *	1995-07-03	1999-07-14	Sankyo Co	Pharmaceutical compositions for the treatment of arteriosclerosis and xanthoma containing an hmg-coa reductase inhibitor
IL120443A (en) *	1996-03-18	2000-07-16	Sankyo Co	Use of an insulin sensitizer for the manufacture of a medicament for the treatment or prophylaxis of pancreatitis
US5889025A (en) *	1996-05-06	1999-03-30	Reddy's Research Foundation	Antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973848B (en) *	1996-05-06	1997-12-02	Reddy Research Foundation	Novel heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5919782A (en) *	1996-05-06	1999-07-06	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5801173A (en) *	1996-05-06	1998-09-01	Dr. Reddy's Research Foundation	Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
CA2257284C (en) *	1996-05-31	2005-10-04	Sankyo Company Limited	Remedy for autoimmune diseases
US6114526A (en) *	1996-07-01	2000-09-05	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) *	1996-07-01	2006-09-05	Dr. Reddy's Laboratories, Limited	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
CA2258949C (en)	1996-07-01	2008-05-06	Reddy-Cheminor, Inc.	Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en)	1996-07-01	2002-04-16	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) *	1996-07-01	1999-03-23	Dr. Reddy's Research Foundation	Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
DE69731840T2 (de) *	1996-07-15	2005-08-04	Sankyo Co., Ltd.	Pharmazeutische Zusammensetzungen enthaltend CS-866 und Insulinresistenz verbessernde Mittel und deren Verwendung zur Behandlung von Arteriosklerose und Xanthom
JP2000514041A (ja) *	1996-07-26	2000-10-24	ドクター・レディーズ・リサーチ・ファウンデーション	抗糖尿病、低脂血、抗高血圧特性を有するチアゾリジンジオン化合物、それらの調製法、及びその薬学的組成物
EP1006794B1 (de)	1997-03-12	2007-11-28	Robert W. Esmond	Verfahren zur behandlung oder prävention der alzheimerischen krankheit
DE19711616A1 (de)	1997-03-20	1998-09-24	Boehringer Mannheim Gmbh	Verbessertes Verfahren zur Herstellung von Thiazolidindionen
BR9810142A (pt)	1997-06-18	2000-08-08	Smithkline Beecham Plc	Tratamento de diabete com tiazolidinadiona e sulfonil-uréia
GB9715295D0 (en) *	1997-07-18	1997-09-24	Smithkline Beecham Plc	Novel method of treatment
GB9715306D0 (en) *	1997-07-18	1997-09-24	Smithkline Beecham Plc	Novel method of treatment
HUP9902721A2 (hu) *	1997-11-25	1999-12-28	The Procter & Gamble Co.	Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület
WO1999030739A1 (en) *	1997-12-16	1999-06-24	Sankyo Company, Limited	Leukemia remedy
CZ20011629A3 (cs) *	1998-11-12	2001-12-12	Smithkline Beecham Plc	Farmaceutický prostředek pro upravené uvolňování senzitizéru inzulínu a jiných antidiabetických přípravků
AR023699A1 (es)	1998-11-12	2002-09-04	Smithkline Beecham Corp	Una composicion farmaceutica que comprende un estabilizador de insulina y un procedimiento para preparar una composicion farmaceutica
GB9824893D0 (en) *	1998-11-12	1999-01-06	Smithkline Beckman Corp	Novel method of treatment
US6191154B1 (en)	1998-11-27	2001-02-20	Case Western Reserve University	Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases
KR20010099634A (ko) *	1999-07-01	2001-11-09	할리 켈빈 비.	텔로머라제 저해제 및 그 사용 방법
JP2001072592A (ja)	1999-07-01	2001-03-21	Kyowa Hakko Kogyo Co Ltd	テロメラーゼ阻害剤
US6878749B2 (en)	1999-09-17	2005-04-12	Novartis Ag	Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes
US6559188B1 (en)	1999-09-17	2003-05-06	Novartis Ag	Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes
CO5200844A1 (es)	1999-09-17	2002-09-27	Novartis Ag	Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes
EP1743655B1 (de)	2000-01-21	2014-06-25	Novartis AG	Zusammensetzungen bestehend aus dipeptidylpeptidase-iv inhibitoren und antidiabetica
JP2001199888A (ja)	2000-01-24	2001-07-24	Fujimoto Brothers:Kk	糖尿病治療剤
US6680387B2 (en)	2000-04-24	2004-01-20	Aryx Therapeutics	Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
GB0014969D0 (en)	2000-06-19	2000-08-09	Smithkline Beecham Plc	Novel method of treatment
WO2002024689A1 (en)	2000-09-21	2002-03-28	Aryx Therapeutics	Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis
US6452014B1 (en)	2000-12-22	2002-09-17	Geron Corporation	Telomerase inhibitors and methods of their use
US7659409B2 (en)	2002-03-19	2010-02-09	Mitsubishi Chemical Corporation	3-Hydroxy-3-(2-thienyl) propionamides and production method thereof, and production method of 3-amino-1-(2-thienyl)-1-propanols using the same
US8268352B2 (en)	2002-08-05	2012-09-18	Torrent Pharmaceuticals Limited	Modified release composition for highly soluble drugs
US8216609B2 (en)	2002-08-05	2012-07-10	Torrent Pharmaceuticals Limited	Modified release composition of highly soluble drugs
PL1954684T3 (pl) *	2005-11-15	2014-10-31	Otsuka Pharma Co Ltd	Związek oksazolowy i kompozycja farmaceutyczna
US20120094959A1 (en)	2010-10-19	2012-04-19	Bonnie Blazer-Yost	Treatment of cystic diseases
EP2914250B1 (de)	2012-11-05	2018-04-04	Commissariat à l'Énergie Atomique et aux Énergies Alternatives	Kombination aus einem antikrebsmittel wie einem tyrosinekinaseinhibitor und einem stat5-antagonisten, vorzugsweise einem thiazolidindion, zur entfernung von hämatologischen krebsstammzellen in vivo und zur verhinderung eines blutkrebsrezidivs
WO2016071727A1 (en)	2014-11-04	2016-05-12	INSERM (Institut National de la Santé et de la Recherche Médicale)	Methods for the prevention and the treatment of rapidly progressive glomerulonephritis

Family Cites Families (5)

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Publication number	Priority date	Publication date	Assignee	Title
JPS5522636A (en) *	1978-08-04	1980-02-18	Takeda Chem Ind Ltd	Thiazoliding derivative
CN1003445B (zh) *	1984-10-03	1989-03-01	武田药品工业株式会社	噻唑烷二酮衍生物，其制备方法和用途
HU210339B (en) *	1985-05-21	1995-03-28	Pfizer	Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect
WO1989008652A1 (en) *	1988-03-08	1989-09-21	Pfizer Inc.	Thiazolidinedione derivatives as hypoglycemic agents
WO1989008650A1 (en) *	1988-03-08	1989-09-21	Pfizer Inc.	Thiazolidinedione hypoglycemic agents

1988
- 1988-03-08 MX MX1517189A patent/MX15171A/es unknown
- 1988-03-08 WO PCT/US1988/000733 patent/WO1989008651A1/en not_active Ceased
1989
- 1989-03-01 EP EP89302017A patent/EP0332332B1/de not_active Expired - Lifetime
- 1989-03-01 AT AT89302017T patent/ATE87624T1/de not_active IP Right Cessation
- 1989-03-01 ES ES89302017T patent/ES2053977T3/es not_active Expired - Lifetime
- 1989-03-01 DE DE8989302017T patent/DE68905639T2/de not_active Expired - Fee Related
- 1989-03-03 IL IL89482A patent/IL89482A/xx not_active IP Right Cessation
- 1989-03-06 MY MYPI89000271A patent/MY103979A/en unknown
- 1989-03-06 EG EG11789A patent/EG19168A/xx active
- 1989-03-06 ZA ZA891680A patent/ZA891680B/xx unknown
- 1989-03-06 PT PT89912A patent/PT89912B/pt not_active IP Right Cessation
- 1989-03-06 CA CA000592855A patent/CA1328873C/en not_active Expired - Fee Related
- 1989-03-07 NZ NZ228249A patent/NZ228249A/xx unknown
- 1989-03-07 PL PL1989278115A patent/PL159728B1/pl unknown
- 1989-03-07 IE IE73889A patent/IE62776B1/en not_active IP Right Cessation
- 1989-03-07 YU YU47989A patent/YU47066B/sh unknown
- 1989-03-07 CZ CS891439A patent/CZ285957B6/cs not_active IP Right Cessation
- 1989-03-07 DD DD89326340A patent/DD279245A5/de not_active IP Right Cessation
- 1989-03-07 DK DK108089A patent/DK108089A/da not_active Application Discontinuation
- 1989-03-07 AU AU31078/89A patent/AU593754B2/en not_active Ceased
- 1989-03-07 KR KR1019890002787A patent/KR910000723B1/ko not_active Expired
- 1989-03-08 JP JP1055968A patent/JP2610990B2/ja not_active Expired - Fee Related
- 1989-03-08 PH PH38301A patent/PH26572A/en unknown
- 1989-11-06 FI FI895258A patent/FI93115C/fi not_active IP Right Cessation
- 1989-11-07 NO NO894425A patent/NO177008C/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR910000723B1 (ko)	1991-01-31
EG19168A (en)	1995-02-28
PH26572A (en)	1992-08-19
DD279245A5 (de)	1990-05-30
AU3107889A (en)	1989-09-14
MX15171A (es)	1993-05-01
PL278115A1 (en)	1989-10-30
NO177008B (no)	1995-03-27
EP0332332A1 (de)	1989-09-13
CZ143989A3 (cs)	1999-06-16
DK108089A (da)	1989-10-27
NO894425D0 (no)	1989-11-07
JPH01272574A (ja)	1989-10-31
WO1989008651A1 (en)	1989-09-21
IE890738L (en)	1989-09-08
ES2053977T3 (es)	1994-08-01
FI93115B (fi)	1994-11-15
ZA891680B (en)	1990-10-31
MY103979A (en)	1993-10-30
PT89912B (pt)	1994-05-31
YU47989A (en)	1990-12-31
CZ285957B6 (cs)	1999-12-15
NO894425L (no)	1989-11-07
EP0332332B1 (de)	1993-03-31
FI93115C (fi)	1995-02-27
ATE87624T1 (de)	1993-04-15
AU593754B2 (en)	1990-02-15
FI895258A0 (fi)	1989-11-06
DE68905639T2 (de)	1993-07-08
PT89912A (pt)	1989-11-10
IL89482A0 (en)	1989-09-10
IL89482A (en)	1993-04-04
JP2610990B2 (ja)	1997-05-14
CA1328873C (en)	1994-04-26
DK108089D0 (da)	1989-03-07
IE62776B1 (en)	1995-02-22
KR890014533A (ko)	1989-10-24
YU47066B (sh)	1994-12-28
NZ228249A (en)	1990-05-28
PL159728B1 (en)	1993-01-29
DE68905639D1 (de)	1993-05-06

Legal Events

Date	Code	Title	Description
2005-11-14	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO177008C (no)	1995-07-05	Analogifremgangsmåte for fremstilling av terapeutisk aktive tiazolidinon-derivater
MY103837A (en)	1993-09-30	Thiazolidinedione derivatives as hypoglycemic agents.
NO903862L (no)	1990-09-05	Fremgangsmaate for fremstilling av en tiazolidindionhypoglykemisk aktiv forbindelse.
IL102573A (en)	1997-04-15	Hypoglycemic thiazolidinediones
CA2163028A1 (en)	1994-12-08	New thiazolidinediones and pharmaceutical agents containing them
ES2132135T3 (es)	1999-08-16	Procedimiento para la preparacion de compuestos de tiazolidina u oxazolidina farmaceuticamente activos mediante una reductasa de levadura.
HUT68721A (en)	1995-07-28	Benzofuran and benzizoxazole derivatives, pharmaceutical composition containing said compounds as active agent and process for preparing them
KR920016422A (ko)	1992-09-24	N-페닐카바메이트 화합물, 이의 제조방법 및 유해한 유기체를 방제하기 위한 살균 조성물
KR880002829A (ko)	1988-05-11	디하이드로피리딘 항알러지제 및 소염제
HU9203284D0 (en)	1992-12-28	Method for producing thiazolidine-2,4-dione derivatives and medical preparatives containing these compounds
DK147588D0 (da)	1988-03-17	Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
NO872781L (no)	1988-01-04	4-(aroylamino)piperidinbutanamid-derivater.
DK0534655T3 (da)	1995-08-28	Thiazolidin-2,4-dioner til behandling af hypertension
NO162462C (no)	1990-01-03	Analogifremgangsmaate for fremstilling av terapeutisk aktive 5-(2-alkoksyfenyl)-tiazolidindion-derivater.
AU532634B2 (en)	1983-10-06	Thiazolyl derivatives