NO20003495D0 - Genmuterte dyr - Google Patents

Genmuterte dyr

Info

Publication number
NO20003495D0
NO20003495D0 NO20003495A NO20003495A NO20003495D0 NO 20003495 D0 NO20003495 D0 NO 20003495D0 NO 20003495 A NO20003495 A NO 20003495A NO 20003495 A NO20003495 A NO 20003495A NO 20003495 D0 NO20003495 D0 NO 20003495D0
Authority
NO
Norway
Prior art keywords
gen
mutated animals
mutated
animals
gen mutated
Prior art date
Application number
NO20003495A
Other languages
English (en)
Other versions
NO20003495L (no
Inventor
Masatoshi Takeda
Junji Takeda
Original Assignee
Daiichi Seiyaku Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Seiyaku Co filed Critical Daiichi Seiyaku Co
Publication of NO20003495D0 publication Critical patent/NO20003495D0/no
Publication of NO20003495L publication Critical patent/NO20003495L/no

Links

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711Alzheimer's disease; Amyloid plaque core protein
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/072Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/105Murine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0306Animal model for genetic diseases
    • A01K2267/0312Animal model for Alzheimer's disease
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Husbandry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
NO20003495A 1998-01-08 2000-07-07 Gen-muterte dyr NO20003495L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP219198 1998-01-08
PCT/JP1999/000015 WO1999034670A1 (en) 1998-01-08 1999-01-07 Gene mutant animals

Publications (2)

Publication Number Publication Date
NO20003495D0 true NO20003495D0 (no) 2000-07-07
NO20003495L NO20003495L (no) 2000-09-07

Family

ID=11522482

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003495A NO20003495L (no) 1998-01-08 2000-07-07 Gen-muterte dyr

Country Status (12)

Country Link
US (1) US7022893B1 (no)
EP (1) EP1044605B1 (no)
JP (1) JP4290329B2 (no)
KR (1) KR100646816B1 (no)
CN (1) CN1292638A (no)
AU (1) AU1784499A (no)
CA (1) CA2317809A1 (no)
DE (1) DE69935903T2 (no)
NO (1) NO20003495L (no)
RU (1) RU2266002C2 (no)
TW (2) TWI240752B (no)
WO (1) WO1999034670A1 (no)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284944B1 (en) 1997-08-29 2001-09-04 Cephalon, Inc, Gene-targeted non-human mammal with a human fad presenilin mutation and generational offspring
WO2002008407A2 (en) * 2000-07-20 2002-01-31 Cephalon, Inc. Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring
AUPR446701A0 (en) 2001-04-18 2001-05-17 Gene Stream Pty Ltd Transgenic mammals for pharmacological and toxicological studies
KR100462180B1 (ko) * 2001-11-20 2004-12-16 (주) 디지탈바이오텍 알츠하이머병 병인 유전자로 형질전환된 동물 및 그 제조방법
KR100584914B1 (ko) * 2004-03-30 2006-05-30 주식회사 뉴로테크 돌연변이 app를 발현하는 알츠하이머병 유발 형질전환마우스
US8124831B2 (en) * 2006-07-06 2012-02-28 Duke University Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase
CN105494263B (zh) * 2015-12-25 2018-11-30 哈尔滨医科大学 一种产生ho-1/app/psen1三转基因阿尔茨海默病小鼠模型的方法
US10889800B2 (en) 2017-05-25 2021-01-12 New York Stem Cell Foundation, Inc. Method and composition for generating basal forebrain cholinergic neurons (BFCNS)
US10463029B1 (en) * 2018-06-07 2019-11-05 Regeneron Pharmaceuticals, Inc. Rodent model of steel syndrome
CN120168665A (zh) 2019-11-05 2025-06-20 弗尔斯蒂血液研究所基金会股份有限公司 胎儿/新生儿同种免疫性血小板减少症的鼠模型
US11266129B2 (en) 2019-11-05 2022-03-08 Versiti Blood Research Institute Foundation, Inc. Murine model of fetal/neonatal alloimmune thrombocytopenia
RU2757114C1 (ru) * 2020-08-05 2021-10-11 Федеральное государственное бюджетное учреждение науки Институт биологии гена Российской академии наук Способ получения линии гуманизированных мышей, трансгенных по hACE2
KR102584857B1 (ko) * 2020-09-23 2023-10-06 재단법인대구경북과학기술원 알츠하이머 동물모델 및 이의 용도
KR20230009140A (ko) * 2021-07-08 2023-01-17 주식회사 엠케이바이오텍 Human mutant Presenilin-1 발현 인지장애 모델 개의 생산
EP4730993A1 (en) 2023-06-20 2026-04-29 Institut National de la Santé et de la Recherche Médicale A new relevant non-human animal model of progressive metabolic dysfunction-associated steatotic liver disease (masld) and atherosclerosis development

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE153376T1 (de) 1988-04-15 1997-06-15 Du Pont Merck Pharma P1-bakteriophagen-klonierungssystem für bis zu 95 kb grossen dna-fragmenten
US5650550A (en) * 1993-10-01 1997-07-22 The United States Of America As Represented By The Department Of Health And Human Services Mutant mice having a deficit of functional estrogen receptors
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
US5986054A (en) * 1995-04-28 1999-11-16 The Hospital For Sick Children, Hsc Research And Development Limited Partnership Genetic sequences and proteins related to alzheimer's disease
JP2001514528A (ja) * 1997-05-14 2001-09-11 メルク エンド カンパニー インコーポレーテッド 天然プレセニリン1ヌルバックグラウンド上で非天然野生型および家族性アルツハイマー病突然変異プレセニリン1タンパク質を発現するトランスジェニック動物

Also Published As

Publication number Publication date
EP1044605B1 (en) 2007-04-25
NO20003495L (no) 2000-09-07
JP4290329B2 (ja) 2009-07-01
DE69935903T2 (de) 2008-01-10
KR20010040330A (ko) 2001-05-15
CN1292638A (zh) 2001-04-25
CA2317809A1 (en) 1999-07-15
TWI240752B (en) 2005-10-01
US7022893B1 (en) 2006-04-04
DE69935903D1 (de) 2007-06-06
TW200529742A (en) 2005-09-16
RU2266002C2 (ru) 2005-12-20
HK1031983A1 (en) 2001-07-06
KR100646816B1 (ko) 2006-11-17
WO1999034670A1 (en) 1999-07-15
EP1044605A4 (en) 2003-05-07
EP1044605A1 (en) 2000-10-18
AU1784499A (en) 1999-07-26

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