NO178542C - Benzo[fÅkinolinoner, farmasöytisk formulering og salt derav - Google Patents

Benzo[fÅkinolinoner, farmasöytisk formulering og salt derav

Info

Publication number
NO178542C
NO178542C NO923265A NO923265A NO178542C NO 178542 C NO178542 C NO 178542C NO 923265 A NO923265 A NO 923265A NO 923265 A NO923265 A NO 923265A NO 178542 C NO178542 C NO 178542C
Authority
NO
Norway
Prior art keywords
phaquinolinones
benzo
salt
pharmaceutical formulation
octahydrobenzo
Prior art date
Application number
NO923265A
Other languages
English (en)
Other versions
NO923265L (no
NO178542B (no
NO923265D0 (no
Inventor
James Edmund Audia
Kenneth Steven Hirsch
Charles David Jones
David Ernest Lawhorn
Loretta Ames Mcquaid
Leland Otto Weigel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO923265D0 publication Critical patent/NO923265D0/no
Publication of NO923265L publication Critical patent/NO923265L/no
Publication of NO178542B publication Critical patent/NO178542B/no
Publication of NO178542C publication Critical patent/NO178542C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/16—Preparation of ethers by reaction of esters of mineral or organic acids with hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/513—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an etherified hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/562—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with nitrogen as the only hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/687—Unsaturated compounds containing a keto groups being part of a ring containing halogen
    • C07C49/697—Unsaturated compounds containing a keto groups being part of a ring containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
    • C07C59/255—Tartaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
NO923265A 1991-08-21 1992-08-20 Benzo[fÅkinolinoner, farmasöytisk formulering og salt derav NO178542C (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74811691A 1991-08-21 1991-08-21
US78103991A 1991-10-21 1991-10-21
US07/927,710 US5239075A (en) 1991-08-21 1992-08-10 Process for the preparation of benzo (f) quinolinones

Publications (4)

Publication Number Publication Date
NO923265D0 NO923265D0 (no) 1992-08-20
NO923265L NO923265L (no) 1993-02-22
NO178542B NO178542B (no) 1996-01-08
NO178542C true NO178542C (no) 1996-04-17

Family

ID=27419359

Family Applications (1)

Application Number Title Priority Date Filing Date
NO923265A NO178542C (no) 1991-08-21 1992-08-20 Benzo[fÅkinolinoner, farmasöytisk formulering og salt derav

Country Status (16)

Country Link
US (6) US5239075A (no)
EP (1) EP0532190B1 (no)
JP (1) JP3504678B2 (no)
KR (1) KR100235562B1 (no)
CN (1) CN1039320C (no)
CA (1) CA2076479A1 (no)
CZ (1) CZ290369B6 (no)
DE (1) DE69231610T2 (no)
FI (1) FI102475B1 (no)
HU (2) HUT68034A (no)
IL (1) IL102881A (no)
MX (1) MX9204817A (no)
NO (1) NO178542C (no)
NZ (1) NZ244038A (no)
RU (1) RU2126386C1 (no)
SG (1) SG67312A1 (no)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones
GB9317314D0 (en) * 1993-08-20 1993-10-06 Smithkline Beecham Corp Compounds
RU2173152C2 (ru) * 1993-10-15 2001-09-10 Мерк Энд Ко., Инк. Способ лечения андрогенной алопеции ингибиторами 5-альфа-редуктазы
US5574160A (en) * 1994-05-26 1996-11-12 Eli Lilly And Company Syntheis of benzoquinolinones
US5578724A (en) * 1994-09-20 1996-11-26 Eli Lilly And Company Process for preparation of benzo[f]quinolinones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB2294712B (en) * 1994-11-01 1998-06-24 Camco Drilling Group Ltd Improvements in or relating to rotary drill bits
US5635197A (en) * 1995-03-21 1997-06-03 Eli Lilly And Company Treatment and prevention of prostatic cancer metastasis
TW450809B (en) * 1995-03-21 2001-08-21 Lilly Co Eli Pharmaceutical compositions for preventing or treating prostatic cancer comprising benzoquinolin-3-one derivatives
US5629007A (en) * 1995-03-21 1997-05-13 Eli Lilly And Company Method of preventing prostatic cancer development
US5550134A (en) * 1995-05-10 1996-08-27 Eli Lilly And Company Methods for inhibiting bone loss
US6111110A (en) * 1996-10-30 2000-08-29 Eli Lilly And Company Synthesis of benzo[f]quinolinones
ID21978A (id) * 1996-10-30 1999-08-19 Lilly Co Eli Sintesa benzo (f) kinolinon
EP0926148A1 (en) 1997-12-23 1999-06-30 Applied Research Systems Ars Holding N.V. Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
US6048869A (en) * 1998-07-29 2000-04-11 Merck & Co., Inc. Tricyclic compounds
EP1149080A2 (en) * 1998-12-07 2001-10-31 Eli Lilly And Company Crystalline form of benzoquinoline-3-one derivative as inhibitor of 5-alpha reductase
CA2354021A1 (en) * 1998-12-07 2000-06-15 Paul James Sirois Crystalline form of an octahydro-benzo(f)quinolin-3-one derivative
GB0222516D0 (en) * 2002-09-27 2002-11-06 Karobio Ab Novel compounds
WO2012024437A1 (en) * 2010-08-17 2012-02-23 Purdue Research Foundation Substituted dibenzonaphthyridines, pharmaceutical uses thereof and processes therfor
RU2019110048A (ru) 2016-10-06 2020-11-06 Ассиа Кемикал Индастрис Лтд. Твердые формы валбеназина
CN115504933B (zh) * 2022-10-13 2024-12-13 深圳万知达企业管理有限公司 一种多取代喹啉酮化合物的制备方法及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4511569A (en) * 1982-08-26 1985-04-16 Schering Corporation Tricyclic lactams and derivatives useful in increasing cardiac contractility
SE8302361D0 (sv) * 1983-04-27 1983-04-27 Astra Laekemedel Ab New tricyclic amines
FI82931C (fi) * 1986-01-23 1991-05-10 Hoffmann La Roche Foerfarande foer framstaellning av nya terapeutiskt anvaendbara bensazecinderivat.
ZA883034B (en) * 1987-04-29 1989-03-29 Smithkline Beckman Corp Steroid 5-alpha-reductase inhibitors
IN167395B (no) * 1987-07-21 1990-10-20 Hoffmann La Roche
CA2011640A1 (en) * 1989-03-20 1990-09-20 F. Hoffmann-La Roche Ag Quinoline derivatives
US5300294A (en) * 1990-06-27 1994-04-05 Smithkline Beecham Corporation Method of treating prostatic adenocarcinoma
US5239075A (en) * 1991-08-21 1993-08-24 Eli Lilly And Company Process for the preparation of benzo (f) quinolinones
US5250539A (en) * 1991-08-21 1993-10-05 Eli Lilly And Company Hexahydrobenzo[f]quinolinones

Also Published As

Publication number Publication date
CZ290369B6 (cs) 2002-07-17
EP0532190A3 (en) 1993-07-14
US5541190A (en) 1996-07-30
CN1071418A (zh) 1993-04-28
NO923265L (no) 1993-02-22
EP0532190B1 (en) 2000-12-27
CN1039320C (zh) 1998-07-29
IL102881A (en) 1999-12-31
JP3504678B2 (ja) 2004-03-08
NO178542B (no) 1996-01-08
IL102881A0 (en) 1993-01-31
US5495021A (en) 1996-02-27
US5239075A (en) 1993-08-24
JPH05239032A (ja) 1993-09-17
SG67312A1 (en) 1999-09-21
CA2076479A1 (en) 1993-02-22
FI923752A0 (fi) 1992-08-20
DE69231610D1 (de) 2001-02-01
FI102475B (fi) 1998-12-15
HUT68034A (en) 1995-05-29
EP0532190A2 (en) 1993-03-17
FI923752A7 (fi) 1993-02-22
FI102475B1 (fi) 1998-12-15
KR100235562B1 (ko) 1999-12-15
MX9204817A (es) 1993-04-01
DE69231610T2 (de) 2001-06-13
NO923265D0 (no) 1992-08-20
NZ244038A (en) 1994-11-25
RU2126386C1 (ru) 1999-02-20
US5334767A (en) 1994-08-02
CZ256692A3 (en) 1993-04-14
US5670512A (en) 1997-09-23
KR930004268A (ko) 1993-03-22
HU211338A9 (en) 1995-11-28
US5710163A (en) 1998-01-20

Similar Documents

Publication Publication Date Title
FI923752A0 (fi) Benso(f)kinolinoner.
IL97025A0 (en) 17beta-substituted-4-aza-5alpha-androstan-3-one derivatives,their preparation and pharmaceutical compositions containing them
BR1100987A (pt) Composto, composição farmacêutica da matéria, e, composição veterinária
NZ240230A (en) Mercaptoacetylamide derivatives; preparation, use and pharmaceutical compositions thereof
NO930950D0 (no) Sammensetninger inneholdende kombinasjoner av overflateaktive midler og derivater av suksinske acyleringsmidler eller hydroksyaromatiske forbindelser og fremgangsmaater for anvendelse av disse
IL103875A0 (en) Piperazinyl-and piperidinyl-cyclohexanol derivatives and pharmaceutical compositions containing the same
NZ218028A (en) Benzimidazole derivatives and pharmaceutical compositions
NO921835D0 (no) Fremgangsmaate for fremstilling av amidinofenylalaninderivat samt anvendelse derav
ATE321543T1 (de) Pharmazeutische zusammensetzungen mit hydroximsäurederivaten
AU2867992A (en) Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
NO933524D0 (no) Krystallisk tiagabinhydrokloridmonohydrat samt fremstilling og anvendelse derav
IL82401A0 (en) Dopamine beta hydroxy-lase inhibiting imidazole derivatives and pharmaceutical compositions containing them
SE8404065D0 (sv) Novel biologically active compounds
FI931160A7 (fi) Meripihkahappoasylointiaineen tai hydroksiaromaattisten yhdisteiden johdannaisia sisältäviä koostumuksia ja niiden käyttö
NO306903B1 (no) 6-(substituert-metylen)-penem'er, farmasöytiske blandinger inneholdende slike, anvendelse derav og mellomprodukter for fremstilling av dem
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
ITMI910456A1 (it) Composizione farmaceutica per il trattamento della cataratta
ATE204278T1 (de) Serotoninergische ergolin derivate
SE8600658D0 (sv) Novel composition of matter
TR27833A (tr) Antelmintik'lerin uygulanmasina mahsus ''pour-on'' formülasyonu.
YU31995A (sh) Benzotiofeni glikopiranozida, postupak za njihovo dobijanje i njihova farmaceutska formulacija
NO923266D0 (no) Heksahydrobenzo(f)quinolinoner
DK601888D0 (da) Anvendelse af 2-pyrimidinyl-1-piperazinderivater
ITMI911445A0 (it) Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva
DK0418990T3 (da) 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler