NO20002967L - Uretaner avledet fra azacycloalkaner, tio og ditio-analoger, samt anvendelse og fremstilling av 2,3 eposkysqualen- lanesterolcyclaseinhibitor - Google Patents
Uretaner avledet fra azacycloalkaner, tio og ditio-analoger, samt anvendelse og fremstilling av 2,3 eposkysqualen- lanesterolcyclaseinhibitorInfo
- Publication number
- NO20002967L NO20002967L NO20002967A NO20002967A NO20002967L NO 20002967 L NO20002967 L NO 20002967L NO 20002967 A NO20002967 A NO 20002967A NO 20002967 A NO20002967 A NO 20002967A NO 20002967 L NO20002967 L NO 20002967L
- Authority
- NO
- Norway
- Prior art keywords
- group
- atom
- represent
- alkyl
- oxygen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
- A23K20/132—Heterocyclic compounds containing only one nitrogen as hetero atom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Cardiology (AREA)
- Birds (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fodder In General (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Det er beskrevet uretaner avledet fra axacykloalkaner i tillegg til tio og ditio- analoger ifølge generell formel (I), hvori m er lik O eller 1, n er lik 1 eller 2, A er en enkeltbinding, en lineær eller forgrenet C^alkylengruppe, en C2-aalkenylen eller C2. aalkylengruppe, idet en umettet gruppe ikke er direkte bundet til resten Y; X og Y er et oksygen eller svovelatom, R1 og R2 er en lineær eller forgrent d-ealkylgruppe, en C^alkengruppe eller Ci^alkenylgruppe, hvorved en multippel binding er isolert fra nitrogen-karbonbindingen, eller R1 og R2 sammen med nitrogenatomet representerer en 5-7 leddet mettet heterocyklisk ring, hvorved en metylengruppe isolert fra nitrogen- atomet kan bli erstattet av et oksygen eller svovelatom eller av en -NH eller -N (alkyl)- gruppe, R3-R6 kan være identiske eller forskjellige og representerer hydrogenatomer eller alkylgrupper, R7 er en C^cykloalkylgruppe, eventuelt en fenyl eller naftylgruppe substituert med to halogenatomer, en alkyl, alkoksy, trifluormetyl eller cyanogruppe eller et hydrogenatomer, forutsatt at A ikke representerer en enkeltbinding, E er et oksygen eller sovelatom, en metylen, karbonyl eller sulfinylgruppe og R8 representerer et hydrogenatom eller E representerer -C(R9R10)-gruppen, hvori R10 og ved sidenav liggende gruppe R8 representerer en karbon-karbon-binding. Det er også beskrevet entaniomerer, diastereomerer og salter derav, spesielt fysiologisk akseptable syre- additive salter med verdifulle egenskaper som utviser en inhiberende effekt på kolesterolbiosyntesen, i tillegg til medikamenter inneholdende nevnte forbindelse, anvendelse derav og en fremgangsmåte for fremstilling derav.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19754796A DE19754796A1 (de) | 1997-12-10 | 1997-12-10 | Neue, von Azacycloalkanen abgeleitete Urethane, ihre Thio- und Dithioanaloga, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| PCT/EP1998/007965 WO1999029669A1 (de) | 1997-12-10 | 1998-12-08 | Von azacycloalkanen abgeleitete urethane, ihre thio- und dithioanaloga, deren herstellung und deren verwendung als 2,3-epoxisqualen-lanosterol-cyclase inhibitoren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20002967D0 NO20002967D0 (no) | 2000-06-09 |
| NO20002967L true NO20002967L (no) | 2000-08-09 |
Family
ID=7851381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20002967A NO20002967L (no) | 1997-12-10 | 2000-06-09 | Uretaner avledet fra azacycloalkaner, tio og ditio-analoger, samt anvendelse og fremstilling av 2,3 eposkysqualen- lanesterolcyclaseinhibitor |
Country Status (27)
| Country | Link |
|---|---|
| EP (1) | EP1060162B1 (no) |
| JP (1) | JP3418688B2 (no) |
| KR (1) | KR20010032977A (no) |
| CN (1) | CN1281434A (no) |
| AR (1) | AR017827A1 (no) |
| AT (1) | ATE234816T1 (no) |
| AU (1) | AU1759499A (no) |
| BG (1) | BG104500A (no) |
| BR (1) | BR9813495A (no) |
| CA (1) | CA2309388A1 (no) |
| CO (1) | CO5370694A1 (no) |
| DE (2) | DE19754796A1 (no) |
| DK (1) | DK1060162T3 (no) |
| EA (1) | EA200000631A1 (no) |
| EE (1) | EE200000342A (no) |
| ES (1) | ES2190130T3 (no) |
| HR (1) | HRP20000377A2 (no) |
| HU (1) | HUP0100335A3 (no) |
| IL (1) | IL135738A0 (no) |
| NO (1) | NO20002967L (no) |
| PL (1) | PL341060A1 (no) |
| PT (1) | PT1060162E (no) |
| SK (1) | SK8612000A3 (no) |
| TR (1) | TR200001635T2 (no) |
| WO (1) | WO1999029669A1 (no) |
| YU (1) | YU35600A (no) |
| ZA (1) | ZA9811262B (no) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040072865A1 (en) * | 2001-01-15 | 2004-04-15 | Bouillot Anne Marie Jeanne | Aryl piperidine derivatives as inducers of ldl-receptor expression |
| JP2004520347A (ja) * | 2001-01-15 | 2004-07-08 | グラクソ グループ リミテッド | Ｌｄｌ−受容体発現のインデューサーとしてのアリールピペリジンおよびピペラジン誘導体 |
| EP1351937A1 (en) * | 2001-01-15 | 2003-10-15 | Glaxo Group Limited | Aryl piperidine derivatives as inducers of ldl-receptor expression |
| DE10132686A1 (de) * | 2001-07-05 | 2003-01-16 | Boehringer Ingelheim Pharma | Heteroarylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
| JP4664634B2 (ja) * | 2003-09-05 | 2011-04-06 | 富山化学工業株式会社 | 新規なベンズアミジン誘導体またはその塩 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04312572A (ja) * | 1991-04-12 | 1992-11-04 | Takeda Chem Ind Ltd | 環状アミン化合物 |
| DE4407138A1 (de) | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aryliden-1-azacycloalkane und Arylalkyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
| DE4407136A1 (de) | 1994-03-04 | 1995-09-07 | Thomae Gmbh Dr K | Aroyl-1-azacycloalkane, deren Salze, diese Verbindungen enthaltende Arzneimittel und deren Verwendung sowie Verfahren zu ihrer Herstellung |
-
1997
- 1997-12-10 DE DE19754796A patent/DE19754796A1/de not_active Withdrawn
-
1998
- 1998-12-08 ES ES98962423T patent/ES2190130T3/es not_active Expired - Lifetime
- 1998-12-08 CN CN98811959A patent/CN1281434A/zh active Pending
- 1998-12-08 TR TR2000/01635T patent/TR200001635T2/xx unknown
- 1998-12-08 KR KR1020007006326A patent/KR20010032977A/ko not_active Withdrawn
- 1998-12-08 BR BR9813495-7A patent/BR9813495A/pt not_active IP Right Cessation
- 1998-12-08 HR HR20000377A patent/HRP20000377A2/hr not_active Application Discontinuation
- 1998-12-08 PT PT98962423T patent/PT1060162E/pt unknown
- 1998-12-08 IL IL13573898A patent/IL135738A0/xx unknown
- 1998-12-08 AU AU17594/99A patent/AU1759499A/en not_active Abandoned
- 1998-12-08 HU HU0100335A patent/HUP0100335A3/hu unknown
- 1998-12-08 AT AT98962423T patent/ATE234816T1/de not_active IP Right Cessation
- 1998-12-08 PL PL98341060A patent/PL341060A1/xx unknown
- 1998-12-08 EE EEP200000342A patent/EE200000342A/xx unknown
- 1998-12-08 EP EP98962423A patent/EP1060162B1/de not_active Expired - Lifetime
- 1998-12-08 CA CA002309388A patent/CA2309388A1/en not_active Abandoned
- 1998-12-08 DE DE59807591T patent/DE59807591D1/de not_active Expired - Fee Related
- 1998-12-08 SK SK861-2000A patent/SK8612000A3/sk unknown
- 1998-12-08 DK DK98962423T patent/DK1060162T3/da active
- 1998-12-08 EA EA200000631A patent/EA200000631A1/ru unknown
- 1998-12-08 WO PCT/EP1998/007965 patent/WO1999029669A1/de not_active Ceased
- 1998-12-08 YU YU35600A patent/YU35600A/sh unknown
- 1998-12-08 JP JP2000524266A patent/JP3418688B2/ja not_active Expired - Fee Related
- 1998-12-09 CO CO98073126A patent/CO5370694A1/es not_active Application Discontinuation
- 1998-12-09 ZA ZA9811262A patent/ZA9811262B/xx unknown
- 1998-12-09 AR ARP980106228A patent/AR017827A1/es not_active Application Discontinuation
-
2000
- 2000-06-02 BG BG104500A patent/BG104500A/bg unknown
- 2000-06-09 NO NO20002967A patent/NO20002967L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0100335A3 (en) | 2001-11-28 |
| EP1060162A1 (de) | 2000-12-20 |
| BR9813495A (pt) | 2000-10-10 |
| DE19754796A1 (de) | 1999-06-17 |
| CN1281434A (zh) | 2001-01-24 |
| DK1060162T3 (da) | 2003-07-14 |
| HUP0100335A2 (hu) | 2001-07-30 |
| JP2001525397A (ja) | 2001-12-11 |
| CO5370694A1 (es) | 2004-02-27 |
| WO1999029669A1 (de) | 1999-06-17 |
| KR20010032977A (ko) | 2001-04-25 |
| HRP20000377A2 (en) | 2000-12-31 |
| PL341060A1 (en) | 2001-03-26 |
| TR200001635T2 (tr) | 2000-11-21 |
| YU35600A (sh) | 2002-09-19 |
| PT1060162E (pt) | 2003-08-29 |
| DE59807591D1 (de) | 2003-04-24 |
| JP3418688B2 (ja) | 2003-06-23 |
| ZA9811262B (en) | 2000-06-09 |
| NO20002967D0 (no) | 2000-06-09 |
| SK8612000A3 (en) | 2000-11-07 |
| AU1759499A (en) | 1999-06-28 |
| ES2190130T3 (es) | 2003-07-16 |
| EE200000342A (et) | 2001-08-15 |
| BG104500A (bg) | 2001-03-30 |
| ATE234816T1 (de) | 2003-04-15 |
| AR017827A1 (es) | 2001-10-24 |
| EP1060162B1 (de) | 2003-03-19 |
| EA200000631A1 (ru) | 2000-12-25 |
| IL135738A0 (en) | 2001-05-20 |
| CA2309388A1 (en) | 1999-06-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |