NO20000542L - Endothelin-antagonister - Google Patents

Endothelin-antagonister

Info

Publication number: NO20000542L
Authority: NO; Norway
Prior art keywords: endothelin antagonists; endothelin; antagonists
Prior art date: 1997-08-04

Application number

NO20000542A

Other languages

English (en)

Norwegian (no)

Other versions

NO20000542D0 (no

Inventor

Martin Winn

Steven A Boyd

Charles W Hutchins

Hwan-Soo Jae

Andrew S Tasker

Thomas W Von Geldern

Jeffrey Alan Kester

Bryan K Sorensen

Bruce G Szczepankiewicz

Kenneth J Henry

Gang Liu

Steven J Wittenberger

Steven A King

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-04

Filing date

2000-02-02

Publication date

2000-04-04

1997-08-04 Priority claimed from US08/905,913 external-priority patent/US6162927A/en

2000-02-02 Application filed by Abbott Lab filed Critical Abbott Lab

2000-02-02 Publication of NO20000542D0 publication Critical patent/NO20000542D0/no

2000-04-04 Publication of NO20000542L publication Critical patent/NO20000542L/no

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
239000005557 antagonist Substances 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pyrrole Compounds (AREA)

NO20000542A 1997-08-04 2000-02-02 Endothelin-antagonister NO20000542L (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US08/905,913 US6162927A (en)	1994-08-19	1997-08-04	Endothelin antagonists
US4895598A	1998-03-27	1998-03-27
PCT/US1998/015479 WO1999006397A2 (fr)	1997-08-04	1998-07-27	Antagonistes d'endotheline

Publications (2)

Publication Number	Publication Date
NO20000542D0 NO20000542D0 (no)	2000-02-02
NO20000542L true NO20000542L (no)	2000-04-04

Family

ID=26726720

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20000542A NO20000542L (no)	1997-08-04	2000-02-02	Endothelin-antagonister

Country Status (16)

Country	Link
EP (1)	EP1003740A2 (fr)
JP (1)	JP2001512119A (fr)
CN (1)	CN1301264A (fr)
AU (1)	AU748469B2 (fr)
BG (1)	BG104216A (fr)
BR (1)	BR9815296A (fr)
CA (1)	CA2297894A1 (fr)
HU (1)	HUP0003484A3 (fr)
IL (1)	IL134175A0 (fr)
NO (1)	NO20000542L (fr)
NZ (1)	NZ502395A (fr)
PL (1)	PL342500A1 (fr)
SK (1)	SK1452000A3 (fr)
TR (4)	TR200101233T2 (fr)
TW (1)	TW552260B (fr)
WO (1)	WO1999006397A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2337230A1 (fr) *	1998-07-15	2000-01-27	Bristol-Myers Squibb Company	Amination reductrice stereoselective de cetones
TWI306760B (en)	2000-08-07	2009-03-01	Abbott Lab	Use of an endothelin et-a receptor antagonist and orally delivered pharmaceutical composition comprising the same
US20040180925A1 (en) *	2000-12-27	2004-09-16	Kenji Matsuno	Dipeptidylpeptidase-IV inhibitor
IL158071A0 (en) *	2001-04-11	2004-03-28	Abbott Lab	Favorable modulation of health-related quality of life and health-related quality-adjusted time-to-progression of disease in patients with prostate cancer
FR2874015B1 (fr) *	2004-08-05	2006-09-15	Sanofi Synthelabo	Derives de n-(1h-indolyl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
FR2880625B1 (fr) *	2005-01-07	2007-03-09	Sanofi Aventis Sa	Derives de n-(heteroaryl)-1h-indole-2-carboxamides, leur preparation et leur application en therapeutique
WO2007034406A1 (fr) *	2005-09-22	2007-03-29	Actelion Pharmaceuticals Ltd	Derives amides d'acide pyrrolidine-3-carboxylique utilises comme inhibiteurs de la renine
CA2697057A1 (fr)	2007-08-22	2009-02-26	Gilead Colorado, Inc.	Therapie pour complications du diabete
WO2011114103A1 (fr)	2010-03-18	2011-09-22	Biolipox Ab	Pyrimidinones pour usage médicamenteux
JO2998B1 (ar)	2010-06-04	2016-09-05	Amgen Inc	مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
MX352672B (es)	2011-09-27	2017-12-04	Amgen Inc	Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
US10531655B2 (en)	2011-12-02	2020-01-14	The Regents Of The University Of California	Reperfusion protection solution and uses thereof
US11407721B2 (en)	2013-02-19	2022-08-09	Amgen Inc.	CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
WO2014134201A1 (fr)	2013-02-28	2014-09-04	Amgen Inc.	Inhibiteur mdm2 dérivé de l'acide benzoïque pour le traitement du cancer
WO2014151863A1 (fr)	2013-03-14	2014-09-25	Amgen Inc.	Composés morpholinone d'acide hétéroaryle utilisés comme inhibiteurs de mdm2 pour le traitement du cancer
MA53572A1 (fr)	2013-06-10	2021-10-29	Amgen Inc	Procédés de production et formes cristallines d'un inhibiteur mdm2
CN104262329A (zh) *	2014-10-22	2015-01-07	南京友杰医药科技有限公司	反式阿曲生坦的制备
GB2606804B (en)	2019-07-17	2023-12-27	2692372 Ontario Inc	Benzenesulfonamide derivatives and uses thereof
WO2023030470A1 (fr) *	2021-09-03	2023-03-09	深圳信立泰药业股份有限公司	Composé antagoniste du récepteur de l'endothéline a (eta), son procédé de préparation et son utilisation médicale
EP4545520A4 (fr) *	2022-07-25	2025-11-26	Shenzhen Salubris Pharm Co Ltd	Sel de composé antagoniste du récepteur de l'endothéline a (eta), son procédé de préparation et son utilisation médicale
CN117447453B (zh) *	2022-07-25	2025-09-30	深圳信立泰药业股份有限公司	一种内皮素a(eta)受体拮抗剂化合物可药用的盐晶型及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5013842A (en) *	1990-01-22	1991-05-07	Monsanto Company	Synthesis of chiral pyrrolidine and piperidine glycosidase inhibitors
AU711832B2 (en) *	1994-08-19	1999-10-21	Abbvie Bahamas Ltd.	Endothelin antagonists
PT888340E (pt) *	1996-02-13	2002-12-31	Abbott Lab	Derivados de acido 4-(benzo-1,3-dioxolil)pirrolidino-3-carboxilico como antagonistas de endotelina
US5618949A (en) *	1996-07-12	1997-04-08	Abbott Laboratories	Process for synthesis of chiral cis- and trans-3-amino-4-substituted pyrrolidine compounds

1998
- 1998-07-27 HU HU0003484A patent/HUP0003484A3/hu unknown
- 1998-07-27 NZ NZ502395A patent/NZ502395A/xx unknown
- 1998-07-27 WO PCT/US1998/015479 patent/WO1999006397A2/fr not_active Ceased
- 1998-07-27 IL IL13417598A patent/IL134175A0/xx unknown
- 1998-07-27 TR TR2001/01233T patent/TR200101233T2/xx unknown
- 1998-07-27 JP JP2000505155A patent/JP2001512119A/ja active Pending
- 1998-07-27 CA CA002297894A patent/CA2297894A1/fr not_active Abandoned
- 1998-07-27 TR TR2001/01234T patent/TR200101234T2/xx unknown
- 1998-07-27 PL PL98342500A patent/PL342500A1/xx not_active Application Discontinuation
- 1998-07-27 TR TR2005/01137T patent/TR200501137T2/xx unknown
- 1998-07-27 EP EP98937139A patent/EP1003740A2/fr not_active Ceased
- 1998-07-27 BR BR9815296-3A patent/BR9815296A/pt not_active Application Discontinuation
- 1998-07-27 AU AU85921/98A patent/AU748469B2/en not_active Ceased
- 1998-07-27 CN CN98809462A patent/CN1301264A/zh active Pending
- 1998-07-27 SK SK145-2000A patent/SK1452000A3/sk unknown
- 1998-07-27 TR TR2000/00993T patent/TR200000993T2/xx unknown
- 1998-08-10 TW TW087112783A patent/TW552260B/zh not_active IP Right Cessation
2000
- 2000-02-02 NO NO20000542A patent/NO20000542L/no not_active Application Discontinuation
- 2000-03-02 BG BG104216A patent/BG104216A/bg unknown

Also Published As

Publication number	Publication date
TR200000993T2 (tr)	2000-12-21
SK1452000A3 (en)	2001-05-10
TR200101234T2 (tr)	2002-06-21
PL342500A1 (en)	2001-06-04
HUP0003484A3 (en)	2002-02-28
AU748469B2 (en)	2002-06-06
CN1301264A (zh)	2001-06-27
TR200501137T2 (tr)	2005-12-21
NZ502395A (en)	2002-08-28
NO20000542D0 (no)	2000-02-02
TW552260B (en)	2003-09-11
AU8592198A (en)	1999-02-22
WO1999006397A3 (fr)	1999-12-09
EP1003740A2 (fr)	2000-05-31
BR9815296A (pt)	2001-11-20
IL134175A0 (en)	2001-04-30
WO1999006397A2 (fr)	1999-02-11
CA2297894A1 (fr)	1999-02-11
BG104216A (bg)	2000-12-29
TR200101233T2 (tr)	2002-06-21
JP2001512119A (ja)	2001-08-21
HUP0003484A2 (hu)	2002-01-28

Legal Events

Date	Code	Title	Description
2005-10-17	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
EP0986385A4 (fr)	2001-05-16	Antagonistes de gonadoliberine
DE59811302D1 (de)	2004-06-09	Mikroemulsion
ID22500A (id)	1999-10-21	Turunan sulfonamida
DK0973746T3 (da)	2004-02-02	Substituerede 3-cyanoquinoliner
ID24430A (id)	2000-07-20	Turunan-turunan benzamidina
FI960953A0 (fi)	1996-02-29	Endoteliinireseptoriantagonisteja
ID23173A (id)	2000-03-23	Turunan pirol trisiklik atau pirazol
NO960473D0 (no)	1996-02-05	Substituerte bifenyl-sulfonamid-endotelin-antagonister
NO20000542D0 (no)	2000-02-02	Endothelin-antagonister
ATE228500T1 (de)	2002-12-15	Npy antagonisten
BR9507220A (pt)	1997-09-09	Antagonistas de receptores de endotelina
DE59813487D1 (de)	2006-05-24	Substituierte 4-benzoyl-pyrazole
DE69636597D1 (de)	2006-11-16	Endothelin rezeptor antagonisten
ID25585A (id)	2000-10-19	Senyawa-senyawa
ZA985209B (en)	1999-01-06	Endothelin antagonists
DE59710430D1 (de)	2003-08-14	Substituierte 4-benzoyl-pyrazole
DE59807877D1 (de)	2003-05-15	Substituierte 4-benzoyl-pyrazole
ID24079A (id)	2000-07-06	Aminoheteroksiklilamida tersubstitusi
DE69735842D1 (de)	2006-06-14	Tuftingnadel
FI972138A0 (fi)	1997-05-20	Returtraog i bestrykningsanordning
DE59810960D1 (de)	2004-04-15	Substituierte phenyluracile
KR980000586U (ko)	1998-03-30	수저통
ZA986908B (en)	1999-04-26	Endothelin antagonists
DK0964867T3 (da)	2005-06-27	Tachykininantagonister
DE59811399D1 (de)	2004-06-17	Substituierte phenyluracile