NO20003730L - Triazolo-pyridazinderivater som ligander for GABA reseptorer - Google Patents

Triazolo-pyridazinderivater som ligander for GABA reseptorer

Info

Publication number
NO20003730L
NO20003730L NO20003730A NO20003730A NO20003730L NO 20003730 L NO20003730 L NO 20003730L NO 20003730 A NO20003730 A NO 20003730A NO 20003730 A NO20003730 A NO 20003730A NO 20003730 L NO20003730 L NO 20003730L
Authority
NO
Norway
Prior art keywords
triazolo
ligands
pyridazine derivatives
gaba receptors
gaba
Prior art date
Application number
NO20003730A
Other languages
English (en)
Other versions
NO20003730D0 (no
NO315516B1 (no
Inventor
William Robert Carling
Jose Luis Castro Pineiro
Ian James Collins
Alexander Richard Guiblin
Timothy Harrison
Andrew Madin
Kevin William Moore
Michael Geoffrey Neil Russell
Gayle Scott
Leslie Joseph Street
Original Assignee
Merck Sharp & Dohne Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9801233.9A external-priority patent/GB9801233D0/en
Priority claimed from GBGB9821517.1A external-priority patent/GB9821517D0/en
Application filed by Merck Sharp & Dohne Ltd filed Critical Merck Sharp & Dohne Ltd
Publication of NO20003730D0 publication Critical patent/NO20003730D0/no
Publication of NO20003730L publication Critical patent/NO20003730L/no
Publication of NO315516B1 publication Critical patent/NO315516B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20003730A 1998-01-21 2000-07-20 Triazolo-pyridazinderivater som ligander for GABA-reseptorer NO315516B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9801233.9A GB9801233D0 (en) 1998-01-21 1998-01-21 Therapeutic agents
GBGB9821517.1A GB9821517D0 (en) 1998-10-02 1998-10-02 Therapeutic agents
PCT/GB1999/000103 WO1999037644A1 (en) 1998-01-21 1999-01-13 Triazolo-pyridazine derivatives as ligands for gaba receptors

Publications (3)

Publication Number Publication Date
NO20003730D0 NO20003730D0 (no) 2000-07-20
NO20003730L true NO20003730L (no) 2000-09-20
NO315516B1 NO315516B1 (no) 2003-09-15

Family

ID=26312988

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20003730A NO315516B1 (no) 1998-01-21 2000-07-20 Triazolo-pyridazinderivater som ligander for GABA-reseptorer

Country Status (24)

Country Link
US (2) US6579875B1 (no)
EP (1) EP1049696A1 (no)
JP (1) JP2002501066A (no)
KR (1) KR20010034257A (no)
CN (1) CN1110498C (no)
AU (1) AU748737B2 (no)
BG (1) BG104671A (no)
BR (1) BR9906905A (no)
CA (1) CA2315763A1 (no)
CZ (1) CZ290883B6 (no)
EA (1) EA002755B1 (no)
EE (1) EE200000430A (no)
GE (1) GEP20032868B (no)
HR (1) HRP20000492A2 (no)
HU (1) HUP0100575A3 (no)
IL (1) IL136442A0 (no)
IS (1) IS5540A (no)
MX (1) MXPA00007135A (no)
NO (1) NO315516B1 (no)
NZ (1) NZ504870A (no)
PL (1) PL341652A1 (no)
SK (1) SK10922000A3 (no)
WO (1) WO1999037644A1 (no)
YU (1) YU43800A (no)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6579875B1 (en) * 1998-01-21 2003-06-17 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors
GB9929685D0 (en) 1999-12-15 2000-02-09 Merck Sharp & Dohme Therapeutic agents
GB0017543D0 (en) 2000-07-17 2000-09-06 Merck Sharp & Dohme Therapeutic agents
WO2005058860A1 (ja) * 2003-12-19 2005-06-30 Ube Industries, Ltd. ４−置換又は非置換テトラヒドロピラン−４−カルボン酸化合物又はそのエステル化合物の製法
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
EP2314289A1 (en) 2005-10-31 2011-04-27 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
PT1966214T (pt) * 2005-12-21 2017-02-03 Janssen Pharmaceutica Nv Triazolpiridazinas como moduladores de tirosina quinase
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
CA2651862A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2008030651A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2123619A1 (de) 2008-05-20 2009-11-25 Bayer Schering Pharma AG Neue [F-18]-Markierte L-Glutaminsäure-und L-Glutaminderivate (II), ihre Verwendung sowie Verfahren zu ihrer Herstellung
EP2328414B1 (en) * 2008-08-29 2013-12-11 Concert Pharmaceuticals Inc. Substituted triazolo-pyridazine derivatives
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2454259A1 (en) * 2009-06-23 2012-05-23 Concert Pharmaceuticals Inc. Deuterium-modified triazolo-pyridazine derivatives as gaba-a receptor modulators
ME02847B (me) 2009-07-27 2018-01-20 Gilead Sciences Inc Fuzionisana heterociklična jedinjenja kao modulatori jonskih kanala
EP2621282B1 (en) 2010-09-28 2020-04-15 The Regents of The University of California Gaba agonists in the treatment of disorders associated with metabolic syndrome and gaba combinations in treatment or prophylaxis of type i diabetes
ES2648820T3 (es) 2011-05-10 2018-01-08 Gilead Sciences, Inc. Compuestos heterocíclicos condensados como moduladores de los canales de sodio
TWI478908B (zh) 2011-07-01 2015-04-01 Gilead Sciences Inc 作為離子通道調節劑之稠合雜環化合物
NO3175985T3 (no) 2011-07-01 2018-04-28
GB201321745D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2017151617A1 (en) 2016-02-29 2017-09-08 Dana-Farber Cancer Institute, Inc. Stapled intracellular-targeting antimicrobial peptides to treat infection
CN107344936B (zh) * 2016-05-06 2022-06-03 上海赛默罗生物科技有限公司 三唑哒嗪类衍生物、其制备方法、药物组合物和用途
CA3067047A1 (en) 2017-07-19 2019-01-24 Dana-Farber Cancer Institute, Inc. Stabilized anti-microbial peptides for the treatment of antibiotic-resistant bacterial infections

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230705A (en) 1976-09-22 1980-10-28 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazines and their uses in treating anxiety
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents
US4112095A (en) 1976-10-07 1978-09-05 American Cyanamid Company 6-Phenyl-1,2,4-triazolo[4,3-b]pyridazine hypotensive agents
PH12424A (en) * 1976-10-26 1979-02-15 American Cyanamid Co Method of treating anxiety in mammals
US4260755A (en) 1979-10-31 1981-04-07 American Cyanamid Company Novel 6-phenyl and substituted 6-phenyl-1,2,4-triazolo[4,3-b]pyridazines
US4260756A (en) * 1979-11-15 1981-04-07 American Cyanamid Company 6- And 8-heteroaryl-1,2,4-triazolo[4,3-b]pyridazines
PH21834A (en) 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4654343A (en) 1985-10-31 1987-03-31 American Cyanamid Company N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas
ATE236904T1 (de) * 1996-07-25 2003-04-15 Merck Sharp & Dohme Substituierte triazolo-pyridazin-derivate als liganden von gaba-rezeptoren
US6579875B1 (en) * 1998-01-21 2003-06-17 Merck Sharp & Dohme Limited Triazolo-pyridazine derivatives as ligands for GABA receptors

Also Published As

Publication number Publication date
IL136442A0 (en) 2001-06-14
NO20003730D0 (no) 2000-07-20
HUP0100575A3 (en) 2003-03-28
BG104671A (en) 2001-05-31
US6579875B1 (en) 2003-06-17
CN1288465A (zh) 2001-03-21
EE200000430A (et) 2001-12-17
BR9906905A (pt) 2000-10-10
SK10922000A3 (sk) 2001-03-12
EA200000783A1 (ru) 2000-12-25
EP1049696A1 (en) 2000-11-08
CZ290883B6 (cs) 2002-11-13
JP2002501066A (ja) 2002-01-15
HRP20000492A2 (en) 2000-12-31
IS5540A (is) 2000-06-16
AU2065799A (en) 1999-08-09
KR20010034257A (ko) 2001-04-25
CA2315763A1 (en) 1999-07-29
CZ20002691A3 (cs) 2000-12-13
US6828322B2 (en) 2004-12-07
US20040063714A1 (en) 2004-04-01
HUP0100575A2 (hu) 2001-09-28
MXPA00007135A (es) 2002-11-07
AU748737B2 (en) 2002-06-13
CN1110498C (zh) 2003-06-04
WO1999037644A1 (en) 1999-07-29
YU43800A (sh) 2002-12-10
NZ504870A (en) 2002-11-26
PL341652A1 (en) 2001-04-23
NO315516B1 (no) 2003-09-15
GEP20032868B (en) 2003-01-27
EA002755B1 (ru) 2002-08-29

Similar Documents

Publication Publication Date Title
NO20003730L (no) Triazolo-pyridazinderivater som ligander for GABA reseptorer
NO20032834D0 (no) Benzimidazol- og pyridylimidazol-derivater som ligander for GABA-reseptorer
NO985874D0 (no) Bestemte fosfinylderivater nyttige som naaladase inhibitorer
NO20006071L (no) Isotiazolderivater nyttige som anti-cancer midler
NO20015477D0 (no) 4,5,6,7-tetrahydroindazol-derivater som anti-tumor midler
AU2002232768A1 (en) Benzimidazole and pyridylimidazole derivatives as ligands for GABA receptors
NO20014412D0 (no) Forbindelser nyttige som anti-inflammatoriske midler
DK1456206T3 (da) Azaindolylalkylaminderivater som 5-hydroxytryptamin-6-ligander
AU2002215100A1 (en) Imidazo-pyrimidine derivatives as ligands for gaba receptors
DK1097127T3 (da) Diacylhydrazinderivater som integrininhibitorer
DK0975623T3 (da) Indazolamidforbindelser som sertoninerge midler
DK1455779T3 (da) Indolylalkylaminderivater som 5-hydroxytryptamin-6-ligander
NO20010331D0 (no) Ftalazinderivater som fosfodiesterase 4-inhibitorer
NO974043D0 (no) Indolderivater som EAA-antagonister
AU4439801A (en) Pyrazolo-triazine derivatives as ligands for gaba receptors
NO20002036L (no) Cyklopentenderivater anvendbare som antagonister for motilinreseptoren
NO20000822D0 (no) Substituerte 4-okso-3-karboksamider som GABA- hjernereseptorligander
DK1007512T3 (da) Forgrenede alkoxysubstituerede 2-aminopyridiner som NOS-inhibitorer
DK0747346T3 (da) N-acyl-2-arylcyclopropylmethylaminderivater som melatonerge midler
NO20006227D0 (no) Tetrahydroquiolinderivater som glycin antagonister
DK1075471T3 (da) Idolylderivater som serotonerge midler
DK1347974T3 (da) Aminotriazolopyridinderivater som adenosinreceptorligander
NO20000094D0 (no) 6-Azaurcilderivater som IL-5 inhibitorer
NO983656D0 (no) Heterocyklyl-ergolinderivater som 5-HT1A reseptorligander
HK1030605A (en) Triazolo-pyridazine derivatives as ligands for gaba receptors

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees