NO20003038L - 4(3)Substituerte-4(3)-aminometyl-(tio)pyran eller - piperidinderivater (=gabapentinanaloger), deres fremstilling og deres anvendelse ved behandling av neurologiske lidelser - Google Patents
4(3)Substituerte-4(3)-aminometyl-(tio)pyran eller - piperidinderivater (=gabapentinanaloger), deres fremstilling og deres anvendelse ved behandling av neurologiske lidelserInfo
- Publication number
- NO20003038L NO20003038L NO20003038A NO20003038A NO20003038L NO 20003038 L NO20003038 L NO 20003038L NO 20003038 A NO20003038 A NO 20003038A NO 20003038 A NO20003038 A NO 20003038A NO 20003038 L NO20003038 L NO 20003038L
- Authority
- NO
- Norway
- Prior art keywords
- pyran
- aminomethyl
- thio
- substituted
- preparation
- Prior art date
Links
- UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical class OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 title 2
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- 229960002870 gabapentin Drugs 0.000 title 1
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- C07F9/655363—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
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- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
- C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6977397P | 1997-12-16 | 1997-12-16 | |
| US10490498P | 1998-10-20 | 1998-10-20 | |
| PCT/US1998/023991 WO1999031057A1 (en) | 1997-12-16 | 1998-11-10 | 4(3)substituted-4(3)-aminomethyl-(thio)pyran or -piperidine derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20003038L true NO20003038L (no) | 2000-06-14 |
| NO20003038D0 NO20003038D0 (no) | 2000-06-14 |
Family
ID=26750407
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003038A NO20003038D0 (no) | 1997-12-16 | 2000-06-14 | 4(3)Substituerte-4(3)-aminometyl-(tio)pyran eller - piperidinderivater (=gabapentinanaloger), deres fremstilling og deres anvendelse ved behandling av neurologiske lidelser |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6545022B1 (no) |
| EP (1) | EP1045834A1 (no) |
| JP (1) | JP2002508352A (no) |
| KR (1) | KR20010033153A (no) |
| CN (1) | CN1279667A (no) |
| AU (1) | AU759392B2 (no) |
| BR (1) | BR9814287A (no) |
| CA (1) | CA2304967C (no) |
| HU (1) | HUP0100069A3 (no) |
| IL (1) | IL135315A0 (no) |
| IS (1) | IS5434A (no) |
| NO (1) | NO20003038D0 (no) |
| NZ (1) | NZ503980A (no) |
| PL (1) | PL341231A1 (no) |
| TR (1) | TR200001800T2 (no) |
| WO (1) | WO1999031057A1 (no) |
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| US6620829B2 (en) | 2000-10-17 | 2003-09-16 | Warner-Lambert Company | Method of treating noninflammatory cartilage damage |
| GB2368579A (en) * | 2000-10-31 | 2002-05-08 | Parke Davis & Co Ltd | Azole pharmaceutical agents |
| WO2002100344A2 (en) | 2001-06-11 | 2002-12-19 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
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| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
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| WO2003099338A2 (en) | 2002-05-17 | 2003-12-04 | Xenoport, Inc. | Amino acid conjugates providing for sustained systemic concentrations of gaba analogues |
| AU2003239752A1 (en) * | 2002-06-27 | 2004-01-19 | Warner-Lambert Company Llc | Use of an alpha2delta ligand such as gabapentin or pregabalin for treating ttention deficit hyperactivity disorder |
| AU2003297927A1 (en) | 2002-12-11 | 2004-06-30 | Xenoport, Inc. | Prodrugs of fused gaba analogs, pharmaceutical compositions and uses thereof |
| ES2341240T3 (es) | 2002-12-13 | 2010-06-17 | Warner-Lambert Company Llc | Ligando alfa-2-delta para tratar los sintomas del tracto urinario inferior. |
| CA2451267A1 (en) | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
| EP1603890A1 (en) * | 2003-03-07 | 2005-12-14 | Warner-Lambert Company LLC | TETRAZOLE AND OXADIAZOLONE SUBSTITUTED &bgr;-AMINO ACID DERIVATIVES |
| WO2005013888A2 (en) * | 2003-05-14 | 2005-02-17 | Cytokinetics, Inc. | Compounds, compositions and methods |
| US20040248979A1 (en) * | 2003-06-03 | 2004-12-09 | Dynogen Pharmaceuticals, Inc. | Method of treating lower urinary tract disorders |
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| MXPA06002789A (es) | 2003-09-12 | 2006-06-14 | Pfizer | Combinaciones que comprenden ligandos alfa-2-delta. |
| RU2458049C2 (ru) * | 2003-09-17 | 2012-08-10 | Ксенопорт, Инк. | Лечение или предупреждение синдрома беспокойных ног с использованием пролекарств аналогов гамк |
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| PL1691811T3 (pl) | 2003-12-11 | 2014-12-31 | Sunovion Pharmaceuticals Inc | Skojarzenie leku uspokajającego i modulatora neuroprzekaźnikowego oraz sposoby poprawy jakości snu i leczenia depresji |
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| US20060025477A1 (en) * | 2004-07-22 | 2006-02-02 | Artman Linda D | Analogs of isovaleramide, a pharmaceutical composition including the same, and a method of treating central nervous system conditions or diseases |
| US7691898B2 (en) * | 2004-10-08 | 2010-04-06 | Kotobuki Pharmaceutical Co., Ltd. | Phosphonic acid derivatives and the treating agents of diseases related hyperphosphatemia |
| EP1811986B1 (en) | 2004-11-04 | 2014-03-26 | XenoPort, Inc. | Gabapentin prodrug sustained release oral dosage forms |
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| UA94979C2 (uk) | 2006-12-22 | 2011-06-25 | Рекордати Айеленд Лимитед | КОМБІНОВАНА ТЕРАПІЯ ПОРУШЕНЬ НИЖНІХ СЕЧОВИВІДНИХ ШЛЯХІВ ЛІГАНДАМИ α2δ І НПЗП |
| US20080306116A1 (en) * | 2007-06-08 | 2008-12-11 | Christ Andreas D | Aryloxazole, aryloxadiazole and benzimidazole derivatives |
| CA2697254A1 (en) * | 2007-08-23 | 2009-02-26 | Novartis Ag | Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors |
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| JP5563483B2 (ja) | 2008-01-25 | 2014-07-30 | ゼノポート,インコーポレイティド | アシロキシアルキルカルバメートプロドラッグの合成に使用されるアシロキシアルキルチオカーボネートの鏡像異性的な分解 |
| EP2116539A1 (en) | 2008-04-25 | 2009-11-11 | Laboratorios Del. Dr. Esteve, S.A. | 1-aryl-3-aminoalkoxy-pyrazoles as sigma ligands enhancing analgesic effects of opioids and attenuating the dependency thereof |
| BRPI0919811B1 (pt) | 2008-10-08 | 2022-04-19 | Xgene Pharmaceutical Inc | Conjugados de gaba e métodos de uso dos mesmos |
| EP2353598A1 (en) | 2010-02-04 | 2011-08-10 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for use in the prevention and/or treatment of postoperative pain |
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| EP2388005A1 (en) | 2010-05-21 | 2011-11-23 | Laboratorios Del. Dr. Esteve, S.A. | Sigma ligands for the prevention and/or treatment of emesis induced by chemotherapy or radiotherapy |
| EP2415471A1 (en) | 2010-08-03 | 2012-02-08 | Laboratorios Del. Dr. Esteve, S.A. | Use of sigma ligands in opioid-induced hyperalgesia |
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| JP6440625B2 (ja) | 2012-11-14 | 2018-12-19 | ザ・ジョンズ・ホプキンス・ユニバーシティー | 精神分裂病を処置するための方法および組成物 |
| US9066853B2 (en) | 2013-01-15 | 2015-06-30 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable fiber |
| AU2014209028C1 (en) | 2013-01-28 | 2019-08-29 | Hector L. Lopez | Methods of improving tolerability, pharmacodynamics, and efficacy of b-alanine and use therefor |
| TW201607539A (zh) | 2013-12-17 | 2016-03-01 | 以斯提夫博士實驗室股份有限公司 | 加巴噴丁類似物和σ受體配體組合物 |
| AU2014364647A1 (en) | 2013-12-17 | 2016-06-23 | Laboratorios Del Dr. Esteve, S.A. | Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) and Sigma receptor ligands combinations |
| US10857157B2 (en) | 2015-01-26 | 2020-12-08 | BioAxone BioSciences, Inc. | Treatment of cerebral cavernous malformations and cerebral aneurysms with rho kinase inhibitors |
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| US10106525B2 (en) | 2015-01-26 | 2018-10-23 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
| US11198680B2 (en) | 2016-12-21 | 2021-12-14 | BioAxone BioSciences, Inc. | Rho kinase inhibitor BA-1049 (R) and active metabolites thereof |
| US10537567B2 (en) | 2017-07-11 | 2020-01-21 | BioAxone BioSciences, Inc. | Kinase inhibitors for treatment of disease |
| AU2019271799B2 (en) | 2018-05-14 | 2023-10-12 | Xgene Pharmaceutical Inc. | Crystalline forms of 1-(acyloxy)-alkyl carbamate drug conjugates of naproxen and pregabalin |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2460891C2 (de) | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US4087544A (en) | 1974-12-21 | 1978-05-02 | Warner-Lambert Company | Treatment of cranial dysfunctions using novel cyclic amino acids |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| FR2674522B1 (fr) * | 1991-03-26 | 1993-07-16 | Lipha | Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant. |
| DK0888325T3 (da) * | 1996-02-07 | 2002-09-16 | Warner Lambert Co | Cykliske aminosyrer som farmaceutiske midler |
| WO1999031075A1 (en) * | 1997-12-16 | 1999-06-24 | Warner-Lambert Company | 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders |
-
1998
- 1998-11-10 KR KR1020007006529A patent/KR20010033153A/ko not_active Ceased
- 1998-11-10 HU HU0100069A patent/HUP0100069A3/hu unknown
- 1998-11-10 WO PCT/US1998/023991 patent/WO1999031057A1/en not_active Ceased
- 1998-11-10 JP JP2000538984A patent/JP2002508352A/ja not_active Abandoned
- 1998-11-10 TR TR2000/01800T patent/TR200001800T2/xx unknown
- 1998-11-10 CA CA002304967A patent/CA2304967C/en not_active Expired - Fee Related
- 1998-11-10 NZ NZ503980A patent/NZ503980A/xx unknown
- 1998-11-10 IL IL13531598A patent/IL135315A0/xx unknown
- 1998-11-10 CN CN98811479A patent/CN1279667A/zh active Pending
- 1998-11-10 BR BR9814287-9A patent/BR9814287A/pt not_active Application Discontinuation
- 1998-11-10 EP EP98958528A patent/EP1045834A1/en not_active Ceased
- 1998-11-10 US US09/529,055 patent/US6545022B1/en not_active Expired - Fee Related
- 1998-11-10 AU AU14554/99A patent/AU759392B2/en not_active Ceased
- 1998-11-10 PL PL98341231A patent/PL341231A1/xx unknown
-
2000
- 2000-04-07 IS IS5434A patent/IS5434A/is unknown
- 2000-06-14 NO NO20003038A patent/NO20003038D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR200001800T2 (tr) | 2001-03-21 |
| CN1279667A (zh) | 2001-01-10 |
| IS5434A (is) | 2000-04-07 |
| HUP0100069A3 (en) | 2002-04-29 |
| PL341231A1 (en) | 2001-03-26 |
| AU759392B2 (en) | 2003-04-10 |
| AU1455499A (en) | 1999-07-05 |
| JP2002508352A (ja) | 2002-03-19 |
| EP1045834A1 (en) | 2000-10-25 |
| US6545022B1 (en) | 2003-04-08 |
| CA2304967A1 (en) | 1999-06-24 |
| BR9814287A (pt) | 2000-10-03 |
| NZ503980A (en) | 2002-09-27 |
| IL135315A0 (en) | 2001-05-20 |
| CA2304967C (en) | 2005-06-14 |
| HUP0100069A2 (hu) | 2001-12-28 |
| NO20003038D0 (no) | 2000-06-14 |
| KR20010033153A (ko) | 2001-04-25 |
| WO1999031057A1 (en) | 1999-06-24 |
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