NO20003828D0 - 2,3,4,5-Tetrahydro-1H-[1,4]-benzodiazepin-3-hydroksamsyrer som matriks-metalloproteinaseinhibitorer - Google Patents

2,3,4,5-Tetrahydro-1H-[1,4]-benzodiazepin-3-hydroksamsyrer som matriks-metalloproteinaseinhibitorer

Info

Publication number: NO20003828D0
Authority: NO; Norway
Prior art keywords: benzodiazepine; tetrahydro; matrix metalloproteinase; metalloproteinase inhibitors; hydroxamic acids
Prior art date: 1998-01-27

Application number

NO20003828A

Other languages

English (en)

Other versions

NO20003828L (no

Inventor

Jay Donald Albright

Efren Guillermo Delos Santos

Xuemei Du

Original Assignee

American Cyanamid Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-01-27

Filing date

2000-07-26

Publication date

2000-07-26

2000-07-26 Application filed by American Cyanamid Co filed Critical American Cyanamid Co

2000-07-26 Publication of NO20003828D0 publication Critical patent/NO20003828D0/no

2000-09-26 Publication of NO20003828L publication Critical patent/NO20003828L/no

Links

239000003771 matrix metalloproteinase inhibitor Substances 0.000 title 1
229940121386 matrix metalloproteinase inhibitor Drugs 0.000 title 1
YWCKAVNWINYYFA-UHFFFAOYSA-N n-hydroxy-2,3,4,5-tetrahydro-1h-1,4-benzodiazepine-3-carboxamide Chemical class C1NC(C(=O)NO)CNC2=CC=CC=C21 YWCKAVNWINYYFA-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO20003828A 1998-01-27 2000-07-26 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepin-3-hydroksamsyrer som matriks-metalloproteinase inhibitorer NO20003828L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US1437498A	1998-01-27	1998-01-27
PCT/US1999/001325 WO1999037625A1 (en)	1998-01-27	1999-01-22	2,3,4,5-tetrahydro-1h-[1,4]-benzodiazepine-3-hydroxamic acids as matrix metalloproteinase inhibitors

Publications (2)

Publication Number	Publication Date
NO20003828D0 true NO20003828D0 (no)	2000-07-26
NO20003828L NO20003828L (no)	2000-09-26

Family

ID=21765097

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20003828A NO20003828L (no)	1998-01-27	2000-07-26	2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepin-3-hydroksamsyrer som matriks-metalloproteinase inhibitorer

Country Status (14)

Country	Link
EP (1)	EP1051407A1 (no)
JP (1)	JP2002501056A (no)
KR (1)	KR20010034406A (no)
CN (1)	CN1293663A (no)
AR (1)	AR017230A1 (no)
AU (1)	AU2240299A (no)
BR (1)	BR9907746A (no)
CA (1)	CA2317546A1 (no)
HU (1)	HUP0100277A3 (no)
IL (1)	IL137162A0 (no)
NO (1)	NO20003828L (no)
PL (1)	PL342045A1 (no)
WO (1)	WO1999037625A1 (no)
ZA (1)	ZA99569B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458783B1 (en) *	1997-09-29	2002-10-01	Bristol-Myers Squibb Company	Non-imidazole benzodiazepine inhibitors of farnesyl protein transferase
US6544984B1 (en)	1999-01-27	2003-04-08	American Cyanamid Company	2,3,4,5-tetrahydro-1H-(1,4)benzodiazepine-3-hydroxamic acids
AR022423A1 (es) *	1999-01-27	2002-09-04	American Cyanamid Co	Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento
US6808902B1 (en)	1999-11-12	2004-10-26	Amgen Inc.	Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules
US7458374B2 (en)	2002-05-13	2008-12-02	Alexza Pharmaceuticals, Inc.	Method and apparatus for vaporizing a compound
US7585493B2 (en)	2001-05-24	2009-09-08	Alexza Pharmaceuticals, Inc.	Thin-film drug delivery article and method of use
US7766013B2 (en)	2001-06-05	2010-08-03	Alexza Pharmaceuticals, Inc.	Aerosol generating method and device
US20070122353A1 (en)	2001-05-24	2007-05-31	Hale Ron L	Drug condensation aerosols and kits
US7090830B2 (en)	2001-05-24	2006-08-15	Alexza Pharmaceuticals, Inc.	Drug condensation aerosols and kits
TR201809678T4 (tr)	2001-06-26	2018-07-23	Amgen Fremont Inc	Opgl ye karşi antikorlar.
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
US7540286B2 (en)	2004-06-03	2009-06-02	Alexza Pharmaceuticals, Inc.	Multiple dose condensation aerosol devices and methods of forming condensation aerosols
AU2004322756B2 (en)	2004-08-12	2011-04-14	Alexza Pharmaceuticals, Inc.	Aerosol drug delivery device incorporating percussively activated heat packages
ES2594867T3 (es)	2007-03-09	2016-12-23	Alexza Pharmaceuticals, Inc.	Unidad de calentamiento para usar en un dispositivo de administración de fármaco
FR2950057B1 (fr)	2009-09-17	2011-08-26	Galderma Res & Dev	Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2950056B1 (fr)	2009-09-17	2011-08-26	Galderma Res & Dev	Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
MX2020007997A (es)	2018-02-02	2020-12-03	Alexza Pharmaceuticals Inc	Dispositivo electrico de aerosol de condensacion.
EP3860608A1 (en)	2018-10-04	2021-08-11	INSERM (Institut National de la Santé et de la Recherche Médicale)	Egfr inhibitors for treating keratodermas

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TR199800849T2 (xx) *	1995-11-13	1998-07-21	Hoechst Aktiengesellschaft	Siklikle heterosiklik N-ikame edilmi� alfa-iminohidroksamla karbon asitleri
EA003294B1 (ru) *	1995-12-08	2003-04-24	Агурон Фармасьютикалс, Инк.	Ингибиторы металлопротеиназы, фармацевтические композиции, их содержащие, и их фармацевтические применения

1999
- 1999-01-22 CN CN99804237A patent/CN1293663A/zh active Pending
- 1999-01-22 EP EP99902417A patent/EP1051407A1/en not_active Withdrawn
- 1999-01-22 BR BR9907746-9A patent/BR9907746A/pt not_active Application Discontinuation
- 1999-01-22 IL IL13716299A patent/IL137162A0/xx unknown
- 1999-01-22 JP JP2000528549A patent/JP2002501056A/ja active Pending
- 1999-01-22 WO PCT/US1999/001325 patent/WO1999037625A1/en not_active Ceased
- 1999-01-22 HU HU0100277A patent/HUP0100277A3/hu unknown
- 1999-01-22 PL PL99342045A patent/PL342045A1/xx unknown
- 1999-01-22 AU AU22402/99A patent/AU2240299A/en not_active Abandoned
- 1999-01-22 KR KR1020007008171A patent/KR20010034406A/ko not_active Withdrawn
- 1999-01-22 CA CA002317546A patent/CA2317546A1/en not_active Abandoned
- 1999-01-26 ZA ZA9900569A patent/ZA99569B/xx unknown
- 1999-01-26 AR ARP990100299A patent/AR017230A1/es unknown
2000
- 2000-07-26 NO NO20003828A patent/NO20003828L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
NO20003828L (no)	2000-09-26
KR20010034406A (ko)	2001-04-25
ZA99569B (en)	2000-07-26
AU2240299A (en)	1999-08-09
PL342045A1 (en)	2001-05-21
IL137162A0 (en)	2001-07-24
JP2002501056A (ja)	2002-01-15
HUP0100277A3 (en)	2002-03-28
EP1051407A1 (en)	2000-11-15
AR017230A1 (es)	2001-08-22
CA2317546A1 (en)	1999-07-29
HUP0100277A2 (hu)	2002-02-28
WO1999037625A1 (en)	1999-07-29
CN1293663A (zh)	2001-05-02
BR9907746A (pt)	2000-10-17

Legal Events

Date	Code	Title	Description
2001-09-10	FC2A	Withdrawal, rejection or dismissal of laid open patent application

Publication	Publication Date	Title
NO20013675D0 (no)	2001-07-26	2,3,4,5-Tetrahydro-1H-[1,4)benzodiazepin-3-hydroksamsyre som matriks-metalloproteinaseinhibitorer
DK2253620T3 (da)	2014-03-31	Substituerede 3-cyanoquinoliner som protein-tyrosinkinase-inhibitorer
DK1114032T3 (da)	2004-08-16	4-aminosubstituerede-2-substituerede-1,2,3,4-tetrahydroquinoliner som CETB-inhibitorer
TR199501472A2 (tr)	1996-07-21	Matriks metaloproteaz inhibitörler.
DK0925303T3 (da)	2003-02-24	Phosphinsyreamider som matrixmetalloproteaseinhibitorer
DE69716934D1 (de)	2002-12-12	1,3-diheterozyklische metalloprotease inhibitoren
ID27884A (id)	2001-05-03	Asam-asam indolealkanoat yang disubstitusikan.
DK1244647T3 (da)	2006-09-25	Quinzolinderivater som VIGF-inhibitorer
EE200000720A (et)	2002-04-15	Uus 3-arüül-2-hüdroksüpropaanhappe derivaat (I)
FI965156A7 (fi)	1996-12-20	Aryylisulfonamido-substituoidut hydroksaamihapot matriisimetalloprotei naasi-inhibiittoreina
DE69914199D1 (de)	2004-02-19	Langsamlaufender hochdruckturbolader
EE200200069A (et)	2003-04-15	Metalloproteinaaside inhibiitoriteks olevad pürimidiin-3,4,6-trioonid
DE69934483D1 (de)	2007-02-01	Hydraulischer antrieb
DK0934259T3 (da)	2003-01-27	Beta-sulfonamidohydroxamsyrer som matrixmetalloproteinase- og TACE-inhibitorer
DK0975623T3 (da)	2002-10-14	Indazolamidforbindelser som sertoninerge midler
IL137162A0 (en)	2001-07-24	2,3,4,5-tetrahydro -1h- [1,4]-benzodiazepine -3- hydroxamic acids as matrix metalloproteinase inhibitors
DK1023268T3 (da)	2003-06-10	Isoquinoliner som urokinaseinhibitorer.
DK0937036T3 (da)	2002-04-02	Substituerede 4-biphenyl-4-hydroxysmørsyrederivater som matrixmetalprotease-inhibitorer
TR199800841A3 (tr)	1998-12-21	Ikame edilmis 6- ve 7-aminotetrahidroisokinolinkarbon asitleri.
DK1047665T3 (da)	2004-02-02	Matrix metalloprotease inhibitorer
DZ2815A1 (fr)	2003-12-01	Inhibiteurs de protéase.
ZA974032B (en)	1998-02-19	Substituted oxobutyric acids as matrix metalloproteinases inhibitors.
NO20011654L (no)	2001-05-30	Benzamidderivater som trombininhibitorer
NO20010400L (no)	2001-03-26	Isokinoliner som urokinaseinhibitorer
DK1147095T3 (da)	2004-11-15	2,3,4,5-Tetrahydro-1H-[1,4]benzodiazepin-3-hydroxamsyrer som matrixmetalloproteinaseinhibitorer