|
US3919102A
(en)
|
1971-03-16 |
1975-11-11 |
Henkel & Cie Gmbh |
Composition and method for activating oxygen utilizing N-acylated tetraaza-bicyclo-nonandiones
|
|
US4637988A
(en)
|
1981-07-01 |
1987-01-20 |
Eastman Kodak Company |
Fluorescent labels for immunoassay
|
|
US4837169A
(en)
|
1981-07-01 |
1989-06-06 |
Eastman Kodak Company |
Polypyridine Fluorescent labels for immunoassay
|
|
US5648063A
(en)
*
|
1981-07-24 |
1997-07-15 |
Schering Aktiengesellschaft |
Sterile composition comprising a chelate complex for magnetic resonance imaging
|
|
US4647447A
(en)
|
1981-07-24 |
1987-03-03 |
Schering Aktiengesellschaft |
Diagnostic media
|
|
US5188816A
(en)
|
1984-10-18 |
1993-02-23 |
Board Of Regents, The University Of Texas System |
Using polyazamacrocyclic compounds for intracellular measurement of metal ions using MRS
|
|
US4678667A
(en)
|
1985-07-02 |
1987-07-07 |
501 Regents of the University of California |
Macrocyclic bifunctional chelating agents
|
|
JPH07110815B2
(ja)
|
1985-11-18 |
1995-11-29 |
ボ−ド・オブ・リ−ジェンツ、ザ・ユニバ−シティ−・オブ・テキサス・システム |
画像及びスペクトル向上（およびスペクトルシフト）のためのポリキレ−ト剤
|
|
US4885363A
(en)
|
1987-04-24 |
1989-12-05 |
E. R. Squibb & Sons, Inc. |
1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
|
|
US4877872A
(en)
|
1986-06-24 |
1989-10-31 |
The University Of Toledo |
Production and use of dimers of hematoporophyrin, purpurins, chlorines and purpurin- and chlorin-complexes
|
|
US5219553A
(en)
|
1986-08-04 |
1993-06-15 |
Salutar, Inc. |
Composition of a n-carboxymethylated tetraazacyclododecane chelating agent, a paramagnetic metal and excess calcium ions for MRI
|
|
US5338532A
(en)
|
1986-08-18 |
1994-08-16 |
The Dow Chemical Company |
Starburst conjugates
|
|
FR2604092B1
(fr)
|
1986-09-19 |
1990-04-13 |
Immunotech Sa |
Immunoreactifs destines a cibler les cellules animales pour leur visualisation ou leur destruction in vivo
|
|
US5135737A
(en)
|
1986-11-10 |
1992-08-04 |
The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon |
Amplifier molecules for enhancement of diagnosis and therapy
|
|
US5672334A
(en)
|
1991-01-16 |
1997-09-30 |
Access Pharmaceuticals, Inc. |
Invivo agents comprising cationic metal chelators with acidic saccharides and glycosaminoglycans
|
|
US4822594A
(en)
|
1987-01-27 |
1989-04-18 |
Gibby Wendell A |
Contrast enhancing agents for magnetic resonance images
|
|
HU208947B
(en)
|
1987-07-16 |
1994-02-28 |
Nycomed As |
Diagnostical compositions and process for producing aminopolycarboxylic acids, their derivatives and metal-kelates
|
|
US5531978A
(en)
|
1987-07-16 |
1996-07-02 |
Nycomed Imaging As |
Aminopolycarboxylic acids and derivatives thereof
|
|
WO1989011475A1
(en)
|
1988-05-25 |
1989-11-30 |
The United States Of America, As Represented By Th |
Macrocyclic chelates and methods of use thereof
|
|
US5162509A
(en)
|
1989-03-06 |
1992-11-10 |
Board Of Regents, The University Of Texas System |
Process for preparing expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
|
|
US5914095A
(en)
*
|
1989-04-07 |
1999-06-22 |
Salutar, Inc. |
Polychelants containg amide bonds
|
|
US5364613A
(en)
*
|
1989-04-07 |
1994-11-15 |
Sieving Paul F |
Polychelants containing macrocyclic chelant moieties
|
|
US5554748A
(en)
|
1989-04-07 |
1996-09-10 |
Nycomed Salutar, Inc. |
Adducts of macrocyclic chelants
|
|
US5230883A
(en)
|
1989-05-04 |
1993-07-27 |
Wisconsin Alumni Research Foundation |
Method for localization and treatment of tumors using polylysine complexes
|
|
US5087440A
(en)
|
1989-07-31 |
1992-02-11 |
Salutar, Inc. |
Heterocyclic derivatives of DTPA used for magnetic resonance imaging
|
|
US5332567A
(en)
|
1989-08-24 |
1994-07-26 |
Immunomedics |
Detection and treatment of infections with immunoconjugates
|
|
US5446145A
(en)
|
1990-01-19 |
1995-08-29 |
Nycomed Salutar, Inc. |
Polychelant compounds
|
|
CA2072080A1
(en)
|
1990-01-19 |
1991-07-20 |
Jo Klaveness |
Chelating compounds
|
|
US5095099A
(en)
|
1990-12-10 |
1992-03-10 |
E. I. Du Pont De Nemours And Company |
Fluorescent compounds for absorption and re-emission of radiation
|
|
US5310539A
(en)
|
1991-04-15 |
1994-05-10 |
Board Of Regents, The University Of Texas System |
Melanin-based agents for image enhancement
|
|
WO1992019264A1
(en)
|
1991-05-01 |
1992-11-12 |
University Of New Mexico |
Biomodulators as universal imaging agents
|
|
AU660033B2
(en)
|
1991-05-23 |
1995-06-08 |
Imarx Pharmaceutical Corp. |
Liposoluble compounds for magnetic resonance imaging
|
|
US5133956A
(en)
*
|
1991-05-30 |
1992-07-28 |
The Dow Chemical Company |
Radiolabeled metal-binding protein for the treatment of arthritis
|
|
US5262532A
(en)
|
1991-07-22 |
1993-11-16 |
E.R. Squibb & Sons, Inc. |
Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging
|
|
US5565552A
(en)
|
1992-01-21 |
1996-10-15 |
Pharmacyclics, Inc. |
Method of expanded porphyrin-oligonucleotide conjugate synthesis
|
|
AU5019193A
(en)
|
1992-08-19 |
1994-03-15 |
Mallinckrodt Medical, Inc. |
Ligands for ga-68 pet heart applications
|
|
US5407657A
(en)
|
1992-09-22 |
1995-04-18 |
Unger; Evan C. |
Hybrid magnetic resonance contrast agents
|
|
US5466439A
(en)
|
1992-11-12 |
1995-11-14 |
Magnetic Research, Inc. |
Polymeric contrast enhancing agents for magnetic resonance images
|
|
US5428156A
(en)
|
1993-04-02 |
1995-06-27 |
Associated Universities, Inc. |
Synthesis of macrocyclic polyaminocarboxylates and their use for preparing stable radiometal antibody immunoconjugates for therapy, spect and pet imaging
|
|
US6120768A
(en)
|
1993-05-17 |
2000-09-19 |
Immunomedics, Inc. |
Dota-biotin derivatives
|
|
US5358704A
(en)
|
1993-09-30 |
1994-10-25 |
Bristol-Myers Squibb |
Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
|
|
US5417959A
(en)
|
1993-10-04 |
1995-05-23 |
Mallinckrodt Medical, Inc. |
Functionalized aza-crytand ligands for diagnostic imaging applications
|
|
DE69426811T2
(de)
*
|
1993-12-30 |
2001-09-13 |
Guerbet, Villepinte |
Polyaminierte Liganden, Metallkomplexe, Verfahren zur Herstellung und diagnostische und therapeutische Verwendungen
|
|
WO1995019185A1
(en)
|
1994-01-14 |
1995-07-20 |
Mallinckrodt Medical, Inc. |
Functionalized aza-macrobicyclic ligands for imaging applications
|
|
US5554749A
(en)
|
1994-01-14 |
1996-09-10 |
Mallinckrodt Medical, Inc. |
Functionalized macrocyclic ligands for imaging applications
|
|
AU1694895A
(en)
|
1994-01-28 |
1995-08-15 |
Mallinckrodt Medical, Inc. |
Functionalized aza-bimacrocyclic ligands for imaging applications
|
|
DE4403789A1
(de)
|
1994-02-03 |
1995-08-10 |
Schering Ag |
Mittel zur visuellen Markierung von Körpergewebe
|
|
GB9404208D0
(en)
|
1994-03-04 |
1994-04-20 |
Nycomed Salutar Inc |
Chelants
|
|
WO1995027705A1
(en)
*
|
1994-04-08 |
1995-10-19 |
Bracco International B.V. |
Aromatic amide compounds and metal chelates thereof
|
|
US5624901A
(en)
|
1994-04-15 |
1997-04-29 |
The Regents Of The University Of California |
3-hydroxy-2(1H)-pyridinone chelating agents
|
|
GB9407812D0
(en)
*
|
1994-04-20 |
1994-06-15 |
Nycomed Salutar Inc |
Compounds
|
|
US6693190B1
(en)
*
|
1994-05-11 |
2004-02-17 |
Bracco International B.V. |
Enhanced relaxivity monomeric and multimeric compounds
|
|
IT1269839B
(it)
*
|
1994-05-26 |
1997-04-15 |
Bracco Spa |
Coniugati di acidi biliari, loro derivati con complessi metallici e relativi usi
|
|
US5622821A
(en)
|
1994-06-29 |
1997-04-22 |
The Regents Of The University Of California |
Luminescent lanthanide chelates and methods of use
|
|
DE4428874A1
(de)
*
|
1994-08-08 |
1996-02-22 |
Schering Ag |
Dimere DTPA-Derivate und deren Metallkomplexe, diese Komplexe enthaltende pharmazeutische Mittel, deren Verwendung in der Diagnostik und Therapie sowie Verfahren zur Herstellung der Komplexe und Mittel
|
|
TW319763B
(no)
*
|
1995-02-01 |
1997-11-11 |
Epix Medical Inc |
|
|
US5955605A
(en)
|
1995-02-21 |
1999-09-21 |
Neorx Corporation |
Biotinidase resistant biotin-DOTA conjugates
|
|
US6713045B1
(en)
*
|
1995-06-02 |
2004-03-30 |
Research Corporation Technologies, Inc. |
Targeted magnetic resonance imaging agents for the detection of physiological processes
|
|
US6770261B2
(en)
|
1995-06-02 |
2004-08-03 |
Research Corporation Technologies |
Magnetic resonance imaging agents for the detection of physiological agents
|
|
US5980862A
(en)
*
|
1995-06-02 |
1999-11-09 |
Research Corporation Technologies |
Magnetic resonance imaging agents for the detection of physiological agents
|
|
US5707605A
(en)
*
|
1995-06-02 |
1998-01-13 |
Research Corporation Technologies |
Magnetic resonance imaging agents for the detection of physiological agents
|
|
ATE266006T1
(de)
|
1995-06-14 |
2004-05-15 |
Univ California |
3-hydroxy-2(1h)-pyridone als chelatbildner
|
|
EP1382332A1
(en)
|
1995-06-26 |
2004-01-21 |
Chelator LLC |
Method for inhibiting bacterial or fungal growth using a polyamine derivative as complexing agent
|
|
CA2240183A1
(en)
*
|
1995-12-12 |
1997-06-19 |
California Institute Of Technology |
Cobalt schiff base compounds
|
|
US5972899A
(en)
*
|
1996-01-25 |
1999-10-26 |
New York University |
Apoptosis induced by Shigella IpaB
|
|
IT1283218B1
(it)
*
|
1996-03-08 |
1998-04-16 |
Bracco Spa |
Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi
|
|
KR20060025233A
(ko)
*
|
1996-04-01 |
2006-03-20 |
에픽스 메디칼, 인코포레이티드 |
생체활성화 진단용 영상 콘트라스트 제제
|
|
WO1997041856A1
(en)
|
1996-05-08 |
1997-11-13 |
Massachusetts Institute Of Technology |
ORGANOMETALLIC LIGANDS FOR THE LOCALIZATION AND QUANTIFICATION OF AMYLOID IN VIVO AND $i(IN VITRO)
|
|
US5900228A
(en)
|
1996-07-31 |
1999-05-04 |
California Institute Of Technology |
Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye
|
|
US6713046B1
(en)
|
1997-10-27 |
2004-03-30 |
Research Corporation Technologies |
Magnetic resonance imaging agents for the delivery of therapeutic agents
|
|
JP2001521011A
(ja)
*
|
1997-10-27 |
2001-11-06 |
カリフォルニア・インスティテュート・オブ・テクノロジー |
治療成分送達のための磁気共鳴イメージング剤
|
|
AU752812B2
(en)
|
1997-11-17 |
2002-10-03 |
Research Corporation Technologies, Inc. |
Magnetic resonance imaging agents for the detection of physiological agents
|
|
US6093382A
(en)
|
1998-05-16 |
2000-07-25 |
Bracco Research Usa Inc. |
Metal complexes derivatized with folate for use in diagnostic and therapeutic applications
|
|
AU755564B2
(en)
*
|
1998-06-20 |
2002-12-12 |
Washington University |
Membrane-permeant peptide complexes for medical imaging, diagnostics, and pharmaceutical therapy
|
|
ES2228536T3
(es)
|
1999-05-14 |
2005-04-16 |
The Regents Of The University Of California |
Soporte macromolecular a base de dextrano para un farmaco y suministro de un agente de diagnosotico.
|
|
AU6386000A
(en)
|
1999-07-29 |
2001-02-19 |
Epix Pharmaceuticals, Inc. |
Targeting multimeric imaging agents through multilocus binding
|
|
WO2001052906A2
(en)
|
2000-01-22 |
2001-07-26 |
Epix Medical, Inc. |
Magnetic resonance imaging using contrast agents prodrugs bioactivated by enzymatic cleavage
|
|
EP1278553A2
(en)
|
2000-05-04 |
2003-01-29 |
Research Corporation Technologies, Inc |
Magnetic resonance imaging agents for the delivery of therapeutic agents
|
|
US6673333B1
(en)
|
2000-05-04 |
2004-01-06 |
Research Corporation Technologies, Inc. |
Functional MRI agents for cancer imaging
|
|
WO2002006287A2
(en)
|
2000-07-17 |
2002-01-24 |
California Institute Of Technology |
Macrocyclic mri contrast agents
|
|
AU2002211517A1
(en)
|
2000-10-04 |
2002-04-15 |
California Institute Of Technology |
Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits
|
|
AU2002251739A1
(en)
|
2001-01-05 |
2002-07-30 |
The General Hospital Corporation |
Activatable imaging probes
|
|
US20030004236A1
(en)
|
2001-04-20 |
2003-01-02 |
Meade Thomas J. |
Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances
|
|
US20030135108A1
(en)
|
2001-05-02 |
2003-07-17 |
Silva Robin M. |
High throughput screening methods using magnetic resonance imaging agents
|
|
US20020197648A1
(en)
|
2001-05-02 |
2002-12-26 |
Silva Robin M. |
High throughput screening methods using magnetic resonance imaging agents
|
|
US20030198597A1
(en)
|
2002-04-22 |
2003-10-23 |
Meade Thomas J. |
Novel macrocyclic activatible magnetic resonance imaging contrast agents
|