NO20001228L - Process for Preparation of N- (5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl) -N-methylmethanesulfonamide - Google Patents

Process for Preparation of N- (5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl) -N-methylmethanesulfonamide

Info

Publication number
NO20001228L
NO20001228L NO20001228A NO20001228A NO20001228L NO 20001228 L NO20001228 L NO 20001228L NO 20001228 A NO20001228 A NO 20001228A NO 20001228 A NO20001228 A NO 20001228A NO 20001228 L NO20001228 L NO 20001228L
Authority
NO
Norway
Prior art keywords
fluorophenyl
diphenylphosphinoylmethyl
isopropylpyrimidin
methylmethanesulfonamide
preparation
Prior art date
Application number
NO20001228A
Other languages
Norwegian (no)
Other versions
NO324982B1 (en
NO20001228D0 (en
Inventor
Walter Brieden
Ulrich Veith
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of NO20001228D0 publication Critical patent/NO20001228D0/en
Publication of NO20001228L publication Critical patent/NO20001228L/en
Publication of NO324982B1 publication Critical patent/NO324982B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (I) is prepared by reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol (II) with chlorodiphenylphosphine (III). Preparation of N-(5-(diphenylphosphinoylmethyl)-4-(4-fluorophenyl)-6- isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide of formula (I) comprises the reaction of (4-(4- fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonyl-aminopyrimidin- 2-yl)methanol of formula (II) with (III). Ph = phenyl; and Ph' = 4-fluorophenyl.
NO20001228A 1999-03-10 2000-03-09 Process for Preparation of N- (5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl) -N-methylmethanesulfonamide NO324982B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99104785 1999-03-10
EP99104786 1999-03-10

Publications (3)

Publication Number Publication Date
NO20001228D0 NO20001228D0 (en) 2000-03-09
NO20001228L true NO20001228L (en) 2000-09-11
NO324982B1 NO324982B1 (en) 2008-01-14

Family

ID=26152921

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20001228A NO324982B1 (en) 1999-03-10 2000-03-09 Process for Preparation of N- (5- (Diphenylphosphinoylmethyl) -4- (4-fluorophenyl) -6-isopropylpyrimidin-2-yl) -N-methylmethanesulfonamide

Country Status (15)

Country Link
EP (1) EP1035127B1 (en)
JP (1) JP4438167B2 (en)
KR (1) KR100586664B1 (en)
CN (1) CN1126755C (en)
AT (1) ATE251633T1 (en)
CA (1) CA2300243C (en)
CZ (1) CZ298235B6 (en)
DE (1) DE50003959D1 (en)
DK (1) DK1035127T3 (en)
ES (1) ES2208167T3 (en)
HU (1) HU224967B1 (en)
NO (1) NO324982B1 (en)
PL (1) PL195166B1 (en)
PT (1) PT1035127E (en)
SK (1) SK284027B6 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA200401533A1 (en) * 2002-05-21 2005-06-30 Ранбакси Лабораторис Лимитед METHOD OF OBTAINING ROSUVASTATIN
US7341743B2 (en) 2004-10-28 2008-03-11 Revlon Consumer Products Corporation Color cosmetic compositions
EP2298745B1 (en) 2008-05-27 2014-09-03 Changzhou Pharmaceutical Factory Preparation method of rosuvastatin calcium and its intermediates

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2648897B2 (en) * 1991-07-01 1997-09-03 塩野義製薬株式会社 Pyrimidine derivatives

Also Published As

Publication number Publication date
CZ2000837A3 (en) 2000-10-11
HU0001127D0 (en) 2000-05-28
HK1029996A1 (en) 2001-04-20
ATE251633T1 (en) 2003-10-15
CN1126755C (en) 2003-11-05
NO324982B1 (en) 2008-01-14
NO20001228D0 (en) 2000-03-09
PT1035127E (en) 2004-02-27
ES2208167T3 (en) 2004-06-16
DE50003959D1 (en) 2003-11-13
CN1272499A (en) 2000-11-08
KR20010006773A (en) 2001-01-26
CA2300243C (en) 2009-12-29
SK3322000A3 (en) 2000-10-09
CA2300243A1 (en) 2000-09-10
HUP0001127A2 (en) 2001-06-28
EP1035127A1 (en) 2000-09-13
DK1035127T3 (en) 2003-11-03
HUP0001127A3 (en) 2003-07-28
CZ298235B6 (en) 2007-08-01
HU224967B1 (en) 2006-04-28
KR100586664B1 (en) 2006-06-07
SK284027B6 (en) 2004-08-03
JP2000309595A (en) 2000-11-07
PL195166B1 (en) 2007-08-31
PL338944A1 (en) 2000-09-11
JP4438167B2 (en) 2010-03-24
EP1035127B1 (en) 2003-10-08

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Legal Events

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