NO20003145L - Process for the preparation of paroxetine hydrochloride - Google Patents
Process for the preparation of paroxetine hydrochlorideInfo
- Publication number
- NO20003145L NO20003145L NO20003145A NO20003145A NO20003145L NO 20003145 L NO20003145 L NO 20003145L NO 20003145 A NO20003145 A NO 20003145A NO 20003145 A NO20003145 A NO 20003145A NO 20003145 L NO20003145 L NO 20003145L
- Authority
- NO
- Norway
- Prior art keywords
- paroxetine hydrochloride
- preparation
- propan
- solution
- solvate
- Prior art date
Links
- AHOUBRCZNHFOSL-UHFFFAOYSA-N 3-(1,3-benzodioxol-5-yloxymethyl)-4-(4-fluorophenyl)piperidine Chemical compound C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 title abstract 8
- 229960005183 paroxetine hydrochloride Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
En fremgangsmåte for fremstilling av paroxetine-hydroklorid propan-2-ol- solvat omfatter dannelse av en løsning av paroxetine-hydroklorid i en blanding av propan-2-ol og et effektivt co-løsningsmiddel og krystallisering av paroxetine-hydroklorid propan-2-ol-solvat fra løsningen.A process for the preparation of paroxetine hydrochloride propan-2-ol solvate comprises the formation of a solution of paroxetine hydrochloride in a mixture of propan-2-ol and an effective co-solvent and crystallization of paroxetine hydrochloride propan-2-ol. -solvate from the solution.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726907.0A GB9726907D0 (en) | 1997-12-19 | 1997-12-19 | Novel compounds |
| PCT/GB1998/003836 WO1999032484A1 (en) | 1997-12-19 | 1998-12-18 | Process for the preparation of paroxetine hydrochloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO20003145D0 NO20003145D0 (en) | 2000-06-16 |
| NO20003145L true NO20003145L (en) | 2000-06-16 |
Family
ID=10823933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20003145A NO20003145L (en) | 1997-12-19 | 2000-06-16 | Process for the preparation of paroxetine hydrochloride |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1042318A1 (en) |
| JP (1) | JP2001526288A (en) |
| KR (1) | KR20010033317A (en) |
| CN (1) | CN1281448A (en) |
| AP (1) | AP2000001836A0 (en) |
| AU (1) | AU1769899A (en) |
| BG (1) | BG104604A (en) |
| BR (1) | BR9813638A (en) |
| CA (1) | CA2315066A1 (en) |
| EA (1) | EA200000689A1 (en) |
| GB (1) | GB9726907D0 (en) |
| HU (1) | HUP0004503A3 (en) |
| ID (1) | ID24733A (en) |
| IL (1) | IL136590A0 (en) |
| NO (1) | NO20003145L (en) |
| OA (1) | OA11635A (en) |
| PL (1) | PL341358A1 (en) |
| SK (1) | SK9242000A3 (en) |
| TR (1) | TR200001933T2 (en) |
| WO (1) | WO1999032484A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9919001D0 (en) * | 1999-08-12 | 1999-10-13 | Smithkline Beecham Plc | Novel process |
| GB9923439D0 (en) * | 1999-10-04 | 1999-12-08 | Smithkline Beecham Plc | Novel process |
| NL1017421C2 (en) | 2001-02-21 | 2002-01-15 | Synthon Bv | Process for the production of paroxetine. |
| IL163593A0 (en) * | 2002-02-22 | 2005-12-18 | Teva Pharma | Preparation of paroxetine involving novel intermediates |
| KR100672184B1 (en) | 2004-09-21 | 2007-01-19 | 주식회사종근당 | Choline or Choline Derivative Salts of Paroxetine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0223403B1 (en) * | 1985-10-25 | 1993-08-04 | Beecham Group Plc | Piperidine derivative, its preparation, and its use as medicament |
| SK283608B6 (en) * | 1995-02-06 | 2003-10-07 | Smithkline Beecham Plc | Anhydrous paroxetine hydrochloride, process for its preparation and use |
| CA2187128A1 (en) * | 1996-10-04 | 1997-06-26 | K. S. Keshava Murthy | New and useful polymorph of anhydrous paroxetine hydrochloride |
-
1997
- 1997-12-19 GB GBGB9726907.0A patent/GB9726907D0/en not_active Ceased
-
1998
- 1998-12-18 EA EA200000689A patent/EA200000689A1/en unknown
- 1998-12-18 CA CA002315066A patent/CA2315066A1/en not_active Abandoned
- 1998-12-18 CN CN98811920A patent/CN1281448A/en active Pending
- 1998-12-18 HU HU0004503A patent/HUP0004503A3/en unknown
- 1998-12-18 EP EP98962563A patent/EP1042318A1/en not_active Withdrawn
- 1998-12-18 OA OA1200000182A patent/OA11635A/en unknown
- 1998-12-18 IL IL13659098A patent/IL136590A0/en unknown
- 1998-12-18 JP JP2000525421A patent/JP2001526288A/en active Pending
- 1998-12-18 PL PL98341358A patent/PL341358A1/en unknown
- 1998-12-18 SK SK924-2000A patent/SK9242000A3/en unknown
- 1998-12-18 BR BR9813638-0A patent/BR9813638A/en not_active Application Discontinuation
- 1998-12-18 AP APAP/P/2000/001836A patent/AP2000001836A0/en unknown
- 1998-12-18 ID IDW20001158A patent/ID24733A/en unknown
- 1998-12-18 KR KR1020007006764A patent/KR20010033317A/en not_active Withdrawn
- 1998-12-18 TR TR2000/01933T patent/TR200001933T2/en unknown
- 1998-12-18 WO PCT/GB1998/003836 patent/WO1999032484A1/en not_active Ceased
- 1998-12-18 AU AU17698/99A patent/AU1769899A/en not_active Abandoned
-
2000
- 2000-06-16 NO NO20003145A patent/NO20003145L/en not_active Application Discontinuation
- 2000-07-13 BG BG104604A patent/BG104604A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0004503A2 (en) | 2002-03-28 |
| OA11635A (en) | 2004-11-22 |
| BR9813638A (en) | 2000-10-17 |
| HUP0004503A3 (en) | 2002-04-29 |
| JP2001526288A (en) | 2001-12-18 |
| AP2000001836A0 (en) | 2000-06-30 |
| EP1042318A1 (en) | 2000-10-11 |
| PL341358A1 (en) | 2001-04-09 |
| WO1999032484A1 (en) | 1999-07-01 |
| NO20003145D0 (en) | 2000-06-16 |
| IL136590A0 (en) | 2001-06-14 |
| ID24733A (en) | 2000-08-03 |
| KR20010033317A (en) | 2001-04-25 |
| SK9242000A3 (en) | 2001-01-18 |
| BG104604A (en) | 2001-03-30 |
| AU1769899A (en) | 1999-07-12 |
| CA2315066A1 (en) | 1999-07-01 |
| CN1281448A (en) | 2001-01-24 |
| TR200001933T2 (en) | 2000-12-21 |
| EA200000689A1 (en) | 2000-12-25 |
| GB9726907D0 (en) | 1998-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |