NO179995C - Fremgangsmåte for fremstilling av legemiddel-lipidsystemer med lav toksisitet inneholdende polyen-antibiotika - Google Patents

Fremgangsmåte for fremstilling av legemiddel-lipidsystemer med lav toksisitet inneholdende polyen-antibiotika

Info

Publication number: NO179995C
Authority: NO; Norway
Prior art keywords: lipid; compositions; preparation; low; systems containing
Prior art date: 1987-03-05

Application number

NO884391A

Other languages

English (en)

Norwegian (no)

Other versions

NO884391L (no

NO179995B (no

NO884391D0 (no

Inventor

Andrew Stuart Janoff

Lawrence Boni

Thomas D Madden

Pieter R Cullis

Robert P Lenk

John J Kearns

Anthony G Durning

Robert Klimchak

Joel Portnoff

Original Assignee

Liposome Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-03-05

Filing date

1988-10-04

Publication date

1997-01-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27361805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO179995(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1988-10-04 Application filed by Liposome Co Inc filed Critical Liposome Co Inc

1988-10-04 Publication of NO884391D0 publication Critical patent/NO884391D0/no

1988-11-24 Publication of NO884391L publication Critical patent/NO884391L/no

1994-10-26 Priority to NO944071A priority Critical patent/NO180147C/no

1996-10-21 Publication of NO179995B publication Critical patent/NO179995B/no

1997-01-29 Publication of NO179995C publication Critical patent/NO179995C/no

1998-03-25 Priority to NO1998013C priority patent/NO1998013I1/no

Links

238000000034 method Methods 0.000 title abstract 4
239000002459 polyene antibiotic agent Substances 0.000 title abstract 2
231100000053 low toxicity Toxicity 0.000 title 1
150000002632 lipids Chemical class 0.000 abstract 5
229940079593 drug Drugs 0.000 abstract 4
239000003814 drug Substances 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 3
CITHEXJVPOWHKC-UUWRZZSWSA-N 1,2-di-O-myristoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCC CITHEXJVPOWHKC-UUWRZZSWSA-N 0.000 abstract 2
229960003724 dimyristoylphosphatidylcholine Drugs 0.000 abstract 2
229960005160 dimyristoylphosphatidylglycerol Drugs 0.000 abstract 2
BPHQZTVXXXJVHI-AJQTZOPKSA-N ditetradecanoyl phosphatidylglycerol Chemical compound CCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@@H](O)CO)OC(=O)CCCCCCCCCCCCC BPHQZTVXXXJVHI-AJQTZOPKSA-N 0.000 abstract 2
APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 abstract 1
241000124008 Mammalia Species 0.000 abstract 1
APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
229960003942 amphotericin b Drugs 0.000 abstract 1
239000012867 bioactive agent Substances 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
230000002209 hydrophobic effect Effects 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
231100000331 toxic Toxicity 0.000 abstract 1
230000002588 toxic effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
- G03B2227/00—Photographic printing apparatus
- G03B2227/32—Projection printing apparatus, e.g. enlarging apparatus, copying camera
- G03B2227/325—Microcapsule copiers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Dispersion Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Vehicle Step Arrangements And Article Storage (AREA)
Catalysts (AREA)
Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)

NO884391A 1987-03-05 1988-10-04 Fremgangsmåte for fremstilling av legemiddel-lipidsystemer med lav toksisitet inneholdende polyen-antibiotika NO179995C (no)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
NO944071A NO180147C (no)	1987-03-05	1994-10-26	Fremgangsmåte for fremstilling av HDLC eller et liposom innbefattende et polyen-antisopp-antibiotikum og et lipid
NO1998013C NO1998013I1 (no)	1987-03-05	1998-03-25	Amfotericin B Lipid-kompleks

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US2215787A	1987-03-05	1987-03-05
US6990887A	1987-07-06	1987-07-06
US7930987A	1987-07-29	1987-07-29
PCT/US1988/000647 WO1988006443A1 (en)	1987-03-05	1988-03-03	Low toxicity drug-lipid systems

Publications (4)

Publication Number	Publication Date
NO884391D0 NO884391D0 (no)	1988-10-04
NO884391L NO884391L (no)	1988-11-24
NO179995B NO179995B (no)	1996-10-21
NO179995C true NO179995C (no)	1997-01-29

Family

ID=27361805

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
NO884391A NO179995C (no)	1987-03-05	1988-10-04	Fremgangsmåte for fremstilling av legemiddel-lipidsystemer med lav toksisitet inneholdende polyen-antibiotika
NO944071A NO180147C (no)	1987-03-05	1994-10-26	Fremgangsmåte for fremstilling av HDLC eller et liposom innbefattende et polyen-antisopp-antibiotikum og et lipid
NO1998012C NO1998012I1 (no)	1987-03-05	1998-03-25	Amfotericin B Lipid-kompleks
NO1998013C NO1998013I1 (no)	1987-03-05	1998-03-25	Amfotericin B Lipid-kompleks

Family Applications After (3)

Application Number	Title	Priority Date	Filing Date
NO944071A NO180147C (no)	1987-03-05	1994-10-26	Fremgangsmåte for fremstilling av HDLC eller et liposom innbefattende et polyen-antisopp-antibiotikum og et lipid
NO1998012C NO1998012I1 (no)	1987-03-05	1998-03-25	Amfotericin B Lipid-kompleks
NO1998013C NO1998013I1 (no)	1987-03-05	1998-03-25	Amfotericin B Lipid-kompleks

Country Status (20)

Country	Link
EP (1)	EP0282405B2 (de)
KR (1)	KR970002870B1 (de)
CN (1)	CN1044093C (de)
AT (1)	ATE118169T1 (de)
AU (1)	AU622405B2 (de)
CA (1)	CA1338701C (de)
DE (1)	DE3852961T3 (de)
DK (1)	DK176010B1 (de)
ES (1)	ES2070131T5 (de)
FI (1)	FI102724B1 (de)
GR (1)	GR3015916T3 (de)
HK (1)	HK1007495A1 (de)
IE (1)	IE67152B1 (de)
IL (1)	IL85607A (de)
LU (1)	LU88684I2 (de)
NL (1)	NL990004I1 (de)
NO (4)	NO179995C (de)
NZ (1)	NZ223660A (de)
PT (1)	PT86913B (de)
WO (1)	WO1988006443A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5178875A (en) *	1991-01-14	1993-01-12	The Board Of Regents, The University Of Texas System	Liposomal-polyene preliposomal powder and method for its preparation
US5830498A (en) *	1987-10-16	1998-11-03	Board Of Regents, The University Of Texas System	Liposomal-polyene preliposomal powder and method for its preparation
AU598958B2 (en)	1987-11-12	1990-07-05	Vestar, Inc.	Improved amphotericin b liposome preparation
JP2798302B2 (ja) *	1989-03-31	1998-09-17	ザリージェンツオブザユニバーシティオブカリフォルニア	リポソームおよび脂質複合体組成物の調製
US5188951A (en) *	1990-04-17	1993-02-23	The Liposome Company, Inc.	Enzymatic synthesis of soluble phosphatides from phospholipids
DE4108903A1 (de) *	1990-08-06	1992-02-13	Nattermann A & Cie	Pharmazeutisches produkt
US5556637A (en) *	1990-08-06	1996-09-17	A. Nattermann & Cie. Gmbh	Water containing liposome system
US5534502A (en) *	1990-11-06	1996-07-09	Nippon Shinyaku Co. Ltd.	Process for producing fat emulsion
WO1992007571A1 (en) *	1990-11-06	1992-05-14	Nippon Shinyaku Co., Ltd.	Process for producing fat emulsion
CA2113272A1 (en) *	1991-08-14	1993-03-04	Francis J. Martin	Hiv-treatment method with low-toxicity amphotericin b
CA2160118A1 (en) *	1993-05-21	1994-12-08	Patrick L. Ahl	Reduction of liposome-induced adverse physiological reactions
US5716526A (en) *	1994-01-14	1998-02-10	The Liposome Company, Inc.	Method of separating materials from liposomes or lipid complexes
US5902604A (en) *	1995-06-06	1999-05-11	Board Of Regents, The University Of Texas System	Submicron liposome suspensions obtained from preliposome lyophilizates
GB2326337A (en)	1997-06-20	1998-12-23	Phares Pharma Holland	Homogeneous lipid compositions for drug delivery
US6165997A (en) *	1997-11-20	2000-12-26	Statens Serum Institut	Phospholipids having antimicrobial activity with or without the presence of antimicrobials
JP2009519250A (ja) *	2005-12-08	2009-05-14	ワイス	リポソーム組成物
KR101132626B1 (ko) *	2009-10-12	2012-04-02	주식회사 녹십자	난용성 약물의 전달을 위한 고밀도지단백 나노입자의 제조방법
AU2010359346B2 (en)	2010-08-20	2015-01-29	Dr. Reddy's Laboratories Sa	Phospholipid depot
EP2629779B1 (de)	2010-10-22	2017-06-21	Dr. Reddy's Laboratories SA.	Verwendung eines lagerstabilen viskösen phospholipid-depots zur wundbehandlung
CN104427977B (zh)	2012-05-10	2018-02-02	佩因拉佛姆有限公司	局部麻醉剂的储库制剂及其制备方法
CN120392779A (zh)	2015-06-15	2025-08-01	华盛顿大学	用于延长血液和淋巴组织中的药物水平的多药脂质纳米颗粒组合物和相关方法
WO2026111657A1 (en) *	2024-11-21	2026-05-28	Agency For Science, Technology And Research	Method of preventing or treating a fungal infection

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4310506A (en) *	1979-02-22	1982-01-12	California Institute Of Technology	Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
FR2521565B1 (fr) *	1982-02-17	1985-07-05	Dior Sa Parfums Christian	Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4604376A (en) *	1982-04-21	1986-08-05	Research Corporation	Enteric compounds and complexes
US4436746A (en) *	1982-09-30	1984-03-13	Ciba-Geigy Corporation	Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4622219A (en) *	1983-06-17	1986-11-11	Haynes Duncan H	Method of inducing local anesthesia using microdroplets of a general anesthetic
IL78929A0 (en) *	1985-07-29	1986-09-30	Abbott Lab	Microemulsion compositions for parenteral administration
IL78930A0 (en) *	1985-07-29	1986-09-30	Abbott Lab	Lyophilized emulsion compositions for parenteral administration

1988
- 1988-02-26 NZ NZ223660A patent/NZ223660A/en unknown
- 1988-02-29 CA CA000560121A patent/CA1338701C/en not_active Expired - Lifetime
- 1988-03-02 IL IL85607A patent/IL85607A/xx not_active IP Right Cessation
- 1988-03-03 AU AU17990/88A patent/AU622405B2/en not_active Expired
- 1988-03-03 IE IE60088A patent/IE67152B1/en not_active IP Right Cessation
- 1988-03-03 KR KR1019880701402A patent/KR970002870B1/ko not_active Expired - Lifetime
- 1988-03-03 WO PCT/US1988/000647 patent/WO1988006443A1/en not_active Ceased
- 1988-03-04 PT PT86913A patent/PT86913B/pt not_active IP Right Cessation
- 1988-03-04 AT AT88400520T patent/ATE118169T1/de active
- 1988-03-04 ES ES88400520T patent/ES2070131T5/es not_active Expired - Lifetime
- 1988-03-04 LU LU88684C patent/LU88684I2/fr unknown
- 1988-03-04 EP EP88400520A patent/EP0282405B2/de not_active Expired - Lifetime
- 1988-03-04 DE DE3852961T patent/DE3852961T3/de not_active Expired - Lifetime
- 1988-03-05 CN CN88101864A patent/CN1044093C/zh not_active Expired - Lifetime
- 1988-10-04 NO NO884391A patent/NO179995C/no not_active IP Right Cessation
1989
- 1989-03-01 DK DK198900980A patent/DK176010B1/da not_active IP Right Cessation
- 1989-09-04 FI FI894161A patent/FI102724B1/fi not_active IP Right Cessation
1994
- 1994-10-26 NO NO944071A patent/NO180147C/no not_active IP Right Cessation
1995
- 1995-04-25 GR GR950401037T patent/GR3015916T3/el unknown
1998
- 1998-03-25 NO NO1998012C patent/NO1998012I1/no unknown
- 1998-03-25 NO NO1998013C patent/NO1998013I1/no unknown
- 1998-06-25 HK HK98106740A patent/HK1007495A1/en not_active IP Right Cessation
1999
- 1999-01-26 NL NL990004C patent/NL990004I1/nl unknown

Also Published As

Publication number	Publication date
NO1998012I1 (no)	1998-03-25
NO884391L (no)	1988-11-24
NO180147C (no)	1997-02-26
CA1338701C (en)	1996-11-12
NL990004I1 (nl)	1999-04-01
ES2070131T5 (es)	1998-10-01
DE3852961T2 (de)	1995-07-06
NO1998013I1 (no)	1998-03-25
AU622405B2 (en)	1992-04-09
IL85607A0 (en)	1988-08-31
ES2070131T3 (es)	1995-06-01
PT86913B (pt)	1993-07-30
FI102724B (fi)	1999-02-15
IE67152B1 (en)	1996-03-06
CN88101864A (zh)	1988-09-28
LU88684I2 (fr)	1996-04-29
GR3015916T3 (en)	1995-07-31
IL85607A (en)	1992-08-18
WO1988006443A1 (en)	1988-09-07
NO180147B (no)	1996-11-18
NO179995B (no)	1996-10-21
IE880600L (en)	1988-09-05
KR970002870B1 (ko)	1997-03-12
HK1007495A1 (en)	1999-04-16
NO944071D0 (no)	1994-10-26
FI894161A0 (fi)	1989-09-04
PT86913A (pt)	1989-03-30
DK98089D0 (da)	1989-03-01
FI102724B1 (fi)	1999-02-15
EP0282405B2 (de)	1998-07-22
DE3852961T3 (de)	1998-12-24
EP0282405A2 (de)	1988-09-14
DK176010B1 (da)	2005-11-28
AU1799088A (en)	1988-09-26
DE3852961D1 (de)	1995-03-23
NZ223660A (en)	1990-11-27
NO884391D0 (no)	1988-10-04
ATE118169T1 (de)	1995-02-15
CN1044093C (zh)	1999-07-14
EP0282405A3 (en)	1989-01-04
NO944071L (no)	1988-11-24
DK98089A (da)	1989-03-01
EP0282405B1 (de)	1995-02-08
KR890700341A (ko)	1989-04-24

Legal Events

Date	Code	Title	Description
2008-03-17	MK1K	Patent expired

Publication	Publication Date	Title
NO944071D0 (no)	1994-10-26	Legemiddel-lipidsystemer med lav toksisitet
RU94027569A (ru)	1996-03-10	Органические соли n,n'-диацетилцистина, способ получения, фармацевтическая композиция, способы лечения
ES2044843T3 (es)	1994-01-16	Uso de antibioticos de quinolona y naftiridina en la preparacion de medicamentos oftalmicos.
DE69113976D1 (de)	1995-11-23	Verfahren zur galenischen herstellung eines therapeutischen mittels, insbesondere auf aspirinbasis.
EG19302A (en)	1994-11-30	Compound with gastric acid inhibitory effect and process for its preparation
DE3269241D1 (en)	1986-03-27	Triazoloquinazolines, process for their preparation and pharmaceutical compositions containing them
GR3004655T3 (de)	1993-04-28
DE3175733D1 (en)	1987-02-05	An orally administered drug form comprising a glycosidic antibiotic and an adjuvant
PT84996A (de)	1987-07-01	Pharmazeutische zubereitung zur behandlung bakterieller infektionen
IL88124A0 (en)	1989-06-30	Pharmaceuticals,phosphorus-containing-2-isoxazolines and isoxazoles contained therein and processes for the preparation of these compounds
HU913937D0 (en)	1992-02-28	10,11,12,13-tetrahydro-demicosine derivatives, method for producing them and pharmaceutical preparatives containing said compounds
EP0281092A3 (de)	1990-05-09	Cephalosporinderivate und Verfahren zu ihrer Herstellung
ITMI930273A0 (it)	1993-02-15	Composti terapeuticamente attivi, utili per il trattamento di malattie connesse con alterata funzionalita' del sistema immunitario procedimento per la loro preparazione e composizione farmaceutiche che li contengono
DK239084A (da)	1984-11-15	2-alkylthio-1-aminoalkyl-2-pyrrolin-3-carbonitriler